{"id":"https://openalex.org/W2978258117","doi":"https://doi.org/10.14309/00000434-200910003-00913","title":"Colonic Kaposi\u02bcs Sarcoma and Diffuse Large B Cell Lymphoma in a Patient with CVID-Associated Enteropathy","display_name":"Colonic Kaposi\u02bcs Sarcoma and Diffuse Large B Cell Lymphoma in a Patient with CVID-Associated Enteropathy","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2978258117","doi":"https://doi.org/10.14309/00000434-200910003-00913","mag":"2978258117"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-200910003-00913","doi":"https://doi.org/10.14309/00000434-200910003-00913","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200910003-00913","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059142660","display_name":"Joel R. Pekow","orcid":"https://orcid.org/0000-0002-4790-8994","observed_orcids":["https://orcid.org/0000-0002-4790-8994"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Pekow","raw_affiliation_strings":["","Department of Medicine, University of Chicago, Chicago, IL","2. Rush University Medical College, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"2. Rush University Medical College, Chicago, IL","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077088911","display_name":"Shriram M. Jakate","orcid":"https://orcid.org/0000-0002-8355-3481","observed_orcids":["https://orcid.org/0000-0002-8355-3481"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shriram Jakate","raw_affiliation_strings":[". Rush University Medical College, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Rush University Medical College, Chicago, IL","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002619544","display_name":"Ali Keshavarzian","orcid":"https://orcid.org/0000-0002-7969-3369","observed_orcids":["https://orcid.org/0000-0002-7969-3369"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Keshavarzian","raw_affiliation_strings":[". Rush University Medical College, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Rush University Medical College, Chicago, IL","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049169459","display_name":"David T. Rubin","orcid":"https://orcid.org/0000-0001-5647-1723","observed_orcids":["https://orcid.org/0000-0001-5647-1723"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rubin","raw_affiliation_strings":["","Department of Medicine, University of Chicago, Chicago, IL","2. Rush University Medical College, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"2. Rush University Medical College, Chicago, IL","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45494532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":null,"first_page":"S337","last_page":"S337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/common-variable-immunodeficiency","display_name":"common variable immunodeficiency","score":0.9660000205039978},{"id":"https://openalex.org/keywords/human-herpesvirus-8","display_name":"human herpesvirus 8","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gastrointestinal-kaposi-s-sarcoma","display_name":"gastrointestinal Kaposi's sarcoma","score":0.7710000276565552},{"id":"https://openalex.org/keywords/colonic-lymphoma","display_name":"colonic lymphoma","score":0.7160000205039978},{"id":"https://openalex.org/keywords/colectomy","display_name":"colectomy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.5479999780654907},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.531000018119812},{"id":"https://openalex.org/keywords/differential-diagnosis-of-inflammatory-bowel-disease","display_name":"inflammatory bowel disease differential diagnosis","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9303743839263916},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.7603049278259277},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.6109250783920288},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5628232955932617},{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.5475195646286011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.53943932056427},{"id":"https://openalex.org/C2776870353","wikidata":"https://www.wikidata.org/wiki/Q677253","display_name":"Sigmoid colon","level":3,"score":0.4619709551334381},{"id":"https://openalex.org/C2778292851","wikidata":"https://www.wikidata.org/wiki/Q2562565","display_name":"Descending colon","level":3,"score":0.4396815598011017},{"id":"https://openalex.org/C2776433325","wikidata":"https://www.wikidata.org/wiki/Q1472818","display_name":"Common variable immunodeficiency","level":3,"score":0.4386006295681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4048674702644348},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.2281111478805542},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.186211496591568},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1838865578174591},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1683247983455658},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-200910003-00913","doi":"https://doi.org/10.14309/00000434-200910003-00913","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200910003-00913","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403720378","https://openalex.org/W4387750925","https://openalex.org/W7113901368","https://openalex.org/W3094314070","https://openalex.org/W2912720429","https://openalex.org/W2990377412","https://openalex.org/W6981941082","https://openalex.org/W2150035599","https://openalex.org/W3094609373","https://openalex.org/W3210116428"],"abstract_inverted_index":{"Purpose:":[0],"44-year-old":[1],"man":[2],"who":[3],"was":[4,16,27,66,81,115,125,136,378],"well":[5,48,104,169],"until":[6,50],"his":[7,55],"20s":[8],"when":[9,54],"he":[10,26,69,97],"developed":[11],"repeated":[12],"parasitic":[13],"infections":[14],"and":[15,35,61,68,120,145,256,382,392],"diagnosed":[17,379],"with":[18,37,110,128,155,173,180,197,216,226,240,278,292,310,323,350,371,380],"common":[19],"variable":[20],"immunodeficiency":[21],"(CVID).":[22],"Eight":[23],"years":[24],"ago,":[25],"started":[28,82],"on":[29,42,83,122,192],"IVIG":[30,90],"because":[31],"of":[32,132,176,184,231,246,259,264,276,300,308,348,366,375,397],"abdominal":[33,56,101],"pain":[34,57,102],"diarrhea":[36],"patchy":[38,149],"active":[39,150],"inflammation":[40,76,151],"seen":[41],"colonoscopy.":[43],"His":[44],"symptoms":[45],"were":[46],"relatively":[47],"controlled":[49],"one":[51],"year":[52,95],"ago":[53],"became":[58],"more":[59],"constant":[60],"severe.":[62],"An":[63,138],"infectious":[64],"workup":[65],"negative":[67],"had":[70,384],"a":[71,129,146,174,204,238,297],"colonoscopy,":[72],"which":[73,386],"showed":[74,223],"scattered":[75],"throughout":[77,152],"the":[78,89,153,159,181,229,247,344,364,388],"colon.":[79,161],"He":[80,114,124,235],"oral":[84],"mesalamine":[85],"in":[86,158,212,321,363,369,401],"addition":[87],"to":[88,99,117,296,306],"infusions":[91],"without":[92],"improvement.":[93],"One":[94],"later,":[96],"continued":[98],"have":[100,118,281,294,312,358],"as":[103,105,168,170],"frequent":[106],"loose":[107],"bowel":[108,272],"movements":[109],"ongoing":[111],"weight":[112],"loss.":[113],"noted":[116],"splenomegaly":[119],"lymphadenopathy":[121],"exam.":[123],"also":[126,280],"pancytopenic":[127],"CD4":[130,283],"count":[131],"179;":[133],"HIV":[134],"antibody":[135],"negative.":[137],"EGD":[139],"revealed":[140,164,189,207,249],"normal":[141],"appearing":[142],"duodenal":[143],"mucosa,":[144],"colonoscopy":[147],"demonstrated":[148],"colon":[154,248],"deep":[156],"ulcers":[157],"sigmoid":[160],"Duodenal":[162],"biopsies":[163,188],"mild":[165],"villous":[166],"blunting":[167],"intraepithelial":[171],"lymphocytosis":[172],"paucity":[175],"plasma":[177],"cells":[178,210,222],"consistent":[179],"previous":[182],"diagnosis":[183,230],"CVID-associated":[185,265],"enteropathy.":[186],"Colon":[187],"viral":[190],"inclusions":[191],"H":[193],"+":[194],"E":[195],"stain":[196],"positive":[198],"immunohistochemical":[199],"staining":[200],"for":[201],"CMV.":[202],"Additionally,":[203],"submucosal":[205],"nodule":[206],"monomorphic":[208],"spindle":[209],"arranged":[211],"an":[213,241],"ill-defined":[214],"fascicles":[215],"extravasated":[217],"red":[218],"blood":[219],"cells.":[220],"Spindle":[221],"nuclear":[224],"reactivity":[225],"HHV-8,":[227],"establishing":[228],"Kaposi's":[232],"sarcoma":[233],"(KS).":[234],"subsequently":[236],"underwent":[237],"colectomy":[239],"ileorectal":[242],"anastamosis.":[243],"Pathologic":[244],"examination":[245],"both":[250],"diffuse":[251],"large":[252],"B":[253],"cell":[254,284],"lymphoma":[255],"multiple":[257],"foci":[258],"KS.":[260,356],"The":[261,315],"endoscopic":[262,316],"appearance":[263],"enteropathy":[266],"can":[267],"be":[268,395],"indistinguishable":[269],"from":[270],"inflammatory":[271],"disease.":[273],"Approximately":[274],"25%":[275],"patients":[277,291,309,334,370,377],"CVID":[279,293,349,381],"low":[282],"counts.":[285],"It":[286],"has":[287],"been":[288,359],"reported":[289,320,346],"that":[290],"up":[295],"5-fold":[298],"risk":[299],"malignancy,":[301],"most":[302,318],"commonly":[303,319],"lymphoma.":[304],"Up":[305],"40%":[307],"KS":[311,324,329,368,385],"gastrointestinal":[313],"involvement.":[314],"finding":[317],"association":[322],"is":[325,330,343],"hemorrhagic":[326],"nodules.":[327],"Gastrointestinal":[328],"typically":[331],"asymptomatic,":[332],"although":[333],"may":[335],"develop":[336],"GI":[337,351,389],"bleeding,":[338],"obstruction":[339],"or":[340],"perforation.":[341],"This":[342],"first":[345],"case":[347,361],"involvement":[352],"complicated":[353],"by":[354],"colonic":[355],"There":[357],"6":[360],"reports":[362],"literature":[365],"visceral":[367],"hypogammaglobulinemia.":[372],"However,":[373],"none":[374,383],"these":[376],"involved":[387],"tract.":[390],"Clinicians":[391],"pathologists":[393],"should":[394],"aware":[396],"this":[398,402],"potential":[399],"complication":[400],"rare":[403],"disorder.":[404]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-10-10T00:00:00"}