{"id":"https://openalex.org/W2972043980","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","title":"The role of Pirh2 C-terminal residues and ubiquitin lysine chains in ubiquitination mechanism.","display_name":"The role of Pirh2 C-terminal residues and ubiquitin lysine chains in ubiquitination mechanism.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2972043980","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","mag":"2972043980"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.11110","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090594357","display_name":"Rami Abou Zeinab","orcid":"https://orcid.org/0009-0000-8527-4163","observed_orcids":["https://orcid.org/0009-0000-8527-4163"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rami Mahmoud Abou Zeinab","raw_affiliation_strings":["University of Alberta, Edmonton, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045264166","display_name":"Roger P. Leng","orcid":"https://orcid.org/0000-0001-9652-4703","observed_orcids":["https://orcid.org/0000-0001-9652-4703"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roger Leng","raw_affiliation_strings":["University of Alberta, Edmonton, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"11110","last_page":"11110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pirh2","display_name":"Pirh2","score":0.996999979019165},{"id":"https://openalex.org/keywords/p53-ubiquitination","display_name":"p53 ubiquitination","score":0.824999988079071},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/self-ubiquitination","display_name":"self-ubiquitination","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/c-terminal-residues","display_name":"C-terminal residues","score":0.5440000295639038},{"id":"https://openalex.org/keywords/ring-finger-domain","display_name":"RING domain","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.75}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.8938044905662537},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.766907811164856},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.6130648851394653},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.4891238808631897},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.44551682472229004},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4449024796485901},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4128648638725281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36335012316703796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3612357974052429},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35002467036247253},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.23842376470565796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15258944034576416}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.11110","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.11110","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006313701","https://openalex.org/W2166727241","https://openalex.org/W2043915519","https://openalex.org/W2229383139","https://openalex.org/W2057186273","https://openalex.org/W2015658287","https://openalex.org/W2796564872","https://openalex.org/W2029679060","https://openalex.org/W2027262316","https://openalex.org/W3032185659"],"abstract_inverted_index":{"11110":[0],"Background:":[1],"Pirh2,":[2,188],"a":[3,11,85,94,101],"p53":[4,15,37,45,68,183,261,313],"inducible":[5],"gene,":[6],"is":[7,62,65,77],"proposed":[8],"to":[9,81,114,123,166,174,192,234,269,297,315],"be":[10,82,270],"main":[12],"regulator":[13],"of":[14,53,59,88,197,220,239,245,260,308],"family":[16],"proteins":[17,310],"fine":[18],"tuning":[19],"the":[20,57,78,97,104,125,132,143,198,202,218,243,256,298,305],"DNA":[21,316],"damage":[22],"response":[23,314],"by":[24,48,289],"acting":[25],"as":[26],"an":[27],"E3":[28,74,273],"ligase.":[29],"A":[30],"negative":[31],"feedback":[32],"loop":[33],"between":[34],"Pirh2":[35,43,64,76,116,121,137,179,215,224,240,249,299,309],"and":[36,131,148,171,182,209,279],"exists":[38],"where":[39,161],"under":[40],"unstressed":[41],"conditions,":[42],"induces":[44],"ubiquitination":[46,117,184],"followed":[47],"proteosomal":[49],"degradation.":[50],"In":[51],"case":[52],"cellular":[54],"stress":[55],"when":[56],"activity":[58,276],"tumor":[60],"suppressors":[61],"essential,":[63],"self-ubiquitinated":[66],"releasing":[67],"continuous":[69],"repression.":[70],"Interestingly":[71],"among":[72],"all":[73,230],"ligases,":[75],"only":[79],"one":[80],"over-expressed":[83],"in":[84,96,103,142,172,255],"wide":[86],"range":[87],"human":[89],"tumors.":[90],"This":[91],"over-expression":[92],"indicates":[93],"disruption":[95],"self-ubiquitination":[98,216,241,250,300],"mechanism":[99,106,118,301],"or":[100,258],"defect":[102],"degradation":[105],"post":[107],"ubiquitination.":[108,284],"Based":[109],"on":[110,223],"that,":[111],"we":[112,177,189],"aimed":[113],"analyze":[115],"through":[119,155],"mapping":[120],"domains":[122,145],"reveal":[124,193],"essential":[126,206],"residues":[127,141,163,195,232],"for":[128,207,272],"this":[129],"process":[130],"ubiquitin":[133,150,211,221,274],"chains":[134],"utilized.":[135],"Methods:":[136],"constructs":[138,152,170],"deleting":[139],"major":[140],"three":[144],"were":[146,153,190,287],"designed,":[147],"also":[149],"mutant":[151],"designed":[154],"single/multiple":[156],"mutations":[157,222],"at":[158],"specific":[159],"positions":[160],"lysine":[162,231,246],"are":[164,205],"mutated":[165,233],"arginine.":[167],"Using":[168],"these":[169],"comparison":[173],"WT":[175],"proteins,":[176],"tested":[178],"in-vitro":[180],"self":[181],"activity.":[185],"Results:":[186],"Regarding":[187],"able":[191],"that":[194,302],"240-250":[196],"c-terminal":[199],"along":[200],"with":[201],"ring":[203],"domain":[204],"self-ubiquitination.K63R":[208],"K48R":[210,278],"did":[212],"not":[213,280],"affect":[214],"minimizing":[217],"impact":[219],"self-ubiquitination.":[225],"However,":[226],"KO,":[227],"which":[228],"had":[229],"arginine,":[235],"showed":[236,252,282],"total":[237],"inhibition":[238],"confirming":[242],"importance":[244],"residues.":[247],"Interestingly,":[248],"reaction":[251],"no":[253],"difference":[254],"presence":[257],"absence":[259],"proteins.":[262],"Concerning":[263],"Pirh2-p53":[264],"ubiquitination,":[265],"K48":[266],"was":[267],"found":[268],"critical":[271],"ligase":[275],"because":[277],"K36R":[281],"defective":[283],"All":[285],"results":[286],"confirmed":[288],"quantifying":[290],"ubiquitin.":[291],"Conclusions:":[292],"Our":[293],"data":[294],"added":[295],"knowledge":[296],"can":[303],"resolve":[304],"constant":[306],"overexpression":[307],"hence":[311],"maximizing":[312],"damage.":[317]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2019-09-12T00:00:00"}
