{"id":"https://openalex.org/W2971663629","doi":null,"title":"Estudo da metila\u00e7\u00e3o em genes de reparo, muta\u00e7\u00e3o no gene BRAF e instabilidade de microssat\u00e9lites em indiv\u00edduos com C\u00e2ncer Colorretal","display_name":"Estudo da metila\u00e7\u00e3o em genes de reparo, muta\u00e7\u00e3o no gene BRAF e instabilidade de microssat\u00e9lites em indiv\u00edduos com C\u00e2ncer Colorretal","publication_year":2011,"publication_date":"2011-04-20","ids":{"openalex":"https://openalex.org/W2971663629","mag":"2971663629"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:2129578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/BUOS-8L7L8Z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1843/BUOS-8L7L8Z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077686787","display_name":"Carla Gomes Rasuck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carla Gomes Rasuck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077686787"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mismatch-repair-genes","display_name":"mismatch repair genes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mlh1","display_name":"MLH1","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pms2","display_name":"PMS2","score":1.0},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9490000009536743},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.8299999833106995},{"id":"https://openalex.org/keywords/replication-errors","display_name":"replication errors","score":0.5799999833106995},{"id":"https://openalex.org/keywords/metachronous-tumors","display_name":"metachronous tumors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/synchronous-tumors","display_name":"synchronous tumors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.49900001287460327},{"id":"https://openalex.org/keywords/family-history-of-cancer","display_name":"family history of cancer","score":0.753000020980835},{"id":"https://openalex.org/keywords/clustering","display_name":"clustering","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6153556108474731},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4370729923248291},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41152840852737427},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3830675482749939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24670913815498352},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16586288809776306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11961182951927185}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:2129578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/BUOS-8L7L8Z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.ufmg.br:1843/BUOS-8L7L8Z","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/BUOS-8L7L8Z","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2971663629","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ufmg.br/bitstream/1843/BUOS-8L7L8Z/1/carla_gomes.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2129578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/BUOS-8L7L8Z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W159734241","https://openalex.org/W597770356","https://openalex.org/W603890602","https://openalex.org/W1481966721","https://openalex.org/W1525985826","https://openalex.org/W1548263718","https://openalex.org/W1939927669","https://openalex.org/W1965301144","https://openalex.org/W1965337318","https://openalex.org/W1965539552","https://openalex.org/W1974439810","https://openalex.org/W1980644634","https://openalex.org/W1981112371","https://openalex.org/W1984192249","https://openalex.org/W1986937402","https://openalex.org/W1987745928","https://openalex.org/W1990233053","https://openalex.org/W1992275069","https://openalex.org/W1992707318","https://openalex.org/W1995819860","https://openalex.org/W2001258296","https://openalex.org/W2003930098","https://openalex.org/W2006412460","https://openalex.org/W2007420407","https://openalex.org/W2013521944","https://openalex.org/W2015536894","https://openalex.org/W2015954973","https://openalex.org/W2015975359","https://openalex.org/W2018663911","https://openalex.org/W2019411198","https://openalex.org/W2023060964","https://openalex.org/W2028121819","https://openalex.org/W2029904263","https://openalex.org/W2032118018","https://openalex.org/W2038332913","https://openalex.org/W2044094123","https://openalex.org/W2048498173","https://openalex.org/W2049282019","https://openalex.org/W2049910278","https://openalex.org/W2056669611","https://openalex.org/W2060391238","https://openalex.org/W2064854706","https://openalex.org/W2065059240","https://openalex.org/W2069312685","https://openalex.org/W2069382191","https://openalex.org/W2076577775","https://openalex.org/W2084657385","https://openalex.org/W2089795878","https://openalex.org/W2094175630","https://openalex.org/W2094281750","https://openalex.org/W2094774960","https://openalex.org/W2095091186","https://openalex.org/W2096371251","https://openalex.org/W2097257602","https://openalex.org/W2098545729","https://openalex.org/W2099648715","https://openalex.org/W2101192995","https://openalex.org/W2102870771","https://openalex.org/W2107539126","https://openalex.org/W2109302214","https://openalex.org/W2112327912","https://openalex.org/W2114545185","https://openalex.org/W2116581671","https://openalex.org/W2121128389","https://openalex.org/W2121641866","https://openalex.org/W2123617415","https://openalex.org/W2128793721","https://openalex.org/W2131348295","https://openalex.org/W2137380291","https://openalex.org/W2138248068","https://openalex.org/W2146061274","https://openalex.org/W2148798004","https://openalex.org/W2150793022","https://openalex.org/W2157636873","https://openalex.org/W2162886392","https://openalex.org/W2163188200","https://openalex.org/W2164617114","https://openalex.org/W2169171389","https://openalex.org/W2473830642"],"related_works":["https://openalex.org/W2097338311","https://openalex.org/W4283220989","https://openalex.org/W2047775504","https://openalex.org/W2079530127","https://openalex.org/W7036218748","https://openalex.org/W2101987123","https://openalex.org/W2129184772","https://openalex.org/W3199437890","https://openalex.org/W4402854500","https://openalex.org/W2913401020"],"abstract_inverted_index":{"Colorectal":[0],"Cancer":[1],"(CRC)":[2],"corresponds":[3],"to":[4,52,64,141,246],"the":[5,23,61,125,134,138],"third":[6],"most":[7,24],"prevalent":[8],"type":[9],"of":[10,27,32,36,42,60,131,150,155,178,202,207,232,236],"cancer.":[11],"Its":[12],"origins":[13],"can":[14],"either":[15],"be":[16,53,242],"sporadic":[17],"or":[18,165,184,228],"inherited,":[19],"being":[20],"Lynch":[21],"Syndrome":[22],"common":[25],"form":[26],"hereditary":[28],"CRC.":[29],"The":[30,58,93,120,145,168,219],"activation":[31],"BRAF":[33],"oncogene,":[34],"inactivation":[35],"mismatch":[37],"repair":[38],"genes":[39,240],"by":[40],"methylation":[41,110,132,213,235],"CpG":[43],"islands,":[44],"and":[45,70,75,80,83,111,117,133,163,181,187,209,234,238],"microsatellite":[46,101,161,188],"instability":[47],"(MSI)":[48],"have":[49],"been":[50],"reported":[51],"involved":[54],"in":[55,88,100,170,216,244],"CRC":[56,66],"development.":[57],"goal":[59],"study":[62],"was":[63,123,148,193],"characterize":[65],"tumors":[67,210],"using":[68],"clinical":[69,227,249],"molecular":[71,84,229],"criteria":[72],"through":[73],"association":[74,104,113,225],"cluster":[76,146,171,217],"analysis.":[77],"Amsterdam":[78],"II":[79],"Bethesda":[81],"guidelines":[82],"variables":[85],"were":[86,136,173,214],"analyzed":[87],"77":[89],"patients":[90],"from":[91],"Brazil.":[92],"positive":[94],"replication":[95],"error":[96],"(RER)":[97],"status,":[98],"based":[99],"instability,":[102,162],"showed":[103,182],"with":[105,114,204,226,248],"metachronous":[106,164],"tumor,":[107,159],"MLH1":[108,237],"gene":[109,122],"inverse":[112],"left":[115],"sided":[116],"synchronous":[118,166],"tumors.":[119,167],"PMS2":[121,239],"considered":[124,137,243],"best":[126,139],"predictor":[127],"for":[128],"differentiating":[129],"levels":[130],"mononucleotide":[135],"markers":[140],"evaluate":[142],"RER":[143],"status.":[144],"1":[147],"characterized":[149],"individuals":[151,169,203],"over":[152],"60":[153],"years":[154,177],"age,":[156,179],"female,":[157],"right-sided":[158],"high":[160],"2":[172],"younger":[174],"than":[175],"45":[176],"male":[180],"left-sided":[183],"rectum":[185],"tumors,":[186],"stability.":[189],"Even":[190],"though":[191],"it":[192],"not":[194,223],"observed":[195],"a":[196,199],"significant":[197],"association,":[198],"higher":[200],"number":[201],"family":[205],"history":[206],"cancer":[208],"without":[211],"promoter":[212],"found":[215],"2.":[218],"V600E":[220],"mutation":[221],"did":[222],"show":[224],"characteristics.":[230],"Evaluation":[231],"MSI":[233],"should":[241],"order":[245],"assist":[247],"diagnosis.":[250]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-09-12T00:00:00"}