{"id":"https://openalex.org/W2976144232","doi":"https://doi.org/10.3390/biom9100550","title":"Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma","display_name":"Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W2976144232","doi":"https://doi.org/10.3390/biom9100550","mag":"2976144232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31575007"},"language":"en","primary_location":{"id":"doi:10.3390/biom9100550","doi":"https://doi.org/10.3390/biom9100550","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom9100550","pdf_url":"https://www.mdpi.com/2218-273X/9/10/550/pdf?version=1569839584","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/9/10/550/pdf?version=1569839584","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100599742","display_name":"Jong Hyun Lee","orcid":"https://orcid.org/0000-0003-1046-897X","observed_orcids":["https://orcid.org/0000-0003-1046-897X"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Hyun Lee","raw_affiliation_strings":["College of Korean Medicine, Kyung Hee University, #47, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Kyung Hee University, #47, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130-701, Korea","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058927102","display_name":"Shobith Rangappa","orcid":"https://orcid.org/0000-0002-9800-7192","observed_orcids":["https://orcid.org/0000-0002-9800-7192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shobith Rangappa","raw_affiliation_strings":["Adichunchanagiri Institute for Molecular Medicine, BG Nagara-571448, Nagamangala Taluk, Mandya District 571448, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adichunchanagiri Institute for Molecular Medicine, BG Nagara-571448, Nagamangala Taluk, Mandya District 571448, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010979184","display_name":"Chakrabhavi Dhananjaya Mohan","orcid":"https://orcid.org/0000-0002-6810-9219","observed_orcids":["https://orcid.org/0000-0002-6810-9219"]},"institutions":[{"id":"https://openalex.org/I204743663","display_name":"University of Mysore","ror":"https://ror.org/012bxv356","country_code":"IN","type":"education","lineage":["https://openalex.org/I204743663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chakrabhavi Dhananjaya Mohan","raw_affiliation_strings":["Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore 570006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore 570006, India","institution_ids":["https://openalex.org/I204743663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021327644","display_name":"Basappa Basappa","orcid":"https://orcid.org/0000-0002-8844-468X","observed_orcids":["https://orcid.org/0000-0002-8844-468X"]},"institutions":[{"id":"https://openalex.org/I204743663","display_name":"University of Mysore","ror":"https://ror.org/012bxv356","country_code":"IN","type":"education","lineage":["https://openalex.org/I204743663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Basappa","raw_affiliation_strings":["Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India"],"raw_orcid":"https://orcid.org/0000-0002-8844-468X","affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India","institution_ids":["https://openalex.org/I204743663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034304968","display_name":"Gautam Sethi","orcid":"https://orcid.org/0000-0002-8677-8475","observed_orcids":["https://orcid.org/0000-0002-8677-8475"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gautam Sethi","raw_affiliation_strings":["Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004560402","display_name":"Zhi\u2010Xiu Lin","orcid":"https://orcid.org/0000-0003-2840-6179","observed_orcids":["https://orcid.org/0000-0003-2840-6179"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhi-Xiu Lin","raw_affiliation_strings":["Faculty of Medicine, The Chinese University of Hong Kong, Rm 101, 1/F Li Wai Chun Building, CUHK, Shatin, N.T. 999077, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, The Chinese University of Hong Kong, Rm 101, 1/F Li Wai Chun Building, CUHK, Shatin, N.T. 999077, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073028598","display_name":"Kanchugarakoppal Subbegowda Rangappa","orcid":"https://orcid.org/0000-0003-0572-6305","observed_orcids":["https://orcid.org/0000-0003-0572-6305"]},"institutions":[{"id":"https://openalex.org/I204743663","display_name":"University of Mysore","ror":"https://ror.org/012bxv356","country_code":"IN","type":"education","lineage":["https://openalex.org/I204743663"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kanchugarakoppal S. Rangappa","raw_affiliation_strings":["Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore 570006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore 570006, India","institution_ids":["https://openalex.org/I204743663"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037236595","display_name":"Kwang Seok Ahn","orcid":"https://orcid.org/0000-0002-2882-0612","observed_orcids":["https://orcid.org/0000-0002-2882-0612"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kwang Seok Ahn","raw_affiliation_strings":["College of Korean Medicine, Kyung Hee University, #47, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130-701, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2882-0612","affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Kyung Hee University, #47, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130-701, Korea","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5037236595","https://openalex.org/A5073028598"],"corresponding_institution_ids":["https://openalex.org/I204743663","https://openalex.org/I35928602","https://openalex.org/I4405259603"],"apc_list":{"value":1200,"currency":"CHF","value_usd":1216},"apc_paid":{"value":1200,"currency":"CHF","value_usd":1216},"fwci":4.8064,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96203942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"10","first_page":"550","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brusatol","display_name":"brusatol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/nrf2-inhibitors","display_name":"Nrf2 inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":1.0},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.7570000290870667},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9190000295639038},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.7230108380317688},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6967790126800537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6467940807342529},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5604667067527771},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4913231432437897},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4662894904613495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3950822353363037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39038392901420593},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34422725439071655},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21481269598007202},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.12830013036727905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061944037675857544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06035959720611572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D036702","descriptor_name":"Quassins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036702","descriptor_name":"Quassins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036702","descriptor_name":"Quassins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom9100550","doi":"https://doi.org/10.3390/biom9100550","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom9100550","pdf_url":"https://www.mdpi.com/2218-273X/9/10/550/pdf?version=1569839584","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmid:31575007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31575007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6843503","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6843503","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/209547","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/209547","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2019","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:58a6329f90734808b53081c9caddf17c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/58a6329f90734808b53081c9caddf17c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 9, Iss 10, p 550 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom9100550","doi":"https://doi.org/10.3390/biom9100550","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom9100550","pdf_url":"https://www.mdpi.com/2218-273X/9/10/550/pdf?version=1569839584","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6399999856948853}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3985117418","display_name":null,"funder_award_id":"2017M3A9E4065333","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4030863319","display_name":null,"funder_award_id":"NRF\u20102017M3A9E4065333","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6003041914","display_name":null,"funder_award_id":"2018R1D1A1B07042969","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7554760274","display_name":null,"funder_award_id":"2017M3A9E4065333","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G7598633756","display_name":null,"funder_award_id":"NRF-2017M3A9E4065333 and 2018R1D1A1B07042969","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328621","display_name":"University of Mysore","ror":"https://ror.org/012bxv356"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2976144232.pdf","grobid_xml":"https://content.openalex.org/works/W2976144232.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W425532948","https://openalex.org/W1048961946","https://openalex.org/W1493557897","https://openalex.org/W1545911557","https://openalex.org/W1562057738","https://openalex.org/W1579890798","https://openalex.org/W1587528990","https://openalex.org/W1599834457","https://openalex.org/W1812164980","https://openalex.org/W1853943513","https://openalex.org/W1934957927","https://openalex.org/W1981840506","https://openalex.org/W1991013609","https://openalex.org/W2016614467","https://openalex.org/W2017779076","https://openalex.org/W2018659577","https://openalex.org/W2022669620","https://openalex.org/W2024964331","https://openalex.org/W2037904071","https://openalex.org/W2045429389","https://openalex.org/W2051724614","https://openalex.org/W2056961869","https://openalex.org/W2068648892","https://openalex.org/W2076971614","https://openalex.org/W2077950988","https://openalex.org/W2095910264","https://openalex.org/W2096182244","https://openalex.org/W2102912734","https://openalex.org/W2107060734","https://openalex.org/W2109786000","https://openalex.org/W2110842318","https://openalex.org/W2116508133","https://openalex.org/W2119130730","https://openalex.org/W2143819289","https://openalex.org/W2149873978","https://openalex.org/W2152750160","https://openalex.org/W2154413149","https://openalex.org/W2157647588","https://openalex.org/W2160417998","https://openalex.org/W2174398469","https://openalex.org/W2190626085","https://openalex.org/W2196215011","https://openalex.org/W2214549326","https://openalex.org/W2241507036","https://openalex.org/W2277406115","https://openalex.org/W2288651793","https://openalex.org/W2325023473","https://openalex.org/W2325707043","https://openalex.org/W2326620506","https://openalex.org/W2341035006","https://openalex.org/W2469918555","https://openalex.org/W2501536493","https://openalex.org/W2504338811","https://openalex.org/W2525431899","https://openalex.org/W2567401674","https://openalex.org/W2589094768","https://openalex.org/W2598653087","https://openalex.org/W2608052093","https://openalex.org/W2620241325","https://openalex.org/W2735458523","https://openalex.org/W2750768719","https://openalex.org/W2754163299","https://openalex.org/W2789698090","https://openalex.org/W2791833522","https://openalex.org/W2800059972","https://openalex.org/W2802296785","https://openalex.org/W2802403129","https://openalex.org/W2806456320","https://openalex.org/W2806658823","https://openalex.org/W2885958700","https://openalex.org/W2888803951","https://openalex.org/W2890743393","https://openalex.org/W2891863700","https://openalex.org/W2896536135","https://openalex.org/W2898079638","https://openalex.org/W2899784880","https://openalex.org/W2903930196","https://openalex.org/W2905373525","https://openalex.org/W2917410143","https://openalex.org/W2937259895","https://openalex.org/W2942536939","https://openalex.org/W2942539217","https://openalex.org/W2949022836","https://openalex.org/W6655150145","https://openalex.org/W6675746912"],"related_works":["https://openalex.org/W1967821671","https://openalex.org/W3030842346","https://openalex.org/W1969795570","https://openalex.org/W2125789691","https://openalex.org/W2063781606","https://openalex.org/W4290263427","https://openalex.org/W2060097039","https://openalex.org/W2023630604","https://openalex.org/W2367544750","https://openalex.org/W2124343538"],"abstract_inverted_index":{"STAT3":[0,52,86,108,126,168],"is":[1],"a":[2,8,27,39,82,164],"latent":[3],"transcription":[4,29],"factor":[5,30],"that":[6,100,110],"plays":[7],"vital":[9],"role":[10,34],"in":[11,35,61,89,155,171],"the":[12,20,36,74,96,105,122,144],"transmission":[13],"of":[14,38,42,51,55,85,107,111,124,149],"extracellular":[15],"signal":[16],"from":[17,95],"receptors":[18],"to":[19,32,47],"nucleus.":[21],"It":[22,120],"has":[23,58],"been":[24,59],"regarded":[25],"as":[26,81,115,163],"master":[28],"due":[31],"its":[33,56,128],"regulation":[37],"broad":[40],"spectrum":[41],"genes,":[43],"which":[44],"can":[45,161],"contribute":[46],"oncogenesis.":[48],"Persistent":[49],"activation":[50,106],"and":[53,67,103,109,118,127,139,142,146],"deregulation":[54],"signaling":[57,87,169],"observed":[60],"various":[62],"human":[63],"cancers":[64],"including":[65],"head":[66],"neck":[68],"squamous":[69],"cell":[70],"carcinoma":[71],"(HNSCC).":[72],"In":[73],"present":[75],"work,":[76],"we":[77],"identified":[78],"brusatol":[79,160],"(BT)":[80],"potential":[83],"blocker":[84],"pathway":[88,170],"diverse":[90,150],"HNSCC":[91,156],"cells.":[92,157],"The":[93],"data":[94],"cell-based":[97],"experiments":[98],"suggested":[99],"BT-induced":[101],"cytotoxicity":[102],"abrogated":[104],"upstream":[112],"kinases":[113],"such":[114],"JAK1,":[116],"JAK2,":[117],"Src.":[119],"reduced":[121],"levels":[123],"nuclear":[125],"DNA":[129],"binding":[130],"ability.":[131],"BT":[132],"treatment":[133],"increased":[134],"annexin-V-positive":[135],"cells,":[136],"promoted":[137],"procaspase-3":[138],"PARP":[140],"cleavage,":[141],"downregulated":[143],"mRNA":[145],"protein":[147],"expression":[148],"proteins":[151],"(Bcl-2,":[152],"Bcl-xl,":[153],"survivin)":[154],"Taken":[158],"together,":[159],"function":[162],"promising":[165],"inhibitor":[166],"targeting":[167],"HNSCC.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}