{"id":"https://openalex.org/W2978339175","doi":"https://doi.org/10.1126/sciadv.aax3641","title":"RNA binding activates RIG-I by releasing an autorepressed signaling domain","display_name":"RNA binding activates RIG-I by releasing an autorepressed signaling domain","publication_year":2019,"publication_date":"2019-10-02","ids":{"openalex":"https://openalex.org/W2978339175","doi":"https://doi.org/10.1126/sciadv.aax3641","mag":"2978339175","pmid":"https://pubmed.ncbi.nlm.nih.gov/31616790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774723"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aax3641","doi":"https://doi.org/10.1126/sciadv.aax3641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax3641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.aax3641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087625863","display_name":"Thayne H. Dickey","orcid":"https://orcid.org/0000-0001-5773-5372","observed_orcids":["https://orcid.org/0000-0001-5773-5372"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. H. Dickey","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0001-5773-5372","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085636762","display_name":"Brian Song","orcid":"https://orcid.org/0000-0003-3061-0769","observed_orcids":["https://orcid.org/0000-0003-3061-0769"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Song","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007909912","display_name":"Anna Marie Pyle","orcid":"https://orcid.org/0000-0001-9045-8872","observed_orcids":["https://orcid.org/0000-0001-9045-8872"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. M. Pyle","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA","Howard Hughes Medical Institute, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0001-9045-8872","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007909912"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.8839,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70198997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"10","first_page":"eaax3641","last_page":"eaax3641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rna-binding","display_name":"RNA binding","score":0.746999979019165},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.4830000102519989},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6555012464523315},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.5774208903312683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5149458050727844},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.4976218044757843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45731115341186523},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40624579787254333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28795063495635986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22000527381896973},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18555977940559387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16317257285118103},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.08769664168357849},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071457","descriptor_name":"DEAD Box Protein 58","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.aax3641","doi":"https://doi.org/10.1126/sciadv.aax3641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax3641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6774723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6774723","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:31616790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31616790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aax3641","doi":"https://doi.org/10.1126/sciadv.aax3641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax3641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1509261556","https://openalex.org/W1828984543","https://openalex.org/W1886265516","https://openalex.org/W1965250565","https://openalex.org/W1965892231","https://openalex.org/W1970743827","https://openalex.org/W1973610263","https://openalex.org/W2007991349","https://openalex.org/W2008601282","https://openalex.org/W2018828712","https://openalex.org/W2032948492","https://openalex.org/W2039885485","https://openalex.org/W2041281845","https://openalex.org/W2043379214","https://openalex.org/W2053665358","https://openalex.org/W2057990302","https://openalex.org/W2061173833","https://openalex.org/W2065868028","https://openalex.org/W2067706259","https://openalex.org/W2080778613","https://openalex.org/W2089054288","https://openalex.org/W2093579074","https://openalex.org/W2097114111","https://openalex.org/W2098614296","https://openalex.org/W2106106042","https://openalex.org/W2107513655","https://openalex.org/W2107962891","https://openalex.org/W2110367525","https://openalex.org/W2120772351","https://openalex.org/W2127832771","https://openalex.org/W2137303998","https://openalex.org/W2141137217","https://openalex.org/W2144362290","https://openalex.org/W2149613931","https://openalex.org/W2158217876","https://openalex.org/W2159829473","https://openalex.org/W2160434954","https://openalex.org/W2163325684","https://openalex.org/W2178253322","https://openalex.org/W2256482451","https://openalex.org/W2297710074","https://openalex.org/W2519450415","https://openalex.org/W2748586815","https://openalex.org/W2760872916","https://openalex.org/W2783161486","https://openalex.org/W2805720835","https://openalex.org/W2884771703","https://openalex.org/W2891912276","https://openalex.org/W2892732519","https://openalex.org/W2904017346","https://openalex.org/W4243831105"],"related_works":["https://openalex.org/W1991579673","https://openalex.org/W1995707457","https://openalex.org/W3200727625","https://openalex.org/W2549310948","https://openalex.org/W2079429068","https://openalex.org/W2060783512","https://openalex.org/W1828984543","https://openalex.org/W2783161486","https://openalex.org/W2511879275","https://openalex.org/W6902506961"],"abstract_inverted_index":{"The":[0],"retinoic":[1],"acid-inducible":[2],"gene":[3],"I":[4],"(RIG-I)":[5],"innate":[6],"immune":[7],"receptor":[8],"is":[9,109,117],"an":[10],"important":[11],"immunotherapeutic":[12],"target,":[13],"but":[14,123],"we":[15],"lack":[16],"approaches":[17],"for":[18,23,58],"monitoring":[19],"the":[20,70,78,83,87,98,113,142],"physical":[21],"basis":[22],"its":[24],"activation":[25,41,61],"in":[26,30,62,127,136],"vitro.":[27],"This":[28,72],"gap":[29],"our":[31],"understanding":[32],"has":[33],"led":[34],"to":[35,76,96,111],"confusion":[36],"about":[37],"mechanisms":[38],"of":[39,69,90,100,144],"RIG-I":[40,60,91,134],"and":[42,46,119,139],"difficulty":[43],"discovering":[44],"agonists":[45],"antagonists.":[47],"We":[48,103],"therefore":[49],"created":[50],"a":[51,124],"novel":[52],"fluorescence":[53],"resonance":[54],"energy":[55],"transfer-based":[56],"method":[57],"measuring":[59],"vitro":[63],"using":[64],"dual":[65],"site-specific":[66],"fluorescent":[67],"labeling":[68],"protein.":[71],"approach":[73],"enables":[74],"us":[75],"measure":[77],"conformational":[79],"change":[80],"that":[81,106],"releases":[82],"signaling":[84,114],"domain":[85],"during":[86],"first":[88],"step":[89],"activation,":[92],"making":[93],"it":[94],"possible":[95],"understand":[97],"role":[99,126],"stimulatory":[101],"ligands.":[102],"have":[104],"found":[105],"RNA":[107],"alone":[108],"sufficient":[110],"eject":[112],"domain,":[115],"ejection":[116],"reversible,":[118],"adenosine":[120],"triphosphate":[121],"plays":[122],"minor":[125],"this":[128],"process.":[129],"These":[130],"findings":[131],"help":[132],"explain":[133],"dysfunction":[135],"autoimmune":[137],"disease,":[138],"they":[140],"inform":[141],"design":[143],"therapeutics":[145],"targeting":[146],"RIG-I.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-10T00:00:00"}
