{"id":"https://openalex.org/W2977635225","doi":"https://doi.org/10.1002/cyto.b.21845","title":"Flow cytometric features of incidental indolent T lymphoblastic proliferations","display_name":"Flow cytometric features of incidental indolent T lymphoblastic proliferations","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W2977635225","doi":"https://doi.org/10.1002/cyto.b.21845","mag":"2977635225","pmid":"https://pubmed.ncbi.nlm.nih.gov/31571375"},"language":"en","primary_location":{"id":"doi:10.1002/cyto.b.21845","doi":"https://doi.org/10.1002/cyto.b.21845","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.21845","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21845","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21845","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020858509","display_name":"Jonathan R. Fromm","orcid":"https://orcid.org/0000-0002-2287-5284","observed_orcids":["https://orcid.org/0000-0002-2287-5284"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan R. Fromm","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054996533","display_name":"Kerstin Lara Edlefsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerstin L. Edlefsen","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088826652","display_name":"Sindhu Cherian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sindhu Cherian","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013754928","display_name":"Brent Lee Wood","orcid":"https://orcid.org/0000-0001-7414-3969","observed_orcids":["https://orcid.org/0000-0001-7414-3969"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent L. Wood","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112421614","display_name":"Lorinda A. Soma","orcid":"https://orcid.org/0000-0003-0606-899X","observed_orcids":["https://orcid.org/0000-0003-0606-899X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Soma","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103186489","display_name":"David Wu","orcid":"https://orcid.org/0000-0001-7729-5730","observed_orcids":["https://orcid.org/0000-0001-7729-5730"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Wu","raw_affiliation_strings":["UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UW Hematopathology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020858509","https://openalex.org/A5103186489"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.6648,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.84584623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"98","issue":"3","first_page":"282","last_page":"287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.28439998626708984,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-cd8-t-cells","display_name":"CD4+CD8+ T cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/castleman-disease","display_name":"Castleman disease","score":0.800000011920929},{"id":"https://openalex.org/keywords/marginal-zone-b-cell-lymphoma","display_name":"marginal zone B-cell lymphoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/t-cell-immunophenotype","display_name":"T-cell immunophenotype","score":0.7860000133514404},{"id":"https://openalex.org/keywords/terminal-deoxynucleotidyl-transferase","display_name":"terminal deoxynucleotidyl transferase","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.8758543729782104},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6549667119979858},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5848388075828552},{"id":"https://openalex.org/C2777478502","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic lymphoma","level":4,"score":0.5802159309387207},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5708916783332825},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49915456771850586},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4746873080730438},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4603689908981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4052990972995758},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.40027856826782227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38491734862327576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3735530972480774},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12426301836967468},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.10296863317489624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cyto.b.21845","doi":"https://doi.org/10.1002/cyto.b.21845","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.21845","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21845","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},{"id":"pmid:31571375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31571375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry. Part B, Clinical cytometry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cyto.b.21845","doi":"https://doi.org/10.1002/cyto.b.21845","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.21845","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21845","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977635225.pdf","grobid_xml":"https://content.openalex.org/works/W2977635225.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W8630125","https://openalex.org/W81490806","https://openalex.org/W2003522587","https://openalex.org/W2018384479","https://openalex.org/W2095148635","https://openalex.org/W2136920402","https://openalex.org/W2164900275","https://openalex.org/W2892650490","https://openalex.org/W4232182676","https://openalex.org/W4236962815","https://openalex.org/W4244063457","https://openalex.org/W7029454581"],"related_works":["https://openalex.org/W2003522587","https://openalex.org/W2329800921","https://openalex.org/W4280496500","https://openalex.org/W7127979470","https://openalex.org/W2112674823","https://openalex.org/W2793498261","https://openalex.org/W3197692317","https://openalex.org/W2325088022","https://openalex.org/W1980408998","https://openalex.org/W3136772129"],"abstract_inverted_index":{"Indolent":[0],"T":[1,19,57,84,100,110,148,164,185,190,217,223],"lymphoblastic":[2,58,186,191],"proliferations":[3,192,207],"have":[4],"been":[5,174],"reported":[6],"rarely":[7],"in":[8,102,116,154,208],"extramedullary":[9],"and":[10,48,73,76],"extrathymic":[11],"tissues.":[12],"Recent":[13],"work":[14],"has":[15,172],"identified":[16,49,113],"these":[17,35,206],"indolent":[18,189],"lymphoblast":[20],"populations":[21,36],"to":[22,65,184,201],"be":[23,194],"mostly":[24],"CD4+/CD8+":[25,147,215],"(characterized":[26],"by":[27,37,166,196],"immunohistochemistry),":[28],"with":[29,55,63,118,124,135],"only":[30,214],"limited":[31],"immunophenotypic":[32,227],"evaluation":[33],"of":[34,67,83,90,107,146,152,162,181,229],"flow":[38],"cytometry":[39],"(FC).":[40],"We":[41],"retrospectively":[42],"reviewed":[43],"our":[44,155],"institutional":[45],"FC":[46,167],"archives":[47],"12":[50],"samples":[51,103,210],"from":[52],"10":[53],"patients":[54],"incidental":[56],"populations.":[59],"Samples":[60],"were":[61,112,143],"characterized":[62],"respect":[64],"expression":[66],"T-cell":[68],"antigens,":[69,75],"CD45,":[70],"TdT,":[71],"CD1a,":[72],"T/NK":[74],"light":[77],"scatter":[78],"properties.":[79],"Overall,":[80],"the":[81,150,226],"proportion":[82],"lymphoblasts":[85,101,111,165],"was":[86,178],"small":[87],"(range":[88],"0.01-8.8%":[89],"white":[91],"cells;":[92],"mean,":[93],"1.7%).":[94],"Histologic":[95],"correlation":[96],"showed":[97],"scattered":[98],"immature":[99,216,222],"without":[104],"overt":[105],"distortion":[106],"underlying":[108],"architecture.":[109],"most":[114],"frequently":[115],"association":[117],"Castleman":[119,125],"disease":[120],"(four)":[121],"or":[122,133],"tissues":[123],"features":[126],"(four),":[127],"marginal":[128],"zone":[129],"B-cell":[130],"lymphoma":[131],"(one),":[132],"tissue":[134],"reactive/atypical":[136],"changes":[137],"(three":[138],"cases).":[139],"Although":[140],"three":[141],"cases":[142,153],"composed":[144],"predominantly":[145],"cells,":[149,224],"majority":[151],"cohort":[156],"(eight)":[157],"included":[158],"a":[159],"major":[160],"subset":[161],"CD4-/CD8-":[163,221],"(one":[168],"case":[169],"CD8+/CD4-),":[170],"which":[171],"not":[173,213],"described":[175],"previously.":[176],"There":[177],"no":[179],"evidence":[180],"subsequent":[182],"progression":[183],"leukemia.":[187],"Incidental,":[188],"may":[193,211],"detected":[195],"clinical":[197,209],"FC.":[198],"In":[199],"contrast":[200],"reports,":[202],"we":[203],"find":[204],"that":[205],"contain":[212],"cells":[218],"but":[219],"also":[220],"expanding":[225],"spectrum":[228],"this":[230],"entity.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-10-10T00:00:00"}
