{"id":"https://openalex.org/W2971369959","doi":"https://doi.org/10.21037/cco.2019.08.15","title":"Immune subgroups and the tumor microenvironment as a potential new biomarker to assess response to immunotherapy","display_name":"Immune subgroups and the tumor microenvironment as a potential new biomarker to assess response to immunotherapy","publication_year":2019,"publication_date":"2019-09-09","ids":{"openalex":"https://openalex.org/W2971369959","doi":"https://doi.org/10.21037/cco.2019.08.15","mag":"2971369959","pmid":"https://pubmed.ncbi.nlm.nih.gov/31500434"},"language":"en","primary_location":{"id":"doi:10.21037/cco.2019.08.15","doi":"https://doi.org/10.21037/cco.2019.08.15","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2019.08.15","pdf_url":"https://cco.amegroups.com/article/viewFile/28769/25245","source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://cco.amegroups.com/article/viewFile/28769/25245","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112586390","display_name":"Shawn Kothari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Kothari","raw_affiliation_strings":["Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]},{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Biological Sciences Division, University of Chicago Medicine, Chicago, IL, USA; Department of Medicine, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA. evokes@medicine.bsd.uchicago.edu","Biological Sciences Division, University of Chicago Medicine, Chicago, IL, USA","Department of Medicine, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, University of Chicago Medicine, Chicago, IL, USA; Department of Medicine, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA. evokes@medicine.bsd.uchicago.edu","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4390039251"]},{"raw_affiliation_string":"Biological Sciences Division, University of Chicago Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"Department of Medicine, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4390039251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063904421"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865","https://openalex.org/I4390039251"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"S1","first_page":"S24","last_page":"S24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9919999837875366},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7580000162124634},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9160000085830688},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.9166103601455688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9073081016540527},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.8185652494430542},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6843456029891968},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5497680902481079},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.535431981086731},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5309897065162659},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5038077235221863},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4722019135951996},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.41346442699432373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.387708455324173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34422212839126587},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28129783272743225},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.27308663725852966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.21037/cco.2019.08.15","doi":"https://doi.org/10.21037/cco.2019.08.15","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2019.08.15","pdf_url":"https://cco.amegroups.com/article/viewFile/28769/25245","source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:31500434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31500434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese clinical oncology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.21037/cco.2019.08.15","doi":"https://doi.org/10.21037/cco.2019.08.15","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cco.2019.08.15","pdf_url":"https://cco.amegroups.com/article/viewFile/28769/25245","source":{"id":"https://openalex.org/S2764664221","display_name":"Chinese Clinical Oncology","issn_l":"2304-3865","issn":["2304-3865","2304-3873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971369959.pdf","grobid_xml":"https://content.openalex.org/works/W2971369959.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2529484692","https://openalex.org/W2899537750","https://openalex.org/W2947026438","https://openalex.org/W4253173218"],"related_works":["https://openalex.org/W3166211548","https://openalex.org/W2789573638","https://openalex.org/W3165501534","https://openalex.org/W3002787057","https://openalex.org/W2765922127","https://openalex.org/W4411103720","https://openalex.org/W7168121003","https://openalex.org/W2988556110","https://openalex.org/W4409910760","https://openalex.org/W3118688064"],"abstract_inverted_index":{"Immunotherapy":[0],"has":[1],"emerged":[2],"as":[3,34,46],"a":[4,35],"new":[5],"standard":[6],"of":[7,27,31],"care":[8],"therapeutic":[9],"option":[10],"for":[11,49],"patients":[12,50],"with":[13,41,51],"recurrent":[14],"or":[15,38,57],"metastatic":[16],"Head":[17],"and":[18],"Neck":[19],"Squamous":[20],"Cell":[21],"Carcinoma.":[22],"Following":[23],"the":[24,29],"recent":[25],"presentation":[26],"Keynote-048,":[28],"use":[30],"Pembrolizumab":[32],"either":[33],"single":[36],"agent":[37],"in":[39,54],"combination":[40],"chemotherapy":[42],"can":[43],"be":[44],"considered":[45],"first-line":[47],"treatment":[48],"measurable":[52],"PD-L1":[53],"their":[55],"tumor":[56],"microenvironment":[58],"(1).":[59]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-12T00:00:00"}