{"id":"https://openalex.org/W2976114805","doi":"https://doi.org/10.2210/pdb5g18/pdb","title":"Direct Observation of Active-site Protonation States in a Class A beta lactamase with a monobactam substrate","display_name":"Direct Observation of Active-site Protonation States in a Class A beta lactamase with a monobactam substrate","publication_year":2016,"publication_date":"2016-03-23","ids":{"openalex":"https://openalex.org/W2976114805","doi":"https://doi.org/10.2210/pdb5g18/pdb","mag":"2976114805"},"language":"en","primary_location":{"id":"doi:10.2210/pdb5g18/pdb","doi":"https://doi.org/10.2210/pdb5g18/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb5g18/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035426386","display_name":"Venu Gopal Vandavasi","orcid":"https://orcid.org/0000-0002-8894-1395","observed_orcids":["https://orcid.org/0000-0002-8894-1395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V.G. Vandavasi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011656540","display_name":"Kevin L. Weiss","orcid":"https://orcid.org/0000-0002-6486-8007","observed_orcids":["https://orcid.org/0000-0002-6486-8007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.L. Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037417242","display_name":"Jerry M. Parks","orcid":"https://orcid.org/0000-0002-3103-9333","observed_orcids":["https://orcid.org/0000-0002-3103-9333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Parks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037343064","display_name":"J.B. Cooper","orcid":"https://orcid.org/0000-0003-2256-1506","observed_orcids":["https://orcid.org/0000-0003-2256-1506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.B. Cooper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110331418","display_name":"Stephan L. Ginell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.L. Ginell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015921759","display_name":"Leighton Coates","orcid":"https://orcid.org/0000-0003-2342-049X","observed_orcids":["https://orcid.org/0000-0003-2342-049X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Coates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/class-a-beta-lactamase","display_name":"class A beta-lactamase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/monobactams","display_name":"monobactams","score":0.8209999799728394},{"id":"https://openalex.org/keywords/enzyme-substrate-complex","display_name":"enzyme-substrate complex","score":0.7239999771118164},{"id":"https://openalex.org/keywords/active-site-residues","display_name":"active site residues","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.7130205631256104},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.7120415568351746},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6429260969161987},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.4667198061943054},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4351862072944641},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4233844578266144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29839855432510376},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.28998392820358276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13768815994262695},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13320353627204895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12731939554214478},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09784585237503052},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.06515321135520935},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2210/pdb5g18/pdb","doi":"https://doi.org/10.2210/pdb5g18/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb5g18/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2790285001","https://openalex.org/W6888876659","https://openalex.org/W6926387222","https://openalex.org/W2535420701","https://openalex.org/W4411718813","https://openalex.org/W2023856915"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2019-10-03T00:00:00"}