{"id":"https://openalex.org/W2977360258","doi":"https://doi.org/10.1021/acs.jpclett.9b02531","title":"Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes","display_name":"Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W2977360258","doi":"https://doi.org/10.1021/acs.jpclett.9b02531","mag":"2977360258","pmid":"https://pubmed.ncbi.nlm.nih.gov/31566982"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpclett.9b02531","doi":"https://doi.org/10.1021/acs.jpclett.9b02531","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.9b02531","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jpclett.9b02531","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067104157","display_name":"Marc Siggel","orcid":"https://orcid.org/0000-0003-3393-4988","observed_orcids":["https://orcid.org/0000-0003-3393-4988"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Siggel","raw_affiliation_strings":["Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3393-4988","affiliations":[{"raw_affiliation_string":"Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","institution_ids":["https://openalex.org/I4210124035"]},{"raw_affiliation_string":"Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062925169","display_name":"Ramachandra M. Bhaskara","orcid":"https://orcid.org/0000-0002-7742-0391","observed_orcids":["https://orcid.org/0000-0002-7742-0391"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ramachandra M. Bhaskara","raw_affiliation_strings":["Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","institution_ids":["https://openalex.org/I4210124035"]},{"raw_affiliation_string":"Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059945365","display_name":"Gerhard Hummer","orcid":"https://orcid.org/0000-0001-7768-746X","observed_orcids":["https://orcid.org/0000-0001-7768-746X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerhard Hummer","raw_affiliation_strings":["Goethe University Frankfurt , , ,","Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany","Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7768-746X","affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt , , ,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Max Planck Institute of Biophysics , , Max-von-Laue Str. 3 , ,","institution_ids":["https://openalex.org/I4210124035"]},{"raw_affiliation_string":"Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]},{"raw_affiliation_string":"Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059945365"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210124035"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.6548,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.61513301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"20","first_page":"6351","last_page":"6354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipid-scramblase","display_name":"phospholipid scramblase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tmem16","display_name":"TMEM16","score":0.7440000176429749},{"id":"https://openalex.org/keywords/lipid-asymmetry","display_name":"lipid asymmetry","score":0.703000009059906},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.6449999809265137},{"id":"https://openalex.org/keywords/vesicle-budding","display_name":"vesicle budding","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lipid-transfer-proteins","display_name":"lipid transfer proteins","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8022490739822388},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.7032677531242371},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6993303894996643},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5931688547134399},{"id":"https://openalex.org/C142874826","wikidata":"https://www.wikidata.org/wiki/Q5353574","display_name":"Elasticity of cell membranes","level":5,"score":0.5670485496520996},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5491835474967957},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5047334432601929},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.49380192160606384},{"id":"https://openalex.org/C38976095","wikidata":"https://www.wikidata.org/wiki/Q752641","display_name":"Asymmetry","level":2,"score":0.4849248230457306},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.4641132950782776},{"id":"https://openalex.org/C2776659728","wikidata":"https://www.wikidata.org/wiki/Q887004","display_name":"Leaflet (botany)","level":2,"score":0.4636263847351074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40231117606163025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2971459925174713},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.2885318994522095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17484602332115173},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08996838331222534},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055330","descriptor_name":"Nectria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jpclett.9b02531","doi":"https://doi.org/10.1021/acs.jpclett.9b02531","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.9b02531","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:31566982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31566982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry letters","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_3173892","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0004-F4CE-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acs.jpclett.9b02531","doi":"https://doi.org/10.1021/acs.jpclett.9b02531","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.9b02531","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1493374012","https://openalex.org/W1871390418","https://openalex.org/W1977163534","https://openalex.org/W1990973079","https://openalex.org/W2010918799","https://openalex.org/W2020291681","https://openalex.org/W2030865312","https://openalex.org/W2037433671","https://openalex.org/W2051864856","https://openalex.org/W2058638622","https://openalex.org/W2063638181","https://openalex.org/W2066104424","https://openalex.org/W2068749469","https://openalex.org/W2069655536","https://openalex.org/W2108713843","https://openalex.org/W2119267663","https://openalex.org/W2125872855","https://openalex.org/W2127505727","https://openalex.org/W2133172971","https://openalex.org/W2148231248","https://openalex.org/W2156851380","https://openalex.org/W2161926177","https://openalex.org/W2165852907","https://openalex.org/W2167037213","https://openalex.org/W2264936970","https://openalex.org/W2295554976","https://openalex.org/W2327174080","https://openalex.org/W2416594970","https://openalex.org/W2554439017","https://openalex.org/W2612605708","https://openalex.org/W2754304658","https://openalex.org/W2768803580","https://openalex.org/W2885454574","https://openalex.org/W2947808797","https://openalex.org/W2948339609","https://openalex.org/W2970557530"],"related_works":["https://openalex.org/W7130563960","https://openalex.org/W4210967415","https://openalex.org/W4402654769","https://openalex.org/W1804087815","https://openalex.org/W4411237229","https://openalex.org/W4246881603","https://openalex.org/W4407437452","https://openalex.org/W2991494067","https://openalex.org/W6959022979","https://openalex.org/W4280582058"],"abstract_inverted_index":{"The":[0],"cell":[1],"membrane":[2,41,103],"and":[3,9,19,99,136],"many":[4],"organellar":[5],"membranes":[6,21,124],"are":[7],"asymmetric":[8,49],"highly":[10,122],"curved.":[11],"In":[12],"experiments,":[13],"it":[14],"is":[15],"challenging":[16],"to":[17,37,55,63,115,128],"reconstitute":[18],"characterize":[20],"that":[22],"differ":[23],"in":[24],"the":[25,39,75,80,85,93,97,106,130],"lipid":[26,46,76,134],"composition":[27],"of":[28,87,121,132],"their":[29],"leaflets.":[30,50],"Here":[31],"we":[32,72],"use":[33],"molecular":[34],"dynamics":[35],"simulations":[36,120],"study":[38,129],"large-scale":[40,102],"shape":[42],"changes":[43],"associated":[44],"with":[45],"shuttling":[47],"between":[48,96],"We":[51],"exploit":[52,116],"leaflet":[53],"asymmetry":[54,118],"create":[56],"a":[57,64,101,110],"stable,":[58],"near-spherical":[59],"vesicle":[60,107],"bud":[61,108],"connected":[62],"flat":[65,111],"bilayer":[66,117],"under":[67],"periodic":[68],"boundary":[69],"conditions.":[70],"Then":[71],"demonstrate":[73],"how":[74],"scramblase":[77],"nhTMEM16":[78],"relaxes":[79],"lipid-number":[81],"asymmetry.":[82],"By":[83],"mediating":[84],"flipping":[86],"lipids,":[88],"this":[89],"transmembrane":[90],"protein":[91],"dissipates":[92],"mechanochemical":[94],"gradient":[95],"leaflets":[98],"drives":[100],"reorganization,":[104],"converting":[105],"into":[109],"membrane.":[112],"Our":[113],"procedure":[114],"for":[119],"curved":[123],"can":[125],"be":[126],"used":[127],"function":[131],"other":[133],"transporters":[135],"membrane-shaping":[137],"proteins.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-10T00:00:00"}
