{"id":"https://openalex.org/W2976039655","doi":"https://doi.org/10.3136/fstr.25.607","title":"Influence of Temperature on the Anti-allergic Activity of Fucoidan Extracted from Saccharina japonica","display_name":"Influence of Temperature on the Anti-allergic Activity of Fucoidan Extracted from Saccharina japonica","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2976039655","doi":"https://doi.org/10.3136/fstr.25.607","mag":"2976039655"},"language":"en","primary_location":{"id":"doi:10.3136/fstr.25.607","doi":"https://doi.org/10.3136/fstr.25.607","is_oa":true,"landing_page_url":"https://doi.org/10.3136/fstr.25.607","pdf_url":"https://www.jstage.jst.go.jp/article/fstr/25/4/25_607/_pdf","source":{"id":"https://openalex.org/S60340032","display_name":"Food Science and Technology Research","issn_l":"1344-6606","issn":["1344-6606","1881-3984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/fstr/25/4/25_607/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Atsuko Morita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuko Morita","raw_affiliation_strings":["Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037371308","display_name":"Yuka Tanino","orcid":"https://orcid.org/0000-0003-0834-6420","observed_orcids":["https://orcid.org/0000-0003-0834-6420"]},"institutions":[{"id":"https://openalex.org/I4210157946","display_name":"Industrial Technology Center of Okayama Prefecture","ror":"https://ror.org/048g28j84","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210157946"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Tanino","raw_affiliation_strings":["Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University","Industrial Technology Center of Okayama Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Industrial Technology Center of Okayama Prefecture","institution_ids":["https://openalex.org/I4210157946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030619631","display_name":"Takao Ojima","orcid":"https://orcid.org/0000-0002-2480-958X","observed_orcids":["https://orcid.org/0000-0002-2480-958X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Ojima","raw_affiliation_strings":["Faculty of Fisheries Science, Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fisheries Science, Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071080832","display_name":"Masashi Mizuno","orcid":"https://orcid.org/0000-0002-6603-1446","observed_orcids":["https://orcid.org/0000-0002-6603-1446"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Mizuno","raw_affiliation_strings":["Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2008,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47143317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"4","first_page":"607","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":1.0},{"id":"https://openalex.org/keywords/saccharina-japonica","display_name":"Laminaria japonica","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antiallergic-activity","display_name":"anti-allergic activity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":0.8420000076293945},{"id":"https://openalex.org/keywords/passive-cutaneous-anaphylaxis","display_name":"passive cutaneous anaphylaxis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/heat-treatment-food-and-biological-processing","display_name":"heat treatment (food and biological processing)","score":0.6060000061988831},{"id":"https://openalex.org/keywords/temperature-response","display_name":"temperature sensitivity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/polysaccharide-fractionation","display_name":"polysaccharide fractionation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/deae-cellulose-chromatography","display_name":"DEAE-cellulose chromatography","score":0.9279999732971191},{"id":"https://openalex.org/keywords/kelp-polysaccharides","display_name":"kelp polysaccharides","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2775909754","wikidata":"https://www.wikidata.org/wiki/Q1144687","display_name":"Fucoidan","level":3,"score":0.9870892763137817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.797569751739502},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.6863222122192383},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6533856987953186},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.5336428880691528},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.4638082981109619},{"id":"https://openalex.org/C2779409272","wikidata":"https://www.wikidata.org/wiki/Q1757789","display_name":"Japonica","level":2,"score":0.42911627888679504},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.41125842928886414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27014443278312683},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.13139772415161133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10197252035140991}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3136/fstr.25.607","doi":"https://doi.org/10.3136/fstr.25.607","is_oa":true,"landing_page_url":"https://doi.org/10.3136/fstr.25.607","pdf_url":"https://www.jstage.jst.go.jp/article/fstr/25/4/25_607/_pdf","source":{"id":"https://openalex.org/S60340032","display_name":"Food Science and Technology Research","issn_l":"1344-6606","issn":["1344-6606","1881-3984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology Research","raw_type":"journal-article"},{"id":"pmh:oai:irdb.nii.ac.jp:01257:0005617225","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14094/90006691","pdf_url":"https://da.lib.kobe-u.ac.jp/da/kernel/90006691/90006691.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Science and Technology Research","raw_type":"journal article"},{"id":"pmh:oai:da.lib.kobe-u.ac.jp:20.500.14094/90006691","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14094/90006691","pdf_url":null,"source":{"id":"https://openalex.org/S4306401924","display_name":"Kobe University Repository Kernel (Kobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I65837984","host_organization_name":"Kobe University","host_organization_lineage":["https://openalex.org/I65837984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Science and Technology Research\u300025(4), 607-611","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3136/fstr.25.607","doi":"https://doi.org/10.3136/fstr.25.607","is_oa":true,"landing_page_url":"https://doi.org/10.3136/fstr.25.607","pdf_url":"https://www.jstage.jst.go.jp/article/fstr/25/4/25_607/_pdf","source":{"id":"https://openalex.org/S60340032","display_name":"Food Science and Technology Research","issn_l":"1344-6606","issn":["1344-6606","1881-3984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5614238637","display_name":"A novel anti-allergic property by food factor possessing high affinity lectin-like protein against IgE","funder_award_id":"18K19741","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2976039655.pdf","grobid_xml":"https://content.openalex.org/works/W2976039655.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W317714569","https://openalex.org/W1173698806","https://openalex.org/W1968834637","https://openalex.org/W1972905372","https://openalex.org/W1978726038","https://openalex.org/W1985917523","https://openalex.org/W2007267973","https://openalex.org/W2007589345","https://openalex.org/W2010953182","https://openalex.org/W2013660949","https://openalex.org/W2022084608","https://openalex.org/W2025737611","https://openalex.org/W2028190708","https://openalex.org/W2043990114","https://openalex.org/W2045605822","https://openalex.org/W2047556994","https://openalex.org/W2090128212","https://openalex.org/W2102139406","https://openalex.org/W2111502907","https://openalex.org/W2120793327","https://openalex.org/W2124092982","https://openalex.org/W2172728173","https://openalex.org/W2407318672","https://openalex.org/W2768331415"],"related_works":["https://openalex.org/W2407318672","https://openalex.org/W7134180382","https://openalex.org/W6885377423","https://openalex.org/W3005478115","https://openalex.org/W3020958496","https://openalex.org/W3042216555","https://openalex.org/W4406731086","https://openalex.org/W2513650855","https://openalex.org/W2075443601","https://openalex.org/W2162004307"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"ascertained":[3],"in":[4,12,22,40,50,109,155],"our":[5],"laboratory":[6],"that":[7,94,119],"fucoidan,":[8],"a":[9,35],"polysaccharide":[10],"contained":[11],"Saccharina":[13],"japonica,":[14],"shows":[15],"anti-allergic":[16,107,133,158],"activity":[17,108,159],"through":[18],"galectin":[19],"9":[20],"secretion":[21],"blood.":[23],"A":[24],"crude":[25,123],"fucoidan":[26,98,124],"fraction":[27,58,70,125],"was":[28,59,92,117],"chromatographically":[29],"fractionated":[30],"into":[31],"three":[32,73],"fractions":[33,74,79,139],"using":[34,61],"Toyopearl-DEAE":[36],"650":[37],"M":[38,48,52,83,86,143,146],"column":[39],"stepwise":[41],"elusion":[42],"with":[43,81,141],"0,":[44],"0.5":[45,82,142],"and":[46,84,135,144],"1.0":[47,85,145],"NaCl":[49,87],"0.05":[51],"Tris-HCl":[53],"buffer":[54],"(pH":[55],"7.4).":[56],"Each":[57],"assessed":[60],"the":[62,72,78,110,122,127,132,137,151,157],"passive":[63],"cutaneous":[64],"anaphylaxis":[65],"(PCA)":[66],"reaction.":[67,112],"The":[68],"non-absorbed":[69,128],"of":[71,97,121,153,160],"suppressed":[75],"PCA,":[76],"whereas":[77],"eluted":[80,140],"did":[88],"not.":[89],"Moreover,":[90],"it":[91,116],"discovered":[93],"heat":[95],"treatment":[96],"at":[99],"50":[100],"\u00b0C":[101],"for":[102],"10":[103],"min":[104],"abolished":[105],"its":[106],"PCA":[111],"Using":[113],"DEAE":[114],"chromatography,":[115],"demonstrated":[118],"heat-treatment":[120],"decreased":[126],"fraction,":[129],"which":[130],"possessed":[131],"activity,":[134],"increased":[136],"two":[138],"NaCl.":[147],"This":[148],"clearly":[149],"revealed":[150],"importance":[152],"temperature":[154],"maintaining":[156],"fucoidan.":[161]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-03T00:00:00"}