{"id":"https://openalex.org/W2977296306","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3941","title":"Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations","display_name":"Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations","publication_year":2019,"publication_date":"2019-10-03","ids":{"openalex":"https://openalex.org/W2977296306","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3941","mag":"2977296306","pmid":"https://pubmed.ncbi.nlm.nih.gov/31580399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6777244"},"language":"en","primary_location":{"id":"doi:10.1001/jamaophthalmol.2019.3941","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3941","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamaophthalmol.2019.3941","pdf_url":null,"source":{"id":"https://openalex.org/S68724622","display_name":"JAMA Ophthalmology","issn_l":"2168-6165","issn":["2168-6165","2168-6173"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6777244/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070524317","display_name":"Michael A. Durante","orcid":"https://orcid.org/0000-0003-3137-6847","observed_orcids":["https://orcid.org/0000-0003-3137-6847"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Durante","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023572418","display_name":"Scott D. Walter","orcid":"https://orcid.org/0000-0003-3492-4650","observed_orcids":["https://orcid.org/0000-0003-3492-4650"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D. Walter","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020672366","display_name":"Manuel A. Paez-Escamilla","orcid":"https://orcid.org/0000-0003-3488-9680","observed_orcids":["https://orcid.org/0000-0003-3488-9680"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel Paez-Escamilla","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062820286","display_name":"Julian V. Tokarev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian Tokarev","raw_affiliation_strings":["Cizik Eye Clinic, University of Texas Health Sciences Center at Houston, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cizik Eye Clinic, University of Texas Health Sciences Center at Houston, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025861423","display_name":"Christina L. Decatur","orcid":"https://orcid.org/0000-0001-9125-1718","observed_orcids":["https://orcid.org/0000-0001-9125-1718"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina L. Decatur","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057215721","display_name":"Sander R. Dubovy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sander R. Dubovy","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025388138","display_name":"Amy C Schefler","orcid":"https://orcid.org/0000-0001-9829-8164","observed_orcids":["https://orcid.org/0000-0001-9829-8164"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4210094205","display_name":"Retina Consultants of Texas","ror":"https://ror.org/00j7qa995","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094205"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy C. Schefler","raw_affiliation_strings":["Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas","Cizik Eye Clinic, University of Texas Health Sciences Center at Houston, Houston","Retina Consultants of Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Cizik Eye Clinic, University of Texas Health Sciences Center at Houston, Houston","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Retina Consultants of Houston, Houston, Texas","institution_ids":["https://openalex.org/I4210094205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077374286","display_name":"J. William Harbour","orcid":"https://orcid.org/0000-0002-1104-9809","observed_orcids":["https://orcid.org/0000-0002-1104-9809"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. William Harbour","raw_affiliation_strings":["Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2064,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75292549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"137","issue":"12","first_page":"1434","last_page":"1434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/intraocular-metastasis","display_name":"intraocular metastasis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bap1-mutation","display_name":"BAP1 mutation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/plaque-brachytherapy","display_name":"plaque brachytherapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/melanocytosis","display_name":"melanocytosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/systemic-metastasis","display_name":"systemic metastasis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5789999961853027},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C37846818","wikidata":"https://www.wikidata.org/wiki/Q18032813","display_name":"BAP1","level":3,"score":0.9235278367996216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.840444803237915},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7190186381340027},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6630080938339233},{"id":"https://openalex.org/C2776713392","wikidata":"https://www.wikidata.org/wiki/Q278859","display_name":"Uvea","level":3,"score":0.6333898901939392},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5776172876358032},{"id":"https://openalex.org/C2779176653","wikidata":"https://www.wikidata.org/wiki/Q18026236","display_name":"GNAQ","level":4,"score":0.4967387318611145},{"id":"https://openalex.org/C2910410966","wikidata":"https://www.wikidata.org/wiki/Q356372","display_name":"Ocular Melanoma","level":3,"score":0.4409264624118805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3992309868335724},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3738211393356323},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3580281734466553},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33460578322410583},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3279593586921692},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28869831562042236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26089194416999817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18864312767982483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08055216073989868},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07004347443580627}],"mesh":[{"descriptor_ui":"D000098943","descriptor_name":"Uveal Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001918","descriptor_name":"Brachytherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015353","descriptor_name":"Eye Enucleation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043802","descriptor_name":"GTP-Binding Protein alpha Subunits, Gq-G11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044963","descriptor_name":"Biopsy, Fine-Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/jamaophthalmol.2019.3941","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3941","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamaophthalmol.2019.3941","pdf_url":null,"source":{"id":"https://openalex.org/S68724622","display_name":"JAMA Ophthalmology","issn_l":"2168-6165","issn":["2168-6165","2168-6173"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmology","raw_type":"journal-article"},{"id":"pmid:31580399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31580399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA ophthalmology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:6777244","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6777244/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"JAMA Ophthalmol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6777244","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6777244/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"JAMA Ophthalmol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G4039377828","display_name":"Molecular Predictive Testing in Ocular Melanoma","funder_award_id":"R01CA125970","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000910759","display_name":"Miami Center for Vision Research","funder_award_id":"P30EY014801","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1996959039","https://openalex.org/W2047271419","https://openalex.org/W2057802075","https://openalex.org/W2065739825","https://openalex.org/W2103450296","https://openalex.org/W2120983130","https://openalex.org/W2123634216","https://openalex.org/W2126037931","https://openalex.org/W2134837534","https://openalex.org/W2461373362","https://openalex.org/W2530391744","https://openalex.org/W2782326528","https://openalex.org/W2782630125","https://openalex.org/W2792204868","https://openalex.org/W2903799300"],"related_works":["https://openalex.org/W3184999169","https://openalex.org/W2948226711","https://openalex.org/W2904679253","https://openalex.org/W2057802075","https://openalex.org/W3081886695","https://openalex.org/W3216080856","https://openalex.org/W2782630125","https://openalex.org/W2802287835","https://openalex.org/W2003179980","https://openalex.org/W2253372848"],"abstract_inverted_index":{"Importance:":[0],"There":[1],"has":[2],"been":[3],"speculation":[4],"on":[5],"the":[6,40,113,140,177,189,213,217,236,244],"pathogenesis":[7,41],"of":[8,34,42,81,179,205,219,239,261],"unilateral":[9,23,43,68,252],"multifocal":[10,24,44,69,173,253],"uveal":[11,25,45,70,97,110,174,254],"melanoma,":[12],"but":[13],"there":[14],"remains":[15],"no":[16],"convincing":[17],"explanation.":[18],"Genetic":[19],"analysis":[20,129],"suggests":[21,224],"that":[22,235,249],"melanoma":[26,98,111,175,255],"may":[27,256],"represent":[28],"intraocular":[29,225],"metastasis":[30,226,240],"with":[31,67,96,101,188,251],"increased":[32,259],"risk":[33,260],"systemic":[35,262],"metastasis.":[36,263],"Objective:":[37],"To":[38],"evaluate":[39],"melanoma.":[46,71],"Design,":[47],"Setting,":[48],"and":[49,64,74,78,104,142,151,170,195,247],"Participants:":[50],"This":[51],"clinical":[52],"case":[53],"series":[54],"was":[55],"conducted":[56],"in":[57,112,157,176,186,209,212,216],"tertiary":[58],"academic":[59],"ocular":[60,120,180],"oncology":[61],"referral":[62],"centers":[63],"included":[65],"patients":[66,86,250],"Main":[72],"Outcomes":[73],"Measures:":[75],"Gene":[76],"expression":[77,134,193],"mutation":[79,223],"profiling":[80],"tumor":[82],"samples.":[83],"Results:":[84],"Four":[85],"(all":[87],"male;":[88],"age":[89],"range,":[90],"54-77":[91],"years)":[92],"who":[93],"were":[94,99,116,145,155,161],"diagnosed":[95],"treated":[100],"plaque":[102],"brachytherapy,":[103],"subsequently":[105],"developed":[106],"a":[107,196,220],"second":[108],"discrete":[109],"same":[114,214],"eye":[115,215,245],"included.":[117],"None":[118],"demonstrated":[119],"or":[121],"oculodermal":[122],"melanocytosis.":[123],"All":[124],"8":[125],"tumors":[126,144,187,211],"available":[127,146],"for":[128,147],"exhibited":[130],"class":[131,190],"2":[132,191],"gene":[133,192,200],"profiles.":[135],"In":[136],"all":[137],"4":[138],"cases,":[139],"initial":[141],"subsequent":[143],"targeted":[148],"DNA":[149],"sequencing":[150],"identical":[152,206],"driver":[153],"mutations":[154,208],"present":[156],"both":[158],"tumors.":[159,231],"Data":[160],"collected":[162],"from":[163],"September":[164],"2015":[165],"to":[166,183],"August":[167],"2018.":[168],"Conclusions":[169],"Relevance:":[171],"Unilateral":[172],"absence":[178,218],"melanocytosis":[181],"appears":[182],"occur":[184],"preferentially":[185],"profile":[194],"BRCA1-associated":[197],"protein":[198],"1":[199],"(BAP1)":[201],"mutation.":[202],"The":[203],"presence":[204],"BAP1":[207,222],"multiple":[210],"germline":[221],"rather":[227],"than":[228],"independent":[229],"primary":[230],"These":[232],"findings":[233],"indicate":[234],"first":[237],"site":[238],"can":[241],"be":[242,257],"within":[243],"itself":[246],"suggest":[248],"at":[258]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-10T00:00:00"}
