{"id":"https://openalex.org/W2970944778","doi":"https://doi.org/10.1177/1747493019869707","title":"System-integrated technology-enabled model of care (SINEMA) to improve the health of stroke patients in rural China: Statistical analysis plan for a cluster-randomized controlled trial","display_name":"System-integrated technology-enabled model of care (SINEMA) to improve the health of stroke patients in rural China: Statistical analysis plan for a cluster-randomized controlled trial","publication_year":2019,"publication_date":"2019-08-28","ids":{"openalex":"https://openalex.org/W2970944778","doi":"https://doi.org/10.1177/1747493019869707","mag":"2970944778","pmid":"https://pubmed.ncbi.nlm.nih.gov/31462178"},"language":"en","primary_location":{"id":"doi:10.1177/1747493019869707","doi":"https://doi.org/10.1177/1747493019869707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1747493019869707","pdf_url":null,"source":{"id":"https://openalex.org/S150089136","display_name":"International Journal of Stroke","issn_l":"1747-4930","issn":["1747-4930","1747-4949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064323775","display_name":"Enying Gong","orcid":"https://orcid.org/0000-0003-2203-0369","observed_orcids":["https://orcid.org/0000-0003-2203-0369"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210159968","display_name":"Duke Kunshan University","ror":"https://ror.org/04sr5ys16","country_code":"CN","type":"education","lineage":["https://openalex.org/I170897317","https://openalex.org/I37461747","https://openalex.org/I4210159968"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Enying Gong","raw_affiliation_strings":["Global Health Research Center, Duke Kunshan University, Jiangsu, China","School of Population and Global Health, The University of Melbourne, Melbourne, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2203-0369","affiliations":[{"raw_affiliation_string":"Global Health Research Center, Duke Kunshan University, Jiangsu, China","institution_ids":["https://openalex.org/I4210159968"]},{"raw_affiliation_string":"School of Population and Global Health, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055316164","display_name":"Lijing L. Yan","orcid":"https://orcid.org/0000-0002-3029-0462","observed_orcids":["https://orcid.org/0000-0002-3029-0462"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210159968","display_name":"Duke Kunshan University","ror":"https://ror.org/04sr5ys16","country_code":"CN","type":"education","lineage":["https://openalex.org/I170897317","https://openalex.org/I37461747","https://openalex.org/I4210159968"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Lijing L Yan","raw_affiliation_strings":["Duke Global Health Institute, Duke University, Durham, NC, USA","Global Health Research Center, Duke Kunshan University, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Global Health Institute, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Global Health Research Center, Duke Kunshan University, Jiangsu, China","institution_ids":["https://openalex.org/I4210159968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003317438","display_name":"Kara McCormack","orcid":"https://orcid.org/0000-0001-9082-9661","observed_orcids":["https://orcid.org/0000-0001-9082-9661"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara McCormack","raw_affiliation_strings":["Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017358207","display_name":"John A. Gallis","orcid":"https://orcid.org/0000-0003-1921-8424","observed_orcids":["https://orcid.org/0000-0003-1921-8424"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A Gallis","raw_affiliation_strings":["Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA","Duke Global Health Institute, Duke University, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-1921-8424","affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Global Health Institute, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068613629","display_name":"Janet Prvu Bettger","orcid":"https://orcid.org/0000-0001-9708-8413","observed_orcids":["https://orcid.org/0000-0001-9708-8413"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Prvu Bettger","raw_affiliation_strings":["Department of Orthopedic Surgery, Duke University, Durham, NC, USA","Duke Global Health Institute, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Global Health Institute, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083697699","display_name":"Elizabeth Louise Turner","orcid":"https://orcid.org/0000-0002-7638-5942","observed_orcids":["https://orcid.org/0000-0002-7638-5942"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth L Turner","raw_affiliation_strings":["Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA","Duke Global Health Institute, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Global Health Institute, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083697699"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.1903,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55529438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"2","first_page":"226","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10912","display_name":"Telemedicine and Telehealth Implementation","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-stroke-prevention","display_name":"secondary stroke prevention","score":0.7559999823570251},{"id":"https://openalex.org/keywords/community-based-intervention","display_name":"community-based intervention","score":0.7609999775886536},{"id":"https://openalex.org/keywords/technology-enabled-care","display_name":"technology-enabled care","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rural-health","display_name":"rural health","score":0.4320000112056732},{"id":"https://openalex.org/keywords/model-of-care","display_name":"models of care","score":0.7450000047683716},{"id":"https://openalex.org/keywords/statistical-analysis-plan","display_name":"statistical analysis plan","score":0.902999997138977},{"id":"https://openalex.org/keywords/missing-data-handling","display_name":"missing data handling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/health-outcomes","display_name":"health outcomes","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7639284133911133},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.6006262898445129},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5664094686508179},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4872809648513794},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.4683116376399994},{"id":"https://openalex.org/C176400912","wikidata":"https://www.wikidata.org/wiki/Q3058662","display_name":"Cluster randomised controlled trial","level":3,"score":0.43797796964645386},{"id":"https://openalex.org/C2776505523","wikidata":"https://www.wikidata.org/wiki/Q4785468","display_name":"Plan (archaeology)","level":2,"score":0.4151355028152466},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16952425241470337},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10147172212600708},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012424","descriptor_name":"Rural Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/1747493019869707","doi":"https://doi.org/10.1177/1747493019869707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1747493019869707","pdf_url":null,"source":{"id":"https://openalex.org/S150089136","display_name":"International Journal of Stroke","issn_l":"1747-4930","issn":["1747-4930","1747-4949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Stroke","raw_type":"journal-article"},{"id":"pmid:31462178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31462178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of stroke : official journal of the International Stroke Society","raw_type":"Clinical Trial Protocol"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[{"id":"https://openalex.org/G1906116817","display_name":null,"funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4962175056","display_name":null,"funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5225150759","display_name":"Technology-EnaSystem-Integratedbled Model of Care Aiming to Improve the Health of Stroke Patients in Resource-Poor Settings in China","funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7829357890","display_name":null,"funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320321637","funder_display_name":"Department for International Development"},{"id":"https://openalex.org/G7866191928","display_name":null,"funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G8954681189","display_name":null,"funder_award_id":"MR/N015967/1","funder_id":"https://openalex.org/F4320319996","funder_display_name":"Department for International Development, UK Government"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319996","display_name":"Department for International Development, UK Government","ror":"https://ror.org/05rf29967"},{"id":"https://openalex.org/F4320321637","display_name":"Department for International Development","ror":"https://ror.org/05rf29967"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1974704788","https://openalex.org/W1978136073","https://openalex.org/W1990166011","https://openalex.org/W2020074777","https://openalex.org/W2022958256","https://openalex.org/W2031756259","https://openalex.org/W2082246284","https://openalex.org/W2091045599","https://openalex.org/W2097395684","https://openalex.org/W2117085209","https://openalex.org/W2130845266","https://openalex.org/W2266233401","https://openalex.org/W2742964921","https://openalex.org/W2789747557","https://openalex.org/W2891343338","https://openalex.org/W4248033032"],"related_works":["https://openalex.org/W2536933977","https://openalex.org/W7165111620","https://openalex.org/W2891343338","https://openalex.org/W4281662685","https://openalex.org/W2905373682","https://openalex.org/W2143922820","https://openalex.org/W2606298897","https://openalex.org/W2601067385","https://openalex.org/W1603928737","https://openalex.org/W4407437280"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,46,110],"system-integrated":[2],"technology-enabled":[3],"model":[4],"of":[5,14,22,71,88,96],"care":[6],"(SINEMA)":[7],"trial":[8,37,106,111],"aimed":[9],"to":[10,39,62,81],"evaluate":[11],"the":[12,30,36,57,89,94,97],"effectiveness":[13,76],"a":[15],"community-based":[16],"multi-component":[17],"intervention":[18],"for":[19,35,75],"secondary":[20,53],"prevention":[21],"stroke":[23],"in":[24,105],"rural":[25],"China.":[26],"OBJECTIVE:":[27],"To":[28],"present":[29],"detailed":[31,47,69],"statistical":[32,90],"analysis":[33,48,60,91,99],"plan":[34,49,92],"prior":[38],"database":[40],"locking":[41],"and":[42,52,101],"data":[43,59,98],"analysis.":[44],"METHODS:":[45],"outlines":[50],"primary":[51],"outcome":[54,84],"measures,":[55],"describes":[56],"over-arching":[58],"principles":[61],"be":[63],"adopted":[64],"as":[65,67,78],"well":[66,79],"more":[68],"descriptions":[70],"specific":[72],"analytical":[73],"approaches":[74],"analyses,":[77],"strategies":[80],"handle":[82],"missing":[83],"data.":[85],"DISCUSSION:":[86],"Publication":[87],"increases":[93],"transparency":[95],"procedure":[100],"reduces":[102],"potential":[103],"bias":[104],"reporting.":[107],"TRIAL":[108],"REGISTRATION:":[109],"was":[112],"registered":[113],"with":[114],"clinicaltrials.gov":[115],"(NCT03185858).":[116]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-05T00:00:00"}