{"id":"https://openalex.org/W2972952182","doi":"https://doi.org/10.3892/etm.2019.7998","title":"Screening and identification of biomarkers associated with clinicopathological parameters and prognosis in oral squamous cell carcinoma","display_name":"Screening and identification of biomarkers associated with clinicopathological parameters and prognosis in oral squamous cell carcinoma","publication_year":2019,"publication_date":"2019-09-11","ids":{"openalex":"https://openalex.org/W2972952182","doi":"https://doi.org/10.3892/etm.2019.7998","mag":"2972952182","pmid":"https://pubmed.ncbi.nlm.nih.gov/31608128","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6778814"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2019.7998","doi":"https://doi.org/10.3892/etm.2019.7998","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2019.7998","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2019.7998/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/etm.2019.7998/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100624446","display_name":"Qiqi Wu","orcid":"https://orcid.org/0009-0002-8210-9095","observed_orcids":["https://orcid.org/0009-0002-8210-9095"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiqi Wu","raw_affiliation_strings":["Department of Endodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078330347","display_name":"Ruoyan Cao","orcid":"https://orcid.org/0000-0003-4152-7450","observed_orcids":["https://orcid.org/0000-0003-4152-7450"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoyan Cao","raw_affiliation_strings":["Department of Prosthodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359210","display_name":"Juan Chen","orcid":"https://orcid.org/0000-0002-4373-2514","observed_orcids":["https://orcid.org/0000-0002-4373-2514"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Chen","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006461150","display_name":"Xiaoli Xie","orcid":"https://orcid.org/0000-0001-6087-1770","observed_orcids":["https://orcid.org/0000-0001-6087-1770"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoli Xie","raw_affiliation_strings":["Department of Endodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endodontics, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410083, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006461150"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":null,"apc_paid":null,"fwci":1.5909,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80308166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"5","first_page":"3579","last_page":"3587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8240000009536743},{"id":"https://openalex.org/keywords/prognostic-genes","display_name":"prognostic genes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.8579999804496765},{"id":"https://openalex.org/keywords/differentially-expressed-mrnas","display_name":"differentially expressed mRNAs","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7710000276565552},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8420000076293945},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7480000257492065},{"id":"https://openalex.org/keywords/statherin","display_name":"statherin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7309642434120178},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5868255496025085},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5136106014251709},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.5067113041877747},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.49235737323760986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47255584597587585},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4426169693470001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4359041154384613},{"id":"https://openalex.org/C158163496","wikidata":"https://www.wikidata.org/wiki/Q5937310","display_name":"Human Protein Atlas","level":4,"score":0.4304071068763733},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4179798364639282},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.41508662700653076},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3491622805595398},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3422541618347168},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3389896750450134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30638477206230164},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22674518823623657},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2210124433040619},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20525339245796204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16261857748031616},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13243532180786133},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.11941325664520264},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/etm.2019.7998","doi":"https://doi.org/10.3892/etm.2019.7998","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2019.7998","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2019.7998/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmid:31608128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31608128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6778814","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6778814/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/etm.2019.7998","doi":"https://doi.org/10.3892/etm.2019.7998","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2019.7998","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2019.7998/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2972952182.pdf","grobid_xml":"https://content.openalex.org/works/W2972952182.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1452821454","https://openalex.org/W1546896134","https://openalex.org/W1848313789","https://openalex.org/W1858946586","https://openalex.org/W1898396310","https://openalex.org/W1978331336","https://openalex.org/W1991629881","https://openalex.org/W2012403833","https://openalex.org/W2015551880","https://openalex.org/W2039852174","https://openalex.org/W2043102080","https://openalex.org/W2060200899","https://openalex.org/W2067269986","https://openalex.org/W2079366155","https://openalex.org/W2109517646","https://openalex.org/W2128433809","https://openalex.org/W2144878747","https://openalex.org/W2151224270","https://openalex.org/W2169626866","https://openalex.org/W2407803281","https://openalex.org/W2473723675","https://openalex.org/W2510383945","https://openalex.org/W2518901521","https://openalex.org/W2523770800","https://openalex.org/W2557212572","https://openalex.org/W2557836311","https://openalex.org/W2558721523","https://openalex.org/W2579941249","https://openalex.org/W2771056794","https://openalex.org/W2771853311","https://openalex.org/W2782743668","https://openalex.org/W2783938954","https://openalex.org/W2791378117","https://openalex.org/W2801757301","https://openalex.org/W2808871471","https://openalex.org/W2884890992","https://openalex.org/W2885593579","https://openalex.org/W2888255768","https://openalex.org/W2893132426","https://openalex.org/W2901817521","https://openalex.org/W2902050261","https://openalex.org/W2974104874","https://openalex.org/W2981312787","https://openalex.org/W6628649089","https://openalex.org/W6713428067","https://openalex.org/W6756077679"],"related_works":["https://openalex.org/W3141115831","https://openalex.org/W3171726257","https://openalex.org/W4284891813","https://openalex.org/W3005587360","https://openalex.org/W2974100694","https://openalex.org/W3111489100","https://openalex.org/W2980425804","https://openalex.org/W3194482067","https://openalex.org/W4402194447","https://openalex.org/W2993706633"],"abstract_inverted_index":{"Oral":[0],"squamous":[1],"cell":[2],"carcinoma":[3],"(OSCC)":[4],"is":[5],"a":[6,34,60,241],"major":[7],"type":[8],"of":[9,12,24,107,110,142,154,163,180,199,249],"malignant":[10],"tumor":[11],"the":[13,20,26,87,104,108,137,193,245,265],"oral":[14],"cavity.":[15],"Despite":[16],"marked":[17],"advances":[18],"in":[19,37,174,192,244,264],"management":[21],"and":[22,53,57,67,79,102,115,136,148,167,187,203,224,247,251,259],"diagnosis":[23],"OSCC,":[25,56],"associated":[27,49,157,205],"overall":[28],"survival":[29,134],"ratio":[30],"has":[31],"only":[32],"exhibited":[33],"modest":[35],"increase":[36],"recent":[38],"years.":[39],"The":[40,74,236],"present":[41],"study":[42],"aimed":[43],"to":[44,58,94,124,230],"identify":[45,95],"potential":[46],"crucial":[47,242],"genes":[48,129,183,201],"with":[50,132,158,218],"clinical":[51,69,98,159],"features":[52],"prognosis":[54],"for":[55,62,256,262],"provide":[59],"basis":[61],"further":[63,254],"investigation.":[64],"RNA-sequencing":[65],"data":[66],"corresponding":[68],"information":[70],"were":[71,84,121,130,151,156,171,190,228],"downloaded":[72],"from":[73],"Cancer":[75],"Genome":[76],"Atlas":[77],"database":[78],"differentially":[80,96],"expressed":[81,97],"mRNAs":[82,100],"(DEmRNAs)":[83],"identified":[85,191,238],"using":[86],"edgeR":[88],"package.":[89],"Bioinformatics":[90],"analysis":[91,114,120],"was":[92],"performed":[93,123],"features-associated":[99],"(CFmRNAs)":[101],"enhance":[103],"current":[105],"knowledge":[106],"function":[109],"them.":[111],"Functional":[112],"enrichment":[113,176],"protein-protein":[116],"interplay":[117],"(PPI)":[118],"network":[119,195],"then":[122],"better":[125],"understand":[126],"CFmRNAs.":[127],"Survival-associated":[128],"analyzed":[131],"Kaplan-Meier":[133],"curves":[135],"log-rank":[138],"test.":[139],"A":[140,161,178,197],"total":[141,162,179,198],"2,013":[143],"DEmRNAs":[144,237],"between":[145],"OSCC":[146,250,263],"samples":[147],"normal":[149],"tissues":[150],"identified,":[152],"180":[153],"which":[155],"features.":[160],"17":[164],"GO":[165],"terms":[166],"4":[168,181,207],"KEGG":[169],"pathways":[170],"significantly":[172],"enriched":[173],"functional":[175],"analysis.":[177,196],"hub":[182],"(albumin,":[184],"statherin,":[185],"neurotensin":[186],"mucin":[188],"7)":[189],"PPI":[194],"6":[200],"(DDB1":[202],"CUL4":[204],"factor":[206],"like":[208,222],"2,":[209],"opiorphin":[210],"prepropeptide,":[211],"R3H":[212],"domain":[213],"containing":[214],"like,":[215],"transmembrane":[216],"phosphatase":[217],"tensin":[219],"homology,":[220],"actin":[221],"8":[223],"protocadherin":[225],"\u03b1":[226],"11)":[227],"observed":[229],"have":[231,240],"an":[232],"influence":[233],"on":[234],"survival.":[235],"may":[239,252],"role":[243],"genesis":[246],"development":[248],"be":[253],"developed":[255],"diagnostic,":[257],"therapeutic":[258],"prognostic":[260],"applications":[261],"future.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-09-19T00:00:00"}
