{"id":"https://openalex.org/W2977411700","doi":"https://doi.org/10.1182/blood.v130.suppl_1.2293.2293","title":"Unbiased Profiling of the Immunomodulatory Properties of Soluble Proteins","display_name":"Unbiased Profiling of the Immunomodulatory Properties of Soluble Proteins","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W2977411700","doi":"https://doi.org/10.1182/blood.v130.suppl_1.2293.2293","mag":"2977411700"},"language":"en","primary_location":{"id":"mag:2977411700","doi":"https://doi.org/10.1182/blood.v130.suppl_1.2293.2293","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/2293/79928/Unbiased-Profiling-of-the-Immunomodulatory","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058217073","display_name":"Nikolaus Krall","orcid":"https://orcid.org/0000-0002-8400-4388","observed_orcids":["https://orcid.org/0000-0002-8400-4388"]},"institutions":[{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nikolaus Krall","raw_affiliation_strings":["cemm, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-8400-4388","affiliations":[{"raw_affiliation_string":"cemm, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045856086","display_name":"Gregory Ian Vladimer","orcid":"https://orcid.org/0000-0003-4205-7585","observed_orcids":["https://orcid.org/0000-0003-4205-7585"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gregory I. Vladimer","raw_affiliation_strings":["CeMM \u2010 Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria"],"raw_orcid":"https://orcid.org/0000-0003-4205-7585","affiliations":[{"raw_affiliation_string":"CeMM \u2010 Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046176713","display_name":"Berend Snijder","orcid":"https://orcid.org/0000-0003-3386-6583","observed_orcids":["https://orcid.org/0000-0003-3386-6583"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Berend Snijder","raw_affiliation_strings":["Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3386-6583","affiliations":[{"raw_affiliation_string":"Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048735162","display_name":"Noemi Meszaros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Noemi Meszaros","raw_affiliation_strings":["CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028170110","display_name":"Nicole M\u00fcller","orcid":"https://orcid.org/0000-0002-7527-5127","observed_orcids":["https://orcid.org/0000-0002-7527-5127"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicole M\u00fcller","raw_affiliation_strings":["Wellcome Trust Sanger Inst., Cambridge, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0002-7527-5127","affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Inst., Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029330044","display_name":"Gavin James Wright","orcid":"https://orcid.org/0000-0003-0537-0863","observed_orcids":["https://orcid.org/0000-0003-0537-0863"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gavin J. Wright","raw_affiliation_strings":["Wellcome Trust Sanger Inst., Cambridge, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0003-0537-0863","affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Inst., Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069216326","display_name":"Giulio Superti\u2010Furga","orcid":"https://orcid.org/0000-0002-0570-1768","observed_orcids":["https://orcid.org/0000-0002-0570-1768"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Giulio Superti\u2010Furga","raw_affiliation_strings":["CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-0570-1768","affiliations":[{"raw_affiliation_string":"CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31984416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":null,"first_page":"2293","last_page":"2293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.23510000109672546,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.23510000109672546,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.09009999781847,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.8090000152587891},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/soluble-protein","display_name":"soluble protein","score":0.703000009059906},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8999999761581421},{"id":"https://openalex.org/keywords/high-content-imaging","display_name":"high-content imaging","score":0.7450000047683716},{"id":"https://openalex.org/keywords/human-peripheral-blood-mononuclear-cells","display_name":"human peripheral blood mononuclear cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5879999995231628},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5419999957084656},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.546999990940094},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.545576810836792},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5313397645950317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5252503752708435},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5236372947692871},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5181916356086731},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.47283798456192017},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.455222487449646},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4483538568019867},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.44247204065322876},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.4126644432544708},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3786163628101349},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.274410605430603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12028369307518005}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2977411700","doi":"https://doi.org/10.1182/blood.v130.suppl_1.2293.2293","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/2293/79928/Unbiased-Profiling-of-the-Immunomodulatory","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2607880713","https://openalex.org/W2795183554","https://openalex.org/W2597802884","https://openalex.org/W4231725730","https://openalex.org/W4413038025","https://openalex.org/W2335229782","https://openalex.org/W2911596860","https://openalex.org/W2594694689","https://openalex.org/W2003772027","https://openalex.org/W4409629286"],"abstract_inverted_index":{"Abstract":[0],"The":[3],"function":[4],"of":[5,157,210,266,273,281,313],"the":[6,22,29,38,50,96,154,220,264,267,282,325],"innate":[7],"and":[8,25,45,66,107,118,133,144,270,284,311,323],"adaptive":[9],"immune":[10,40,268],"system":[11,41,269],"is":[12],"tightly":[13],"controlled":[14],"by":[15,208,225],"soluble":[16,119,135],"signals":[17],"such":[18],"as":[19],"cytokines":[20,117,132],"on":[21,28],"one":[23,217],"hand":[24],"cell-cell":[26,158,176,211,221,238],"interactions":[27,159],"other.":[30],"Immunotherapeutics":[31],"modulate":[32],"these":[33],"signaling":[34],"axes":[35],"to":[36,48,63,93,113,130,171,188,216,219,258],"direct":[37],"human":[39,83],"against":[42],"malignant":[43],"cells":[44,110],"are":[46,69,127],"promising":[47],"revolutionize":[49],"way":[51],"how":[52],"we":[53,73,232],"treat":[54],"cancer.":[55],"Yet,":[56],"not":[57],"all":[58],"malignancies":[59],"respond":[60],"equally":[61],"well":[62],"existing":[64],"immunotherapy":[65],"new":[67],"targets":[68],"required.":[70],"Here":[72],"use":[74],"a":[75,147,191,260,318],"novel":[76],"high":[77,139,327],"content":[78,328],"imaging":[79,329],"method":[80,256,283],"compatible":[81],"with":[82,115,190,227,275],"PBMCs":[84],"(Vladimer,":[85],"Snijder":[86],"et":[87],"al.,":[88],"Nat.":[89],"Chem.":[90],"Biol.":[91],"2017)":[92],"systematically":[94],"quantify":[95],"physical":[97],"interaction":[98,177,212,222,239],"patterns":[99,178,213],"between":[100,237],"CD3,":[101],"CD4,":[102],"CD8,":[103],"CD11c,":[104],"CD14,":[105],"CD19":[106],"CD56":[108],"positive":[109],"in":[111,138,146,160,175,186,214,249],"response":[112,187,215],"perturbation":[114],"90":[116],"cell-surface":[120],"receptors":[121],"ex":[122],"vivo":[123],".":[124],"Whilst":[125],"there":[126],"many":[128],"tools":[129],"measure":[131],"other":[134],"immunoregulatory":[136],"factors":[137],"throughput":[140],"(e.g.,":[141,150],"alpha":[142],"screen),":[143],"potentially":[145],"multiplexed":[148],"fashion":[149],"cytokine":[151],"bead":[152],"arrays),":[153],"systematic":[155],"measurement":[156],"high-throughput":[161],"has":[162],"so":[163,200],"far":[164,201],"been":[165],"elusive.":[166],"We":[168,197],"were":[169],"able":[170],"identify":[172],"specific":[173],"changes":[174,223],"that":[179,199,234,316],"could":[180],"be":[181,206,288],"reproduced":[182],"over":[183],"different":[184],"donors":[185],"treatment":[189,218],"protein":[192],"or":[193],"small":[194],"molecule":[195],"perturbations.":[196],"hypothesise":[198,233],"unknown":[202],"immunomodulatory":[203,229,277],"functions":[204],"can":[205,241],"inferred":[207],"comparison":[209],"induced":[224],"molecules":[226,274],"known":[228],"properties.":[230,278],"Further,":[231],"coregulation":[235],"analysis":[236],"pairs":[240],"map":[242],"out":[243],"cell":[244],"contact":[245],"dependent":[246],"regulatory":[247],"circuits":[248],"an":[250],"unbiased":[251],"manner.":[252],"Overall,":[254],"our":[255],"promises":[257],"become":[259],"valuable":[261],"tool":[262],"for":[263,322],"study":[265],"phenotypic":[271],"discovery":[272],"desired":[276],"An":[279],"overview":[280],"preliminary":[285],"results":[286],"will":[287],"presented.":[289],"Disclosures":[293],"Krall:":[295],"Allcyte":[296,301,314,332],"Gmbh:":[297,302],"Equity":[298,303,307,334],"Ownership.":[299,304,335],"Vladimer:":[300],"Snijder:":[305],"Allcyte:":[306],"Ownership,":[308],"Other:":[309],"founder":[310],"shareholder":[312],"GmbH":[315],"holds":[317],"worldwide":[319],"exclusive":[320],"license":[321],"commercializes":[324],"Pharmacoscopy":[326],"technology..":[330],"Superti-Furga:":[331],"GmbH:":[333]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-10-10T00:00:00"}