{"id":"https://openalex.org/W2973571998","doi":"https://doi.org/10.1002/jor.24479","title":"Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition","display_name":"Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition","publication_year":2019,"publication_date":"2019-09-19","ids":{"openalex":"https://openalex.org/W2973571998","doi":"https://doi.org/10.1002/jor.24479","mag":"2973571998","pmid":"https://pubmed.ncbi.nlm.nih.gov/31535728","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7065106"},"language":"en","primary_location":{"id":"doi:10.1002/jor.24479","doi":"https://doi.org/10.1002/jor.24479","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24479","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24479","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24479","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031345492","display_name":"Miitu K. M. Honkanen","orcid":"https://orcid.org/0000-0002-2548-4457","observed_orcids":["https://orcid.org/0000-0002-2548-4457"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Miitu K. M. Honkanen","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-2548-4457","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053876538","display_name":"Annina E. A. Saukko","orcid":"https://orcid.org/0000-0001-8678-4675","observed_orcids":["https://orcid.org/0000-0001-8678-4675"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Annina E. A. Saukko","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Department of Medical Physics, Turku University Hospital, Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0001-8678-4675","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Medical Physics, Turku University Hospital, Turku, Finland","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049415581","display_name":"Mikael J. Turunen","orcid":"https://orcid.org/0000-0003-1093-1178","observed_orcids":["https://orcid.org/0000-0003-1093-1178"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikael J. Turunen","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","SIB Labs, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-1093-1178","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"SIB Labs, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039974579","display_name":"Rubina S. Shaikh","orcid":"https://orcid.org/0000-0003-4184-8254","observed_orcids":["https://orcid.org/0000-0003-4184-8254"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Rubina Shaikh","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-4184-8254","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035069374","display_name":"Mithilesh Prakash","orcid":"https://orcid.org/0000-0002-3853-4126","observed_orcids":["https://orcid.org/0000-0002-3853-4126"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mithilesh Prakash","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-3853-4126","affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025266813","display_name":"Goran Lovri\u0107","orcid":"https://orcid.org/0000-0002-0833-4043","observed_orcids":["https://orcid.org/0000-0002-0833-4043"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I4387155338","display_name":"Swiss Light Source","ror":"https://ror.org/04xrb7c55","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908","https://openalex.org/I4387155338"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Goran Lovric","raw_affiliation_strings":["Centre d'lmagerie BioM\u00e9dicale \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland","Swiss Light Source Paul Scherrer Institute Villigen Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0833-4043","affiliations":[{"raw_affiliation_string":"Centre d'lmagerie BioM\u00e9dicale \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Light Source Paul Scherrer Institute Villigen Switzerland","institution_ids":["https://openalex.org/I2802229908","https://openalex.org/I4387155338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001266988","display_name":"Antti Joukainen","orcid":"https://orcid.org/0000-0002-1428-5700","observed_orcids":["https://orcid.org/0000-0002-1428-5700"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti Joukainen","raw_affiliation_strings":["Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-1428-5700","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043080116","display_name":"Heikki Kr\u00f6ger","orcid":"https://orcid.org/0000-0003-4245-8186","observed_orcids":["https://orcid.org/0000-0003-4245-8186"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heikki Kr\u00f6ger","raw_affiliation_strings":["Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-4245-8186","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001975624","display_name":"Mark W. Grinstaff","orcid":"https://orcid.org/0000-0002-5453-3668","observed_orcids":["https://orcid.org/0000-0002-5453-3668"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W. Grinstaff","raw_affiliation_strings":["Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5453-3668","affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061605544","display_name":"Juha T\u00f6yr\u00e4s","orcid":"https://orcid.org/0000-0002-8035-1606","observed_orcids":["https://orcid.org/0000-0002-8035-1606"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["AU","FI"],"is_corresponding":false,"raw_author_name":"Juha T\u00f6yr\u00e4s","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland","School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8035-1606","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5031345492"],"corresponding_institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":2500,"currency":"EUR","value_usd":2696},"fwci":1.7104,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83692823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"38","issue":"3","first_page":"563","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11183","display_name":"Advanced X-ray Imaging Techniques","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dual-energy-imaging","display_name":"dual-energy imaging","score":0.6159999966621399},{"id":"https://openalex.org/keywords/gadoteridol","display_name":"gadoteridol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/proteoglycan-content","display_name":"proteoglycan content","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cartilage-water-content","display_name":"cartilage water content","score":0.9190000295639038},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cartilage-biomechanical-properties","display_name":"cartilage biomechanical properties","score":0.8690000176429749},{"id":"https://openalex.org/keywords/beam-hardening-artifacts","display_name":"beam hardening artifacts","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7538124322891235},{"id":"https://openalex.org/C21368211","wikidata":"https://www.wikidata.org/wiki/Q689863","display_name":"Synchrotron","level":2,"score":0.6879807710647583},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5963259339332581},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5577467083930969},{"id":"https://openalex.org/C16332341","wikidata":"https://www.wikidata.org/wiki/Q212871","display_name":"Synchrotron radiation","level":2,"score":0.5531156659126282},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.5307925343513489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5119439363479614},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.43859100341796875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.43748247623443604},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.335452675819397},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2576165795326233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18158608675003052},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.15175741910934448},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13579237461090088},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08553576469421387},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002102","descriptor_name":"Cadaver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017356","descriptor_name":"Synchrotrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1002/jor.24479","doi":"https://doi.org/10.1002/jor.24479","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24479","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24479","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6026670","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7065106","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7065106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7065106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop Res","raw_type":"Text"},{"id":"pmid:31535728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31535728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"},{"id":"pmh:oai:dora:psi_28298","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:28298","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:28298/PDF/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:erepo.uef.fi:123456789/7967","doi":null,"is_oa":true,"landing_page_url":"https://erepo.uef.fi/handle/123456789/7967","pdf_url":"https://erepo.uef.fi/bitstreams/cc97d5c3-85ce-4d79-9486-341b3e8a09ca/download","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:271564","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/162300","pdf_url":"https://infoscience.epfl.ch/bitstreams/0b3600f6-9908-4756-a99d-c7e3fc1b6ebe/download","source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:utupub.fi:11111/48885","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/48885","pdf_url":"https://www.utupub.fi/bitstreams/ecfe919f-b0a9-4d8d-991a-9b582a8dc74b/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/185861","raw_type":null},{"id":"pmh:oai:www.utupub.fi:10024/185861","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/10024/185861","pdf_url":"https://www.utupub.fi/bitstream/10024/185861/1/jor.24479.pdf","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:arrow.tudublin.ie:scschphyart-1247","doi":null,"is_oa":true,"landing_page_url":"https://arrow.tudublin.ie/scschphyart/232","pdf_url":null,"source":{"id":"https://openalex.org/S4377196307","display_name":"Arrow - TU Dublin (Technological University Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/jor.24479","doi":"https://doi.org/10.1002/jor.24479","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24479","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24479","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1471191486","display_name":null,"funder_award_id":"5041778","funder_id":"https://openalex.org/F4320322356","funder_display_name":"Kuopion Yliopistollinen Sairaala"},{"id":"https://openalex.org/G4152787313","display_name":null,"funder_award_id":"5041778","funder_id":"https://openalex.org/F4320323337","funder_display_name":"Tekniikan Edist\u00e4miss\u00e4\u00e4ti\u00f6"},{"id":"https://openalex.org/G4409209161","display_name":null,"funder_award_id":"5041744","funder_id":"https://openalex.org/F4320322356","funder_display_name":"Kuopion Yliopistollinen Sairaala"},{"id":"https://openalex.org/G6200854686","display_name":null,"funder_award_id":"5041769","funder_id":"https://openalex.org/F4320322356","funder_display_name":"Kuopion Yliopistollinen Sairaala"},{"id":"https://openalex.org/G6671322778","display_name":null,"funder_award_id":"X02DA","funder_id":"https://openalex.org/F4320322463","funder_display_name":"Paul Scherrer Institut"},{"id":"https://openalex.org/G911673570","display_name":null,"funder_award_id":"307932","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320310055","display_name":"It\u00e4-Suomen Yliopisto","ror":"https://ror.org/00cyydd11"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321109","display_name":"Suomalainen Tiedeakatemia","ror":"https://ror.org/01njdr168"},{"id":"https://openalex.org/F4320322356","display_name":"Kuopion Yliopistollinen Sairaala","ror":"https://ror.org/00fqdfs68"},{"id":"https://openalex.org/F4320322456","display_name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03bj5da63"},{"id":"https://openalex.org/F4320322463","display_name":"Paul Scherrer Institut","ror":"https://ror.org/03eh3y714"},{"id":"https://openalex.org/F4320323337","display_name":"Tekniikan Edist\u00e4miss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03f420b93"},{"id":"https://openalex.org/F4320334901","display_name":"Jenny ja Antti Wihurin Rahasto","ror":"https://ror.org/01gpyzq83"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2973571998.pdf","grobid_xml":"https://content.openalex.org/works/W2973571998.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W44674334","https://openalex.org/W206711978","https://openalex.org/W614568434","https://openalex.org/W1580157778","https://openalex.org/W1796554278","https://openalex.org/W1945216193","https://openalex.org/W1966432237","https://openalex.org/W1990488312","https://openalex.org/W1992173705","https://openalex.org/W1993840291","https://openalex.org/W2007696224","https://openalex.org/W2010091461","https://openalex.org/W2011038175","https://openalex.org/W2016792397","https://openalex.org/W2042167236","https://openalex.org/W2045942656","https://openalex.org/W2048131429","https://openalex.org/W2058754065","https://openalex.org/W2067856121","https://openalex.org/W2072786965","https://openalex.org/W2075403284","https://openalex.org/W2077083595","https://openalex.org/W2097137621","https://openalex.org/W2099427592","https://openalex.org/W2131907878","https://openalex.org/W2132323306","https://openalex.org/W2132486511","https://openalex.org/W2136321899","https://openalex.org/W2148693270","https://openalex.org/W2167037356","https://openalex.org/W2168576724","https://openalex.org/W2288707769","https://openalex.org/W2317938739","https://openalex.org/W2512111109","https://openalex.org/W2517453663","https://openalex.org/W2518198922","https://openalex.org/W2521386967","https://openalex.org/W2594432989","https://openalex.org/W2597258933","https://openalex.org/W2625307552","https://openalex.org/W2751816443","https://openalex.org/W2754049912","https://openalex.org/W2797071843","https://openalex.org/W2918719114","https://openalex.org/W2943903333","https://openalex.org/W4205938305","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W2943903333","https://openalex.org/W3032988961","https://openalex.org/W2918719114","https://openalex.org/W2977495963","https://openalex.org/W2797071843","https://openalex.org/W4404920744","https://openalex.org/W2754049912","https://openalex.org/W2167298868","https://openalex.org/W4408997470","https://openalex.org/W4324142043"],"abstract_inverted_index":{"Dual":[0],"contrast":[1,45,89,130,227,251],"micro":[2],"computed":[3],"tomography":[4],"(CT)":[5],"shows":[6],"potential":[7,41],"for":[8,47,196],"detecting":[9],"articular":[10,233],"cartilage":[11,49,187,199,234],"degeneration.":[12],"However,":[13],"the":[14,39,43,53,61,179,186,193,225,249,257],"performance":[15],"of":[16,42,135,178,231,261,270,280],"conventional":[17,262],"CT":[18,263],"systems":[19],"is":[20,253],"limited":[21,255],"by":[22,256,274],"beam":[23,72,258],"hardening,":[24],"low":[25],"image":[26,75],"resolution":[27],"(full-body":[28],"CT),":[29],"and":[30,73,97,100,113,125,140,151,169,204,212,237],"long":[31],"acquisition":[32],"times":[33],"(conventional":[34],"microCT).":[35],"Therefore,":[36],"to":[37],"reveal":[38],"full":[40],"dual":[44,129,220,226,250],"technique":[46,54,131,222,252],"imaging":[48],"composition":[50],"we":[51],"employ":[52],"using":[55,119,245],"synchrotron":[56,67,103,246],"microCT.":[57,247],"We":[58],"hypothesize":[59],"that":[60],"above-mentioned":[62],"limitations":[63],"are":[64],"overcome":[65],"with":[66,102,164,182,224],"microCT":[68,104],"utilizing":[69],"monochromatic":[70,121],"X-ray":[71,122],"fast":[74],"acquisition.":[76],"Human":[77],"osteochondral":[78],"samples":[79],"(n":[80],"=":[81],"41,":[82],"four":[83],"cadavers)":[84],"were":[85],"immersed":[86],"in":[87,167],"a":[88],"agent":[90,228],"solution":[91],"containing":[92],"two":[93,120],"agents":[94],"(cationic":[95],"CA4+":[96,136,165,180,242],"non-ionic":[98],"gadoteridol)":[99],"imaged":[101],"at":[105,114,172],"an":[106],"early":[107],"diffusion":[108,115,174],"time":[109,175],"point":[110],"(2":[111],"h)":[112,118],"equilibrium":[116],"(72":[117],"energies":[123],"(32":[124],"34":[126],"keV).":[127],"The":[128,219,267],"enabled":[132],"simultaneous":[133],"determination":[134],"(i.e.,":[137,142],"proteoglycan":[138,149,200,235],"content)":[139,144],"gadoteridol":[141,183],"water":[143],"partitions":[145],"within":[146,185],"cartilage.":[147],"Cartilage":[148,214],"content":[150,236],"biomechanical":[152,202,238],"properties":[153,239],"correlated":[154],"significantly":[155,188],"(0.327":[156],"<":[157,159,162,190],"r":[158],"0.736,":[160],"p":[161],"0.05)":[163,191],"partition":[166,181,184,243],"superficial":[168],"middle":[170],"zones":[171],"both":[173],"points.":[176],"Normalization":[177],"(p":[189],"improved":[192],"detection":[194],"sensitivity":[195],"human":[197,232],"osteoarthritic":[198],"content,":[201],"properties,":[203],"overall":[205],"condition":[206],"(Mankin,":[207],"Osteoarthritis":[208],"Research":[209,282],"Society":[210,216],"International,":[211],"International":[213],"Repair":[215],"grading":[217],"systems).":[218],"energy":[221],"combined":[223],"enables":[229],"assessment":[230],"based":[240],"on":[241,278],"determined":[244],"Additionally,":[248],"not":[254],"hardening":[259],"artifact":[260],"systems.":[264],"\u00a9":[265],"2019":[266],"Authors.":[268],"Journal":[269],"Orthopaedic":[271,281],"Research\u00ae":[272],"published":[273],"Wiley":[275],"Periodicals,":[276],"Inc.":[277],"behalf":[279],"Society.":[283],"J":[284],"Orthop":[285],"Res":[286],"38:563-573,":[287],"2020.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-09-26T00:00:00"}