{"id":"https://openalex.org/W2972002279","doi":"https://doi.org/10.1177/0967772019866954","title":"Carl and Gerty Cori: A collaboration that changed the face of biochemistry","display_name":"Carl and Gerty Cori: A collaboration that changed the face of biochemistry","publication_year":2019,"publication_date":"2019-09-02","ids":{"openalex":"https://openalex.org/W2972002279","doi":"https://doi.org/10.1177/0967772019866954","mag":"2972002279","pmid":"https://pubmed.ncbi.nlm.nih.gov/31475888"},"language":"en","primary_location":{"id":"doi:10.1177/0967772019866954","doi":"https://doi.org/10.1177/0967772019866954","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0967772019866954","pdf_url":null,"source":{"id":"https://openalex.org/S125323095","display_name":"Journal of Medical Biography","issn_l":"0967-7720","issn":["0967-7720","1758-1087"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-class-a","anvur-scientific","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Biography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ronald P Rubin","orcid":"https://orcid.org/0000-0003-4902-4516","observed_orcids":["https://orcid.org/0000-0003-4902-4516"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald P Rubin","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4902-4516","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":8.7876,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.97320554,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"29","issue":"3","first_page":"143","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13495","display_name":"Biographical and Historical Analysis","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12990","display_name":"Medical History and Innovations","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cori-cycle","display_name":"Cori cycle","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glycogen-metabolism","display_name":"glycogen metabolism","score":0.9409999847412109},{"id":"https://openalex.org/keywords/muscle-phosphorylase","display_name":"muscle phosphorylase","score":0.6520000100135803},{"id":"https://openalex.org/keywords/glucose-1-phosphate","display_name":"glucose-1-phosphate","score":0.7820000052452087},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7940000295639038},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6510000228881836},{"id":"https://openalex.org/keywords/liver-glycogen","display_name":"liver glycogen","score":0.48500001430511475},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.6150000095367432},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.45399999618530273},{"id":"https://openalex.org/keywords/enzymatic-phosphorylation","display_name":"enzyme phosphorylation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/women-in-science","display_name":"women in science","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C204779464","wikidata":"https://www.wikidata.org/wiki/Q412061","display_name":"Glycogen phosphorylase","level":3,"score":0.8311673402786255},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.7420283555984497},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5476294755935669},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.5243471264839172},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5075665712356567},{"id":"https://openalex.org/C78245214","wikidata":"https://www.wikidata.org/wiki/Q1532471","display_name":"Glycogen debranching enzyme","level":4,"score":0.4886379837989807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48598751425743103},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.41775691509246826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3886585831642151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3062710762023926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29595649242401123}],"mesh":[{"descriptor_ui":"D001317","descriptor_name":"Austria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018153","descriptor_name":"Czech Republic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0967772019866954","doi":"https://doi.org/10.1177/0967772019866954","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0967772019866954","pdf_url":null,"source":{"id":"https://openalex.org/S125323095","display_name":"Journal of Medical Biography","issn_l":"0967-7720","issn":["0967-7720","1758-1087"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-class-a","anvur-scientific","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Biography","raw_type":"journal-article"},{"id":"pmid:31475888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31475888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical biography","raw_type":"Biography"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W37138735","https://openalex.org/W112215338","https://openalex.org/W152365453","https://openalex.org/W987884066","https://openalex.org/W1018229225","https://openalex.org/W1548175159","https://openalex.org/W1792813549","https://openalex.org/W1988814893","https://openalex.org/W2081596883","https://openalex.org/W2111845517","https://openalex.org/W2147702476","https://openalex.org/W2276748530","https://openalex.org/W2319959066","https://openalex.org/W2419283777","https://openalex.org/W2422571981","https://openalex.org/W3120478861","https://openalex.org/W3139046397"],"related_works":["https://openalex.org/W1998933786","https://openalex.org/W2044842424","https://openalex.org/W4242062079","https://openalex.org/W4237608993","https://openalex.org/W4240978570","https://openalex.org/W2956805348","https://openalex.org/W154572281","https://openalex.org/W3011780241","https://openalex.org/W4214757988","https://openalex.org/W4382940415"],"abstract_inverted_index":{"Carl":[0],"Cori":[1,4,35,168],"and":[2,17,25,48,66,98,109,137],"Gerty":[3,167],"elucidated":[5],"basic":[6],"biochemical":[7],"mechanisms":[8],"involved":[9],"in":[10,46,54,70,83,114],"the":[11,34,37,71,80,90,107,132,159,163,170],"utilization":[12],"of":[13,106,126,147],"energy":[14,81],"by":[15,39],"muscle":[16,84,100],"liver,":[18],"first":[19,171],"at":[20,27,149],"Roswell":[21],"Park":[22],"Cancer":[23],"Institute":[24],"then":[26,50],"Washington":[28,150],"University.":[29],"In":[30,157],"1929,":[31],"they":[32,73,102],"formulated":[33],"cycle,":[36],"process":[38],"which":[40,152],"glycogen":[41,53,60,94],"is":[42,49],"converted":[43],"to":[44,52,122,174],"glucose":[45],"liver":[47],"reconverted":[51],"muscle.":[55],"They":[56,86],"later":[57,87],"found":[58],"that":[59,76,92],"breakdown":[61],"yielded":[62],"glucose-1-phosphate":[63],"(Cori":[64],"ester)":[65],"lactate,":[67],"key":[68],"intermediates":[69],"cycle;":[72],"also":[74,142],"established":[75],"lactic":[77],"acid":[78],"provided":[79],"employed":[82],"contraction.":[85],"discovered":[88],"phosphorylase,":[89,101],"enzyme":[91,108,138],"catalyzed":[93],"breakdown.":[95],"After":[96],"purifiying":[97],"crystallizing":[99],"identified":[103],"two":[104],"forms":[105],"defined":[110],"their":[111],"respective":[112],"roles":[113],"metabolic":[115],"regulation.":[116],"These":[117],"studies":[118],"emboldened":[119],"other":[120],"scientists":[121],"advance":[123],"our":[124],"knowledge":[125],"fundamental":[127],"regulatory":[128],"processes":[129],"such":[130],"as":[131],"adenylate":[133],"cyclase-cyclic":[134],"AMP":[135],"system":[136],"phosphorylation.":[139],"The":[140],"Coris":[141,160],"built":[143],"a":[144],"world-renowned":[145],"Department":[146],"Biochemistry":[148],"University,":[151],"included":[153],"seven":[154],"future":[155],"Nobelists.":[156],"1947,":[158],"were":[161],"awarded":[162],"Nobel":[164],"Prize,":[165],"with":[166],"being":[169],"American":[172],"woman":[173],"win":[175],"this":[176],"prestigious":[177],"honor.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-12T00:00:00"}