{"id":"https://openalex.org/W2977985773","doi":"https://doi.org/10.1093/annonc/mdz253.057","title":"Master checkpoint Cbl-b inhibition: Anti-tumour efficacy in a murine colorectal cancer model following siRNA-based cell therapy","display_name":"Master checkpoint Cbl-b inhibition: Anti-tumour efficacy in a murine colorectal cancer model following siRNA-based cell therapy","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2977985773","doi":"https://doi.org/10.1093/annonc/mdz253.057","mag":"2977985773"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdz253.057","doi":"https://doi.org/10.1093/annonc/mdz253.057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz253.057","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)59443-1/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annalsofoncology.org/article/S0923-7534(19)59443-1/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090120853","display_name":"Kathrin Thell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156824","display_name":"Apeiron Biologics (Austria)","ror":"https://ror.org/058kq6588","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210156824"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K. Thell","raw_affiliation_strings":["Research & Development, Apeiron Biologics AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Apeiron Biologics AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210156824"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Urban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156824","display_name":"Apeiron Biologics (Austria)","ror":"https://ror.org/058kq6588","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210156824"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Urban","raw_affiliation_strings":["Research & Development, Apeiron Biologics AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Apeiron Biologics AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210156824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029076564","display_name":"Julia Harrauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156824","display_name":"Apeiron Biologics (Austria)","ror":"https://ror.org/058kq6588","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210156824"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J. Harrauer","raw_affiliation_strings":["Research & Development, Apeiron Biologics AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Apeiron Biologics AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210156824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071589941","display_name":"Isabella Haslinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156824","display_name":"Apeiron Biologics (Austria)","ror":"https://ror.org/058kq6588","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210156824"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"I. Haslinger","raw_affiliation_strings":["Research & Development, Apeiron Biologics AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Apeiron Biologics AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210156824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019047983","display_name":"Mario Kuttke","orcid":"https://orcid.org/0000-0003-3517-2841","observed_orcids":["https://orcid.org/0000-0003-3517-2841"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Kuttke","raw_affiliation_strings":["Institute of Physiology, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068358361","display_name":"Julia S. Brunner","orcid":"https://orcid.org/0000-0002-3195-147X","observed_orcids":["https://orcid.org/0000-0002-3195-147X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J.S. Brunner","raw_affiliation_strings":["Institute of Physiology, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079225705","display_name":"Andrea Vogel","orcid":"https://orcid.org/0000-0002-2613-140X","observed_orcids":["https://orcid.org/0000-0002-2613-140X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Vogel","raw_affiliation_strings":["Institute of Physiology, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032093610","display_name":"Gernot Schabbauer","orcid":"https://orcid.org/0000-0002-7490-8009","observed_orcids":["https://orcid.org/0000-0002-7490-8009"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G. Schabbauer","raw_affiliation_strings":["Institute of Physiology, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059310975","display_name":"Josef Martin Penninger","orcid":"https://orcid.org/0000-0002-8194-3777","observed_orcids":["https://orcid.org/0000-0002-8194-3777"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Penninger","raw_affiliation_strings":["Life Sciences Institute & Dept of Medical Genetics, University of British Columbia, Vancover, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Institute & Dept of Medical Genetics, University of British Columbia, Vancover, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053485404","display_name":"Anderson S. Gaweco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156824","display_name":"Apeiron Biologics (Austria)","ror":"https://ror.org/058kq6588","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210156824"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Gaweco","raw_affiliation_strings":["Global Clinical Development, Apeiron Biologics AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Clinical Development, Apeiron Biologics AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210156824"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":null,"fwci":0.4476,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62462794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"30","issue":null,"first_page":"v503","last_page":"v504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cbl-b","display_name":"Cbl-b","score":0.9940000176429749},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.7089999914169312},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mc38-tumor-model","display_name":"MC38 tumor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.777999997138977},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6632905602455139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.631837010383606},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6196915507316589},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5957980155944824},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5307497978210449},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5228184461593628},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5162382125854492},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4664299786090851},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30128657817840576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19993743300437927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12062767148017883},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdz253.057","doi":"https://doi.org/10.1093/annonc/mdz253.057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz253.057","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)59443-1/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdz253.057","doi":"https://doi.org/10.1093/annonc/mdz253.057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdz253.057","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(19)59443-1/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977985773.pdf","grobid_xml":"https://content.openalex.org/works/W2977985773.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993613817","https://openalex.org/W2891398773","https://openalex.org/W4308395750","https://openalex.org/W2892310485","https://openalex.org/W4365511966","https://openalex.org/W2783823284","https://openalex.org/W4308396769","https://openalex.org/W2230828584","https://openalex.org/W2052542332","https://openalex.org/W7220400638"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-10-10T00:00:00"}