{"id":"https://openalex.org/W2976602014","doi":null,"title":"Mdivi-1 pretreatment mitigates isoflurane-induced cognitive deficits in developmental rats.","display_name":"Mdivi-1 pretreatment mitigates isoflurane-induced cognitive deficits in developmental rats.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2976602014","mag":"2976602014","pmid":"https://pubmed.ncbi.nlm.nih.gov/29511437","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835808"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5835808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835808","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101545643","display_name":"Jie Gao","orcid":"https://orcid.org/0000-0002-0621-0629","observed_orcids":["https://orcid.org/0000-0002-0621-0629"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Gao","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072828514","display_name":"Ailin Luo","orcid":"https://orcid.org/0000-0001-8826-5588","observed_orcids":["https://orcid.org/0000-0001-8826-5588"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ailin Luo","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729704","display_name":"Jing Yan","orcid":"https://orcid.org/0000-0003-3616-072X","observed_orcids":["https://orcid.org/0000-0003-3616-072X"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yan","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036289734","display_name":"Xi Fang","orcid":"https://orcid.org/0000-0002-5212-6866","observed_orcids":["https://orcid.org/0000-0002-5212-6866"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Fang","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002919820","display_name":"Xiaole Tang","orcid":"https://orcid.org/0009-0003-8070-0591","observed_orcids":["https://orcid.org/0009-0003-8070-0591"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaole Tang","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103281937","display_name":"Yilin Zhao","orcid":"https://orcid.org/0000-0003-2587-0400","observed_orcids":["https://orcid.org/0000-0003-2587-0400"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Zhao","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100780832","display_name":"Shiyong Li","orcid":"https://orcid.org/0000-0001-7442-1826","observed_orcids":["https://orcid.org/0000-0001-7442-1826"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyong Li","raw_affiliation_strings":["Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology1095 Jiefang Avenue, Wuhan 430030, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3567,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.48973747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"432","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9200000166893005},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mdivi-1","display_name":"Mdivi-1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.6740000247955322},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5680000185966492},{"id":"https://openalex.org/keywords/synaptic-injury","display_name":"synaptic injury","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bax-translocation","display_name":"Bax translocation","score":0.796999990940094},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neonatal-anesthesia","display_name":"neonatal anesthesia","score":0.6370000243186951},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.737839937210083},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.7285904884338379},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7174787521362305},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5653814673423767},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5302735567092896},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5214756727218628},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4967830777168274},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3858136534690857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.377811461687088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3611051142215729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34773826599121094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33365076780319214},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3099018931388855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16369503736495972},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.09576800465583801},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5835808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:29511437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29511437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2976602014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29511437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5835808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W206966289","https://openalex.org/W1515322286","https://openalex.org/W1766576124","https://openalex.org/W1838116882","https://openalex.org/W1966923900","https://openalex.org/W1969849548","https://openalex.org/W1970248089","https://openalex.org/W1970663322","https://openalex.org/W1973966118","https://openalex.org/W1974750801","https://openalex.org/W1996234796","https://openalex.org/W2002285262","https://openalex.org/W2008584420","https://openalex.org/W2011278616","https://openalex.org/W2018720554","https://openalex.org/W2020680478","https://openalex.org/W2032817697","https://openalex.org/W2036386225","https://openalex.org/W2045232627","https://openalex.org/W2047460306","https://openalex.org/W2047917515","https://openalex.org/W2049992435","https://openalex.org/W2051490833","https://openalex.org/W2054251296","https://openalex.org/W2055976032","https://openalex.org/W2058218592","https://openalex.org/W2059009119","https://openalex.org/W2061902760","https://openalex.org/W2065018825","https://openalex.org/W2072014371","https://openalex.org/W2074905627","https://openalex.org/W2075466397","https://openalex.org/W2080779842","https://openalex.org/W2082970812","https://openalex.org/W2085367705","https://openalex.org/W2094162211","https://openalex.org/W2100569554","https://openalex.org/W2101187510","https://openalex.org/W2113917457","https://openalex.org/W2120795431","https://openalex.org/W2124390363","https://openalex.org/W2136960006","https://openalex.org/W2138357624","https://openalex.org/W2139554185","https://openalex.org/W2155978870","https://openalex.org/W2161291398","https://openalex.org/W2162633290","https://openalex.org/W2168681379","https://openalex.org/W2169798151","https://openalex.org/W2172204522","https://openalex.org/W2179947625","https://openalex.org/W2273341597","https://openalex.org/W2274245595","https://openalex.org/W2307842559","https://openalex.org/W2308940318"],"related_works":["https://openalex.org/W2307842559","https://openalex.org/W3162704524","https://openalex.org/W2770346970","https://openalex.org/W2580792070","https://openalex.org/W1974451632","https://openalex.org/W2731100712","https://openalex.org/W2777164985","https://openalex.org/W3035674276","https://openalex.org/W2149509906","https://openalex.org/W2608713782"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"indicates":[2],"that":[3,92],"general":[4],"anesthetics":[5,18],"can":[6,79],"cause":[7],"acute":[8],"neuroapoptosis":[9],"and":[10,29,32,70,105,110,137,139,151,164,182,189,196,208,211,214],"long-term":[11,197,217],"cognitive":[12,166,198,218],"deficit":[13,167],"in":[14,55,68,154,168],"models":[15],"exposed":[16,174],"to":[17,34,75,114,175,185,192],"during":[19],"the":[20,38,60,87,122,159,193,216],"brain":[21],"growth-spurt":[22],"period.":[23],"Anesthetics-induced":[24],"imbalance":[25,39],"of":[26,44,63,108,135,161,171,227],"mitochondrial":[27,64,133,187,206],"fusion":[28],"fission":[30,188,207],"preceded":[31],"contributed":[33,191],"developmental":[35,81,228],"neuroapoptosis.":[36],"Accordingly,":[37],"was":[40,49],"accompanied":[41],"by":[42,84,231],"activation":[43,153,181],"dynamin-related":[45],"protein":[46],"(Drp)1":[47],"which":[48],"closely":[50],"associated":[51],"with":[52,117,126],"synaptic":[53,162,194,212],"degeneration":[54],"neurodegenerative":[56],"diseases.":[57],"Based":[58],"on":[59],"neuroprotective":[61],"role":[62],"division":[65],"inhibitor-1":[66],"(mdivi-1)":[67],"neurodegeneration":[69],"stroke,":[71],"we":[72,90],"set":[73],"out":[74],"examine":[76],"whether":[77],"mdivi-1":[78,127,157,201,221],"mitigate":[80],"neurotoxicity":[82,229],"induced":[83,230],"isoflurane.":[85,176,232],"In":[86],"present":[88],"study,":[89],"showed":[91],"2%":[93],"isoflurane":[94],"exposure":[95],"for":[96,225],"2":[97],"h":[98],"triggered":[99],"Drp1":[100,109,136,180],"dephosphorylation":[101],"at":[102],"serine":[103],"656":[104],"increased":[106],"translocation":[107,134,183],"Bax":[111,138],"from":[112],"cytosol":[113],"mitochondria,":[115],"concomitant":[116],"cytochrome":[118,147],"C":[119,148],"leakage":[120],"into":[121],"cytosol.":[123],"Remarkably,":[124],"pretreatment":[125,202],"not":[128],"only":[129],"alleviated":[130],"isoflurane-induced":[131,179],"disturbed":[132],"almost":[140],"restored":[141],"morphological":[142],"changes,":[143],"but":[144],"also":[145],"inhibited":[146],"release,":[149],"caspase9":[150],"caspase3":[152],"hippocampi.":[155],"Furthermore,":[156],"mitigated":[158,209],"loss":[160],"proteins":[163],"long-lasting":[165],"later":[169],"life":[170],"rats":[172],"neonatally":[173],"Taken":[177],"together,":[178],"led":[184],"excessive":[186,205],"subsequently":[190],"injury":[195],"impairment.":[199],"However,":[200],"prevented":[203],"Drp1-dependent":[204],"neuro-apoptosis":[210],"injury,":[213],"improved":[215],"function.":[219],"Thus":[220],"holds":[222],"far-reaching":[223],"insight":[224],"prophylaxis":[226]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-10-03T00:00:00"}