{"id":"https://openalex.org/W2971700331","doi":"https://doi.org/10.1371/journal.pone.0221159","title":"Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection","display_name":"Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection","publication_year":2019,"publication_date":"2019-09-06","ids":{"openalex":"https://openalex.org/W2971700331","doi":"https://doi.org/10.1371/journal.pone.0221159","mag":"2971700331","pmid":"https://pubmed.ncbi.nlm.nih.gov/31490965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6730907"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0221159","doi":"https://doi.org/10.1371/journal.pone.0221159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0221159","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0221159&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0221159&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008619492","display_name":"Jeffy George","orcid":"https://orcid.org/0000-0003-1144-9244","observed_orcids":["https://orcid.org/0000-0003-1144-9244"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffy George","raw_affiliation_strings":["F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan C. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan C. Johnson","raw_affiliation_strings":["F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067302232","display_name":"Mary Joseph Mattapallil","orcid":"https://orcid.org/0000-0003-0615-7343","observed_orcids":["https://orcid.org/0000-0003-0615-7343"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Mattapallil","raw_affiliation_strings":["National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046668675","display_name":"Lynnsey A. Renn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynnsey Renn","raw_affiliation_strings":["Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029312666","display_name":"Ronald L. Rabin","orcid":"https://orcid.org/0000-0003-3496-0504","observed_orcids":["https://orcid.org/0000-0003-3496-0504"]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Rabin","raw_affiliation_strings":["Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078961974","display_name":"Douglas Scott Merrell","orcid":"https://orcid.org/0000-0001-7095-5177","observed_orcids":["https://orcid.org/0000-0001-7095-5177","https://orcid.org/0000-0002-2114-2951"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Scott Merrell","raw_affiliation_strings":["F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078755301","display_name":"Joseph J. Mattapallil","orcid":"https://orcid.org/0000-0002-7412-9507","observed_orcids":["https://orcid.org/0000-0002-7412-9507"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph J. Mattapallil","raw_affiliation_strings":["F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7412-9507","affiliations":[{"raw_affiliation_string":"F. Edward H\u00e9bert School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078755301"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":0.6997,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66077552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"9","first_page":"e0221159","last_page":"e0221159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.828000009059906},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8700000047683716},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8889999985694885},{"id":"https://openalex.org/keywords/central-memory-cd4-t-cells","display_name":"central memory CD4+ T cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7099999785423279},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/early-infection","display_name":"early infection","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mcp-1-ccl2","display_name":"CCL2/MCP-1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7480000257492065},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interferon-omega","display_name":"interferon omega","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.7607160806655884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7054018974304199},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.6966540813446045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6684593558311462},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5027673244476318},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.49626976251602173},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.474385529756546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46422454714775085},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4562358856201172},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.4476821720600128},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4235781729221344},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4123651385307312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.401515930891037},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39466017484664917},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.28685471415519714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1478608250617981},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054371","descriptor_name":"Chemokine CXCL11","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0221159","doi":"https://doi.org/10.1371/journal.pone.0221159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0221159","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0221159&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5703914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6730907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6730907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6730907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:31490965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31490965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b9dd614f8e2c4502846b7fc5898f9921","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9dd614f8e2c4502846b7fc5898f9921","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 9, p e0221159 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/9781388","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Gender_differences_in_innate_responses_and_gene_expression_profiles_in_memory_CD4_T_cells_are_apparent_very_early_during_acute_simian_immunodeficiency_virus_infection/9781388","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0221159","doi":"https://doi.org/10.1371/journal.pone.0221159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0221159","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0221159&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8948818222","display_name":null,"funder_award_id":"R0731976","funder_id":"https://openalex.org/F4320332504","funder_display_name":"Uniformed Services University of the Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332504","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971700331.pdf","grobid_xml":"https://content.openalex.org/works/W2971700331.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W150683224","https://openalex.org/W1522340644","https://openalex.org/W1547507373","https://openalex.org/W1547840497","https://openalex.org/W1605087789","https://openalex.org/W1725506219","https://openalex.org/W1828298093","https://openalex.org/W1888844556","https://openalex.org/W1953974801","https://openalex.org/W1964967659","https://openalex.org/W1970657570","https://openalex.org/W1971587568","https://openalex.org/W1974730522","https://openalex.org/W1976256751","https://openalex.org/W1977485148","https://openalex.org/W1977665434","https://openalex.org/W1978383659","https://openalex.org/W1981459523","https://openalex.org/W1984999783","https://openalex.org/W1988785144","https://openalex.org/W1995343199","https://openalex.org/W1999396723","https://openalex.org/W2001137507","https://openalex.org/W2002915050","https://openalex.org/W2004948071","https://openalex.org/W2005503720","https://openalex.org/W2008994596","https://openalex.org/W2010480763","https://openalex.org/W2014536097","https://openalex.org/W2021530971","https://openalex.org/W2027798298","https://openalex.org/W2028165104","https://openalex.org/W2029174607","https://openalex.org/W2030514786","https://openalex.org/W2037427174","https://openalex.org/W2050017294","https://openalex.org/W2051836910","https://openalex.org/W2061480204","https://openalex.org/W2063905670","https://openalex.org/W2076092191","https://openalex.org/W2077741244","https://openalex.org/W2081209458","https://openalex.org/W2082474786","https://openalex.org/W2082510200","https://openalex.org/W2084533546","https://openalex.org/W2085069678","https://openalex.org/W2095709591","https://openalex.org/W2095968013","https://openalex.org/W2109018840","https://openalex.org/W2109196769","https://openalex.org/W2111866704","https://openalex.org/W2117403896","https://openalex.org/W2124566937","https://openalex.org/W2124775637","https://openalex.org/W2133115875","https://openalex.org/W2134943078","https://openalex.org/W2139537135","https://openalex.org/W2139660948","https://openalex.org/W2142503382","https://openalex.org/W2144645089","https://openalex.org/W2149492547","https://openalex.org/W2150240056","https://openalex.org/W2154296640","https://openalex.org/W2157526967","https://openalex.org/W2159402147","https://openalex.org/W2163038685","https://openalex.org/W2163409650","https://openalex.org/W2171088586","https://openalex.org/W2173859862","https://openalex.org/W2287101173","https://openalex.org/W2339763143","https://openalex.org/W2400206822","https://openalex.org/W2414709197","https://openalex.org/W2520091797","https://openalex.org/W2528082263","https://openalex.org/W2559341989","https://openalex.org/W2752337702","https://openalex.org/W2770628918","https://openalex.org/W2789758412","https://openalex.org/W2791671465","https://openalex.org/W2890736750","https://openalex.org/W2906587554","https://openalex.org/W2946749496"],"related_works":["https://openalex.org/W2305416250","https://openalex.org/W7171495011","https://openalex.org/W4406628281","https://openalex.org/W7095774090","https://openalex.org/W2108685671","https://openalex.org/W7098516994","https://openalex.org/W1899095331","https://openalex.org/W2130643797","https://openalex.org/W2061480204","https://openalex.org/W2156539335"],"abstract_inverted_index":{"Gender":[0],"differences":[1,29,180],"in":[2,45,100,110,148,181],"Human":[3],"immunodeficiency":[4,18],"virus":[5,19],"(HIV)":[6],"disease":[7],"progression":[8],"and":[9,90,120,132,143],"comorbidities":[10],"have":[11],"been":[12],"extensively":[13],"reported.":[14],"Using":[15],"the":[16,35,46,135,149,168,188],"simian":[17],"(SIV)":[20],"infected":[21],"rhesus":[22],"macaque":[23],"model,":[24],"we":[25],"show":[26],"that":[27,93,167],"these":[28],"are":[30],"apparent":[31],"very":[32,185],"early":[33,186],"during":[34,172,187],"course":[36,189],"of":[37,48,72,87,113,125,138,152,190],"infection.":[38,192],"Though":[39,122],"there":[40],"were":[41,63,104,145],"no":[42],"major":[43],"changes":[44],"proportions":[47],"CD4":[49,57],"T":[50,58],"cells":[51,59],"or":[52],"its":[53],"subsets,":[54],"central":[55],"memory":[56],"from":[60],"female":[61,133,153],"macaques":[62,154],"found":[64],"to":[65,81,161],"differentially":[66],"regulate":[67],"a":[68,107],"significantly":[69,146],"larger":[70],"number":[71],"genes":[73],"at":[74,95,155],"day":[75,96,156],"4":[76],"post-infection":[77],"(PI)":[78],"as":[79,117,159],"compared":[80,160],"males.":[82],"Pathway":[83],"analysis":[84],"revealed":[85],"divergence":[86],"both":[88],"canonical":[89],"biological":[91],"pathways":[92],"persisted":[94],"10":[97,157],"PI.":[98],"Changes":[99],"gene":[101],"expression":[102,136],"profiles":[103],"accompanied":[105],"by":[106,178],"significant":[108],"increase":[109],"plasma":[111,123],"levels":[112,124,137],"pro-inflammatory":[114],"mediators":[115],"such":[116],"MCP-1/CCL2,":[118],"I-TAC/CXCL11,":[119],"MIF.":[121],"IFN\u03b1":[126,139],"did":[127],"not":[128],"differ":[129],"between":[130],"male":[131,162],"macaques,":[134],"subtype-14,":[140],"16,":[141],"IFN\u03b2,":[142],"IFN\u03c9":[144],"upregulated":[147],"lymph":[150],"nodes":[151],"PI":[158],"macaques.":[163],"Our":[164],"results":[165],"suggest":[166],"pathogenic":[169],"sequelae":[170],"seen":[171],"chronic":[173],"infection":[174],"may":[175],"be":[176],"shaped":[177],"gender":[179],"immune":[182],"responses":[183],"induced":[184],"HIV":[191]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-12T00:00:00"}