{"id":"https://openalex.org/W2974698555","doi":"https://doi.org/10.1074/jbc.h119.010823","title":"Catching a complex for optimal signaling","display_name":"Catching a complex for optimal signaling","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2974698555","doi":"https://doi.org/10.1074/jbc.h119.010823","mag":"2974698555","pmid":"https://pubmed.ncbi.nlm.nih.gov/31541026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6755816"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.h119.010823","doi":"https://doi.org/10.1074/jbc.h119.010823","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.h119.010823","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.h119.010823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048766408","display_name":"Dirk M. Zajonc","orcid":"https://orcid.org/0000-0001-7215-1981","observed_orcids":["https://orcid.org/0000-0001-7215-1981"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dirk M. Zajonc","raw_affiliation_strings":["Cancer Immunology Discovery Oncology R&D Group, Pfizer Inc., San Diego, California 92121 Dirk.Zajonc@pfizer.com","Cancer Immunology Discovery Oncology R&D Group, Pfizer Inc., San Diego, California 92121"],"raw_orcid":"https://orcid.org/0000-0001-7215-1981","affiliations":[{"raw_affiliation_string":"Cancer Immunology Discovery Oncology R&D Group, Pfizer Inc., San Diego, California 92121 Dirk.Zajonc@pfizer.com","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Cancer Immunology Discovery Oncology R&D Group, Pfizer Inc., San Diego, California 92121","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048766408"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0827,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39339541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"294","issue":"38","first_page":"13887","last_page":"13888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.22110000252723694,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agonistic-antibodies","display_name":"agonistic antibodies","score":0.984000027179718},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.5070000290870667},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.8019999861717224},{"id":"https://openalex.org/keywords/antibody-selection","display_name":"antibody selection","score":0.5479999780654907},{"id":"https://openalex.org/keywords/ligand-independent-activation","display_name":"ligand-independent receptor activation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dimer-interface","display_name":"dimer interface","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7049998044967651},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6279095411300659},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5123172998428345},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47305789589881897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4444258511066437},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43272462487220764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4120423495769501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3870980441570282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2078598141670227},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13784044981002808}],"mesh":[{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.h119.010823","doi":"https://doi.org/10.1074/jbc.h119.010823","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.h119.010823","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6755816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6755816","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:31541026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31541026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.h119.010823","doi":"https://doi.org/10.1074/jbc.h119.010823","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.h119.010823","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2014930718","https://openalex.org/W2018480371","https://openalex.org/W2043046650","https://openalex.org/W2097814320","https://openalex.org/W2116364705","https://openalex.org/W2144120552","https://openalex.org/W2167230971","https://openalex.org/W2952779287","https://openalex.org/W2966351120"],"related_works":["https://openalex.org/W2966351120","https://openalex.org/W3010619892","https://openalex.org/W2070645153","https://openalex.org/W2054154416","https://openalex.org/W2062750277","https://openalex.org/W1979874324","https://openalex.org/W4416448040","https://openalex.org/W2512279472","https://openalex.org/W1601053065","https://openalex.org/W3161377034"],"abstract_inverted_index":{"Agonistic":[0],"antibodies":[1,21,38],"are":[2],"powerful":[3,69],"tools":[4],"to":[5,35,53,83],"dimerize":[6],"receptors":[7,82],"in":[8,47,87],"the":[9,24,65,88],"absence":[10,89],"of":[11,78,90],"ligand":[12],"binding,":[13],"but":[14],"high-fidelity":[15],"receptor":[16],"activation":[17],"requires":[18],"that":[19,39,62],"these":[20],"accurately":[22],"recapitulate":[23],"native":[25,49],"dimeric":[26],"state.":[27],"Spangler":[28],"et":[29],"al.":[30],"employ":[31],"a":[32,41,54,57,76],"clever":[33],"approach":[34,70],"select":[36],"for":[37,75],"bind":[40],"specific":[42],"IL-4R\u03b1/\u03b3":[43],"c":[44],"heterodimeric":[45,81],"complex":[46],"its":[48],"signaling":[50],"conformation,":[51],"leading":[52],"monovalent":[55],"\"stapler,\"":[56],"single-chain":[58],"variable":[59],"fragment":[60],"(scFv)":[61],"binds":[63],"at":[64],"dimerization":[66],"interface.":[67],"This":[68],"can":[71],"be":[72],"further":[73],"exploited":[74],"variety":[77],"homo-":[79],"or":[80],"achieve":[84],"signaling,":[85],"especially":[86],"endogenous":[91],"ligand.":[92]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-26T00:00:00"}