{"id":"https://openalex.org/W2972608544","doi":"https://doi.org/10.1039/c9nr05758g","title":"Nanoparticle-mediated delivery of siRNA into zebrafish heart: a cell-level investigation on the biodistribution and gene silencing effects","display_name":"Nanoparticle-mediated delivery of siRNA into zebrafish heart: a cell-level investigation on the biodistribution and gene silencing effects","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2972608544","doi":"https://doi.org/10.1039/c9nr05758g","mag":"2972608544","pmid":"https://pubmed.ncbi.nlm.nih.gov/31576876"},"language":"en","primary_location":{"id":"doi:10.1039/c9nr05758g","doi":"https://doi.org/10.1039/c9nr05758g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9nr05758g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027918199","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0001-7779-6957","observed_orcids":["https://orcid.org/0000-0001-7779-6957"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Beijing","China","College of Engineering","Department of Biomedical Engineering","Peking University","Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China","Nano Medical Technology Research Institute, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"],"raw_orcid":"https://orcid.org/0000-0001-7779-6957","affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Nano Medical Technology Research Institute, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442289","display_name":"Xi Wang","orcid":"https://orcid.org/0000-0003-3415-7092","observed_orcids":["https://orcid.org/0000-0003-3415-7092"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Wang","raw_affiliation_strings":["Beijing","China","College of Engineering","Department of Biomedical Engineering","Peking University","Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081180912","display_name":"Lu Gao","orcid":"https://orcid.org/0000-0002-7384-6889","observed_orcids":["https://orcid.org/0000-0002-7384-6889"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Gao","raw_affiliation_strings":["Beijing","Beijing Key Laboratory of Cardiometabolic Molecular Medicine","China","Institute of Molecular Medicine","Peking University","Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"Beijing Key Laboratory of Cardiometabolic Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112075406","display_name":"Liu-Yi Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu-Yi Meng","raw_affiliation_strings":["Beijing","China","Peking University","School of Life Sciences","School of Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001745072","display_name":"Jing-Ming Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Ming Xie","raw_affiliation_strings":["Beijing","China","College of Engineering","Department of Biomedical Engineering","Peking University","Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020085314","display_name":"Jing\u2010Wei Xiong","orcid":"https://orcid.org/0000-0001-8438-4782","observed_orcids":["https://orcid.org/0000-0001-8438-4782"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Wei Xiong","raw_affiliation_strings":["Beijing","Beijing Key Laboratory of Cardiometabolic Molecular Medicine","China","Institute of Molecular Medicine","Peking University","Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"Beijing Key Laboratory of Cardiometabolic Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034483827","display_name":"Ying Luo","orcid":"https://orcid.org/0000-0001-9834-9419","observed_orcids":["https://orcid.org/0000-0001-9834-9419","https://orcid.org/0000-0002-6089-5104"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Luo","raw_affiliation_strings":["Beijing","China","College of Engineering","Department of Biomedical Engineering","Peking University","Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9834-9419","affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034483827"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":0.8057,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68147274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"39","first_page":"18052","last_page":"18064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-nanoparticles","display_name":"siRNA nanoparticles","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nanoparticle-biodistribution","display_name":"nanoparticle biodistribution","score":0.9319999814033508},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6930000185966492},{"id":"https://openalex.org/keywords/zebrafish-heart","display_name":"zebrafish heart","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transgenic-zebrafish","display_name":"transgenic zebrafish","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cardiac-gene-therapy","display_name":"cardiac gene therapy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.6299999952316284},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.9594525098800659},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.8485795259475708},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7124670743942261},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5493714809417725},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5048626065254211},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4833250045776367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44242382049560547},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.41614818572998047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41316935420036316},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.39780452847480774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38493022322654724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29794231057167053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25006234645843506},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1265748143196106},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11774379014968872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10830825567245483}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c9nr05758g","doi":"https://doi.org/10.1039/c9nr05758g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9nr05758g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:31576876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31576876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3968689318","display_name":null,"funder_award_id":"2016YFC1101301","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6538527704","display_name":null,"funder_award_id":"31322021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7277001889","display_name":null,"funder_award_id":"31370955","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W781480130","https://openalex.org/W1052441802","https://openalex.org/W1197053736","https://openalex.org/W1479909557","https://openalex.org/W1525465078","https://openalex.org/W1840805957","https://openalex.org/W1874889006","https://openalex.org/W1880563629","https://openalex.org/W1965128951","https://openalex.org/W1966120037","https://openalex.org/W1978094989","https://openalex.org/W1980758898","https://openalex.org/W1982268334","https://openalex.org/W1985596847","https://openalex.org/W1988464677","https://openalex.org/W1992663358","https://openalex.org/W2007631412","https://openalex.org/W2012632646","https://openalex.org/W2029773083","https://openalex.org/W2030067432","https://openalex.org/W2043121996","https://openalex.org/W2049978396","https://openalex.org/W2050195517","https://openalex.org/W2053740860","https://openalex.org/W2054792206","https://openalex.org/W2058248291","https://openalex.org/W2062186255","https://openalex.org/W2067796149","https://openalex.org/W2068217608","https://openalex.org/W2073999055","https://openalex.org/W2082472219","https://openalex.org/W2098565706","https://openalex.org/W2106989823","https://openalex.org/W2121634364","https://openalex.org/W2123950519","https://openalex.org/W2126747203","https://openalex.org/W2130797803","https://openalex.org/W2136973716","https://openalex.org/W2143463421","https://openalex.org/W2146576596","https://openalex.org/W2151509589","https://openalex.org/W2157571064","https://openalex.org/W2157758537","https://openalex.org/W2167752478","https://openalex.org/W2191780303","https://openalex.org/W2305729456","https://openalex.org/W2310958769","https://openalex.org/W2320613810","https://openalex.org/W2322473086","https://openalex.org/W2324195065","https://openalex.org/W2342299888","https://openalex.org/W2342811791","https://openalex.org/W2343123299","https://openalex.org/W2405505865","https://openalex.org/W2411145445","https://openalex.org/W2462031667","https://openalex.org/W2513240428","https://openalex.org/W2519536988","https://openalex.org/W2538196258","https://openalex.org/W2564043830","https://openalex.org/W2606562166","https://openalex.org/W2624985846","https://openalex.org/W2626252985","https://openalex.org/W2697082363","https://openalex.org/W2740769662","https://openalex.org/W2751184724","https://openalex.org/W2801185907"],"related_works":["https://openalex.org/W2321167350","https://openalex.org/W2886937772","https://openalex.org/W2979767858","https://openalex.org/W1197053736","https://openalex.org/W2324306022","https://openalex.org/W2002050544","https://openalex.org/W2047649998","https://openalex.org/W2081042870","https://openalex.org/W4409051938","https://openalex.org/W4394767635"],"abstract_inverted_index":{"Nanomaterials":[0],"hold":[1],"promise":[2],"for":[3],"the":[4,20,29,34,37,46,51,59,67,87,109,118,150,163,178,192,201],"delivery":[5,39,60,187],"of":[6,19,24,36,90,94,128,153,203],"nucleic":[7],"acids":[8],"to":[9,45,86,132,180,184,196,199],"facilitate":[10],"gene":[11,52,121,140],"therapy":[12],"in":[13,21,40,49,64,96,124,142,145,166,170,188,208],"cardiac":[14,41],"diseases.":[15],"However,":[16],"as":[17],"much":[18],"vivo":[22],"study":[23],"nanomaterials":[25],"was":[26,43,56,103],"conducted":[27],"via":[28],"\"trial":[30],"and":[31,62,101,156,177,191],"error\"":[32],"method,":[33],"understanding":[35],"nanomaterial-mediated":[38],"tissue":[42,190],"limited":[44],"gross":[47],"efficiency":[48,169],"manipulating":[50],"expression":[53],"while":[54],"little":[55],"known":[57],"about":[58],"process":[61],"mechanism":[63],"particular":[65],"at":[66,108],"cell":[68,110],"level.":[69],"In":[70],"this":[71],"study,":[72],"small":[73],"interfering":[74],"RNA":[75],"(siRNA)":[76],"nanoparticles":[77,95,136,155,158],"formulated":[78],"with":[79,106],"a":[80,125,175],"polyamidoamine":[81],"(PAMAM)":[82],"nanomaterial":[83],"were":[84,130],"applied":[85],"injured":[88],"heart":[89],"zebrafish.":[91],"The":[92,147],"distribution":[93,119,152],"cardiomyocytes,":[97],"endothelial":[98],"cells,":[99],"macrophages":[100],"leukocytes":[102],"quantitatively":[104],"analyzed":[105,131],"precision":[107],"level":[111],"by":[112],"using":[113],"transgenic":[114],"models.":[115],"Based":[116],"on":[117],"characteristics,":[120],"silencing":[122,141],"effects":[123],"specific":[126],"group":[127],"cells":[129,144],"illustrate":[133],"how":[134,157],"siRNA":[135,154],"could":[137,159],"get":[138],"potent":[139],"different":[143,171],"vivo.":[146],"results":[148],"elucidated":[149],"heterogeneous":[151],"be":[160],"efficient":[161],"despite":[162],"significant":[164],"difference":[165],"cellular":[167,182],"uptake":[168],"cells.":[172],"It":[173],"demonstrated":[174],"paradigm":[176],"need":[179],"decouple":[181],"processes":[183],"understand":[185],"nanoparticle-mediated":[186],"complex":[189],"investigation/methodology":[193],"may":[194],"lead":[195],"important":[197],"information":[198],"guide":[200],"design":[202],"advanced":[204],"targeted":[205],"drug-delivery":[206],"systems":[207],"heart.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-09-19T00:00:00"}