{"id":"https://openalex.org/W2974147992","doi":"https://doi.org/10.1016/j.celrep.2019.08.043","title":"Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues","display_name":"Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2974147992","doi":"https://doi.org/10.1016/j.celrep.2019.08.043","mag":"2974147992","pmid":"https://pubmed.ncbi.nlm.nih.gov/31533046"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2019.08.043","doi":"https://doi.org/10.1016/j.celrep.2019.08.043","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2019.08.043","pdf_url":"http://www.cell.com/article/S2211124719310915/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124719310915/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109904887","display_name":"Tea Shavlakadze","orcid":"https://orcid.org/0000-0002-1326-3286","observed_orcids":["https://orcid.org/0000-0002-1326-3286"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tea Shavlakadze","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: tea.shavlakadze@novartis.com","Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: tea.shavlakadze@novartis.com","institution_ids":[]},{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083112693","display_name":"Melody K. Morris","orcid":"https://orcid.org/0000-0003-2030-3466","observed_orcids":["https://orcid.org/0000-0003-2030-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melody Morris","raw_affiliation_strings":["Respiratory Diseases, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Diseases, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102014286","display_name":"Jian Chen Fang","orcid":"https://orcid.org/0000-0003-0096-1146","observed_orcids":["https://orcid.org/0000-0003-0096-1146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Fang","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078316479","display_name":"Sharon Xuesong Wang","orcid":"https://orcid.org/0000-0002-6937-9034","observed_orcids":["https://orcid.org/0000-0002-6937-9034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon X. Wang","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058166806","display_name":"Jiang Zhu","orcid":"https://orcid.org/0000-0001-9764-8281","observed_orcids":["https://orcid.org/0000-0001-9764-8281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang Zhu","raw_affiliation_strings":["Informatics Systems and Data Analysis, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics Systems and Data Analysis, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059338233","display_name":"Weihua Zhou","orcid":"https://orcid.org/0000-0003-0259-0828","observed_orcids":["https://orcid.org/0000-0003-0259-0828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weihua Zhou","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026392259","display_name":"Herman W. Tse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herman W. Tse","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068589408","display_name":"Ricardo Mondrag\u00f3n-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-5645-3090","observed_orcids":["https://orcid.org/0000-0001-5645-3090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricardo Mondragon-Gonzalez","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013224356","display_name":"Guglielmo Roma","orcid":"https://orcid.org/0000-0002-8020-4219","observed_orcids":["https://orcid.org/0000-0002-8020-4219"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Guglielmo Roma","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054558716","display_name":"David J. Glass","orcid":"https://orcid.org/0000-0001-6187-4164","observed_orcids":["https://orcid.org/0000-0001-6187-4164"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David J. Glass","raw_affiliation_strings":["Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: david_glass@hms.harvard.edu","Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: david_glass@hms.harvard.edu","institution_ids":[]},{"raw_affiliation_string":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054558716","https://openalex.org/A5109904887"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":6.249,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.98217822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"28","issue":"12","first_page":"3263","last_page":"3273.e3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7919999957084656},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.7250000238418579},{"id":"https://openalex.org/keywords/multi-tissue-transcriptomics","display_name":"multi-tissue transcriptomics","score":0.5929999947547913},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5809999704360962},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":1.0},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.6499999761581421},{"id":"https://openalex.org/keywords/age-markers","display_name":"age markers","score":0.4560000002384186},{"id":"https://openalex.org/keywords/organ-specific-aging","display_name":"organ-specific aging","score":0.5130000114440918},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6584693789482117},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6185083985328674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5739457011222839},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5019876956939697},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.43494313955307007},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4331493377685547},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4250413775444031},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42155370116233826},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30690282583236694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2657202482223511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2104496955871582}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.celrep.2019.08.043","doi":"https://doi.org/10.1016/j.celrep.2019.08.043","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2019.08.043","pdf_url":"http://www.cell.com/article/S2211124719310915/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"doi:10.1101/717835","doi":"https://doi.org/10.1101/717835","is_oa":true,"landing_page_url":"https://doi.org/10.1101/717835","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/28/717835.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31533046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31533046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dec339453fa64d06ac15ef5d74a9de35","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dec339453fa64d06ac15ef5d74a9de35","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 28, Iss 12, Pp 3263-3273.e3 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2019.08.043","doi":"https://doi.org/10.1016/j.celrep.2019.08.043","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2019.08.043","pdf_url":"http://www.cell.com/article/S2211124719310915/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320333796","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2974147992.pdf","grobid_xml":"https://content.openalex.org/works/W2974147992.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1456373634","https://openalex.org/W1585224687","https://openalex.org/W1891854262","https://openalex.org/W1969885044","https://openalex.org/W1978161786","https://openalex.org/W2010583480","https://openalex.org/W2014677321","https://openalex.org/W2017472601","https://openalex.org/W2019041167","https://openalex.org/W2026397702","https://openalex.org/W2027272551","https://openalex.org/W2047319406","https://openalex.org/W2048376025","https://openalex.org/W2061924523","https://openalex.org/W2074514239","https://openalex.org/W2088972090","https://openalex.org/W2096000142","https://openalex.org/W2097103188","https://openalex.org/W2108700752","https://openalex.org/W2112357770","https://openalex.org/W2117266418","https://openalex.org/W2119711206","https://openalex.org/W2137331540","https://openalex.org/W2146512944","https://openalex.org/W2149524489","https://openalex.org/W2156003677","https://openalex.org/W2166682872","https://openalex.org/W2169455496","https://openalex.org/W2169519600","https://openalex.org/W2192726773","https://openalex.org/W2215361131","https://openalex.org/W2340076510","https://openalex.org/W2406571591","https://openalex.org/W2440683773","https://openalex.org/W2513714775","https://openalex.org/W2516117533","https://openalex.org/W2782332875","https://openalex.org/W2791857022","https://openalex.org/W2799913710","https://openalex.org/W2898925737","https://openalex.org/W2911642321","https://openalex.org/W2920207301","https://openalex.org/W2952626583"],"related_works":["https://openalex.org/W7154491106","https://openalex.org/W2102042645","https://openalex.org/W2063508090","https://openalex.org/W4211083427","https://openalex.org/W6927680216","https://openalex.org/W7095906016","https://openalex.org/W3042406747","https://openalex.org/W2000821658","https://openalex.org/W7016043166","https://openalex.org/W4313827673"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,64,67,86,89,129],"changes":[3],"in":[4,60,71,80,128,132],"gene":[5,31],"expression":[6,32],"that":[7,58,109],"occur":[8],"as":[9],"a":[10,17,27],"result":[11],"of":[12,42,66,88,95,103,122,141],"age,":[13],"which":[14],"might":[15],"create":[16],"permissive":[18],"or":[19,83],"causal":[20],"environment":[21],"for":[22],"age-related":[23,30],"diseases,":[24],"we":[25],"produce":[26],"multi-time":[28],"point":[29,106],"signature":[33],"(AGES)":[34],"from":[35],"liver,":[36],"kidney,":[37],"skeletal":[38],"muscle,":[39],"and":[40,51,100,105],"hippocampus":[41],"rats,":[43],"comparing":[44],"6-,":[45],"9-,":[46],"12-,":[47],"18-,":[48],"21-,":[49],"24-,":[50],"27-month-old":[52],"animals.":[53],"We":[54],"focus":[55],"on":[56],"genes":[57,123],"changed":[59],"one":[61],"direction":[62],"throughout":[63,85],"lifespan":[65,87],"animal,":[68],"either":[69],"early":[70],"life":[72,81],"(early":[73],"logistic":[74],"changes),":[75],"at":[76],"mid-age":[77],"(mid-logistic),":[78],"late":[79],"(late-logistic),":[82],"linearly,":[84],"animal.":[90],"The":[91],"pathways":[92],"perturbed":[93],"because":[94],"chronological":[96],"age":[97],"demonstrate":[98],"organ-specific":[99],"more-global":[101],"effects":[102],"aging":[104,127],"to":[107,115],"mechanisms":[108],"could":[110],"potentially":[111],"be":[112,138],"counter-regulated":[113],"pharmacologically":[114],"treat":[116],"age-associated":[117],"diseases.":[118],"A":[119],"small":[120],"number":[121],"are":[124],"regulated":[125],"by":[126],"same":[130],"manner":[131],"every":[133],"tissue,":[134],"suggesting":[135],"they":[136],"may":[137],"more-universal":[139],"markers":[140],"aging.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-09-26T00:00:00"}