{"id":"https://openalex.org/W2975715185","doi":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","title":"Estimation of cognitive brain activity in sickle cell disease using functional near-infrared spectroscopy and dynamic systems modeling","display_name":"Estimation of cognitive brain activity in sickle cell disease using functional near-infrared spectroscopy and dynamic systems modeling","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2975715185","doi":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","mag":"2975715185"},"language":"en","primary_location":{"id":"doi:10.3389/conf.fnhum.2018.227.00096","doi":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","is_oa":true,"landing_page_url":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","pdf_url":null,"source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"John Sunwoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Sunwoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Payal Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Payal Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009351200","display_name":"Wanwara Thuptimdang","orcid":"https://orcid.org/0009-0000-3769-5967","observed_orcids":["https://orcid.org/0009-0000-3769-5967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanwara Thuptimdang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057278617","display_name":"Maha Khaleel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maha Khaleel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Coates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112451575","display_name":"Michael C. K. Khoo","orcid":"https://orcid.org/0000-0001-7680-5989","observed_orcids":["https://orcid.org/0000-0001-7680-5989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Khoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25285925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/functional-near-infrared-spectroscopy","display_name":"functional near-infrared spectroscopy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dynamic-system-modeling","display_name":"dynamic system modeling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cerebral-hemodynamics","display_name":"cerebral hemodynamics","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C130796691","wikidata":"https://www.wikidata.org/wiki/Q750537","display_name":"Functional near-infrared spectroscopy","level":4,"score":0.713576078414917},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.5986043810844421},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.596314013004303},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5129935145378113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4557085633277893},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4483460783958435},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.4412899613380432},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3948816657066345},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.382388710975647},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.36085936427116394},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.21108123660087585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/conf.fnhum.2018.227.00096","doi":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","is_oa":true,"landing_page_url":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","pdf_url":null,"source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/conf.fnhum.2018.227.00096","doi":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","is_oa":true,"landing_page_url":"https://doi.org/10.3389/conf.fnhum.2018.227.00096","pdf_url":null,"source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387701073","https://openalex.org/W4300838007","https://openalex.org/W7223013771","https://openalex.org/W3208783905","https://openalex.org/W7172000954","https://openalex.org/W2030676075","https://openalex.org/W2323235679","https://openalex.org/W2169777108","https://openalex.org/W4412649543","https://openalex.org/W1995663796"],"abstract_inverted_index":{"Event":[0,4],"Abstract":[1,839,841,913],"Back":[2,915],"to":[3,83,158,167,212,233,257,277,320,462,470,491,552,579,597,695,720,825,916,930],"Estimation":[5,660],"of":[6,39,49,98,125,198,226,347,366,438,517,574,584,602,661,736,752,776,809],"cognitive":[7,92,111,662],"brain":[8,127,133,663],"activity":[9,604,664],"in":[10,69,75,135,262,289,298,456,495,502,541,665,688,727,844,908,924,928],"sickle":[11,70,666],"cell":[12,71,667],"disease":[13,72,668],"using":[14,192,669],"functional":[15,670],"near-infrared":[16,671],"spectroscopy":[17,120,672],"and":[18,33,58,94,116,150,154,174,183,220,264,266,271,280,295,330,344,356,391,409,441,444,452,480,499,571,588,656,673,702,723,765,772,782,789,830],"dynamic":[19,674],"systems":[20,164,675],"modeling":[21,165,319,528,550],"John":[22,806,846,861,877,892],"Sunwoo1*,":[23],"Payal":[24,848,863,879,894],"Shah2,":[25],"Wanwara":[26,850,865,881,896],"Thuptimdang1,":[27],"Maha":[28,852,867,883,898],"Khaleel2,":[29],"Thomas":[30,854,869,885,900],"D.":[31],"Coates2":[32],"Michael":[34,857,872,888,903],"C.":[35],"Khoo1":[36],"1":[37,612],"University":[38,808],"Southern":[40,810],"California,":[41,811],"Biomedical":[42,812],"Engineering,":[43,813],"United":[44,62,631,816],"States":[45,63],"2":[46],"Children's":[47],"Hospital":[48],"Los":[50,814],"Angeles,":[51,815],"Children\u2019s":[52],"Center":[53],"for":[54,110,130,374,411],"Cancer,":[55],"Blood":[56],"Disease":[57],"Bone":[59],"Marrow":[60],"Transplantation,":[61],"Introduction:":[64],"Frequent":[65],"vaso-occlusive":[66],"pain":[67],"crises":[68],"(SCD)":[73],"result":[74],"silent":[76],"infarcts":[77],"as":[78,80,106,114,247,352,363,419,514,717,747,749],"well":[79,748],"permanent":[81],"damage":[82],"critical":[84],"organs,":[85],"including":[86],"the":[87,170,179,184,188,214,229,238,241,245,248,259,311,322,336,341,345,348,357,367,381,388,392,396,403,439,457,466,485,493,497,505,515,542,568,572,575,581,593,607,713,728,734,750,774,780,933],"brain.":[88],"This":[89,821],"can":[90,156,558],"cause":[91],"impairment":[93],"impact":[95],"patients\u2019":[96],"quality":[97],"life.":[99],"The":[100,253,414,429,522,686,725,842],"prefrontal":[101,136],"cortex":[102],"(PFC)":[103],"is":[104,122,731,919],"known":[105],"a":[107,163,235,267,272,296,549,718,757],"control":[108],"tower":[109],"functions,":[112],"such":[113,503],"reasoning":[115],"memorizing.":[117],"Functional":[118],"infrared":[119],"(fNIRS)":[121],"becoming":[123],"one":[124,249],"popular":[126],"imaging":[128],"tools":[129],"characterizing":[131],"altered":[132],"responses":[134,190,216],"cortex.":[137],"However,":[138],"fNIRS":[139,254,337,358,393,421,431,459,543,595],"signals":[140,351,405,416,422,432,524,556,578],"also":[141],"contain":[142],"non-neuronal":[143,472],"fluctuations":[144,587],"originating":[145],"from":[146,217,326,406,450,484,535,564,592],"scalp":[147,180,327,589,617],"blood":[148,181,282,328,454,481,590,618],"flow":[149,182,329,455,482,591],"other":[151,471,536],"systemic":[152,323],"changes,":[153],"this":[155,689,936],"lead":[157],"false":[159],"conclusions.":[160],"We":[161,176,194,285,339,369,384,546,566],"propose":[162],"technique":[166,551],"filter":[168],"out":[169,478],"confounding":[171,538,582],"influences.":[172],"Methods":[173],"Methods:":[175],"hypothesized":[177],"that":[178,332,504,557],"respiration":[185,331],"could":[186,530],"confound":[187,559],"neurocognitive":[189,215,560],"obtained":[191,563],"fNIRS.":[193,565],"designed":[195],"different":[196],"levels":[197],"n-back":[199,227,308,440],"memory":[200],"workload":[201],"tasks":[202],"(n":[203],"[difficulty":[204],"level]":[205],"=":[206],"0,":[207],"1,":[208],"2,":[209],"or":[210,360,508,700,739,835],"3),":[211],"obtain":[213,598],"14":[218],"SCD":[219],"15":[221],"controls.":[222],"During":[223],"each":[224,412,436,737],"level":[225,516],"task,":[228],"subject":[230,694,775],"was":[231,244,255,314],"instructed":[232],"press":[234],"button":[236],"on":[237,935],"keyboard":[239],"when":[240],"revealed":[242],"letter":[243],"same":[246],"shown":[250],"n-turns":[251],"ago.":[252],"used":[256,276,317,340,370],"record":[258,278],"hemodynamics":[260],"changes":[261],"PFC":[263,290,603],"scalp,":[265],"nasal":[268],"CO2":[269,279,343,451,479,570,623],"analyzer":[270],"finger":[273,281,349,453,576],"photoplethysmogram":[274,350,577],"were":[275,304,417,425,433,447,489],"flow,":[283,619],"respectively.":[284],"anticipated":[286],"an":[287,364,599],"increase":[288],"oxygenated":[291],"hemoglobin":[292],"content":[293,300,934],"(Hbo)":[294],"decrease":[297],"de-oxygenated":[299],"(Hbr)":[301],"while":[302],"subjects":[303],"completing":[305],"more":[306,512],"difficult":[307],"tasks.":[309,610],"After":[310,475],"recording":[312],"session":[313],"over,":[315],"we":[316,401,476,488],"Laguerre-Volterra":[318],"estimate":[321,553,601],"influences":[324,449,483,583],"originated":[325],"had":[333],"potentially":[334],"contaminated":[335],"measurement.":[338,544],"end-tidal":[342,569],"amplitude":[346,573],"two":[353,389],"input":[354],"parameters":[355],"Hbo":[359,408,498,507],"Hbr":[361,410,500,509],"signal":[362,460,467,596],"output":[365],"model.":[368],"Laguerre":[371],"basis":[372],"functions":[373],"estimating":[375],"impulse":[376],"responses,":[377],"which":[378],"helped":[379],"minimize":[380],"fitting":[382],"time.":[383],"assumed":[385],"linearity":[386],"between":[387],"inputs":[390],"output.":[394],"Using":[395],"optimal":[397],"model":[398],"found":[399],"here,":[400],"estimated":[402],"residual":[404,415,506,523],"all":[407,932],"channel.":[413],"saved":[418],"\u2018filtered\u2019":[420],"assuming":[423],"they":[424],"corrected":[426],"neuronal":[427,533],"activities.":[428],"filtered":[430,477],"grouped":[434],"by":[435,606,706,733],"difficulty":[437,518],"averaged.":[442],"Results":[443],"Discussion:":[445],"There":[446],"noticeable":[448],"original":[458,486,594],"(up":[461],"~65%":[463],"combined),":[464],"suggesting":[465],"contamination":[468],"due":[469],"physiological":[473,537],"factors.":[474],"fNIRS,":[487,614],"able":[490],"see":[492,792,931],"improvements":[494],"both":[496],"trends,":[501],"trends":[510],"became":[511],"predictable":[513],"increased":[519],"(Figure":[520],"1).":[521],"showed":[525],"how":[526],"our":[527],"method":[529],"help":[531],"separate":[532],"activities":[534],"factors":[539],"mixed":[540],"Conclusions:":[545],"have":[547,691],"employed":[548],"unknown":[554],"biological":[555],"response":[561],"results":[562],"utilized":[567],"remove":[580],"arterial":[585],"PCO2":[586],"improved":[600],"stimulated":[605],"imposed":[608],"mental":[609],"Figure":[611],"Keywords:":[613],"modeling,":[615],"n-back,":[616],"Photoplethysmogram,":[620],"ETCO2,":[621],"PFC,":[622],"Conference:":[624],"2nd":[625,679],"International":[626,680],"Neuroergonomics":[627,644,681],"Conference,":[628],"Philadelphia,":[629],"PA,":[630],"States,":[632,817],"27":[633,800],"Jun":[634],"-":[635],"29":[636],"Jun,":[637],"2018.":[638],"Presentation":[639,642],"Type:":[640],"Oral":[641],"Topic:":[643],"Citation:":[645],"Sunwoo":[646,847,862,878,893],"J,":[647],"Shah":[648,849,864,880,895],"P,":[649],"Thuptimdang":[650,851,866,882,897],"W,":[651],"Khaleel":[652,853,868,884,899],"M,":[653],"Coates":[654,856,871,887,902],"TD":[655],"Khoo":[657,859,874,890,905],"MC":[658],"(2019).":[659],"modeling.":[676],"Conference":[677],"Abstract:":[678],"Conference.":[682],"doi:":[683],"10.3389/conf.fnhum.2018.227.00096":[684],"Copyright:":[685],"abstracts":[687,730],"collection":[690,751],"not":[692,704],"been":[693],"any":[696],"Frontiers":[697,714,783,829,845,909],"peer":[698],"review":[699],"checks,":[701],"are":[703,709,754,784],"endorsed":[705],"Frontiers.":[707],"They":[708],"made":[710],"available":[711],"through":[712],"publishing":[715],"platform":[716],"service":[719],"conference":[721],"organizers":[722],"presenters.":[724],"copyright":[726],"individual":[729],"owned":[732],"author":[735],"abstract":[738],"his/her":[740],"employer":[741],"unless":[742],"otherwise":[743],"stated.":[744],"Each":[745],"abstract,":[746],"abstracts,":[753],"published":[755],"under":[756],"Creative":[758],"Commons":[759],"CC-BY":[760],"4.0":[761],"(attribution)":[762],"licence":[763],"(https://creativecommons.org/licenses/by/4.0/)":[764],"may":[766],"thus":[767],"be":[768,773,826],"reproduced,":[769],"translated,":[770],"adapted":[771],"derivative":[777],"works":[778],"provided":[779],"authors":[781],"attributed.":[785],"For":[786],"Frontiers\u2019":[787],"terms":[788],"conditions":[790],"please":[791],"https://www.frontiersin.org/legal/terms-and-conditions.":[793],"Received:":[794],"21":[795],"Mar":[796],"2018;":[797],"Published":[798],"Online:":[799],"Sep":[801],"2019.":[802],"*":[803],"Correspondence:":[804],"Mr.":[805],"Sunwoo,":[807],"johnsunw@usc.edu":[818],"Login":[819],"Required":[820],"action":[822],"requires":[823],"you":[824],"registered":[827],"with":[828],"logged":[831],"in.":[832],"To":[833],"register":[834],"login":[836],"click":[837],"here.":[838],"Info":[840],"Authors":[843],"D":[855,870,886,901],"C":[858,873,889,904],"Google":[860,875,910],"Scholar":[876,911],"PubMed":[891,912],"Related":[906],"Article":[907],"Close":[914],"top":[917],"Javascript":[918,923],"disabled.":[920],"Please":[921],"enable":[922],"your":[925],"browser":[926],"settings":[927],"order":[929],"page.":[937]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-10-03T00:00:00"}
