{"id":"https://openalex.org/W2972025247","doi":"https://doi.org/10.1161/hyp.74.suppl_1.120","title":"Abstract 120: Protective Role of Vascular Smooth Muscle Rho-Related BTB Domain Containing Protein 1 in Hypertension and Arterial Stiffness","display_name":"Abstract 120: Protective Role of Vascular Smooth Muscle Rho-Related BTB Domain Containing Protein 1 in Hypertension and Arterial Stiffness","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2972025247","doi":"https://doi.org/10.1161/hyp.74.suppl_1.120","mag":"2972025247"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.74.suppl_1.120","doi":"https://doi.org/10.1161/hyp.74.suppl_1.120","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.74.suppl_1.120","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076730910","display_name":"Shi Fang","orcid":"https://orcid.org/0000-0001-7095-6997","observed_orcids":["https://orcid.org/0000-0001-7095-6997"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shi Fang","raw_affiliation_strings":["Med College of Wisconsin, Wauwatosa, WI","Shi Fang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med College of Wisconsin, Wauwatosa, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Shi Fang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026836502","display_name":"Masashi Mukohda","orcid":"https://orcid.org/0000-0003-1774-4156","observed_orcids":["https://orcid.org/0000-0003-1774-4156"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Mukohda","raw_affiliation_strings":["Univ of Iowa, Iowa City, IA","Masashi Mukohda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Masashi Mukohda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056524939","display_name":"Jing Feng Wu","orcid":"https://orcid.org/0000-0003-2013-2863","observed_orcids":["https://orcid.org/0000-0003-2013-2863"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wu","raw_affiliation_strings":["Med College of Wisconsin, Wauwatosa, WI","Jing Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med College of Wisconsin, Wauwatosa, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Jing Wu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102922683","display_name":"Anand R. Nair","orcid":"https://orcid.org/0000-0002-4067-1306","observed_orcids":["https://orcid.org/0000-0002-4067-1306"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand R. Nair","raw_affiliation_strings":["Univ of Iowa, Iowa City, IA","Anand R. Nair"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Anand R. Nair","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029551526","display_name":"Xuebo Liu","orcid":"https://orcid.org/0000-0001-6370-2868","observed_orcids":["https://orcid.org/0000-0001-6370-2868"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xuebo Liu","raw_affiliation_strings":["Univ of Iowa, Iowa City, IA","Xuebo Liu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Xuebo Liu","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113951844","display_name":"Ko\u2010Ting Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ko-Ting Lu","raw_affiliation_strings":["Med College of Wisconsin, Wauwatosa, WI","Ko-Ting Lu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med College of Wisconsin, Wauwatosa, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Ko-Ting Lu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103981936","display_name":"Debbie Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debbie R. Davis","raw_affiliation_strings":["Univ of Iowa, Iowa City, IA","Debbie R. Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Debbie R. Davis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085327021","display_name":"Frederick W. Quelle","orcid":"https://orcid.org/0000-0002-1184-6170","observed_orcids":["https://orcid.org/0000-0002-1184-6170"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick W. Quelle","raw_affiliation_strings":["Univ of Iowa, Iowa City, IA","Frederick W. Quelle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Frederick W. Quelle","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022804707","display_name":"Curt D. Sigmund","orcid":"https://orcid.org/0000-0002-1453-0921","observed_orcids":["https://orcid.org/0000-0002-1453-0921"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt D. Sigmund","raw_affiliation_strings":["Med College of Wisconsin, Wauwatosa, WI","Curt D. Sigmund"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med College of Wisconsin, Wauwatosa, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Curt D. Sigmund","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.1543000042438507,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.8650000095367432},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8560000061988831},{"id":"https://openalex.org/keywords/phosphodiesterase-type-5","display_name":"phosphodiesterase 5","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cul3","display_name":"CUL3","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.777999997138977},{"id":"https://openalex.org/keywords/mln4924","display_name":"MLN4924","score":0.7990000247955322},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.5690000057220459},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.6320000290870667},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.6940000057220459},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6673617362976074},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6103799939155579},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6003934144973755},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5948123931884766},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4959164559841156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4617154598236084},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4394088089466095},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4309018850326538},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.41676953434944153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4048757553100586},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3217787742614746},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2085602581501007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1351132094860077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.74.suppl_1.120","doi":"https://doi.org/10.1161/hyp.74.suppl_1.120","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.74.suppl_1.120","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3017122714","https://openalex.org/W3084126325","https://openalex.org/W3175818788","https://openalex.org/W2904776045","https://openalex.org/W2922968728","https://openalex.org/W3173042066","https://openalex.org/W4300598900","https://openalex.org/W3196526543","https://openalex.org/W4389023271","https://openalex.org/W4225413334"],"abstract_inverted_index":{"Rho-related":[0],"BTB":[1],"domain":[2],"containing":[3],"protein":[4],"1":[5],"(RhoBTB1)":[6],"is":[7],"an":[8],"atypical":[9],"GTPase":[10],"associated":[11],"with":[12,168,180,268],"human":[13],"hypertension.":[14,75],"RhoBTB1":[15,40,63,78,98,141,163,173,178,195,257,269,279],"was":[16,91,99,115,126,237,280],"decreased":[17,238],"in":[18,30,69,81,94,106,120,138,155,221,239,293],"aorta":[19,222],"from":[20,88],"mice":[21,167,244],"expressing":[22],"a":[23,144,291],"hypertension":[24],"(HT)-causing":[25],"PPAR\u03b3":[26],"mutation":[27,154],"(P467L)":[28],"specifically":[29],"vascular":[31,189],"smooth":[32],"muscle":[33],"(VSM,":[34],"S-P467L":[35],"mice).":[36],"Restoration":[37],"of":[38,62,177,193,199,277],"VSM":[39,169,278],"improved":[41],"vasodilation,":[42],"reversed":[43],"arterial":[44,228,295],"stiffness":[45,229],"and":[46,64,77,84,133,188,210,218,223,263],"HT":[47,187,209,288],"by":[48,128,232],"suppressing":[49],"phosphodiesterase":[50],"5":[51],"(PDE5)":[52],"activity.":[53],"Here":[54],"we":[55],"sought":[56],"to":[57,102,212,216,242,283],"reveal":[58],"the":[59,194],"molecular":[60],"function":[61],"study":[65],"its":[66],"protective":[67],"role":[68],"Angiotensin":[70],"II":[71,158,185,201,208,247,273,286],"(Ang":[72],"II)":[73],"induced":[74,186],"PDE5":[76,104,118,124,136,265],"reciprocally":[79],"co-immunoprecipitated":[80],"HEK293":[82,89,121],"cells;":[83],"notably,":[85],"endogenous":[86],"Cullin3":[87],"cells":[90],"also":[92,160],"present":[93],"RhoBTB1/PDE5":[95],"immunoprecipitant.":[96],"Whereas,":[97],"not":[100,204,281],"sufficient":[101,282],"inhibit":[103],"activity":[105,137],"vitro":[107],"(1.9\u00b10.2":[108],"vs":[109,250],"1.7":[110],"\u00b10.2":[111],"nmol/min/mg,":[112],"n=3),":[113],"it":[114],"required":[116],"for":[117,147],"ubiquitination":[119,125],"cells.":[122],"RhoBTB1-mediated":[123],"blunted":[127],"pan-Cullin":[129],"inhibitor":[130],"MLN4924":[131,134],"treatment,":[132],"increased":[135],"aorta.":[139],"Thus,":[140],"serves":[142,258],"as":[143,230,259],"substrate":[145,261],"adaptor":[146,262],"Cullin3-Ring":[148],"ubiquitin":[149],"ligase":[150],"(CRL3)":[151],"complex.":[152],"Like":[153],"PPAR\u03b3,":[156],"Ang":[157,184,200,207,246,272,285],"infusion":[159,202,248],"reduced":[161],"aortic":[162,233],"expression.":[164,175],"We":[165],"generated":[166],"specific,":[170],"tamoxifen":[171,181],"inducible":[172],"(S-RhoBTB1)":[174],"Activation":[176],"expression":[179],"partially":[182,270],"prevented":[183],"dysfunction.":[190],"However,":[191],"activation":[192],"transgene":[196],"after":[197],"2-week":[198],"did":[203],"reverse":[205,213,284],"established":[206],"failed":[211],"impaired":[214],"vasodilation":[215],"acetylcholine":[217],"sodium":[219],"nitroprusside":[220],"carotid":[224],"artery.":[225],"Remarkably":[226],"however,":[227],"measured":[231],"Pulse":[234],"Wave":[235],"Velocity":[236],"S-RhoBTB1":[240],"compared":[241],"non-transgenic":[243],"receiving":[245],"(4.6\u00b10.4":[249],"3.2\u00b10.3":[251],"mm/ms,":[252],"p<0.05,":[253],"n=5-7).":[254],"In":[255],"conclusion,":[256],"CRL3":[260],"promotes":[264],"ubiquitination.":[266],"Pretreatment":[267],"prevents":[271],"HT,":[274],"while":[275],"restoration":[276],"mediated":[287],"but":[289],"showed":[290],"potential":[292],"reducing":[294],"stiffness.":[296]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-09-12T00:00:00"}