{"id":"https://openalex.org/W2972020168","doi":"https://doi.org/10.1016/j.bmc.2019.115086","title":"Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure","display_name":"Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure","publication_year":2019,"publication_date":"2019-09-04","ids":{"openalex":"https://openalex.org/W2972020168","doi":"https://doi.org/10.1016/j.bmc.2019.115086","mag":"2972020168","pmid":"https://pubmed.ncbi.nlm.nih.gov/31515057"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2019.115086","doi":"https://doi.org/10.1016/j.bmc.2019.115086","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2019.115086","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086790197","display_name":"Stanislav Kalinin","orcid":"https://orcid.org/0000-0002-6421-1208","observed_orcids":["https://orcid.org/0000-0002-6421-1208"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Stanislav Kalinin","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010580528","display_name":"Annika Valtari","orcid":"https://orcid.org/0000-0002-9905-8709","observed_orcids":["https://orcid.org/0000-0002-9905-8709"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Annika Valtari","raw_affiliation_strings":["School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091424033","display_name":"Marika Ruponen","orcid":"https://orcid.org/0000-0002-1369-9565","observed_orcids":["https://orcid.org/0000-0002-1369-9565"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marika Ruponen","raw_affiliation_strings":["School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038861002","display_name":"Elisa Toropainen","orcid":"https://orcid.org/0000-0003-2109-3632","observed_orcids":["https://orcid.org/0000-0003-2109-3632"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Elisa Toropainen","raw_affiliation_strings":["School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072675383","display_name":"Alexander A Kovalenko","orcid":"https://orcid.org/0000-0002-4991-9515","observed_orcids":["https://orcid.org/0000-0002-4991-9515"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Kovalenko","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018378636","display_name":"Alessio Nocentini","orcid":"https://orcid.org/0000-0003-3342-702X","observed_orcids":["https://orcid.org/0000-0003-3342-702X"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Nocentini","raw_affiliation_strings":["Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066407233","display_name":"Maxim Gureev","orcid":"https://orcid.org/0000-0002-0385-922X","observed_orcids":["https://orcid.org/0000-0002-0385-922X"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim Gureev","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russian Federation","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068847009","display_name":"Dmitry Viktorovich Dar\u2019in","orcid":"https://orcid.org/0000-0002-0413-7413","observed_orcids":["https://orcid.org/0000-0002-0413-7413"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Dar'in","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065810893","display_name":"Arto O. Urtti","orcid":"https://orcid.org/0000-0001-6064-3102","observed_orcids":["https://orcid.org/0000-0001-6064-3102"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI","RU"],"is_corresponding":true,"raw_author_name":"Arto Urtti","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg 199034, Russian Federation; School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland; Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland","Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland","Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation; School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland; Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I172901346","https://openalex.org/I175532246"]},{"raw_affiliation_string":"Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]},{"raw_affiliation_string":"School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035013697","display_name":"Claudiu Trandafir Supuran","orcid":"https://orcid.org/0000-0003-4262-0323","observed_orcids":["https://orcid.org/0000-0003-4262-0323"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudiu T. Supuran","raw_affiliation_strings":["Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049458503","display_name":"Mikhail Krasavin","orcid":"https://orcid.org/0000-0002-0200-4772","observed_orcids":["https://orcid.org/0000-0002-0200-4772"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Mikhail Krasavin","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035013697","https://openalex.org/A5049458503","https://openalex.org/A5065810893"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I172901346","https://openalex.org/I175532246","https://openalex.org/I45084792"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.873,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6863114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"21","first_page":"115086","last_page":"115086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii-inhibitors","display_name":"carbonic anhydrase II inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/1-3-oxazoles","display_name":"1,3-oxazoles","score":0.8360000252723694},{"id":"https://openalex.org/keywords/benzenesulfonamide","display_name":"benzenesulfonamide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hydrophilic-drugs","display_name":"hydrophilic drugs","score":0.7419999837875366},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dorzolamide","display_name":"dorzolamide","score":0.8029999732971191},{"id":"https://openalex.org/keywords/corneal-permeability","display_name":"corneal permeability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/conjunctiva","display_name":"conjunctiva","score":0.5979999899864197},{"id":"https://openalex.org/keywords/sclera","display_name":"sclera","score":0.8769999742507935},{"id":"https://openalex.org/keywords/enzyme-selectivity","display_name":"enzyme selectivity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/eye-drops","display_name":"eye drops","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9280315637588501},{"id":"https://openalex.org/C2776727336","wikidata":"https://www.wikidata.org/wiki/Q415401","display_name":"Dorzolamide","level":4,"score":0.8807622194290161},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.7799500226974487},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.7012445330619812},{"id":"https://openalex.org/C2778327999","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Carboxamide","level":2,"score":0.6418675184249878},{"id":"https://openalex.org/C2777405951","wikidata":"https://www.wikidata.org/wiki/Q413690","display_name":"Acetazolamide","level":2,"score":0.5461084842681885},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.466553658246994},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.46496039628982544},{"id":"https://openalex.org/C2778076468","wikidata":"https://www.wikidata.org/wiki/Q414238","display_name":"Carbonic anhydrase inhibitor","level":4,"score":0.44580990076065063},{"id":"https://openalex.org/C2776836360","wikidata":"https://www.wikidata.org/wiki/Q2741084","display_name":"Rhodanine","level":2,"score":0.44364890456199646},{"id":"https://openalex.org/C2776769776","wikidata":"https://www.wikidata.org/wiki/Q900898","display_name":"Probenecid","level":2,"score":0.4223710894584656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4180677831172943},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.41777223348617554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.384100079536438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2969677448272705},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2842070758342743},{"id":"https://openalex.org/C2778073030","wikidata":"https://www.wikidata.org/wiki/Q413994","display_name":"Timolol","level":3,"score":0.283095121383667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21592110395431519},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bmc.2019.115086","doi":"https://doi.org/10.1016/j.bmc.2019.115086","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2019.115086","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:31515057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31515057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1262722","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/1262722","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321912","display_name":"Ministry of Education and Science of the Russian Federation","ror":"https://ror.org/00ghqgy32"},{"id":"https://openalex.org/F4320322515","display_name":"Saint Petersburg State University","ror":"https://ror.org/023znxa73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W793656391","https://openalex.org/W825937647","https://openalex.org/W1225376777","https://openalex.org/W1231951729","https://openalex.org/W1573899446","https://openalex.org/W1941251942","https://openalex.org/W1973990425","https://openalex.org/W1975579638","https://openalex.org/W1975818527","https://openalex.org/W2001033822","https://openalex.org/W2004165733","https://openalex.org/W2011950726","https://openalex.org/W2019800569","https://openalex.org/W2023903257","https://openalex.org/W2031168104","https://openalex.org/W2035483433","https://openalex.org/W2040219113","https://openalex.org/W2049312911","https://openalex.org/W2054162695","https://openalex.org/W2055064998","https://openalex.org/W2065784836","https://openalex.org/W2092891745","https://openalex.org/W2094102770","https://openalex.org/W2094382267","https://openalex.org/W2118262335","https://openalex.org/W2130479394","https://openalex.org/W2409016771","https://openalex.org/W2485864578","https://openalex.org/W2567416294","https://openalex.org/W2611479822","https://openalex.org/W2735939980","https://openalex.org/W2784537797","https://openalex.org/W2891940234","https://openalex.org/W2917545014","https://openalex.org/W3133623653","https://openalex.org/W4206485229","https://openalex.org/W4211156112"],"related_works":["https://openalex.org/W6958427669","https://openalex.org/W2001216966","https://openalex.org/W1987053794","https://openalex.org/W3004699774","https://openalex.org/W2735939980","https://openalex.org/W2033002582","https://openalex.org/W2034948004","https://openalex.org/W2209091908","https://openalex.org/W3184252488","https://openalex.org/W4416565567"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-09-12T00:00:00"}