{"id":"https://openalex.org/W2974239187","doi":"https://doi.org/10.1186/s12903-019-0904-4","title":"Pilot GWAS of caries in African-Americans shows genetic heterogeneity","display_name":"Pilot GWAS of caries in African-Americans shows genetic heterogeneity","publication_year":2019,"publication_date":"2019-09-18","ids":{"openalex":"https://openalex.org/W2974239187","doi":"https://doi.org/10.1186/s12903-019-0904-4","mag":"2974239187","pmid":"https://pubmed.ncbi.nlm.nih.gov/31533690","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6751797"},"language":"en","primary_location":{"id":"doi:10.1186/s12903-019-0904-4","doi":"https://doi.org/10.1186/s12903-019-0904-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-019-0904-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12903-019-0904-4.pdf","source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12903-019-0904-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054911540","display_name":"Ekaterina Orlova","orcid":"https://orcid.org/0000-0002-7129-5796","observed_orcids":["https://orcid.org/0000-0002-7129-5796"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Orlova","raw_affiliation_strings":["Department of Human Genetics, Pittsburgh, USA"],"raw_orcid":"https://orcid.org/0000-0002-7129-5796","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020430278","display_name":"Jenna C. Carlson","orcid":"https://orcid.org/0000-0001-5483-0833","observed_orcids":["https://orcid.org/0000-0001-5483-0833"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Carlson","raw_affiliation_strings":["Department of Biostatistics, Graduate School of Public Health, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Graduate School of Public Health, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016157611","display_name":"M. K. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. K. Lee","raw_affiliation_strings":["Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052349035","display_name":"Eleanor Feingold","orcid":"https://orcid.org/0000-0003-2898-6484","observed_orcids":["https://orcid.org/0000-0003-2898-6484"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Feingold","raw_affiliation_strings":["Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","Department of Biostatistics, Graduate School of Public Health, Pittsburgh, USA","Department of Human Genetics, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Biostatistics, Graduate School of Public Health, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Human Genetics, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059822764","display_name":"Daniel W. McNeil","orcid":"https://orcid.org/0000-0002-0766-8455","observed_orcids":["https://orcid.org/0000-0002-0766-8455"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. W. McNeil","raw_affiliation_strings":["Departments of Psychology, & Dental Practice and Rural Health, West Virginia University, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychology, & Dental Practice and Rural Health, West Virginia University, Morgantown, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082186980","display_name":"Richard J. Crout","orcid":"https://orcid.org/0000-0002-7695-5685","observed_orcids":["https://orcid.org/0000-0002-7695-5685"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Crout","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031197372","display_name":"Robert J. Weyant","orcid":"https://orcid.org/0000-0002-5252-9120","observed_orcids":["https://orcid.org/0000-0002-5252-9120"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Weyant","raw_affiliation_strings":["Department of Dental Public Health and Information Management, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Public Health and Information Management, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064886913","display_name":"Mary L. Marazita","orcid":"https://orcid.org/0000-0002-2648-2832","observed_orcids":["https://orcid.org/0000-0002-2648-2832"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Marazita","raw_affiliation_strings":["Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","Clinical and Translational Sciences Institute, University of Pittsburgh, Pittsburgh, PA, USA","Department of Human Genetics, Pittsburgh, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Clinical and Translational Sciences Institute, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Human Genetics, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033510739","display_name":"John R. Shaffer","orcid":"https://orcid.org/0000-0003-1897-1131","observed_orcids":["https://orcid.org/0000-0003-1897-1131"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. R. Shaffer","raw_affiliation_strings":["Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA. john.r.shaffer@pitt.edu","Department of Human Genetics, Pittsburgh, USA. john.r.shaffer@pitt.edu","Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA. john.r.shaffer@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Human Genetics, Pittsburgh, USA. john.r.shaffer@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Craniofacial and Dental Genetics, Dept. of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033510739"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":1.4932,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81686901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"215","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":1.0},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.8460000157356262},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dmfs-index","display_name":"DMFS index","score":0.6010000109672546},{"id":"https://openalex.org/keywords/dmft-index","display_name":"DMFT index","score":0.9380000233650208},{"id":"https://openalex.org/keywords/defb1","display_name":"DEFB1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tuft1","display_name":"TUFT1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oral-health-disparities","display_name":"oral health disparities","score":0.6779999732971191},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.5509999990463257},{"id":"https://openalex.org/keywords/ancestry-adjustment","display_name":"ancestry adjustment","score":0.43700000643730164},{"id":"https://openalex.org/keywords/children-and-adults","display_name":"children and adults","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7830321192741394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6816483736038208},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6618208289146423},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5016016960144043},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42864349484443665},{"id":"https://openalex.org/C193262319","wikidata":"https://www.wikidata.org/wiki/Q5532875","display_name":"Genetic admixture","level":3,"score":0.41113120317459106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40117862820625305},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3979002833366394},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3212782144546509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18566614389419556},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.18523800373077393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17818844318389893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14786866307258606},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08034151792526245},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12903-019-0904-4","doi":"https://doi.org/10.1186/s12903-019-0904-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-019-0904-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12903-019-0904-4.pdf","source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6751797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6751797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"Text"},{"id":"pmid:31533690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31533690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC oral health","raw_type":"Journal Article"},{"id":"pmh:oai:researchrepository.wvu.edu:faculty_publications-2629","doi":null,"is_oa":true,"landing_page_url":"https://researchrepository.wvu.edu/faculty_publications/1688","pdf_url":"https://researchrepository.wvu.edu/faculty_publications/1688","source":{"id":"https://openalex.org/S4306402612","display_name":"The Research Repository @ WVU (West Virginia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12097938","host_organization_name":"West Virginia University","host_organization_lineage":["https://openalex.org/I12097938"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty & Staff Scholarship","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f615c5605882401fa2a3377eed56f8bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f615c5605882401fa2a3377eed56f8bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Oral Health, Vol 19, Iss 1, Pp 1-21 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12903-019-0904-4","doi":"https://doi.org/10.1186/s12903-019-0904-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-019-0904-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12903-019-0904-4.pdf","source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2787165048","display_name":"Modeling childhood dental caries patterns for genomic and epigenetic analysis","funder_award_id":"R03DE024264","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3874702986","display_name":"Dental Caries: Whole Genome Association and Gene x Environment Studies","funder_award_id":"U01DE018903","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4403401385","display_name":"Factors Contributing to Oral Health Disparities in Appalachia","funder_award_id":"R01DE014899","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4576530895","display_name":"Genome Wide Association Coordinating Center","funder_award_id":"U01HG004446","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7093047072","display_name":null,"funder_award_id":"HHSN268200782096C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8267674335","display_name":null,"funder_award_id":"HHSN268200782096C","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2974239187.pdf","grobid_xml":"https://content.openalex.org/works/W2974239187.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W18131555","https://openalex.org/W105869970","https://openalex.org/W900373682","https://openalex.org/W1568024981","https://openalex.org/W1574049399","https://openalex.org/W1639629788","https://openalex.org/W1653899755","https://openalex.org/W1747499909","https://openalex.org/W1916325998","https://openalex.org/W1940268096","https://openalex.org/W1964063358","https://openalex.org/W1965732593","https://openalex.org/W1969176674","https://openalex.org/W1971185090","https://openalex.org/W1974044871","https://openalex.org/W1976844911","https://openalex.org/W1979590128","https://openalex.org/W1979594866","https://openalex.org/W1979818004","https://openalex.org/W1980173287","https://openalex.org/W1980283778","https://openalex.org/W1984874332","https://openalex.org/W1992005334","https://openalex.org/W1992436001","https://openalex.org/W1992740869","https://openalex.org/W1993740238","https://openalex.org/W1998917867","https://openalex.org/W2000180714","https://openalex.org/W2001390177","https://openalex.org/W2004027999","https://openalex.org/W2007834782","https://openalex.org/W2008886432","https://openalex.org/W2014719990","https://openalex.org/W2015682384","https://openalex.org/W2017490259","https://openalex.org/W2020602326","https://openalex.org/W2021152776","https://openalex.org/W2023007719","https://openalex.org/W2024891255","https://openalex.org/W2026690575","https://openalex.org/W2026839621","https://openalex.org/W2026880110","https://openalex.org/W2027337609","https://openalex.org/W2027694148","https://openalex.org/W2028415076","https://openalex.org/W2033308434","https://openalex.org/W2033470634","https://openalex.org/W2038515422","https://openalex.org/W2040120039","https://openalex.org/W2041641034","https://openalex.org/W2042395000","https://openalex.org/W2043664746","https://openalex.org/W2044394552","https://openalex.org/W2053481553","https://openalex.org/W2054681151","https://openalex.org/W2056906503","https://openalex.org/W2057198053","https://openalex.org/W2057616764","https://openalex.org/W2059697362","https://openalex.org/W2061255261","https://openalex.org/W2061539393","https://openalex.org/W2064594026","https://openalex.org/W2069384013","https://openalex.org/W2075214755","https://openalex.org/W2077771769","https://openalex.org/W2078982676","https://openalex.org/W2084365809","https://openalex.org/W2086989226","https://openalex.org/W2088273716","https://openalex.org/W2092813294","https://openalex.org/W2095456034","https://openalex.org/W2099282917","https://openalex.org/W2104742449","https://openalex.org/W2105296502","https://openalex.org/W2106683162","https://openalex.org/W2107855917","https://openalex.org/W2111184696","https://openalex.org/W2112474407","https://openalex.org/W2112869109","https://openalex.org/W2113393382","https://openalex.org/W2114369447","https://openalex.org/W2116552870","https://openalex.org/W2123942182","https://openalex.org/W2125550499","https://openalex.org/W2126776706","https://openalex.org/W2129150286","https://openalex.org/W2138471534","https://openalex.org/W2140026462","https://openalex.org/W2141948326","https://openalex.org/W2142813137","https://openalex.org/W2143258592","https://openalex.org/W2144629683","https://openalex.org/W2146708231","https://openalex.org/W2148659975","https://openalex.org/W2150088795","https://openalex.org/W2153453036","https://openalex.org/W2161633633","https://openalex.org/W2163195604","https://openalex.org/W2166055002","https://openalex.org/W2166569849","https://openalex.org/W2166984987","https://openalex.org/W2168530048","https://openalex.org/W2168552231","https://openalex.org/W2169115160","https://openalex.org/W2169857330","https://openalex.org/W2171064678","https://openalex.org/W2172712625","https://openalex.org/W2176137439","https://openalex.org/W2187949133","https://openalex.org/W2190630339","https://openalex.org/W2235975933","https://openalex.org/W2252484848","https://openalex.org/W2282400964","https://openalex.org/W2289232260","https://openalex.org/W2289678000","https://openalex.org/W2295177260","https://openalex.org/W2302148582","https://openalex.org/W2330448180","https://openalex.org/W2337778730","https://openalex.org/W2367683267","https://openalex.org/W2403437397","https://openalex.org/W2413159899","https://openalex.org/W2418292160","https://openalex.org/W2462372951","https://openalex.org/W2514452363","https://openalex.org/W2514485857","https://openalex.org/W2517599669","https://openalex.org/W2521203066","https://openalex.org/W2522000161","https://openalex.org/W2528684781","https://openalex.org/W2529974075","https://openalex.org/W2552029935","https://openalex.org/W2556418453","https://openalex.org/W2560053841","https://openalex.org/W2560111513","https://openalex.org/W2565504617","https://openalex.org/W2566867329","https://openalex.org/W2567175349","https://openalex.org/W2582743722","https://openalex.org/W2590327141","https://openalex.org/W2600657177","https://openalex.org/W2616568460","https://openalex.org/W2616598126","https://openalex.org/W2621100586","https://openalex.org/W2623189098","https://openalex.org/W2728017684","https://openalex.org/W2739956055","https://openalex.org/W2765734308","https://openalex.org/W2952013316","https://openalex.org/W2976895467","https://openalex.org/W4211005027","https://openalex.org/W4252458773","https://openalex.org/W6600727459"],"related_works":["https://openalex.org/W6901810224","https://openalex.org/W2256302415","https://openalex.org/W4414691426","https://openalex.org/W2125550499","https://openalex.org/W6977010004","https://openalex.org/W7039031416","https://openalex.org/W2168552231","https://openalex.org/W2784696894","https://openalex.org/W3203603517","https://openalex.org/W2329269260"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Dental":[2],"caries":[3,44,61,170,225,266,287],"is":[4,19],"the":[5,11,76,114,153,161,235,243,260,272,276,292],"most":[6],"common":[7],"chronic":[8],"disease":[9],"in":[10,46,62,82,113,169,238,246,259,280,288],"US":[12],"and":[13,21,70,91,130,183,205,240,270,282,297],"disproportionately":[14],"affects":[15],"racial/ethnic":[16],"minorities.":[17],"Caries":[18,86],"heritable,":[20],"though":[22,158],"genetic":[23,222,250,263,284],"heterogeneity":[24,223,251],"exists":[25],"between":[26,202,229],"ancestries":[27],"for":[28,78,100,127,155,224,232,275],"a":[29,38],"substantial":[30],"portion":[31],"of":[32,43,59,134,138,160,194,234,242,262,278,286,294],"loci":[33,151,199,237,245],"associated":[34],"with":[35,102,125],"complex":[36],"disease,":[37],"genome-wide":[39,156],"association":[40,101],"study":[41],"(GWAS)":[42],"specifically":[45],"African":[47,64,203],"Americans":[48,204],"has":[49],"not":[50],"been":[51],"performed":[52,56,121],"previously.":[53],"Methods":[54],"We":[55],"exploratory":[57],"GWAS":[58,119],"dental":[60,96],"109":[63],"American":[65],"adults":[66],"(age":[67,73],">":[68],"18)":[69],"96":[71],"children":[72,211],"3\u201312)":[74],"from":[75],"Center":[77],"Oral":[79],"Health":[80],"Research":[81],"Appalachia":[83],"(COHRA1":[84],"cohort).":[85],"phenotypes":[87],"(DMFS,":[88],"DMFT,":[89],"dft,":[90],"dfs":[92],"indices)":[93],"assessed":[94],"by":[95],"exams":[97],"were":[98,143,164,200],"tested":[99],"5":[103,218],"million":[104,140],"genotyped":[105],"or":[106],"imputed":[107],"single":[108],"nucleotide":[109],"polymorphisms":[110],"(SNPs),":[111],"separately":[112],"two":[115,131],"age":[116],"groups.":[117],"The":[118,249],"was":[120,227],"using":[122],"linear":[123],"regression":[124],"adjustment":[126],"age,":[128],"sex,":[129],"principal":[132],"components":[133],"ancestry.":[135],"A":[136],"maximum":[137],"1":[139],"adaptive":[141],"permutations":[142],"run":[144],"to":[145,265,290,298],"determine":[146],"empirical":[147],"significance.":[148],"Results":[149],"No":[150],"met":[152],"threshold":[154],"significance,":[157],"some":[159],"strongest":[162],"signals":[163],"near":[165],"genes":[166],"previously":[167],"implicated":[168],"such":[171],"as":[172],"antimicrobial":[173],"peptide":[174],"DEFB1":[175],"(rs2515501;":[176],"p":[177,186],"=":[178,187,209,213],"4.54":[179],"\u00d7":[180,189,219],"10\u2212":[181,190,220],"6)":[182],"TUFT1":[184],"(rs11805632;":[185],"5.15":[188],"6).":[191],"Effect":[192],"estimates":[193],"lead":[195],"SNPs":[196],"at":[197],"suggestive":[198,236,244],"compared":[201],"Caucasians":[206],"(adults":[207],"N":[208,212],"918;":[210],"983).":[214],"Significant":[215],"(p":[216],"<":[217],"8)":[221],"risk":[226],"found":[228],"racial":[230,268],"groups":[231],"50%":[233],"children,":[239],"12\u201318%":[241],"adults.":[247],"Conclusions":[248],"results":[252],"suggest":[253],"that":[254],"there":[255],"may":[256],"be":[257],"differences":[258],"contributions":[261],"variants":[264],"across":[267],"groups,":[269],"highlight":[271],"critical":[273],"need":[274],"inclusion":[277],"minorities":[279],"subsequent":[281],"larger":[283],"studies":[285],"order":[289],"meet":[291],"goals":[293],"precision":[295],"medicine":[296],"reduce":[299],"oral":[300],"health":[301],"disparities.":[302]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-09-26T00:00:00"}
