{"id":"https://openalex.org/W2971360170","doi":"https://doi.org/10.1002/hed.25910","title":"A pilot study of the pan\u2010class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancer","display_name":"A pilot study of the pan\u2010class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancer","publication_year":2019,"publication_date":"2019-09-04","ids":{"openalex":"https://openalex.org/W2971360170","doi":"https://doi.org/10.1002/hed.25910","mag":"2971360170","pmid":"https://pubmed.ncbi.nlm.nih.gov/31486207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258680"},"language":"en","primary_location":{"id":"doi:10.1002/hed.25910","doi":"https://doi.org/10.1002/hed.25910","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hed.25910","pdf_url":null,"source":{"id":"https://openalex.org/S4210201749","display_name":"Head & Neck","issn_l":"1043-3074","issn":["1043-3074","1097-0347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head & Neck","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020832184","display_name":"Ryan J. Brisson","orcid":"https://orcid.org/0000-0002-5691-267X","observed_orcids":["https://orcid.org/0000-0002-5691-267X"]},"institutions":[{"id":"https://openalex.org/I177721651","display_name":"Oakland University","ror":"https://ror.org/01ythxj32","country_code":"US","type":"education","lineage":["https://openalex.org/I177721651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Brisson","raw_affiliation_strings":["Oakland University William Beaumont School of Medicine, Rochester, Michigan"],"raw_orcid":"https://orcid.org/0000-0002-5691-267X","affiliations":[{"raw_affiliation_string":"Oakland University William Beaumont School of Medicine, Rochester, Michigan","institution_ids":["https://openalex.org/I177721651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048899616","display_name":"Sara E. Kochanny","orcid":"https://orcid.org/0000-0003-3755-1175","observed_orcids":["https://orcid.org/0000-0003-3755-1175"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Kochanny","raw_affiliation_strings":["Department of Medicine, The University of Chicago Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054739978","display_name":"Saba Arshad","orcid":"https://orcid.org/0000-0001-8097-4814","observed_orcids":["https://orcid.org/0000-0001-8097-4814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saba Arshad","raw_affiliation_strings":["Department of Medicine, Blake Medical Center, Bradenton, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Blake Medical Center, Bradenton, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037253945","display_name":"Allison Dekker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Dekker","raw_affiliation_strings":["Department of Medicine, The University of Chicago Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038392549","display_name":"Jonas A. DeSouza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96048030","display_name":"Humana (United States)","ror":"https://ror.org/04gxnqr83","country_code":"US","type":"company","lineage":["https://openalex.org/I96048030"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas A. DeSouza","raw_affiliation_strings":["Humana, Louisville, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humana, Louisville, Kentucky","institution_ids":["https://openalex.org/I96048030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013717696","display_name":"Vassiliki Saloura","orcid":"https://orcid.org/0000-0002-9736-8578","observed_orcids":["https://orcid.org/0000-0002-9736-8578"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vassiliki Saloura","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]},{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","The University of Chicago Comprehensive Cancer Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"The University of Chicago Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4390039251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008467612","display_name":"Tanguy Y. Seiwert","orcid":"https://orcid.org/0000-0001-7919-8272","observed_orcids":["https://orcid.org/0000-0001-7919-8272"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]},{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tanguy Y. Seiwert","raw_affiliation_strings":["Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","The University of Chicago Comprehensive Cancer Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"The University of Chicago Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4390039251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008467612"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865","https://openalex.org/I4390039251"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":2.4827,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88762136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"41","issue":"11","first_page":"3842","last_page":"3849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buparlisib","display_name":"buparlisib","score":1.0},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/recurrent-or-metastatic-head-and-neck-cancer","display_name":"recurrent or metastatic head and neck cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.890999972820282},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.4320000112056732},{"id":"https://openalex.org/keywords/egfr-inhibition","display_name":"EGFR inhibition","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9848811626434326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.876707911491394},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6460263729095459},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6161884069442749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5834267735481262},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5130568742752075},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45784395933151245},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.11139139533042908}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/hed.25910","doi":"https://doi.org/10.1002/hed.25910","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hed.25910","pdf_url":null,"source":{"id":"https://openalex.org/S4210201749","display_name":"Head & Neck","issn_l":"1043-3074","issn":["1043-3074","1097-0347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head & Neck","raw_type":"journal-article"},{"id":"pmid:31486207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31486207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head & neck","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:pubmedcentral.nih.gov:8258680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Head Neck","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8258680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Head Neck","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G9000861697","display_name":"The Role of Protein Methylation in Squamous Cell Carcinoma of the Head and Neck","funder_award_id":"ZIABC011831","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000893449","display_name":"IMRRT for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma","funder_award_id":"ZIABC011859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1977267072","https://openalex.org/W2014620054","https://openalex.org/W2071588497","https://openalex.org/W2091695507","https://openalex.org/W2102317912","https://openalex.org/W2112845420","https://openalex.org/W2116123484","https://openalex.org/W2136871952","https://openalex.org/W2145478177","https://openalex.org/W2149447281","https://openalex.org/W2165404212","https://openalex.org/W2238997491","https://openalex.org/W2401455386","https://openalex.org/W2529484692","https://openalex.org/W2582286477","https://openalex.org/W2735625431","https://openalex.org/W2775764871","https://openalex.org/W2781525129","https://openalex.org/W2890654504","https://openalex.org/W2907059169"],"related_works":["https://openalex.org/W2892335027","https://openalex.org/W3166697471","https://openalex.org/W2042288129","https://openalex.org/W2486369884","https://openalex.org/W3177225317","https://openalex.org/W3096757781","https://openalex.org/W7208772653","https://openalex.org/W2582286477","https://openalex.org/W4387930721","https://openalex.org/W2517319223"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"assessed":[3],"the":[4,10],"maximum":[5],"tolerated":[6],"dose":[7,50,64,105,110],"(MTD)":[8],"of":[9,51,67,72],"PI3K":[11],"inhibitor":[12],"buparlisib":[13,42,52,73,129],"given":[14,40,82],"concurrently":[15],"with":[16,33,80,99,143],"cetuximab":[17,81,135,144],"in":[18,55],"recurrent":[19],"and":[20,24,46,118],"metastatic":[21],"(R/M)":[22],"head":[23],"neck":[25],"squamous":[26],"cell":[27],"carcinoma":[28],"(HNSCC).":[29],"METHODS:":[30],"Twelve":[31],"patients":[32,92],"R/M":[34],"HNSCC":[35],"were":[36,39,103],"enrolled.":[37],"Patients":[38,140],"oral":[41],"starting":[43,87],"day":[44,88],"7":[45],"daily":[47,79,133],"thereafter.":[48],"The":[49,70],"was":[53,76],"escalated":[54],"a":[56,63,115],"3":[57,59],"+":[58],"design":[60],"followed":[61],"by":[62],"expansion":[65],"cohort":[66],"6":[68],"patients.":[69],"MTD":[71],"per":[74],"protocol":[75],"100":[77,131],"mg":[78,132],"intravenously":[83],"every":[84],"14":[85],"days":[86],"0.":[89],"RESULTS:":[90],"Ten":[91],"had":[93],"\u22652":[94],"previous":[95],"treatment":[96],"regimens":[97],"(11":[98],"prior":[100],"cetuximab).":[101],"There":[102],"no":[104],"limiting":[106],"toxicities":[107],"observed":[108],"during":[109],"escalation.":[111],"One":[112],"patient":[113],"achieved":[114,120],"partial":[116],"response":[117],"4":[119],"stable":[121],"disease.":[122],"CONCLUSION:":[123],"Based":[124],"on":[125],"this":[126,149],"pilot":[127],"study,":[128],"at":[130],"plus":[134],"proved":[136],"to":[137],"be":[138],"well-tolerated.":[139],"previously":[141],"treated":[142],"monotherapy":[145],"showed":[146],"benefit":[147],"from":[148],"combination.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-12T00:00:00"}