{"id":"https://openalex.org/W2973973351","doi":null,"title":"Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.","display_name":"Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2973973351","mag":"2973973351","pmid":"https://pubmed.ncbi.nlm.nih.gov/30988246"},"language":"en","primary_location":{"id":"pmh:oai:ijkd.org:article/4237","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/4237","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/4237/1055","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ijkd.org/index.php/ijkd/article/download/4237/1055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108496577","display_name":"Masaki Goto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Goto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090064043","display_name":"Yasunori Suematsu","orcid":"https://orcid.org/0000-0001-7966-5977","observed_orcids":["https://orcid.org/0000-0001-7966-5977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasunori Suematsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076871855","display_name":"Ane Cl\u00e1udia Fernandes Nunes","orcid":"https://orcid.org/0000-0002-7838-6463","observed_orcids":["https://orcid.org/0000-0002-7838-6463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ane C F Nunes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018989064","display_name":"Wanghui Jing","orcid":"https://orcid.org/0000-0001-9594-2989","observed_orcids":["https://orcid.org/0000-0001-9594-2989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanghui Jing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025927168","display_name":"Mahyar Khazaeli","orcid":"https://orcid.org/0000-0001-8645-4203","observed_orcids":["https://orcid.org/0000-0001-8645-4203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahyar Khazaeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090252275","display_name":"Wei Ling Lau","orcid":"https://orcid.org/0000-0002-3118-1073","observed_orcids":["https://orcid.org/0000-0002-3118-1073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Ling Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056238061","display_name":"Nosratola D. Vaziri","orcid":"https://orcid.org/0000-0002-2015-8599","observed_orcids":["https://orcid.org/0000-0002-2015-8599"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nosratola D Vaziri","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA. ndvaziri@uci.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA. ndvaziri@uci.edu","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8996,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7774148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"2","first_page":"98","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.09679999947547913,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferric-citrate","display_name":"ferric citrate","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/phosphate-binders","display_name":"phosphate binders","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.48899999260902405},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiomyocyte-size","display_name":"cardiomyocyte size","score":0.7310000061988831},{"id":"https://openalex.org/keywords/myocardin","display_name":"myocardin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/iron-supplementation","display_name":"iron supplementation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8508214354515076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7720850706100464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6901077032089233},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.6180924773216248},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5886011719703674},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5473532676696777},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4794663190841675},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.425403356552124},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.42131954431533813},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.19886061549186707}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:ijkd.org:article/4237","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/4237","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/4237/1055","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:30988246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30988246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of kidney diseases","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9fb2x88d","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9fb2x88d","pdf_url":"https://escholarship.org/uc/item/9fb2x88d","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian journal of kidney diseases, vol 13, iss 2","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9fb2x88d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9fb2x88d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian journal of kidney diseases, vol 13, iss 2","raw_type":"article"},{"id":"mag:2973973351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30988246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ijkd.org:article/4237","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/4237","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/4237/1055","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323314","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154"},{"id":"https://openalex.org/F4320325454","display_name":"Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering","ror":"https://ror.org/00ma7c320"},{"id":"https://openalex.org/F4320336557","display_name":"Ci\u00eancia sem Fronteiras","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2973973351.pdf","grobid_xml":"https://content.openalex.org/works/W2973973351.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2893794857"],"related_works":["https://openalex.org/W2990459802","https://openalex.org/W2887158331","https://openalex.org/W4224239653","https://openalex.org/W2982691844","https://openalex.org/W3114352878","https://openalex.org/W7037644915","https://openalex.org/W4396998715","https://openalex.org/W3029038440","https://openalex.org/W2029401802","https://openalex.org/W4391119861"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Chronic":[1],"kidney":[2],"disease":[3],"(CKD)":[4],"promotes":[5],"hypertrophy":[6,70,157,224],"and":[7,11,42,45,61,71,85,108,127,132,151,158,167,174,177,186,198,206,219,225],"fibrosis":[8,131,185,226],"in":[9,29,49,227],"heart,":[10],"increases":[12],"the":[13,59,139,194],"risk":[14],"of":[15,63,65,120,129,196,200],"cardiovascular":[16,109,220],"mortality.":[17],"Ferric":[18],"citrate":[19,67,163,191,215],"is":[20],"a":[21,96],"dietary":[22],"phosphate":[23,173],"binder":[24],"used":[25],"to":[26,36,57,81,138],"control":[27,87],"hyperphosphatemia":[28],"CKD":[30,50,82,89,142,228],"patients.":[31,51],"It":[32],"has":[33],"been":[34],"shown":[35],"raise":[37],"iron":[38,169],"stores,":[39],"improve":[40],"anemia":[41],"secondary":[43],"hyperparathyroidism,":[44],"decrease":[46],"vascular":[47],"calcification":[48],"The":[52],"present":[53],"study":[54],"was":[55],"done":[56],"explore":[58],"effects":[60],"mechanism":[62],"actions":[64],"ferric":[66,100,162,190,214],"on":[68],"cardiac":[69,125,183],"fibrosis.":[72,159],"MATERIALS":[73],"AND":[74],"METHODS:":[75],"Male":[76],"SD":[77],"rats":[78,90],"were":[79,91,134],"randomized":[80],"(5/6":[83],"nephrectomized)":[84],"sham-operated":[86],"groups.":[88],"fed":[92],"regular":[93],"diet":[94,97],"or":[95],"containing":[98],"4%":[99],"citrate.":[101],"After":[102],"8":[103],"weeks,":[104],"hemoglobin,":[105],"renal":[106,217],"function":[107],"endpoints":[110],"including":[111,222],"blood":[112],"pressure,":[113],"heart/body":[114,180],"weight":[115,181],"ratio,":[116,182],"serum":[117,147,168,172],"N-terminal":[118],"prohormone":[119],"brain":[121],"natriuretic":[122],"peptide":[123],"(NT-proBNP),":[124],"histology":[126],"markers":[128],"hypertrophy,":[130,184],"inflammation":[133],"assessed.":[135],"RESULTS:":[136],"Compared":[137],"controls,":[140],"untreated":[141],"group":[143],"exhibited":[144],"hypertension,":[145,179],"elevated":[146],"urea,":[148],"creatinine,":[149],"phosphate,":[150],"NT-proBNP":[152,175],"concentrations,":[153,170],"anemia,":[154],"cardiomegaly":[155],",cardiac":[156],"Treatment":[160,212],"with":[161,213],"significantly":[164],"increased":[165],"hemoglobin":[166],"reduced":[171,193],"levels":[176],"ameliorated":[178],"inflammation.":[187],"In":[188],"addition,":[189],"administration":[192],"size":[195],"cardiomyocytes":[197],"expressions":[199],"myocardin,":[201],"transforming":[202],"growth":[203],"factor-\u03b2,":[204],"interleukin-6":[205],"monocyte":[207],"chemotactic":[208],"protein":[209],"1.":[210],"CONCLUSIONS:":[211],"attenuated":[216],"failure":[218],"abnormalities":[221],"myocardial":[223],"rats.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-09-26T00:00:00"}