{"id":"https://openalex.org/W2976647152","doi":"https://doi.org/10.1161/hypertensionaha.119.13664","title":"Blood Pressure Variability and Progression of Clinical Alzheimer Disease","display_name":"Blood Pressure Variability and Progression of Clinical Alzheimer Disease","publication_year":2019,"publication_date":"2019-09-23","ids":{"openalex":"https://openalex.org/W2976647152","doi":"https://doi.org/10.1161/hypertensionaha.119.13664","mag":"2976647152","pmid":"https://pubmed.ncbi.nlm.nih.gov/31542965"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.119.13664","doi":"https://doi.org/10.1161/hypertensionaha.119.13664","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.119.13664","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.119.13664","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.119.13664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108681832","display_name":"Rianne A.A. de Heus","orcid":"https://orcid.org/0000-0001-9676-001X","observed_orcids":["https://orcid.org/0000-0001-9676-001X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rianne A.A. de Heus","raw_affiliation_strings":["From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","Rianne A.A. de Heus From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]},{"raw_affiliation_string":"Rianne A.A. de Heus From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029136789","display_name":"Marcel G. M. Olde Rikkert","orcid":"https://orcid.org/0000-0003-1397-1677","observed_orcids":["https://orcid.org/0000-0003-1397-1677"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel G.M. Olde Rikkert","raw_affiliation_strings":["From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","Marcel G.M. Olde Rikkert From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]},{"raw_affiliation_string":"Marcel G.M. Olde Rikkert From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052944986","display_name":"Phillip J. Tully","orcid":"https://orcid.org/0000-0003-2807-1313","observed_orcids":["https://orcid.org/0000-0003-2807-1313"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Phillip J. Tully","raw_affiliation_strings":["School of Medicine, The University of Adelaide, Australia (P.J.T.)","Phillip J. Tully School of Medicine, The University of Adelaide, Australia (P.J.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, The University of Adelaide, Australia (P.J.T.)","institution_ids":["https://openalex.org/I5681781"]},{"raw_affiliation_string":"Phillip J. Tully School of Medicine, The University of Adelaide, Australia (P.J.T.)","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071373873","display_name":"BRIAN A. LAWLOR","orcid":"https://orcid.org/0000-0002-5012-2116","observed_orcids":["https://orcid.org/0000-0002-5012-2116"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brian A. Lawlor","raw_affiliation_strings":["Department of Medical Gerontology, Trinity College Institute of Neuroscience, Dublin, Ireland (B.A.L.)","Mercer\u2019s Institute for Research on Ageing, St. James\u2019s Hospital, Dublin, Ireland (B.A.L.)","Brian A. Lawlor Mercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland (B.A.L.) Department of Medical Gerontology, Trinity College Institute of Neuroscience, Dublin, Ireland (B.A.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gerontology, Trinity College Institute of Neuroscience, Dublin, Ireland (B.A.L.)","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Mercer\u2019s Institute for Research on Ageing, St. James\u2019s Hospital, Dublin, Ireland (B.A.L.)","institution_ids":["https://openalex.org/I4210154619"]},{"raw_affiliation_string":"Brian A. Lawlor Mercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland (B.A.L.) Department of Medical Gerontology, Trinity College Institute of Neuroscience, Dublin, Ireland (B.A.L.)","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012964731","display_name":"Jurgen A.H.R. Claassen","orcid":"https://orcid.org/0000-0002-1778-8151","observed_orcids":["https://orcid.org/0000-0002-1778-8151"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jurgen A.H.R. Claassen","raw_affiliation_strings":["From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Geriatric Medicine, Radboud umc University Medical Center, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., M.G.M.O.R., J.A.H.R.C.)","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the NILVAD Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the NILVAD Study Group","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5692,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.9863716,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"74","issue":"5","first_page":"1172","last_page":"1180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-pressure-variability","display_name":"blood pressure variability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8999999761581421},{"id":"https://openalex.org/keywords/functional-decline","display_name":"functional decline","score":0.9819999933242798},{"id":"https://openalex.org/keywords/visit-to-visit-blood-pressure-variability","display_name":"visit-to-visit blood pressure variability","score":0.7450000047683716},{"id":"https://openalex.org/keywords/home-blood-pressure-monitoring","display_name":"home blood pressure monitoring","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nilvadipine","display_name":"nilvadipine","score":0.8069999814033508},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.617536723613739},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6122702360153198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5698671340942383},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.48680397868156433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41449978947639465},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3984576463699341}],"mesh":[{"descriptor_ui":"D000073216","descriptor_name":"Mental Status and Dementia Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1161/hypertensionaha.119.13664","doi":"https://doi.org/10.1161/hypertensionaha.119.13664","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.119.13664","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.119.13664","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:31542965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31542965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:figshare.com:article/28356623","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Blood_pressure_variability_and_progression_of_clinical_Alzheimer_disease/28356623","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/209401","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/209401","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:rune.une.edu.au:1959.11/51722","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1959.11/51722","pdf_url":null,"source":{"id":"https://openalex.org/S7407055448","display_name":"RUNE (Research UNE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/209401","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/209401","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hypertension, 74, 1172 - 1180","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.119.13664","doi":"https://doi.org/10.1161/hypertensionaha.119.13664","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.119.13664","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.119.13664","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2976647152.pdf","grobid_xml":"https://content.openalex.org/works/W2976647152.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W142128493","https://openalex.org/W152398027","https://openalex.org/W234565542","https://openalex.org/W1500668502","https://openalex.org/W1561543161","https://openalex.org/W1953027527","https://openalex.org/W1970578311","https://openalex.org/W1970696063","https://openalex.org/W1975409580","https://openalex.org/W1988381397","https://openalex.org/W1992998861","https://openalex.org/W1995540073","https://openalex.org/W2007392207","https://openalex.org/W2018279377","https://openalex.org/W2025309234","https://openalex.org/W2028507273","https://openalex.org/W2034897558","https://openalex.org/W2036821862","https://openalex.org/W2043522411","https://openalex.org/W2043618136","https://openalex.org/W2048075564","https://openalex.org/W2052742260","https://openalex.org/W2055268621","https://openalex.org/W2061175143","https://openalex.org/W2064192867","https://openalex.org/W2065301205","https://openalex.org/W2074245499","https://openalex.org/W2089716682","https://openalex.org/W2102343148","https://openalex.org/W2112650958","https://openalex.org/W2116224448","https://openalex.org/W2123940611","https://openalex.org/W2125062701","https://openalex.org/W2127606189","https://openalex.org/W2145130062","https://openalex.org/W2148197167","https://openalex.org/W2170814973","https://openalex.org/W2171629589","https://openalex.org/W2313739417","https://openalex.org/W2314365807","https://openalex.org/W2397251281","https://openalex.org/W2407490484","https://openalex.org/W2408213223","https://openalex.org/W2474981734","https://openalex.org/W2505774393","https://openalex.org/W2524359746","https://openalex.org/W2530115453","https://openalex.org/W2583882258","https://openalex.org/W2616216465","https://openalex.org/W2622018490","https://openalex.org/W2736307756","https://openalex.org/W2742309698","https://openalex.org/W2787861519","https://openalex.org/W2790460340","https://openalex.org/W2794431792","https://openalex.org/W2795208805","https://openalex.org/W2798054687","https://openalex.org/W2802170692","https://openalex.org/W2807495507","https://openalex.org/W2807665547","https://openalex.org/W2808600489","https://openalex.org/W2884013251","https://openalex.org/W2888589263","https://openalex.org/W2891955176","https://openalex.org/W2903676197","https://openalex.org/W2925070304","https://openalex.org/W2946578677","https://openalex.org/W2984530294"],"related_works":["https://openalex.org/W2061508275","https://openalex.org/W2148197167","https://openalex.org/W2925070304","https://openalex.org/W2314365807","https://openalex.org/W234565542","https://openalex.org/W4287313056","https://openalex.org/W4415280107","https://openalex.org/W6926559513","https://openalex.org/W3178121119","https://openalex.org/W2051742690"],"abstract_inverted_index":{"Blood":[0],"pressure":[1,13],"variability":[2],"(BPV)":[3],"has":[4],"been":[5],"shown":[6],"to":[7,51,70,92,293],"have":[8],"predictive":[9],"value":[10],"over":[11],"blood":[12],"(BP)":[14],"levels":[15],"alone":[16],"in":[17,29,49,82,98,137,155,296],"stroke":[18],"patients.":[19,217],"We":[20],"assessed":[21,77],"whether":[22],"BPV":[23,75,142,205,212,224,277,287],"predicts":[24],"cognitive":[25],"and":[26,104,111,225,236,275],"functional":[27],"decline":[28,295],"Alzheimer":[30,58,284,299],"disease,":[31],"using":[32,78],"data":[33],"from":[34],"a":[35,83,290],"randomized":[36],"trial":[37],"(NILVAD":[38],"[A":[39],"European":[40],"Multicentre":[41],"Double-blind":[42],"Placebo-controlled":[43],"Phase":[44],"III":[45],"Trial":[46,302],"of":[47,88,116,126,141,203,283],"Nilvadipine":[48],"Mild":[50],"Moderate":[52],"Alzheimer\u2019s":[53,99,147,228],"Disease]).":[54],"Patients":[55],"with":[56,123,153,281,298],"mild-to-moderate":[57],"disease":[59],"were":[60,96,131,220,257],"included":[61],"if":[62],"they":[63],"had":[64,143],"\u22653":[65],"office":[66],"BP":[67,80,125],"measurements":[68,81],"available":[69,214],"determine":[71],"visit-to-visit":[72,204,274],"BPV.":[73,94],"Day-to-day":[74,211],"was":[76,90,177,200,213],"home":[79],"subsample.":[84],"The":[85],"variation":[86],"independent":[87],"mean":[89,124],"used":[91],"calculate":[93],"Outcomes":[95],"change":[97],"Disease":[100,148,229],"Assessment":[101,106,149,208,230,238],"Scale\u2013cognitive":[102,150,231],"subscale-12":[103],"Disability":[105,207,237],"for":[107,209,215,239,259],"Dementia":[108,240],"after":[109,180,247,252],"1":[110,134,248],"1.5":[112,181,253],"years.":[113,254],"A":[114],"total":[115],"460":[117],"patients":[118,136,154,297],"aged":[119],"72.1":[120],"(SD=8.1)":[121],"years,":[122],"134.0/75.1":[127],"(10.9/6.3)":[128],"mm":[129],"Hg":[130],"included.":[132],"After":[133],"year,":[135,249],"the":[138,156],"highest":[139],"quartile":[140,158],"deteriorated":[144],"more":[145],"on":[146,206,227],"subscale":[151,232],"compared":[152],"lowest":[157],"(systolic:":[159,183,233,241],"\u03b2,":[160,168,184,192],"2.24":[161],"[95%":[162,170,186,194],"CI,":[163,171,187,195],"0.11\u20134.38],":[164],"P":[165,173,189,197,234,242,245],"=0.040;":[166],"diastolic:":[167,191,244],"2.54":[169],"0.33\u20134.75]":[172],"=0.024).":[174],"This":[175],"association":[176],"still":[178],"present":[179],"years":[182],"2.86":[185],"0.35\u20135.36],":[188],"=0.026;":[190],"3.30":[193],"0.67\u20135.93],":[196],"=0.014).":[198],"There":[199],"no":[201],"effect":[202],"Dementia.":[210],"46":[216],"Significant":[218],"associations":[219,256],"observed":[221],"between":[222],"day-to-day":[223,276],"deterioration":[226],"=0.036)":[235],"=0.020;":[243],"=0.007)":[246],"but":[250],"not":[251],"All":[255],"adjusted":[258],"potential":[260],"confounders,":[261],"including":[262],"intervention":[263],"group.":[264],"In":[265],"conclusion,":[266],"this":[267],"post":[268],"hoc":[269],"analysis":[270],"indicates":[271],"that":[272],"higher":[273],"might":[278],"be":[279,289],"associated":[280],"progression":[282],"disease.":[285,300],"Targeting":[286],"may":[288],"future":[291],"target":[292],"slow":[294],"Clinical":[301],"Registration":[303],"URL:":[304],"https://www.clinicaltrials.gov":[305],".":[306],"Unique":[307],"identifier:":[308],"NCT02017340.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-10-03T00:00:00"}
