{"id":"https://openalex.org/W2978047381","doi":"https://doi.org/10.14309/00000434-200809001-00793","title":"Ischemic Hepatitis Secondary to Obstructive Sleep Apnea (OSA)","display_name":"Ischemic Hepatitis Secondary to Obstructive Sleep Apnea (OSA)","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2978047381","doi":"https://doi.org/10.14309/00000434-200809001-00793","mag":"2978047381"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-200809001-00793","doi":"https://doi.org/10.14309/00000434-200809001-00793","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200809001-00793","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062554046","display_name":"Anita Bhushan","orcid":"https://orcid.org/0009-0004-8056-5219","observed_orcids":["https://orcid.org/0009-0004-8056-5219"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anita Bhushan","raw_affiliation_strings":["Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012239800","display_name":"Patrick S. Kamath","orcid":"https://orcid.org/0000-0002-7888-1165","observed_orcids":["https://orcid.org/0000-0002-7888-1165"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Kamath","raw_affiliation_strings":["Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062554046"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44770458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"103","issue":null,"first_page":"S312","last_page":"S313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-hepatitis","display_name":"ischemic hepatitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":1.0},{"id":"https://openalex.org/keywords/arterial-hypoxemia","display_name":"arterial hypoxemia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/acute-liver-injury","display_name":"acute liver injury","score":0.8370000123977661},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"steatohepatitis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/nocturnal-hypoxemia","display_name":"nocturnal hypoxemia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.7490000128746033},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9562111496925354},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.618000864982605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6124894022941589},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.48788952827453613},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.4870877265930176},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48461899161338806},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.45591673254966736},{"id":"https://openalex.org/C2779864607","wikidata":"https://www.wikidata.org/wiki/Q19720556","display_name":"Centrilobular necrosis","level":3,"score":0.4430781602859497},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44057103991508484},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.43197542428970337},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4251213073730469},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4232466220855713},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.3488598167896271},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.16407063603401184}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-200809001-00793","doi":"https://doi.org/10.14309/00000434-200809001-00793","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200809001-00793","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023338192","https://openalex.org/W4240619162","https://openalex.org/W2026677462","https://openalex.org/W1996563013","https://openalex.org/W3106662718","https://openalex.org/W1996298304","https://openalex.org/W1992142896","https://openalex.org/W2192025299","https://openalex.org/W2073948664","https://openalex.org/W2357177496"],"abstract_inverted_index":{"Purpose:":[0],"Ischemic":[1,35,284],"hepatitis":[2,36,146,285],"refers":[3],"to":[4,29,41,66,230,256,293],"diffuse":[5],"hepatic":[6,13],"injury":[7,64],"which":[8],"results":[9],"from":[10],"imbalance":[11],"between":[12],"oxygen":[14,98,229],"supply":[15],"and":[16,81,125,143,149,166,177,198,209,227,244,276,315],"demand.":[17],"Patients":[18],"with":[19,57,61,77,87,97,113,260],"OSA":[20,67,84,291,320],"have":[21],"recurrent":[22],"episodes":[23],"of":[24,48,54,83,100,158,290,306,311,317,319,325,333],"respiratory":[25],"airflow":[26],"obstruction":[27],"secondary":[28,40,65,292],"upper":[30],"airway":[31],"collapse":[32],"during":[33,234],"sleep.":[34,235],"may,":[37],"therefore,":[38],"occur":[39],"severe":[42,294],"arterial":[43,295],"hypoxemia":[44],"as":[45],"a":[46,52,55,249,272,287,326],"result":[47,322],"OSA.":[49],"We":[50],"report":[51],"case":[53],"patient":[56,92,222,254],"class":[58,78],"III":[59,79],"obesity":[60,80],"acute":[62,329],"liver":[63,111,188,308,330],"induced":[68],"hypoxemia.":[69,296],"Methods:":[70],"A":[71,186],"53":[72],"year":[73],"old":[74],"Caucasian":[75],"male":[76],"history":[82],"was":[85,93,120,128,154,184,190,219,223],"admitted":[86],"lower":[88],"extremity":[89],"cellulitis.":[90],"The":[91,212,221],"afebrile,":[94],"hemodynamically":[95],"stable":[96],"saturation":[99,217,233],"87%":[101],"on":[102,225],"room":[103],"air.":[104],"Laboratory":[105],"studies":[106],"were":[107,151],"significant":[108,261],"for":[109,145,280],"elevated":[110],"transaminases":[112],"AST":[114],"1020,":[115],"ALT":[116],"2202.":[117],"Total":[118],"bilirubin":[119,123],"0.9,":[121],"direct":[122],"0.4":[124],"alkaline":[126],"phosphatase":[127],"within":[129],"normal":[130,164,174],"limits.":[131],"History":[132],"did":[133],"not":[134],"suggest":[135],"viral,":[136],"autoimmune":[137],"or":[138],"drug-induced":[139],"hepatitis.":[140],"Autoimmune":[141],"markers":[142],"serologies":[144],"A,":[147],"B":[148],"C":[150],"negative.":[152],"There":[153],"no":[155],"clinical":[156],"evidence":[157],"cardiac":[159],"failure.":[160],"Results:":[161],"Echocardiogram":[162],"showed":[163,193,207],"left":[165],"right":[167],"systolic":[168],"function.":[169],"Right":[170],"heart":[171],"catheterization":[172],"revealed":[173],"pulmonary":[175],"artery":[176],"wedge":[178],"pressures.":[179],"Hepatic":[180],"portal":[181],"vein":[182],"gradient":[183],"normal.":[185],"transjugular":[187],"biopsy":[189],"performed.":[191],"Histopathology":[192],"zone":[194],"3":[195,250],"hepatocellular":[196],"necrosis,":[197],"mildly":[199],"active":[200],"steatohepatitis":[201],"without":[202],"fibrosis.":[203],"Nocturnal":[204],"pulse":[205,265],"oximetry":[206],"multiple":[208],"profound":[210],"desaturations.":[211],"cumulative":[213],"time":[214],"spent":[215],"at":[216],"<85%":[218],"87%.":[220],"started":[224],"CPAP":[226,258],"supplemental":[228],"maintain":[231],"optimal":[232],"Liver":[236,334],"enzymes":[237],"improved":[238],"over":[239],"the":[240,253,303],"next":[241],"few":[242],"days":[243],"eventually":[245],"completely":[246],"normalized.":[247],"On":[248],"month":[251],"follow-up,":[252],"continues":[255],"use":[257],"machine":[259],"improvement":[262],"in":[263,271,302,323],"nocturnal":[264],"oximetry.":[266],"He":[267],"has":[268],"been":[269],"enrolled":[270],"weight":[273],"reduction":[274],"program":[275],"is":[277,286],"undergoing":[278],"evaluation":[279],"bariatric":[281],"surgery.":[282],"Conclusion:":[283],"rare":[288],"manifestation":[289],"This":[297],"entity":[298],"should":[299],"be":[300],"considered":[301],"differential":[304],"diagnosis":[305],"ischemic":[307],"injury.":[309],"Institution":[310],"correct":[312],"management":[313],"strategies":[314],"prevention":[316,324],"complications":[318],"can":[321],"potentially":[327],"fatal":[328],"injury.Figure:":[331],"Graph":[332],"Transaminases":[335]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-10T00:00:00"}