{"id":"https://openalex.org/W2971908118","doi":"https://doi.org/10.1158/0008-5472.can-18-4058","title":"Heparanase Accelerates Obesity-Associated Breast Cancer Progression","display_name":"Heparanase Accelerates Obesity-Associated Breast Cancer Progression","publication_year":2019,"publication_date":"2019-09-03","ids":{"openalex":"https://openalex.org/W2971908118","doi":"https://doi.org/10.1158/0008-5472.can-18-4058","mag":"2971908118","pmid":"https://pubmed.ncbi.nlm.nih.gov/31481501"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-18-4058","doi":"https://doi.org/10.1158/0008-5472.can-18-4058","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-4058","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2971908118"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070030129","display_name":"Esther Hermano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Esther Hermano","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rachel Goldberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rachel Goldberg","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024844809","display_name":"Ariel M. Rubinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ariel M. Rubinstein","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002724338","display_name":"Amir Sonnenblick","orcid":"https://orcid.org/0000-0003-1954-4633","observed_orcids":["https://orcid.org/0000-0003-1954-4633"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amir Sonnenblick","raw_affiliation_strings":["2Oncology Division, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Oncology Division, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070520238","display_name":"Bella Maly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Bella Maly","raw_affiliation_strings":["3Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065977744","display_name":"Daniela Nahmias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniela Nahmias","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101542837","display_name":"Jinping Li","orcid":"https://orcid.org/0000-0001-7706-0587","observed_orcids":["https://orcid.org/0000-0001-7706-0587"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jin-Ping Li","raw_affiliation_strings":["4Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037625247","display_name":"Marinka A.H. Bakker","orcid":"https://orcid.org/0000-0002-1947-8747","observed_orcids":["https://orcid.org/0000-0002-1947-8747"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marinka A.H. Bakker","raw_affiliation_strings":["5Nephrology Research Laboratory, Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1947-8747","affiliations":[{"raw_affiliation_string":"5Nephrology Research Laboratory, Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080020086","display_name":"Johan van der Vlag","orcid":"https://orcid.org/0000-0001-7843-5918","observed_orcids":["https://orcid.org/0000-0001-7843-5918"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan van der Vlag","raw_affiliation_strings":["5Nephrology Research Laboratory, Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7843-5918","affiliations":[{"raw_affiliation_string":"5Nephrology Research Laboratory, Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037824025","display_name":"Isra\u00ebl Vlodavsky","orcid":"https://orcid.org/0000-0001-9921-898X","observed_orcids":["https://orcid.org/0000-0001-9921-898X"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Israel Vlodavsky","raw_affiliation_strings":["6Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0001-9921-898X","affiliations":[{"raw_affiliation_string":"6Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075618091","display_name":"Tamar Peretz","orcid":"https://orcid.org/0000-0001-8016-4010","observed_orcids":["https://orcid.org/0000-0001-8016-4010"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tamar Peretz","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","7Hebrew University Medical School, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]},{"raw_affiliation_string":"7Hebrew University Medical School, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075683085","display_name":"Michael Elkin","orcid":"https://orcid.org/0000-0003-4257-2122","observed_orcids":["https://orcid.org/0000-0003-4257-2122"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Michael Elkin","raw_affiliation_strings":["1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","7Hebrew University Medical School, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]},{"raw_affiliation_string":"7Hebrew University Medical School, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5075683085"],"corresponding_institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"],"apc_list":null,"apc_paid":null,"fwci":1.6249,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.79931844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"79","issue":"20","first_page":"5342","last_page":"5354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparanase","display_name":"heparanase","score":1.0},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adipose-tissue-macrophages","display_name":"adipose tissue macrophages","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8849999904632568},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.7739999890327454},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.8050000071525574},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7440000176429749},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2777478136","wikidata":"https://www.wikidata.org/wiki/Q909646","display_name":"Heparanase","level":4,"score":0.9225606918334961},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6720511317253113},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.621949315071106},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5419053435325623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.533845067024231},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5202335119247437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5028099417686462},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.4863637089729309},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4830054044723511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47435033321380615},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46973973512649536},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.45526909828186035},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.41665154695510864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33454233407974243},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3097819685935974},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099175","descriptor_name":"Heparanase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-18-4058","doi":"https://doi.org/10.1158/0008-5472.can-18-4058","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-4058","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:31481501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31481501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/209955","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/209955","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/209955","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/209955","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 79, 5342 - 5354","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1287064546","display_name":null,"funder_award_id":"806/14, 1715/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G1361043626","display_name":null,"funder_award_id":"806/14","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G1716017170","display_name":null,"funder_award_id":"601/14","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G3175393918","display_name":null,"funder_award_id":"1715/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G4295984186","display_name":null,"funder_award_id":"666/16","funder_id":"https://openalex.org/F4320309420","funder_display_name":"Legacy Heritage Fund"},{"id":"https://openalex.org/G7630906897","display_name":null,"funder_award_id":"2572/16","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G978793790","display_name":null,"funder_award_id":"601/14, 2572/16","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320309420","display_name":"Legacy Heritage Fund","ror":"https://ror.org/0370d4798"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1605603917","https://openalex.org/W1908117589","https://openalex.org/W1963904011","https://openalex.org/W1965520866","https://openalex.org/W1973576115","https://openalex.org/W1976124684","https://openalex.org/W1986498550","https://openalex.org/W1997613697","https://openalex.org/W2001718789","https://openalex.org/W2005189391","https://openalex.org/W2018794044","https://openalex.org/W2025668535","https://openalex.org/W2044099124","https://openalex.org/W2044663587","https://openalex.org/W2049056185","https://openalex.org/W2054617985","https://openalex.org/W2055475863","https://openalex.org/W2063477340","https://openalex.org/W2070105244","https://openalex.org/W2074143255","https://openalex.org/W2079431196","https://openalex.org/W2082615072","https://openalex.org/W2087590639","https://openalex.org/W2094418078","https://openalex.org/W2099687396","https://openalex.org/W2099951919","https://openalex.org/W2101650103","https://openalex.org/W2129853779","https://openalex.org/W2137274603","https://openalex.org/W2140619213","https://openalex.org/W2145533373","https://openalex.org/W2145697808","https://openalex.org/W2146470188","https://openalex.org/W2147617210","https://openalex.org/W2151413880","https://openalex.org/W2152688545","https://openalex.org/W2156280702","https://openalex.org/W2158208709","https://openalex.org/W2159154148","https://openalex.org/W2160980758","https://openalex.org/W2165604976","https://openalex.org/W2276765336","https://openalex.org/W2508265039","https://openalex.org/W2539079898","https://openalex.org/W2551524950","https://openalex.org/W2556968169","https://openalex.org/W2582686270","https://openalex.org/W2586073949","https://openalex.org/W2598884823","https://openalex.org/W2611395550","https://openalex.org/W2621095654","https://openalex.org/W2754187761","https://openalex.org/W2763216026","https://openalex.org/W2767825527","https://openalex.org/W2899984019","https://openalex.org/W6636107082","https://openalex.org/W6650764659","https://openalex.org/W6671113689"],"related_works":["https://openalex.org/W4295592471","https://openalex.org/W2957558366","https://openalex.org/W4240107773","https://openalex.org/W4412060556","https://openalex.org/W2168730134","https://openalex.org/W1986498550","https://openalex.org/W3173929868","https://openalex.org/W1529996928","https://openalex.org/W2394655361","https://openalex.org/W4399848302"],"abstract_inverted_index":{"Abstract":[0],"Obese":[1],"women":[2],"have":[3],"higher":[4],"risk":[5],"of":[6,20,58,69,74,81,140,157,177,181,190,195,236,245,269],"bearing":[7],"breast":[8,111,170,196,229,250,262],"tumors":[9,210],"that":[10,93,99,127],"are":[11],"highly":[12],"aggressive":[13],"and":[14,27,52,84,132,135,193,217,228,252,261],"resistant":[15],"to":[16,30,71,149,204,225,258],"therapies.":[17],"Tumor-promoting":[18],"effects":[19,73],"obesity":[21,75,227,260],"occur":[22],"locally":[23],"via":[24,39],"adipose":[25,131,146],"inflammation":[26],"related":[28],"alterations":[29],"the":[31,67,79,95,137,243],"extracellular":[32],"matrix":[33],"(ECM)":[34],"as":[35,37],"well":[36,77],"systemically":[38],"circulating":[40],"metabolic":[41],"mediators":[42,152],"(e.g.,":[43],"free":[44],"fatty":[45],"acids,":[46],"FFA)":[47],"associated":[48],"with":[49],"excess":[50],"adiposity":[51],"implicated":[53],"in":[54,62,103,108,119,130,162,168,188,209,231,247,264],"toll-like":[55],"receptor-mediated":[56],"activation":[57,189],"macrophages\u2014key":[59],"cellular":[60],"players":[61],"obesity-related":[63],"cancer":[64,230,251,263],"progression.":[65],"Although":[66],"contribution":[68],"macrophages":[70,148],"proneoplastic":[72],"is":[76,88,105],"documented,":[78],"role":[80,244],"ECM":[82],"components":[83],"their":[85],"enzymatic":[86],"degradation":[87],"less":[89],"appreciated.":[90],"We":[91],"show":[92],"heparanase,":[94],"sole":[96],"mammalian":[97],"endoglucuronidase":[98],"cleaves":[100],"heparan":[101],"sulfate":[102],"ECM,":[104],"preferentially":[106],"expressed":[107],"clinical/experimental":[109],"obesity-associated":[110,249],"tumors.":[112,171],"Heparanase":[113,121,142],"deficiency":[114],"abolished":[115],"obesity-accelerated":[116],"tumor":[117,133,197],"progression":[118],"vivo.":[120],"orchestrated":[122],"a":[123,159,218,232,254,265],"complex":[124],"molecular":[125],"program":[126],"occurred":[128],"concurrently":[129],"tissue":[134,147],"sustained":[136],"cancer-promoting":[138],"action":[139],"obesity.":[141],"was":[143],"required":[144],"for":[145,154,206,221],"produce":[150],"inflammatory":[151],"responsible":[153],"local":[155],"induction":[156],"aromatase,":[158],"rate-limiting":[160],"enzyme":[161],"estrogen":[163],"biosynthesis.":[164],"Estrogen":[165],"upregulated":[166],"heparanase":[167,178,207,246],"hormone-responsive":[169],"In":[172],"subsequent":[173],"stages,":[174],"elevated":[175],"levels":[176],"induced":[179],"acquisition":[180],"procancerous":[182],"phenotype":[183],"by":[184],"tumor-associated":[185],"macrophages,":[186],"resulting":[187],"tumor-promoting":[191],"signaling":[192],"acceleration":[194],"growth":[198],"under":[199],"obese":[200,237,270],"conditions.":[201],"As":[202],"techniques":[203],"screen":[205],"expression":[208],"become":[211],"available,":[212],"these":[213],"findings":[214],"provide":[215],"rational":[216],"mechanistic":[219],"basis":[220],"designing":[222],"antiheparanase":[223],"approaches":[224],"uncouple":[226,259],"rapidly":[233,266],"growing":[234,267],"population":[235,268],"patients.":[238,271],"Significance:":[239],"This":[240],"study":[241],"reveals":[242],"promoting":[248],"provides":[253],"mechanistically":[255],"informed":[256],"approach":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-09-12T00:00:00"}