{"id":"https://openalex.org/W2977317368","doi":"https://doi.org/10.14309/00000434-201610001-01045","title":"Rates of Mucosal Healing and Correlation to Clinical Assessment in Pediatric Crohn\u02bcs Disease","display_name":"Rates of Mucosal Healing and Correlation to Clinical Assessment in Pediatric Crohn\u02bcs Disease","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2977317368","doi":"https://doi.org/10.14309/00000434-201610001-01045","mag":"2977317368"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201610001-01045","doi":"https://doi.org/10.14309/00000434-201610001-01045","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201610001-01045","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066089573","display_name":"Denise Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Do","raw_affiliation_strings":[". Rainbow Babies and Children's Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Rainbow Babies and Children's Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009073378","display_name":"Megha Mehta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megha Mehta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sharon Perry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon Perry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027713579","display_name":"Judy B. Splawski","orcid":"https://orcid.org/0000-0002-9294-1160","observed_orcids":["https://orcid.org/0000-0002-9294-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judy Splawski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080838490","display_name":"Thomas J. Sferra","orcid":"https://orcid.org/0000-0001-6893-9880","observed_orcids":["https://orcid.org/0000-0001-6893-9880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Sferra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015076381","display_name":"Jonathan Moses","orcid":"https://orcid.org/0000-0002-6660-4494","observed_orcids":["https://orcid.org/0000-0002-6660-4494"]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Moses","raw_affiliation_strings":[". Rainbow Babies and Children's Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Rainbow Babies and Children's Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210151235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24867758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"111","issue":null,"first_page":"S454","last_page":"S454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-crohn-s-disease","display_name":"pediatric Crohn's disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.9160000085830688},{"id":"https://openalex.org/keywords/physician-s-global-assessment","display_name":"physician global assessment","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.8920000195503235},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7300000190734863},{"id":"https://openalex.org/keywords/endoscopic-assessment","display_name":"endoscopic assessment","score":0.7080000042915344},{"id":"https://openalex.org/keywords/treatment-endpoints","display_name":"treatment endpoints","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9723203778266907},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5892859697341919},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5380406379699707},{"id":"https://openalex.org/C2992200296","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn disease","level":4,"score":0.5034112334251404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3079383969306946}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201610001-01045","doi":"https://doi.org/10.14309/00000434-201610001-01045","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201610001-01045","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2712240418","https://openalex.org/W4256026989","https://openalex.org/W4250254262","https://openalex.org/W2292659784","https://openalex.org/W2562002834","https://openalex.org/W3151053106","https://openalex.org/W2077120361","https://openalex.org/W3208508893","https://openalex.org/W2054570260","https://openalex.org/W4225497276"],"abstract_inverted_index":{"Introduction:":[0],"Therapeutic":[1],"endpoints":[2],"for":[3,68,262,335],"inflammatory":[4],"bowel":[5],"disease":[6,71,90],"(IBD)":[7],"have":[8,29],"evolved":[9],"over":[10],"time":[11],"with":[12,52,65,78,244,252,267,284,301,329],"mucosal":[13,48,63,76,151,159,214,223,253,259,294,320,339],"healing":[14,49,64,77,152,215,224,254,260,321,340],"as":[15,155,228,271],"a":[16,289],"viable":[17],"clinical":[18,53,79,226,282,333],"endpoint.":[19],"Recent":[20],"adult":[21,303],"data":[22,307],"suggest":[23],"patients":[24,91,174,203,336],"who":[25,337],"achieve":[26,338],"this":[27],"endpoint":[28],"fewer":[30],"hospitalizations,":[31],"lower":[32],"surgery":[33],"rates,":[34],"and":[35,50,111,128,150,168,175,189,197,225,314,326],"remain":[36],"in":[37,102,299,327,346],"remission":[38,80,227],"longer.":[39],"There":[40],"are":[41,298],"few":[42],"pediatric":[43,69,350],"studies":[44],"reporting":[45],"rates":[46,318],"of":[47,62,109,158,202,292,319,343,349],"correlation":[51],"assessment.":[54],"Our":[55,296],"aim":[56],"was":[57,86,133,153,162,217,232,246,265],"to":[58,74,184,310,315],"examine":[59],"the":[60,136,156,220,247,272,285,302,332,347],"rate":[61,216,261],"standard":[66],"therapies":[67],"Crohn's":[70,89,351],"and,":[72],"secondarily,":[73],"correlate":[75],"rates.":[81],"Methods:":[82],"Retrospective":[83],"chart":[84],"review":[85],"performed":[87,163],"on":[88],"seen":[92],"by":[93,146,230],"Pediatric":[94],"Gastroenterology":[95],"at":[96],"Rainbow":[97],"Babies":[98],"&":[99],"Children's":[100],"Hospital":[101],"Cleveland,":[103],"OH":[104],"diagnosed":[105],"between":[106,222,322],"5-18":[107],"years":[108],"age":[110],"had":[112,204],"two":[113,147],"or":[114],"more":[115],"endoscopies":[116,177],"within":[117],"two-year":[118],"intervals.":[119],"Data":[120],"collected":[121],"included":[122],"patient":[123],"demographics,":[124],"medical":[125],"therapy":[126,242,249,324],"used,":[127],"laboratory":[129],"findings.":[130],"Clinical":[131],"activity":[132],"assessed":[134],"using":[135,164],"Physician":[137],"Global":[138],"Assessment":[139],"(PGA).":[140],"Endoscopic":[141],"images":[142],"were":[143,178,192,195],"independently":[144],"reviewed":[145],"staff":[148],"physicians":[149],"defined":[154,229],"absence":[157],"ulceration.":[160],"Analysis":[161],"Fisher's":[165],"exact":[166],"test":[167],"Chi":[169],"square":[170],"analyses.":[171],"Results:":[172],"37":[173],"91":[176],"reviewed.":[179],"Ages":[180],"ranged":[181],"from":[182],"6.6":[183],"17.5":[185],"years.":[186],"20":[187],"males":[188],"17":[190],"females":[191],"reviewed,":[193],"(73%":[194],"Caucasian":[196],"21.6%":[198],"African-American).":[199],"The":[200,212,257],"majority":[201],"1-2":[205],"repeat":[206],"endoscopies,":[207],"approximately":[208],"1":[209],"year":[210],"apart.":[211],"overall":[213,258],"40.7%;":[218],"however,":[219],"association":[221],"PGA":[231,286],"not":[233,288],"clinically":[234],"significant":[235],"(p":[236],"=":[237],"0.137).":[238],"Moreover,":[239],"anti-TNF":[240,268,323],"combination":[241,328],"(anti-TNF":[243],"immunomodulator)":[245],"only":[248],"significantly":[250],"associated":[251],"(p=0.037).":[255],"Conclusion:":[256],"our":[263,278,312],"cohort":[264],"40.7%,":[266],"plus":[269],"immmunomodulator":[270],"most":[273],"effective":[274],"therapy.":[275],"In":[276],"addition,":[277],"results":[279],"indicate":[280],"that":[281],"assessment":[283],"is":[287,308],"reliable":[290],"means":[291],"identifying":[293],"healing.":[295],"findings":[297],"line":[300],"IBD":[304],"literature.":[305],"Prospective":[306],"required":[309],"confirm":[311],"observations":[313],"further":[316],"compare":[317],"alone":[325],"immunomodulators.":[330],"Examining":[331],"outcomes":[334],"would":[341],"be":[342],"great":[344],"benefit":[345],"management":[348],"disease.":[352]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-10-10T00:00:00"}