{"id":"https://openalex.org/W2976919829","doi":"https://doi.org/10.4103/jioh.jioh_66_19","title":"Analysis of serum zinc and copper levels in patients with oral potentially malignant disorders: A cross-sectional study","display_name":"Analysis of serum zinc and copper levels in patients with oral potentially malignant disorders: A cross-sectional study","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2976919829","doi":"https://doi.org/10.4103/jioh.jioh_66_19","mag":"2976919829"},"language":"en","primary_location":{"id":"doi:10.4103/jioh.jioh_66_19","doi":"https://doi.org/10.4103/jioh.jioh_66_19","is_oa":false,"landing_page_url":"https://doi.org/10.4103/jioh.jioh_66_19","pdf_url":null,"source":{"id":"https://openalex.org/S2764586409","display_name":"Journal of international oral health","issn_l":"0976-1799","issn":["0976-1799","0976-7428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Oral Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103711733","display_name":"Ranjana Garg","orcid":"https://orcid.org/0000-0002-0124-511X","observed_orcids":["https://orcid.org/0000-0002-0124-511X"]},"institutions":[{"id":"https://openalex.org/I902764099","display_name":"SEGi University","ror":"https://ror.org/05crr5s63","country_code":"MY","type":"education","lineage":["https://openalex.org/I902764099"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Ranjana Garg","raw_affiliation_strings":["Faculty of Dentistry, SEGi University, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, SEGi University, Selangor, Malaysia","institution_ids":["https://openalex.org/I902764099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060971875","display_name":"Vivek Vijay Gupta","orcid":"https://orcid.org/0000-0001-8716-9543","observed_orcids":["https://orcid.org/0000-0001-8716-9543"]},"institutions":[{"id":"https://openalex.org/I902764099","display_name":"SEGi University","ror":"https://ror.org/05crr5s63","country_code":"MY","type":"education","lineage":["https://openalex.org/I902764099"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"VivekV Gupta","raw_affiliation_strings":["Faculty of Dentistry, SEGi University, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, SEGi University, Selangor, Malaysia","institution_ids":["https://openalex.org/I902764099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112471129","display_name":"DanielD Dicksit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902764099","display_name":"SEGi University","ror":"https://ror.org/05crr5s63","country_code":"MY","type":"education","lineage":["https://openalex.org/I902764099"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"DanielD Dicksit","raw_affiliation_strings":["Faculty of Dentistry, SEGi University, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, SEGi University, Selangor, Malaysia","institution_ids":["https://openalex.org/I902764099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103711733"],"corresponding_institution_ids":["https://openalex.org/I902764099"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"208","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-zinc","display_name":"serum zinc","score":0.7170000076293945},{"id":"https://openalex.org/keywords/serum-copper","display_name":"serum copper","score":1.0},{"id":"https://openalex.org/keywords/oral-premalignant-lesions","display_name":"oral potentially malignant disorders","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oral-submucous-fibrosis","display_name":"oral submucous fibrosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/leukoplakia","display_name":"leukoplakia","score":0.949999988079071},{"id":"https://openalex.org/keywords/oral-lichen-planus","display_name":"oral lichen planus","score":1.0},{"id":"https://openalex.org/keywords/trace-elements","display_name":"trace elements","score":0.9649999737739563},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9259999990463257},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.722000002861023},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2780672762","wikidata":"https://www.wikidata.org/wiki/Q7099404","display_name":"Oral submucous fibrosis","level":2,"score":0.7960721254348755},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.6228077411651611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6220264434814453},{"id":"https://openalex.org/C2776201145","wikidata":"https://www.wikidata.org/wiki/Q848371","display_name":"Oral lichen planus","level":2,"score":0.6101731061935425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6047874093055725},{"id":"https://openalex.org/C2909065260","wikidata":"https://www.wikidata.org/wiki/Q838145","display_name":"Oral leukoplakia","level":4,"score":0.5758819580078125},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5596430897712708},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5459961891174316},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5109845399856567},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4604218006134033},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.4420657753944397},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4417960047721863},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.41926059126853943},{"id":"https://openalex.org/C2777550702","wikidata":"https://www.wikidata.org/wiki/Q838145","display_name":"Leukoplakia","level":3,"score":0.39967891573905945},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38863638043403625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16373983025550842},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09258988499641418},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/jioh.jioh_66_19","doi":"https://doi.org/10.4103/jioh.jioh_66_19","is_oa":false,"landing_page_url":"https://doi.org/10.4103/jioh.jioh_66_19","pdf_url":null,"source":{"id":"https://openalex.org/S2764586409","display_name":"Journal of international oral health","issn_l":"0976-1799","issn":["0976-1799","0976-7428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Oral Health","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1980431323","https://openalex.org/W1990742392","https://openalex.org/W2004596931","https://openalex.org/W2030137203","https://openalex.org/W2069974995","https://openalex.org/W2075644244","https://openalex.org/W2108055826","https://openalex.org/W2314847084","https://openalex.org/W2327357116","https://openalex.org/W2529015933","https://openalex.org/W2531352562","https://openalex.org/W2776152832","https://openalex.org/W2810343872","https://openalex.org/W2886396926","https://openalex.org/W2923756156"],"related_works":["https://openalex.org/W2314847084","https://openalex.org/W149272744","https://openalex.org/W4302030430","https://openalex.org/W3151717196","https://openalex.org/W4401390344","https://openalex.org/W2728187999","https://openalex.org/W2418111740","https://openalex.org/W2030137203","https://openalex.org/W7221556356","https://openalex.org/W2317100650"],"abstract_inverted_index":{"Aims":[0],"and":[1,5,27,43,52,60,66,77,98,102,122,141,175,230,255],"Objectives:":[2],"Copper":[3],"(Cu)":[4],"Zinc":[6],"(Zn)":[7],"are":[8],"the":[9,22,38,55,58,63,110,116,135,147,154,158,162,189,196,204,216,222],"important":[10,16],"trace":[11],"elements":[12],"that":[13,187],"play":[14],"an":[15,123],"role":[17],"in":[18,40,46,180,188,195,215,225,237,257],"various":[19],"functions":[20],"of":[21,32,62,73,81,93,115,198,207,218,240,252],"human":[23],"body":[24],"at":[25],"cellular":[26],"molecular":[28],"level.":[29],"The":[30],"purpose":[31],"this":[33,69],"study":[34],"was":[35,119,126,201,213],"to":[36,53,186],"assess":[37],"alterations":[39],"serum":[41,138,199,219,243],"Cu":[42,140,200,229,244],"Zn":[44,142,220,231],"levels":[45,143,172,177,197,217,232,245],"oral":[47,85,94],"potentially":[48],"malignant":[49],"disorders":[50],"(OPMDs)":[51],"correlate":[54],"variations":[56],"with":[57,182,203,221],"severity":[59,256],"progression":[61,224,254],"OPMDs.":[64,241],"Materials":[65],"Methods:":[67],"In":[68],"institution-based":[70],"study,":[71],"20":[72,99],"each":[74],"clinically":[75,90],"diagnosed":[76,91],"histopathologically":[78],"proven":[79],"cases":[80,92],"leukoplakia":[82],"(Group":[83,88],"1),":[84],"lichen":[86],"planus":[87],"2),":[89],"submucous":[95],"fibrosis":[96],"(OSMF)":[97],"healthy":[100],"age":[101],"sex":[103],"matched":[104],"controls":[105],"were":[106,132,144,151,173,178],"taken":[107],"based":[108],"on":[109],"clinical":[111],"staging.":[112],"Clinical":[113],"examination":[114],"selected":[117],"subjects":[118],"carried":[120],"out":[121],"informed":[124],"consent":[125],"obtained,":[127],"following":[128],"which":[129],"blood":[130],"samples":[131],"collected":[133],"from":[134],"participants.":[136],"After":[137],"separation,":[139],"analyzed":[145],"using":[146,157],"colorimetric":[148],"method.":[149],"Data":[150],"sent":[152],"for":[153,161],"statistical":[155,210],"analysis":[156],"Statistical":[159],"Package":[160],"Social":[163],"Sciences":[164],"(SPSS)":[165],"software,":[166],"version":[167],"21.0.":[168],"Results:":[169],"Serum":[170,228],"copper":[171],"increased":[174],"zinc":[176],"decreased":[179],"patients":[181],"OPMDs":[183],"when":[184],"compared":[185],"control":[190],"group.":[191],"However,":[192],"gradual":[193],"increase":[194],"found":[202],"advancing":[205],"stages":[206],"OSMF.":[208,226,258],"No":[209],"significant":[211],"relation":[212],"observed":[214],"disease":[223,253],"Conclusion:":[227],"can":[233,246],"have":[234],"diagnostic":[235],"significance":[236],"early":[238],"evaluation":[239],"Increased":[242],"be":[247],"used":[248],"as":[249],"a":[250],"marker":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-10-03T00:00:00"}