{"id":"https://openalex.org/W2972018032","doi":"https://doi.org/10.1136/bmjresp-2019-000415","title":"Analysis of serious adverse events in a paediatric fast breathing pneumonia clinical trial in Malawi","display_name":"Analysis of serious adverse events in a paediatric fast breathing pneumonia clinical trial in Malawi","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2972018032","doi":"https://doi.org/10.1136/bmjresp-2019-000415","mag":"2972018032","pmid":"https://pubmed.ncbi.nlm.nih.gov/31548894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6733335"},"language":"en","primary_location":{"id":"doi:10.1136/bmjresp-2019-000415","doi":"https://doi.org/10.1136/bmjresp-2019-000415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjresp-2019-000415","pdf_url":"https://bmjopenrespres.bmj.com/content/bmjresp/6/1/e000415.full.pdf","source":{"id":"https://openalex.org/S2736820664","display_name":"BMJ Open Respiratory Research","issn_l":"2052-4439","issn":["2052-4439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopenrespres.bmj.com/content/bmjresp/6/1/e000415.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064678320","display_name":"Evangelyn Nkwopara","orcid":"https://orcid.org/0000-0002-1078-7375","observed_orcids":["https://orcid.org/0000-0002-1078-7375"]},"institutions":[{"id":"https://openalex.org/I1290748110","display_name":"Save the Children","ror":"https://ror.org/036jr6x18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290748110"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evangelyn Nkwopara","raw_affiliation_strings":["International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA"],"raw_orcid":"https://orcid.org/0000-0002-1078-7375","affiliations":[{"raw_affiliation_string":"International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA","institution_ids":["https://openalex.org/I1290748110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032082972","display_name":"Robert H. Schmicker","orcid":"https://orcid.org/0000-0001-7100-7910","observed_orcids":["https://orcid.org/0000-0001-7100-7910"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Schmicker","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047169151","display_name":"Tisungane Mvalo","orcid":"https://orcid.org/0000-0002-6775-7919","observed_orcids":["https://orcid.org/0000-0002-6775-7919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tisungane Mvalo","raw_affiliation_strings":["Department of Pediatrics, University of North Carolina Project, Lilongwe Medical Relief Fund Trust, Lilongwe, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of North Carolina Project, Lilongwe Medical Relief Fund Trust, Lilongwe, Malawi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029140923","display_name":"Melda Phiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melda Phiri","raw_affiliation_strings":["Department of Pediatrics, University of North Carolina Project, Lilongwe Medical Relief Fund Trust, Lilongwe, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of North Carolina Project, Lilongwe Medical Relief Fund Trust, Lilongwe, Malawi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002249741","display_name":"Ajib Phiri","orcid":"https://orcid.org/0000-0002-1615-0164","observed_orcids":["https://orcid.org/0000-0002-1615-0164"]},"institutions":[{"id":"https://openalex.org/I157591606","display_name":"University of Malawi","ror":"https://ror.org/04vtx5s55","country_code":"MW","type":"education","lineage":["https://openalex.org/I157591606"]}],"countries":["MW"],"is_corresponding":false,"raw_author_name":"Ajib Phiri","raw_affiliation_strings":["Department of Pediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi","institution_ids":["https://openalex.org/I157591606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015812295","display_name":"Mari T. Couasnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290748110","display_name":"Save the Children","ror":"https://ror.org/036jr6x18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290748110"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari Couasnon","raw_affiliation_strings":["International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA","institution_ids":["https://openalex.org/I1290748110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014703174","display_name":"Eric D. McCollum","orcid":"https://orcid.org/0000-0002-1872-5566","observed_orcids":["https://orcid.org/0000-0002-1872-5566"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. McCollum","raw_affiliation_strings":["Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0002-1872-5566","affiliations":[{"raw_affiliation_string":"Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003071158","display_name":"Amy Sarah Ginsburg","orcid":"https://orcid.org/0000-0002-2291-2276","observed_orcids":["https://orcid.org/0000-0002-2291-2276"]},"institutions":[{"id":"https://openalex.org/I1290748110","display_name":"Save the Children","ror":"https://ror.org/036jr6x18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290748110"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Sarah Ginsburg","raw_affiliation_strings":["International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA","institution_ids":["https://openalex.org/I1290748110"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064678320"],"corresponding_institution_ids":["https://openalex.org/I1290748110"],"apc_list":{"value":1700,"currency":"GBP","value_usd":2085},"apc_paid":{"value":2703,"currency":"EUR","value_usd":2915},"fwci":0.7613,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72154721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"e000415","last_page":"e000415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.7519999742507935},{"id":"https://openalex.org/keywords/amoxicillin","display_name":"amoxicillin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/childhood-pneumonia","display_name":"pediatric pneumonia","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hiv-negative-children","display_name":"HIV-negative children","score":0.7059999704360962},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5370000004768372},{"id":"https://openalex.org/keywords/gastroenteritis","display_name":"gastroenteritis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/recurrent-pneumonia","display_name":"recurrent pneumonia","score":0.6610000133514404},{"id":"https://openalex.org/keywords/malawi","display_name":"Malawi","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9425992965698242},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.846580445766449},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.6449613571166992},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6239908337593079},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6079728007316589},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47884225845336914},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4553433656692505},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44428080320358276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38068386912345886},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12027472257614136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008295","descriptor_name":"Malawi","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059246","descriptor_name":"Tachypnea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D059246","descriptor_name":"Tachypnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1136/bmjresp-2019-000415","doi":"https://doi.org/10.1136/bmjresp-2019-000415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjresp-2019-000415","pdf_url":"https://bmjopenrespres.bmj.com/content/bmjresp/6/1/e000415.full.pdf","source":{"id":"https://openalex.org/S2736820664","display_name":"BMJ Open Respiratory Research","issn_l":"2052-4439","issn":["2052-4439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6733335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6733335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Respir Res","raw_type":"Text"},{"id":"pmid:31548894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31548894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open respiratory research","raw_type":"Clinical Trial, Phase IV"},{"id":"pmh:oai:doaj.org/article:f100ab66102c4387b6ab7a5894480f2f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f100ab66102c4387b6ab7a5894480f2f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open Respiratory Research, Vol 6, Iss 1 (2019)","raw_type":"article"},{"id":"doi:10.60692/339wd-98s82","doi":"https://doi.org/10.60692/339wd-98s82","is_oa":true,"landing_page_url":"https://doi.org/10.60692/339wd-98s82","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/gvk53-mr452","doi":"https://doi.org/10.60692/gvk53-mr452","is_oa":true,"landing_page_url":"https://doi.org/10.60692/gvk53-mr452","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1136/bmjresp-2019-000415","doi":"https://doi.org/10.1136/bmjresp-2019-000415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjresp-2019-000415","pdf_url":"https://bmjopenrespres.bmj.com/content/bmjresp/6/1/e000415.full.pdf","source":{"id":"https://openalex.org/S2736820664","display_name":"BMJ Open Respiratory Research","issn_l":"2052-4439","issn":["2052-4439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6824964742","display_name":null,"funder_award_id":"OPP1105080","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G9000865266","display_name":"Multidisciplinary Training Program in Pediatric Pulmonary","funder_award_id":"T32HL072748","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2972018032.pdf","grobid_xml":"https://content.openalex.org/works/W2972018032.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2073569962","https://openalex.org/W2105597307","https://openalex.org/W2125881047","https://openalex.org/W2150069228","https://openalex.org/W2599585540","https://openalex.org/W2901440732"],"related_works":["https://openalex.org/W4214941793","https://openalex.org/W2901440732","https://openalex.org/W2321467555","https://openalex.org/W2236965982","https://openalex.org/W3030659786","https://openalex.org/W7097745079","https://openalex.org/W2112972128","https://openalex.org/W4308831809","https://openalex.org/W3193879002","https://openalex.org/W7212260977"],"abstract_inverted_index":{"Introduction:":[0],"Pneumonia":[1],"is":[2],"the":[3,41,162,174,211,216,236],"leading":[4],"infectious":[5],"killer":[6],"of":[7,35,51,56,69,127,152,159,167,213],"children.":[8],"We":[9],"conducted":[10],"a":[11,67,146,170],"double-blind,":[12],"randomised":[13,77],"controlled":[14],"non-inferiority":[15],"trial":[16,42],"comparing":[17],"placebo":[18,80,239],"to":[19,45,78,91,144,190],"amoxicillin":[20,82,175,237,242],"treatment":[21,128],"for":[22,64,83,88,121],"fast":[23,62,139,226],"breathing":[24,63,75,140,227],"pneumonia":[25,52,141,202,228],"in":[26,32,206,234],"HIV-negative":[27],"children":[28,60,137,219],"aged":[29],"2-59":[30],"months":[31],"Malawi.":[33],"Occurrence":[34],"serious":[36],"adverse":[37],"events":[38],"(SAEs)":[39],"during":[40,112],"were":[43,76,114,119,142,154,178,185,199],"examined":[44],"assess":[46],"disease":[47],"progression,":[48],"co-morbidities,":[49],"recurrence":[50],"and":[53,66,86,95,103,111,129,181,195,209,238,241],"side":[54],"effects":[55],"amoxicillin.":[57],"Methods:":[58],"Enrolled":[59],"with":[61,138,169],"age":[65,160],"history":[68],"cough":[70],"<14":[71],"days":[72,90],"or":[73,81,204],"difficult":[74],"either":[79,207],"3":[84],"days,":[85],"followed":[87],"14":[89],"track":[92],"clinical":[93,229],"characteristics":[94],"outcomes.":[96],"Medical":[97],"history,":[98],"physical":[99],"exam,":[100],"laboratory":[101],"results":[102],"any":[104],"chest":[105],"radiographs":[106],"collected":[107],"at":[108],"screening,":[109],"enrolment":[110],"hospitalisation":[113],"evaluated.":[115],"All":[116],"SAE":[117],"reports":[118],"reviewed":[120],"additional":[122],"information":[123],"regarding":[124],"hospitalisation,":[125],"course":[126],"outcome.":[130],"Results:":[131],"In":[132,173,224],"total,":[133],"102/1126":[134],"(9.0%)":[135],"enrolled":[136],"reported":[143],"have":[145],"SAE.":[147,172],"Seventy-five":[148],"per":[149],"cent":[150],"(n=77)":[151],"SAEs":[153,180,203,231],"pneumonia-related":[155,171],"(p<0.01).":[156],"Children<2":[157],"years":[158],"represented":[161],"greatest":[163],"proportion":[164],"(61/77,":[165],"79.2%)":[166],"those":[168],"group,":[176,208],"there":[177],"46":[179],"5":[182],"(10.9%)":[183],"cases":[184],"identified":[186],"as":[187],"possibly":[188],"related":[189],"study":[191],"drug":[192],"(4":[193],"gastroenteritis":[194],"1":[196],"fever).":[197],"There":[198],"no":[200],"life-threatening":[201],"deaths":[205],"by":[210],"time":[212],"exit":[214],"from":[215],"study,":[217],"all":[218],"recovered":[220],"without":[221],"sequelae.":[222],"Discussion:":[223],"this":[225],"trial,":[230],"occurred":[232],"infrequently":[233],"both":[235],"groups,":[240],"was":[243],"well":[244],"tolerated.":[245],"Trial":[246],"registration":[247],"number:":[248],"NCT02760420.":[249],"https://clinicaltrials.gov/ct2/show/NCT02760420?term=ginsburg&rank=9.":[250]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-12T00:00:00"}