{"id":"https://openalex.org/W2977280321","doi":"https://doi.org/10.3390/nu11102354","title":"Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice","display_name":"Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice","publication_year":2019,"publication_date":"2019-10-02","ids":{"openalex":"https://openalex.org/W2977280321","doi":"https://doi.org/10.3390/nu11102354","mag":"2977280321","pmid":"https://pubmed.ncbi.nlm.nih.gov/31581754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6835603"},"language":"en","primary_location":{"id":"doi:10.3390/nu11102354","doi":"https://doi.org/10.3390/nu11102354","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11102354","pdf_url":"https://www.mdpi.com/2072-6643/11/10/2354/pdf?version=1570692059","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/11/10/2354/pdf?version=1570692059","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066871890","display_name":"Da-Bin Myung","orcid":"https://orcid.org/0000-0003-4781-8208","observed_orcids":["https://orcid.org/0000-0003-4781-8208"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da-Bin Myung","raw_affiliation_strings":["Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4781-8208","affiliations":[{"raw_affiliation_string":"Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015881907","display_name":"Hee-Soo Han","orcid":"https://orcid.org/0000-0002-2377-0847","observed_orcids":["https://orcid.org/0000-0002-2377-0847"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Soo Han","raw_affiliation_strings":["Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102991544","display_name":"Ji\u2010Sun Shin","orcid":"https://orcid.org/0000-0001-7255-051X","observed_orcids":["https://orcid.org/0000-0001-7255-051X"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Sun Shin","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7255-051X","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674273","display_name":"Ji Yeon Park","orcid":"https://orcid.org/0000-0001-6420-8482","observed_orcids":["https://orcid.org/0000-0001-6420-8482","https://orcid.org/0009-0004-9802-7275"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Yeon Park","raw_affiliation_strings":["Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023639573","display_name":"Hanjun Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Jun Hwang","raw_affiliation_strings":["Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112417977","display_name":"Hyoung Ja Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyoung Ja Kim","raw_affiliation_strings":["Molecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Seoul 02792, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Seoul 02792, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101809496","display_name":"Hye Shin Ahn","orcid":"https://orcid.org/0000-0002-0484-234X","observed_orcids":["https://orcid.org/0000-0002-0484-234X"]},"institutions":[{"id":"https://openalex.org/I4405267993","display_name":"Cosmax Inc. (South Korea)","ror":"https://ror.org/05acby202","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405267993"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Shin Ahn","raw_affiliation_strings":["Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea","institution_ids":["https://openalex.org/I4405267993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734966","display_name":"Sun Hee Lee","orcid":"https://orcid.org/0000-0003-2908-5231","observed_orcids":["https://orcid.org/0000-0003-2908-5231"]},"institutions":[{"id":"https://openalex.org/I4405267993","display_name":"Cosmax Inc. (South Korea)","ror":"https://ror.org/05acby202","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405267993"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sun Hee Lee","raw_affiliation_strings":["Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea","institution_ids":["https://openalex.org/I4405267993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073243425","display_name":"Kyung\u2010Tae Lee","orcid":"https://orcid.org/0000-0002-3141-3727","observed_orcids":["https://orcid.org/0000-0002-3141-3727"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung-Tae Lee","raw_affiliation_strings":["Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3141-3727","affiliations":[{"raw_affiliation_string":"Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073243425","https://openalex.org/A5100734966"],"corresponding_institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405267993"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2026},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2026},"fwci":7.5328,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.97925048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"2354","last_page":"2354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrangenol","display_name":"hydrangenol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydrangea-serrata","display_name":"Hydrangea serrata","score":0.9789999723434448},{"id":"https://openalex.org/keywords/uv-b-irradiation","display_name":"UVB irradiation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.7170000076293945},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/involucrin","display_name":"involucrin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/filaggrin","display_name":"filaggrin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aquaporin-3","display_name":"AQP3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antioxidant-genes","display_name":"antioxidant genes","score":0.6039999723434448},{"id":"https://openalex.org/keywords/hairless-mice","display_name":"hairless mice","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.8436383008956909},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5731759071350098},{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.5163934826850891},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46974876523017883},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.4564729332923889},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.44306686520576477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4406062960624695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4398086667060852},{"id":"https://openalex.org/C2781173740","wikidata":"https://www.wikidata.org/wiki/Q18026132","display_name":"GCLM","level":5,"score":0.4152447581291199},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.414800226688385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3529040515422821},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27795925736427307},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.1585119068622589},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08356589078903198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090602","descriptor_name":"Collagen Type I, alpha 1 Chain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008812","descriptor_name":"Mice, Hairless","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031966","descriptor_name":"Hydrangea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049934","descriptor_name":"Isocoumarins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D049934","descriptor_name":"Isocoumarins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/nu11102354","doi":"https://doi.org/10.3390/nu11102354","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11102354","pdf_url":"https://www.mdpi.com/2072-6643/11/10/2354/pdf?version=1570692059","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6835603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6835603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:31581754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31581754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:75cc0b3e7d1b44c3908156417ec17045","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/75cc0b3e7d1b44c3908156417ec17045","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrients, Vol 11, Iss 10, p 2354 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nu11102354","doi":"https://doi.org/10.3390/nu11102354","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu11102354","pdf_url":"https://www.mdpi.com/2072-6643/11/10/2354/pdf?version=1570692059","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4416913934","display_name":null,"funder_award_id":"117070-03","funder_id":"https://openalex.org/F4320322068","funder_display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries"}],"funders":[{"id":"https://openalex.org/F4320322068","display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","ror":"https://ror.org/00c25dn03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977280321.pdf","grobid_xml":"https://content.openalex.org/works/W2977280321.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W122450722","https://openalex.org/W1728722352","https://openalex.org/W1826137220","https://openalex.org/W1968551495","https://openalex.org/W2001018304","https://openalex.org/W2002531179","https://openalex.org/W2007146099","https://openalex.org/W2007318121","https://openalex.org/W2008820810","https://openalex.org/W2013305350","https://openalex.org/W2016478164","https://openalex.org/W2017609866","https://openalex.org/W2024837178","https://openalex.org/W2032017022","https://openalex.org/W2032896969","https://openalex.org/W2040971099","https://openalex.org/W2044280032","https://openalex.org/W2044284455","https://openalex.org/W2045318927","https://openalex.org/W2046756676","https://openalex.org/W2049693200","https://openalex.org/W2052813747","https://openalex.org/W2054374698","https://openalex.org/W2054988846","https://openalex.org/W2057267126","https://openalex.org/W2065895195","https://openalex.org/W2069456037","https://openalex.org/W2072212732","https://openalex.org/W2076571568","https://openalex.org/W2089708939","https://openalex.org/W2092608508","https://openalex.org/W2100859158","https://openalex.org/W2101089137","https://openalex.org/W2115914792","https://openalex.org/W2117800935","https://openalex.org/W2121511326","https://openalex.org/W2135319665","https://openalex.org/W2158046173","https://openalex.org/W2171409611","https://openalex.org/W2312256607","https://openalex.org/W2320751016","https://openalex.org/W2409710963","https://openalex.org/W2467949190","https://openalex.org/W2476542314","https://openalex.org/W2528040020","https://openalex.org/W2562433766","https://openalex.org/W2595642624","https://openalex.org/W2599638325","https://openalex.org/W2734749797","https://openalex.org/W2754691730","https://openalex.org/W2761995438","https://openalex.org/W2769955933","https://openalex.org/W2780716966","https://openalex.org/W2780965738","https://openalex.org/W2782711276","https://openalex.org/W2783483586","https://openalex.org/W2794848018","https://openalex.org/W2900047541","https://openalex.org/W2907498593","https://openalex.org/W2912704270","https://openalex.org/W2918972776"],"related_works":["https://openalex.org/W2915924151","https://openalex.org/W2918972776","https://openalex.org/W4378072190","https://openalex.org/W3000150612","https://openalex.org/W2924873497","https://openalex.org/W1536122023","https://openalex.org/W4378348802","https://openalex.org/W3029352171","https://openalex.org/W3169194885","https://openalex.org/W4311793470"],"abstract_inverted_index":{"leaves":[0],"exerts":[1],"antiphotoaging":[2,12],"activity":[3],"in":[4,14,38],"vitro.":[5],"In":[6],"this":[7],"study,":[8],"we":[9],"determined":[10],"its":[11],"effect":[13],"UVB-irradiated":[15],"HR-1":[16],"hairless":[17],"mice.":[18],"We":[19],"evaluated":[20],"wrinkle":[21,43,167],"formation,":[22,44],"skin":[23],"thickness,":[24,46],"histological":[25],"characteristics,":[26],"and":[27,29,34,48,58,92,111,118,121,151,172,176,183],"mRNA":[28],"protein":[30,106,114],"expression":[31,54,80,95,130,179],"using":[32],"qRT-PCR":[33],"Western":[35],"blot":[36],"analysis":[37],"dorsal":[39,45],"skins.":[40],"Hydrangenol":[41,51,100,127],"mitigated":[42],"dehydration,":[47],"collagen":[49,77],"degradation.":[50],"increased":[52,84],"the":[53,74,79,102,129,178],"of":[55,76,81,104,123,131,180],"involucrin,":[56],"filaggrin,":[57],"aquaporin-3":[59],"(AQP3)":[60],"as":[61,63],"well":[62],"hyaluronic":[64],"acid":[65],"(HA)":[66],"production":[67],"via":[68],"hyaluronidase":[69],"(HYAL)-1/-2":[70],"downregulation.":[71],"Consistent":[72],"with":[73],"recovery":[75],"composition,":[78],"Pro-COL1A1":[82],"was":[83,96],"by":[85,98,169],"hydrangenol.":[86,99],"Matrix":[87],"metalloproteinase":[88],"(MMP)-1/-3,":[89],"cyclooxygenase-2":[90],"(COX-2),":[91],"interleukin-6":[93],"(IL-6)":[94],"reduced":[97],"attenuated":[101],"phosphorylation":[103],"mitogen-activated":[105],"kinases":[107],"(MAPKs)":[108],"including":[109],"ERK":[110],"p38,":[112],"activator":[113],"1":[115,125,143],"(AP-1)":[116],"subunit,":[117],"signal":[119],"transduction":[120],"activation":[122],"transcription":[124],"(STAT1).":[126],"upregulated":[128],"nuclear":[132],"factor-E2-related":[133],"factor":[134],"2":[135],"(Nrf2),":[136],"heme":[137],"oxygenase-1":[138],"(HO-1),":[139],"NAD(P)H":[140],"quinone":[141],"dehydrogenase":[142],"(NQO-1),":[144],"glutamate":[145,152],"cysteine":[146,153],"ligase":[147,154],"modifier":[148],"subunit":[149,156],"(GCLM),":[150],"catalysis":[155],"(GCLC).":[157],"Taken":[158],"together,":[159],"our":[160],"data":[161],"suggest":[162],"that":[163],"hydrangenol":[164],"can":[165],"prevent":[166],"formation":[168],"reducing":[170],"MMP":[171],"inflammatory":[173],"cytokine":[174],"levels":[175],"increasing":[177],"moisturizing":[181],"factors":[182],"antioxidant":[184],"genes.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-10-10T00:00:00"}
