{"id":"https://openalex.org/W2977264104","doi":"https://doi.org/10.1002/cncr.32542","title":"Health care utilization and steroid\u2010refractory toxicities from immune checkpoint inhibitors","display_name":"Health care utilization and steroid\u2010refractory toxicities from immune checkpoint inhibitors","publication_year":2019,"publication_date":"2019-10-03","ids":{"openalex":"https://openalex.org/W2977264104","doi":"https://doi.org/10.1002/cncr.32542","mag":"2977264104","pmid":"https://pubmed.ncbi.nlm.nih.gov/31580492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6952563"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.32542","doi":"https://doi.org/10.1002/cncr.32542","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32542","pdf_url":"https://acsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32542","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://acsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32542","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113881762","display_name":"Laura X. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura X. Wang","raw_affiliation_strings":["Vanderbilt School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050098540","display_name":"Henry T. Quach","orcid":"https://orcid.org/0000-0001-9142-6397","observed_orcids":["https://orcid.org/0000-0001-9142-6397"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry T. Quach","raw_affiliation_strings":["Vanderbilt School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009536315","display_name":"Nikil V. Moodabigil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikil V. Moodabigil","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068498659","display_name":"Elizabeth J. Davis","orcid":"https://orcid.org/0000-0001-7626-2435","observed_orcids":["https://orcid.org/0000-0001-7626-2435"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Davis","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075566772","display_name":"Jeffrey Alan Sosman","orcid":"https://orcid.org/0000-0002-0650-9698","observed_orcids":["https://orcid.org/0000-0002-0650-9698"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Sosman","raw_affiliation_strings":["Department of Medicine, Northwestern University Medical Center and Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Northwestern University Medical Center and Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041418355","display_name":"Stacie B. Dusetzina","orcid":"https://orcid.org/0000-0002-3907-9196","observed_orcids":["https://orcid.org/0000-0002-3907-9196"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacie B. Dusetzina","raw_affiliation_strings":["Department of Health Policy, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Policy, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025067315","display_name":"Douglas Buckner Johnson","orcid":"https://orcid.org/0000-0002-6390-773X","observed_orcids":["https://orcid.org/0000-0002-6390-773X"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas B. Johnson","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee"],"raw_orcid":"https://orcid.org/0000-0002-6390-773X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025067315"],"corresponding_institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.0422,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.78078856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"126","issue":"2","first_page":"322","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.847000002861023},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.8050000071525574},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9544562101364136},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8512541651725769},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7594267129898071},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.651619017124176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6281722187995911},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5282430052757263},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4968726933002472},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45987218618392944},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.45125189423561096},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3480394184589386},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.17065981030464172},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074324","descriptor_name":"Ipilimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010342","descriptor_name":"Patient Acceptance of Health Care","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.32542","doi":"https://doi.org/10.1002/cncr.32542","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32542","pdf_url":"https://acsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32542","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:31580492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31580492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6713323","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6952563","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6952563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6952563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cncr.32542","doi":"https://doi.org/10.1002/cncr.32542","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32542","pdf_url":"https://acsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32542","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2001365093","display_name":null,"funder_award_id":"NCI K23 CA204726","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G26160426","display_name":"Predicting and profiling long-term survival after immune checkpoint inhibition","funder_award_id":"K23CA204726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7776168312","display_name":"(PQ8) Patient- and tumor-specific biomarkers and mechanisms that predict irAEs resulting from checkpoint inhibition","funder_award_id":"R01CA227481","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000083166","display_name":"Vanderbilt Clinical Oncology Research Career Development Award","funder_award_id":"K12CA090625","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000919000","display_name":"Long-Term Cardiovascular Sequelae of Cancer Immunotherapies","funder_award_id":"R01HL155990","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G95646643","display_name":null,"funder_award_id":"CA204726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320307013","display_name":"Melanoma Research Foundation","ror":"https://ror.org/00wyk1t96"},{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977264104.pdf","grobid_xml":"https://content.openalex.org/works/W2977264104.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1809627231","https://openalex.org/W2019607817","https://openalex.org/W2097995306","https://openalex.org/W2128035403","https://openalex.org/W2148587601","https://openalex.org/W2164838411","https://openalex.org/W2338494814","https://openalex.org/W2515516401","https://openalex.org/W2519469881","https://openalex.org/W2547133566","https://openalex.org/W2549481046","https://openalex.org/W2553340100","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2580311324","https://openalex.org/W2749408522","https://openalex.org/W2753432434","https://openalex.org/W2783137027","https://openalex.org/W2791483720","https://openalex.org/W2793167197","https://openalex.org/W2800213865","https://openalex.org/W2877328171","https://openalex.org/W2888298425","https://openalex.org/W2891486030","https://openalex.org/W2895125473","https://openalex.org/W2896600825","https://openalex.org/W2916440172"],"related_works":["https://openalex.org/W3003593122","https://openalex.org/W2762827891","https://openalex.org/W2248168298","https://openalex.org/W2786993313","https://openalex.org/W2891595323","https://openalex.org/W3170700008","https://openalex.org/W3042663922","https://openalex.org/W2999691828","https://openalex.org/W2466451466","https://openalex.org/W3152854050"],"abstract_inverted_index":{"BACKGROUND:":[0],"Anti-programmed":[1],"death":[2],"protein":[3],"1":[4],"(anti-PD-1)":[5],"agents":[6],"have":[7,169],"transformed":[8],"the":[9,18,222,274,285],"treatment":[10],"of":[11,20,63,83,195,251,258,288],"advanced":[12],"melanoma":[13,39,56],"and":[14,23,65,81,88,92,118,141,151,189,253,260,281],"other":[15],"cancers,":[16],"but":[17],"rates":[19,257],"steroid-refractory":[21,155,261],"toxicities":[22,156,262],"health":[24],"care":[25],"utilization":[26],"are":[27],"not":[28],"well":[29],"described.":[30],"This":[31,48],"study":[32,49],"assessed":[33],"these":[34],"endpoints":[35],"in":[36,212,284],"patients":[37,53,164,213],"with":[38,41,43,54,58,248,266],"treated":[40,57,247,265],"anti-PD-1":[42,59,267],"or":[44,60,178],"without":[45],"ipilimumab.":[46],"METHODS:":[47],"retrospectively":[50],"evaluated":[51],"344":[52],"metastatic":[55],"a":[61,191,233,249,278],"combination":[62,100,250],"ipilimumab":[64,252],"nivolumab":[66,254],"at":[67],"Vanderbilt":[68],"University":[69],"Medical":[70],"Center":[71],"from":[72,239],"2009":[73],"to":[74,105,122,152,168,209,241],"2018.":[75],"The":[76],"incidence,":[77],"types,":[78],"grades,":[79],"management,":[80],"outcomes":[82],"immune-related":[84],"adverse":[85],"events":[86],"(irAEs)":[87],"hospitalizations":[89,180,207,228,270],"for":[90,181,229],"irAEs":[91,107,182],"disease":[93,210],"progression":[94,211],"were":[95,102,119,165,271],"assessed.":[96],"RESULTS:":[97],"Patients":[98,246],"on":[99,110],"therapy":[101],"more":[103,120,166],"likely":[104,121,167],"develop":[106],"than":[108,263],"those":[109,264],"monotherapy":[111],"(72%":[112],"vs":[113,127,136,146,158,173,184,199],"37%;":[114],"P":[115,129,138,148,160,175,186,202],"<":[116,130,139,149,161,176],".001)":[117,150,177,188],"require":[123],"systemic":[124],"steroids":[125],"(61%":[126],"20%;":[128],".001),":[131,140],"steroid":[132],"dose":[133],"re-escalation":[134],"(23%":[135,157],"6%;":[137],"second-line":[142],"immunosuppressive":[143],"use":[144],"(17%":[145],"2%;":[147],"suffer":[153],"high-dose":[154],"3%;":[159,185],".001).":[162],"Combination-treated":[163],"any":[170],"hospitalization":[171,196,259],"(32%":[172],"7%;":[174],"multiple":[179],"(11%":[183],"=":[187,203],"had":[190,255],"longer":[192],"average":[193],"time":[194,238],"(mean,":[197],"1.92":[198],"0.62":[200],"days;":[201],".002).":[204],"Among":[205],"176":[206],"related":[208],"who":[214],"died":[215],"during":[216],"evaluable":[217],"follow-up,":[218],"69%":[219],"occurred":[220,283],"within":[221],"90":[223],"days":[224],"before":[225],"death.":[226],"Early":[227],"disease-related":[230],"reasons":[231],"portended":[232,277],"very":[234],"poor":[235,279],"prognosis":[236],"(median":[237],"admission":[240],"death,":[242],"58":[243],"days).":[244],"CONCLUSIONS:":[245],"higher":[256],"monotherapy.":[268],"Disease-associated":[269],"similar":[272],"between":[273],"2":[275],"groups,":[276],"prognosis,":[280],"mostly":[282],"last":[286],"months":[287],"life.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-10-10T00:00:00"}
