{"id":"https://openalex.org/W2977416360","doi":null,"title":"Iron regulation in neonatal rat cardiac myocytes","display_name":"Iron regulation in neonatal rat cardiac myocytes","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2977416360","mag":"2977416360"},"language":"en","primary_location":{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.21133274","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ33937.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ33937.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/e8f9bff0-695e-4e39-a6f5-aefd2ee2744d/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045526160","display_name":"Josephine Barbara Sirna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Josephine Barbara Sirna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045526160"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-regulation","display_name":"iron regulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.8029999732971191},{"id":"https://openalex.org/keywords/iron-regulatory-proteins","display_name":"iron regulatory proteins","score":0.8519999980926514},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/iron-responsive-element","display_name":"iron-responsive element","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neonatal-rat-heart","display_name":"neonatal rat heart","score":0.7379999756813049},{"id":"https://openalex.org/keywords/iron-toxicity","display_name":"iron toxicity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6103901863098145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4426419138908386},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3789437711238861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3530815541744232},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3484385907649994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32744961977005005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3239786624908447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32244473695755005}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.21133274","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ33937.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ33937.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/12244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/12244","pdf_url":"https://utoronto.scholaris.ca/bitstreams/e8f9bff0-695e-4e39-a6f5-aefd2ee2744d/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.630.1095","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.630.1095","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.collectionscanada.gc.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ33937.pdf","raw_type":"text"},{"id":"mag:2977416360","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/12244/1/MQ33937.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/12244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/12244","pdf_url":"https://utoronto.scholaris.ca/bitstreams/e8f9bff0-695e-4e39-a6f5-aefd2ee2744d/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977416360.pdf","grobid_xml":"https://content.openalex.org/works/W2977416360.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W70018918","https://openalex.org/W153290133","https://openalex.org/W217134834","https://openalex.org/W1514932744","https://openalex.org/W1547645050","https://openalex.org/W1594056720","https://openalex.org/W1595921363","https://openalex.org/W1734082729","https://openalex.org/W1791262955","https://openalex.org/W1971099877","https://openalex.org/W1979644010","https://openalex.org/W1983880247","https://openalex.org/W1993492379","https://openalex.org/W2001884514","https://openalex.org/W2005806732","https://openalex.org/W2010346856","https://openalex.org/W2010883644","https://openalex.org/W2014496233","https://openalex.org/W2019026345","https://openalex.org/W2040386899","https://openalex.org/W2043833934","https://openalex.org/W2051819610","https://openalex.org/W2055667111","https://openalex.org/W2062908728","https://openalex.org/W2065352821","https://openalex.org/W2066743380","https://openalex.org/W2070888838","https://openalex.org/W2077680450","https://openalex.org/W2082338698","https://openalex.org/W2085866164","https://openalex.org/W2128635872","https://openalex.org/W2134812217","https://openalex.org/W2187929378","https://openalex.org/W2216471839","https://openalex.org/W2337170605","https://openalex.org/W2386592320","https://openalex.org/W2397340255","https://openalex.org/W2412276431"],"related_works":["https://openalex.org/W2066407704","https://openalex.org/W2091028610","https://openalex.org/W7098040899","https://openalex.org/W7099895147","https://openalex.org/W7095238137","https://openalex.org/W2134651498","https://openalex.org/W6981633122","https://openalex.org/W7098196133","https://openalex.org/W2281791876","https://openalex.org/W2737684876"],"abstract_inverted_index":{"Cardiac":[0],"iron":[1,75,117,124],"overload":[2],"is":[3],"the":[4,33,36,70],"major":[5],"cause":[6],"of":[7,24,35,73,123,133],"morbidity":[8],"and":[9,50,60,87],"mortality":[10],"in":[11,20,44,55,83,89,99,115,126,136],"iron-loading":[12],"diseases.":[13],"Iron-induced":[14,53],"cardiac":[15,28,45,127],"dysfunction":[16],"can":[17],"be":[18,111],"mimicked":[19],"vitro":[21],"using":[22],"cultures":[23],"iron-loaded":[25],"neonatal":[26],"rat":[27],"myocytes.":[29,100],"In":[30,77],"this":[31,108],"study,":[32],"presence":[34],"Iron":[37,61],"Regulatory":[38],"Protein":[39],"(IRP)":[40],"has":[41],"been":[42],"demonstrated":[43],"myocytes":[46,128],"by":[47,69],"mRNA":[48,58,104],"expression":[49,59],"RNA-binding":[51],"activity.":[52],"changes":[54,114],"transferrin":[56],"receptor":[57],"Responsive":[62],"Element":[63],"(IRE)-IRP":[64],"binding":[65],"occurred":[66],"as":[67],"predicted":[68],"IRP":[71,91],"system":[72],"cellular":[74,116],"control.":[76],"addition,":[78],"an":[79],"iron-induced":[80],"dose-dependent":[81],"increase":[82],"ferritin":[84],"transcript":[85,109],"levels":[86,105],"decrease":[88],"total":[90],"indicated":[92],"that":[93,107],"other":[94],"iron-sensitive":[95],"controls":[96],"may":[97,110],"exist":[98],"Furthermore,":[101],"increased":[102],"GAPDH":[103],"suggest":[106],"sensitive":[112],"to":[113],"status.":[118],"Attaining":[119],"a":[120],"greater":[121],"knowledge":[122],"regulation":[125],"will":[129],"further":[130],"our":[131],"understanding":[132],"iron's":[134],"toxicity":[135],"heart":[137],"cells.":[138]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-10-10T00:00:00"}