{"id":"https://openalex.org/W2971306116","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3305","title":"Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion","display_name":"Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion","publication_year":2019,"publication_date":"2019-08-29","ids":{"openalex":"https://openalex.org/W2971306116","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3305","mag":"2971306116","pmid":"https://pubmed.ncbi.nlm.nih.gov/31465100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6865295"},"language":"en","primary_location":{"id":"doi:10.1001/jamaophthalmol.2019.3305","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3305","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaophthalmol.2019.3305","pdf_url":"https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2748911/jamaophthalmology_hykin_2019_oi_190060.pdf","source":{"id":"https://openalex.org/S68724622","display_name":"JAMA Ophthalmology","issn_l":"2168-6165","issn":["2168-6165","2168-6173"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2748911/jamaophthalmology_hykin_2019_oi_190060.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055076524","display_name":"Philip G. Hykin","orcid":"https://orcid.org/0000-0003-0459-0055","observed_orcids":["https://orcid.org/0000-0003-0459-0055"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210088407","display_name":"NIHR Moorfields Biomedical Research Centre","ror":"https://ror.org/004hydx84","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1325675289","https://openalex.org/I34931013","https://openalex.org/I4210088407","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philip Hykin","raw_affiliation_strings":["National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210088407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076798733","display_name":"Andrew Toby Prevost","orcid":"https://orcid.org/0000-0003-1723-0796","observed_orcids":["https://orcid.org/0000-0003-1723-0796"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Toby Prevost","raw_affiliation_strings":["Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081078840","display_name":"Joana Carvalho Vasconcelos","orcid":"https://orcid.org/0000-0001-7709-4058","observed_orcids":["https://orcid.org/0000-0001-7709-4058"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joana C. Vasconcelos","raw_affiliation_strings":["Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063912274","display_name":"Caroline Murphy","orcid":"https://orcid.org/0000-0001-7547-8998","observed_orcids":["https://orcid.org/0000-0001-7547-8998"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210113441","display_name":"Kings Health Partners","ror":"https://ror.org/01xcsye48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210113441"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline Murphy","raw_affiliation_strings":["King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210113441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026390715","display_name":"Joanna Kelly","orcid":"https://orcid.org/0000-0002-4389-5284","observed_orcids":["https://orcid.org/0000-0002-4389-5284"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210113441","display_name":"Kings Health Partners","ror":"https://ror.org/01xcsye48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210113441"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna Kelly","raw_affiliation_strings":["King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210113441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221719","display_name":"Jayashree Ramu","orcid":"https://orcid.org/0000-0002-7411-1729","observed_orcids":["https://orcid.org/0000-0002-7411-1729"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210088407","display_name":"NIHR Moorfields Biomedical Research Centre","ror":"https://ror.org/004hydx84","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1325675289","https://openalex.org/I34931013","https://openalex.org/I4210088407","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jayashree Ramu","raw_affiliation_strings":["National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210088407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013800809","display_name":"Barry Hounsome","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210113441","display_name":"Kings Health Partners","ror":"https://ror.org/01xcsye48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210113441"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barry Hounsome","raw_affiliation_strings":["King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's Clinical Trials Unit, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210113441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009328256","display_name":"Yit Chiun Yang","orcid":"https://orcid.org/0000-0002-5392-5133","observed_orcids":["https://orcid.org/0000-0002-5392-5133"]},"institutions":[{"id":"https://openalex.org/I4210154635","display_name":"Wolverhampton Hospital","ror":"https://ror.org/04d7nv189","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210154635"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yit Yang","raw_affiliation_strings":["Wolverhampton Eye Infirmary, Wolverhampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolverhampton Eye Infirmary, Wolverhampton, United Kingdom","institution_ids":["https://openalex.org/I4210154635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072357388","display_name":"Simon Peter Harding","orcid":"https://orcid.org/0000-0003-4676-1158","observed_orcids":["https://orcid.org/0000-0003-4676-1158"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon P Harding","raw_affiliation_strings":["Eye and Vision Science, University of Liverpool, St Paul\u2019s Eye Unit, Royal Liverpool University Hospitals, Members of Liverpool Health Partners, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye and Vision Science, University of Liverpool, St Paul\u2019s Eye Unit, Royal Liverpool University Hospitals, Members of Liverpool Health Partners, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072541133","display_name":"Andrew John Lotery","orcid":"https://orcid.org/0000-0001-5541-4305","observed_orcids":["https://orcid.org/0000-0001-5541-4305"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Lotery","raw_affiliation_strings":["Department of Medicine, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019521414","display_name":"Usha Chakravarthy","orcid":"https://orcid.org/0000-0002-2606-3734","observed_orcids":["https://orcid.org/0000-0002-2606-3734"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Usha Chakravarthy","raw_affiliation_strings":["Biomedical Sciences, Queen\u2019s University of Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Queen\u2019s University of Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066434934","display_name":"Sobha Sivaprasad","orcid":"https://orcid.org/0000-0001-8952-0659","observed_orcids":["https://orcid.org/0000-0001-8952-0659"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210088407","display_name":"NIHR Moorfields Biomedical Research Centre","ror":"https://ror.org/004hydx84","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1325675289","https://openalex.org/I34931013","https://openalex.org/I4210088407","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sobha Sivaprasad","raw_affiliation_strings":["National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health Research, Moorfields Biomedical Research Centre, London, United Kingdom","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210088407"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the LEAVO Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the LEAVO Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5055076524"],"corresponding_institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210088407"],"apc_list":null,"apc_paid":null,"fwci":15.5012,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.99703976,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"137","issue":"11","first_page":"1256","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-retinal-vein-occlusion","display_name":"central retinal vein occlusion","score":0.921999990940094},{"id":"https://openalex.org/keywords/macular-edema","display_name":"macular edema","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.9610000252723694},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":1.0},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8550000190734863},{"id":"https://openalex.org/keywords/central-subfield-thickness","display_name":"central subfield thickness","score":0.6840000152587891},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.3160000145435333},{"id":"https://openalex.org/keywords/retinal-detachment-risk","display_name":"retinal detachment risk","score":0.3149999976158142},{"id":"https://openalex.org/keywords/retinal-neovascularization","display_name":"retinal neovascularization","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9686588644981384},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.9257792234420776},{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9207916259765625},{"id":"https://openalex.org/C2778844676","wikidata":"https://www.wikidata.org/wiki/Q190831","display_name":"Central retinal vein occlusion","level":4,"score":0.7925035953521729},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7339204549789429},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.7281780242919922},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6795378923416138},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6048617362976074},{"id":"https://openalex.org/C2780261187","wikidata":"https://www.wikidata.org/wiki/Q4956400","display_name":"Branch retinal vein occlusion","level":4,"score":0.4709395170211792},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4491727352142334},{"id":"https://openalex.org/C2780699112","wikidata":"https://www.wikidata.org/wiki/Q7246796","display_name":"Pro re nata","level":5,"score":0.437411367893219},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2889888286590576},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06373879313468933}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1001/jamaophthalmol.2019.3305","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3305","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaophthalmol.2019.3305","pdf_url":"https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2748911/jamaophthalmology_hykin_2019_oi_190060.pdf","source":{"id":"https://openalex.org/S68724622","display_name":"JAMA Ophthalmology","issn_l":"2168-6165","issn":["2168-6165","2168-6173"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6865295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6865295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmol","raw_type":"Text"},{"id":"pmid:31465100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31465100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:433978","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1001/jamaophthalmol.2019.3305>).","pdf_url":"https://eprints.soton.ac.uk/433978/1/jamaophthalmology_hykin_2019_oi_190060.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/4d88ad62-61ad-4595-b9fb-315f3482e8d5","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/4d88ad62-61ad-4595-b9fb-315f3482e8d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hykin, P, Prevost, A T, Vasconcelos, J C, Murphy, C, Kelly, J, Ramu, J, Hounsome, B, Yang, Y, Harding, S P, Lotery, A, Chakravarthy, U & Sivaprasad, S 2019, 'Clinical Effectiveness of Intravitreal Therapy with Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion : A Randomized Clinical Trial', JAMA Ophthalmology, vol. 137, no. 11, pp. 1256-1264. https://doi.org/10.1001/jamaophthalmol.2019.3305","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1001/jamaophthalmol.2019.3305","doi":"https://doi.org/10.1001/jamaophthalmol.2019.3305","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaophthalmol.2019.3305","pdf_url":"https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2748911/jamaophthalmology_hykin_2019_oi_190060.pdf","source":{"id":"https://openalex.org/S68724622","display_name":"JAMA Ophthalmology","issn_l":"2168-6165","issn":["2168-6165","2168-6173"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1615731325","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0515-10020","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320312775","display_name":"United Kingdom Clinical Research Collaboration","ror":"https://ror.org/025ecp212"},{"id":"https://openalex.org/F4320313322","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693"},{"id":"https://openalex.org/F4320315702","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320982","display_name":"James Cook University","ror":"https://ror.org/04gsp2c11"},{"id":"https://openalex.org/F4320327683","display_name":"Moorfields Eye Hospital NHS Foundation Trust","ror":"https://ror.org/03tb37539"},{"id":"https://openalex.org/F4320330053","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971306116.pdf","grobid_xml":"https://content.openalex.org/works/W2971306116.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1500728559","https://openalex.org/W1971399814","https://openalex.org/W1976154023","https://openalex.org/W1978704499","https://openalex.org/W1983722797","https://openalex.org/W2005866783","https://openalex.org/W2047858191","https://openalex.org/W2048931126","https://openalex.org/W2052204551","https://openalex.org/W2061410297","https://openalex.org/W2078040311","https://openalex.org/W2144771657","https://openalex.org/W2153879487","https://openalex.org/W2154073405","https://openalex.org/W2172223254","https://openalex.org/W2285674438","https://openalex.org/W2612836720","https://openalex.org/W2750557461","https://openalex.org/W2750848006","https://openalex.org/W2886062143","https://openalex.org/W4247169749","https://openalex.org/W4249999102","https://openalex.org/W4285698150"],"related_works":["https://openalex.org/W3167360781","https://openalex.org/W4312411090","https://openalex.org/W2521155275","https://openalex.org/W2612836720","https://openalex.org/W2588621177","https://openalex.org/W2739886523","https://openalex.org/W2124680922","https://openalex.org/W2177245277","https://openalex.org/W2895848666","https://openalex.org/W2606213351"],"abstract_inverted_index":{"IMPORTANCE:":[0],"The":[1,255,321],"comparative":[2],"clinical":[3],"effectiveness":[4],"of":[5,13,105,145,171,221,225,251,364],"ranibizumab,":[6,267],"aflibercept,":[7,271],"and":[8,132,135,229,272],"bevacizumab":[9,32,187,276,383,412],"for":[10,47,194,266,270,275],"the":[11,126,207,218,222,227,230,334,340,393],"management":[12],"macular":[14,51,103,365],"edema":[15,104,366],"due":[16,100,367],"to":[17,101,157,166,283,294,304,315,353,368],"central":[18,142],"retinal":[19],"vein":[20],"occlusion":[21],"(CRVO)":[22],"is":[23],"unclear.":[24],"OBJECTIVE:":[25],"To":[26],"determine":[27],"whether":[28],"intravitreal":[29,169],"aflibercept":[30,179,335,374],"or":[31,96,148,186,405],"compared":[33,375,384,413],"with":[34,49,110,246,376,385,414],"ranibizumab":[35,172,284,305,341,386],"results":[36],"in":[37,42,67,125,204,206,259,333,339,360,380,395],"a":[38,247],"noninferior":[39,282,303],"mean":[40,202,248,256,286,307,329],"change":[41,203,394],"vision":[43,361,381,390],"at":[44,82,210,277,346],"100":[45,195,211,278,347],"weeks":[46,212],"eyes":[48],"CRVO-related":[50,102],"edema.":[52],"DESIGN,":[53],"SETTING,":[54],"AND":[55,199,356],"PARTICIPANTS:":[56],"This":[57],"prospective,":[58],"3-arm,":[59],"double-masked,":[60],"randomized":[61,164],"noninferiority":[62,214],"trial":[63],"(Lucentis,":[64],"Eylea,":[65],"Avastin":[66],"Vein":[68],"Occlusion":[69],"[LEAVO]":[70],"Study)":[71],"took":[72],"place":[73],"from":[74,153,398],"December":[75,79],"12,":[76],"2014,":[77],"through":[78],"16,":[80],"2016,":[81],"44":[83],"UK":[84],"National":[85],"Health":[86],"Service":[87],"ophthalmology":[88],"departments.":[89],"Inclusion":[90],"criteria":[91],"included":[92],"age":[93,250],"18":[94],"years":[95],"older,":[97],"visual":[98,112,396],"impairment":[99],"less":[106],"than":[107,338],"12":[108],"months":[109],"best-corrected":[111],"acuity":[113,397],"(BCVA)":[114],"Early":[115],"Treatment":[116],"Diabetic":[117],"Retinopathy":[118],"Study":[119],"letter":[120,261],"score":[121,262],"(approximate":[122],"Snellen":[123],"equivalent)":[124],"study":[127,208],"eye":[128,209],"between":[129],"19":[130],"(20/400)":[131],"78":[133],"(20/32),":[134],"spectral":[136],"domain":[137],"optical":[138],"coherence":[139],"tomography":[140],"imaging":[141],"subfield":[143],"thickness":[144],"320":[146],"\u03bcm":[147],"greater.":[149],"Data":[150],"were":[151,163,234,244,326,331,370,387],"analyzed":[152],"March":[154],"4,":[155],"2019,":[156],"April":[158],"26,":[159],"2019.":[160],"INTERVENTIONS:":[161],"Participants":[162],"(1:1:1)":[165],"receive":[167],"repeated":[168],"injections":[170,330],"(0.5":[173],"mg/0.05":[174,181,189],"mL)":[175,182,190],"(n":[176,183,191],"=":[177,184,192,319],"155),":[178],"(2.0":[180],"154),":[185],"(1.25":[188],"154)":[193],"weeks.":[196,279],"MAIN":[197],"OUTCOMES":[198],"MEASURES:":[200],"Adjusted":[201],"BCVA":[205,260,287,308],"wherein":[213],"was":[215,263,281,301],"concluded":[216],"if":[217],"lower":[219],"bounds":[220],"95%":[223,291,312,350],"CI":[224],"both":[226],"intention-to-treat":[228],"per":[231,322],"protocol":[232,323],"analyses":[233],"above":[235],"-5":[236],"letters.":[237],"RESULTS:":[238],"Of":[239],"463":[240],"participants,":[241],"265":[242],"(57.2%)":[243],"male,":[245],"(SD)":[249,257],"69.1":[252],"(13.0)":[253],"years.":[254],"gain":[258],"12.5":[264],"(21.1)":[265],"15.1":[268],"(18.7)":[269],"9.8":[273],"(21.4)":[274],"Aflibercept":[280],"(intention-to-treat-adjusted":[285,306],"difference,":[288,309],"2.23":[289],"letters;":[290,296,311,317],"CI,":[292,313,351],"-2.17":[293],"6.63":[295],"P":[297,318],"<":[298],".001).":[299],"Bevacizumab":[300],"not":[302,407],"-1.73":[310],"-6.12":[314],"2.67":[316],".07).":[320],"analysis":[324],"conclusions":[325],"similar.":[327],"Fewer":[328],"given":[332],"group":[336,343],"(10.0)":[337],"(11.8)":[342],"(mean":[344],"difference":[345],"weeks,":[348],"-1.9;":[349],"-2.9":[352],"-0.8).":[354],"CONCLUSIONS":[355],"RELEVANCE:":[357],"Mean":[358,378],"changes":[359,379],"after":[362],"treatment":[363],"CRVO":[369],"no":[371],"worse":[372,404,409],"using":[373,382,411],"ranibizumab.":[377],"inconclusive":[388],"regarding":[389],"outcomes":[391],"(ie,":[392],"baseline,":[399],"on":[400],"average,":[401],"may":[402,406],"be":[403,408],"when":[410],"ranibizumab).":[415],"TRIAL":[416],"REGISTRATION:":[417],"ISRCTN13623634.":[418]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-05T00:00:00"}