{"id":"https://openalex.org/W2978280164","doi":"https://doi.org/10.14309/00000434-201410002-01315","title":"A Rare Presentation of Autoimmune Hepatitis Associated With Peripheral Eosinophilia","display_name":"A Rare Presentation of Autoimmune Hepatitis Associated With Peripheral Eosinophilia","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2978280164","doi":"https://doi.org/10.14309/00000434-201410002-01315","mag":"2978280164"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201410002-01315","doi":"https://doi.org/10.14309/00000434-201410002-01315","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201410002-01315","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086651561","display_name":"Kartik Ramakrishna","orcid":"https://orcid.org/0000-0002-5092-2068","observed_orcids":["https://orcid.org/0000-0002-5092-2068"]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartik Ramakrishna","raw_affiliation_strings":["Unity Health System, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unity Health System, Rochester, NY","institution_ids":["https://openalex.org/I4210098088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049468845","display_name":"Kaartik Soota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaartik Soota","raw_affiliation_strings":["Unity Health System, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unity Health System, Rochester, NY","institution_ids":["https://openalex.org/I4210098088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075838338","display_name":"Gokul Samudrala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gokul Samudrala","raw_affiliation_strings":["Unity Health System, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unity Health System, Rochester, NY","institution_ids":["https://openalex.org/I4210098088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109476831","display_name":"Manuel Matos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel Matos","raw_affiliation_strings":["Unity Health System, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unity Health System, Rochester, NY","institution_ids":["https://openalex.org/I4210098088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016642963","display_name":"Deerajnath Lingutla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deerajnath Lingutla","raw_affiliation_strings":["Unity Health System, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unity Health System, Rochester, NY","institution_ids":["https://openalex.org/I4210098088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210098088"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39471341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":null,"first_page":"S387","last_page":"S387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peripheral-eosinophilia","display_name":"peripheral eosinophilia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypergammaglobulinemia","display_name":"hypergammaglobulinemia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.574999988079071},{"id":"https://openalex.org/keywords/hepatosplenomegaly","display_name":"hepatosplenomegaly","score":0.7680000066757202},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.47999998927116394},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8809396028518677},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.7787778377532959},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.5877945423126221},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.568494439125061},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.5357702374458313},{"id":"https://openalex.org/C2779440204","wikidata":"https://www.wikidata.org/wiki/Q1260186","display_name":"Hepatosplenomegaly","level":3,"score":0.5024302005767822},{"id":"https://openalex.org/C2780514984","wikidata":"https://www.wikidata.org/wiki/Q17146775","display_name":"Hypergammaglobulinemia","level":3,"score":0.5000922679901123},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4678305685520172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4669782817363739},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.443350225687027},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.43700048327445984},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4262779951095581},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3657922148704529},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.3231549859046936},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201410002-01315","doi":"https://doi.org/10.14309/00000434-201410002-01315","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201410002-01315","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979542215","https://openalex.org/W4409986563","https://openalex.org/W4285404816","https://openalex.org/W96339927","https://openalex.org/W4403720895","https://openalex.org/W4403720935","https://openalex.org/W3036204586","https://openalex.org/W88035417","https://openalex.org/W4321786456","https://openalex.org/W2313980402"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,82,290,319],"clinical":[2,291],"presentation":[3,292],"of":[4,24,48,64,84,185,217,231,284,296,321,332,350,356,386],"autoimmune":[5,309],"hepatitis":[6,66,212],"(AIH)":[7],"is":[8,280,327,370],"highly":[9],"variable":[10],"and":[11,54,71,79,122,132,151,169,187,198,204,224,244,270,311,362],"provides":[12],"a":[13,21,25,45,180,229,245,287],"significant":[14,354],"diagnostic":[15],"challenge":[16],"for":[17,134],"physicians.":[18],"We":[19],"present":[20],"rare":[22],"case":[23],"young":[26],"female":[27,38,288],"with":[28,30,39,44,68,94,102,194,213,249,257,259,286,306,335,358,380,382],"AIH-associated":[29],"peripheral":[31,322,336],"eosinophilia.":[32],"Case":[33],"Report:":[34],"A":[35,67,139,353],"24-year-old":[36],"white":[37],"an":[40,62,281],"intellectual":[41],"disability":[42],"presented":[43],"2-week":[46],"history":[47],"mild":[49],"fever,":[50],"new":[51],"onset":[52],"ascites,":[53,77,168],"leg":[55],"swelling.":[56],"Two":[57],"months":[58],"ago,":[59],"she":[60],"had":[61],"episode":[63],"acute":[65],"positive":[69,240],"IgG":[70,140],"IgM":[72,145],"antibodies.":[73],"Physical":[74],"examination":[75,131],"revealed":[76,179],"hepatomegaly,":[78],"pedal":[80],"edema.":[81,172],"rest":[83],"her":[85,237,262,271],"exam":[86],"was":[87,146,157,161,174,192,233,252,345],"unremarkable.":[88,175],"Laboratory":[89],"data":[90],"showed":[91,128,165,210],"leukocytosis":[92],"(12.7)":[93],"eosinophilia":[95,323,337],"(64%).":[96],"Liver":[97,208],"function":[98],"tests":[99],"were":[100,136,154,206],"abnormal":[101],"bilirubin":[103],"1.4":[104],"mg/dL,":[105],"albumin":[106,183],"2.8":[107,186],"g/dL,":[108,112],"elevated":[109],"globulin":[110],"4.7":[111],"ALT":[113],"212":[114],"U/L,":[115,118,121],"AST":[116],"234":[117],"ALP":[119],"209":[120],"INR":[123],"1.53.":[124],"Serum":[125],"protein":[126],"electrophoresis":[127],"hypergammaglobulinemia.":[129],"Stool":[130],"serology":[133],"parasites":[135],"negative.":[137,155],"Hepatitis":[138],"antibody":[141],"remained":[142],"reactive":[143],"while":[144],"now":[147],"equivocal.":[148],"HBsAg,":[149],"anti-HCV,":[150],"serum":[152,181],"acetaminophen":[153],"ANA":[156],"positive.":[158],"Total":[159],"complement":[160],"low.":[162],"CT":[163],"abdomen":[164],"hepatosplenomegaly,":[166],"marked":[167],"abdominal":[170],"wall":[171],"ECHO":[173],"Ascitic":[176],"fluid":[177],"analysis":[178],"ascites":[182],"gradient":[184],"unremarkable":[188],"cytology.":[189],"Bone":[190],"marrow":[191],"normocellular":[193],"iron":[195],"deficiency,":[196],"eosinophilia,":[197],"no":[199],"increase":[200],"in":[201,261,316,324,341,372],"blasts.":[202],"Cytogenetics":[203],"FISH":[205],"normal.":[207],"biopsy":[209,247],"chronic":[211,297],"moderate":[214],"periportal":[215],"infiltrate":[216],"small":[218],"lymphocytes,":[219],"plasma":[220],"cells,":[221],"few":[222,330],"eosinophils,":[223],"extensive":[225],"bridging":[226],"fibrosis.":[227],"Hence,":[228,367],"diagnosis":[230],"AIH":[232,279,333,359],"made":[234],"based":[235],"on":[236,254],"presentation,":[238],"hypergammaglobulinemia,":[239],"ANA,":[241],"low":[242],"complement,":[243],"liver":[246,265,285,298],"compatible":[248],"AIH.":[250],"She":[251],"started":[253],"steroids,":[255],"along":[256],"diuretics,":[258],"improvement":[260],"symptoms.":[263],"Her":[264],"enzymes":[266],"continued":[267],"to":[268,276],"improve":[269],"eosinophil":[272],"count":[273],"normalized":[274],"prior":[275],"discharge.":[277],"Discussion:":[278],"inflammatory":[282],"disease":[283],"preponderance.":[289],"mainly":[293],"includes":[294,377],"features":[295],"disease.":[299],"It":[300],"can,":[301],"at":[302],"times,":[303],"be":[304],"associated":[305,334],"other":[307,387],"extra-hepatic":[308],"disorders":[310],"overlap":[312],"syndromes":[313],"not":[314],"seen":[315],"our":[317,325],"patient.":[318],"cause":[320],"patient":[326],"unclear.":[328],"Very":[329],"cases":[331],"have":[338],"been":[339],"reported":[340],"literature.":[342],"Hypereosinophilic":[343],"syndrome":[344],"excluded":[346],"by":[347],"the":[348,384],"lack":[349],"organ":[351],"involvement.":[352],"percentage":[355],"patients":[357],"develop":[360,364],"cirrhosis,":[361],"5%":[363],"hepatocellular":[365],"cancer.":[366],"cancer":[368],"surveillance":[369],"important":[371],"these":[373],"patients.":[374],"Treatment":[375],"usually":[376],"steroid":[378],"therapy":[379],"or":[381],"out":[383],"use":[385],"immunosuppressive":[388],"therapy.":[389]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-10-10T00:00:00"}