{"id":"https://openalex.org/W2970720231","doi":"https://doi.org/10.21705/mcbs.v3i2.60","title":"Antioxidant, \u03b1-Glucosidase Inhibitory Activity and Molecular Docking Study of Gallic Acid, Quercetin and Rutin: A Comparative Study","display_name":"Antioxidant, \u03b1-Glucosidase Inhibitory Activity and Molecular Docking Study of Gallic Acid, Quercetin and Rutin: A Comparative Study","publication_year":2019,"publication_date":"2019-08-31","ids":{"openalex":"https://openalex.org/W2970720231","doi":"https://doi.org/10.21705/mcbs.v3i2.60","mag":"2970720231"},"language":"en","primary_location":{"id":"doi:10.21705/mcbs.v3i2.60","doi":"https://doi.org/10.21705/mcbs.v3i2.60","is_oa":true,"landing_page_url":"https://doi.org/10.21705/mcbs.v3i2.60","pdf_url":null,"source":{"id":"https://openalex.org/S4210240226","display_name":"Molecular and Cellular Biomedical Sciences","issn_l":"2527-3442","issn":["2527-3442","2527-4384"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315016","host_organization_name":"Cell and BioPharmaceutical Institute","host_organization_lineage":["https://openalex.org/P4310315016"],"host_organization_lineage_names":["Cell and BioPharmaceutical Institute"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biomedical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21705/mcbs.v3i2.60","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033958482","display_name":"Agus Limanto","orcid":"https://orcid.org/0000-0002-6037-1271","observed_orcids":["https://orcid.org/0000-0002-6037-1271"]},"institutions":[{"id":"https://openalex.org/I3129847783","display_name":"Krida Wacana Christian University","ror":"https://ror.org/05bq6ng76","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129847783"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Agus Limanto","raw_affiliation_strings":["Department of Biochemistry, Krida Wacana Christian University, Jakarta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Krida Wacana Christian University, Jakarta","institution_ids":["https://openalex.org/I3129847783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065784857","display_name":"Adelina Simamora","orcid":"https://orcid.org/0000-0002-7337-093X","observed_orcids":["https://orcid.org/0000-0002-7337-093X"]},"institutions":[{"id":"https://openalex.org/I3129847783","display_name":"Krida Wacana Christian University","ror":"https://ror.org/05bq6ng76","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129847783"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Adelina Simamora","raw_affiliation_strings":["Department of Biochemistry, Krida Wacana Christian University, Jakarta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Krida Wacana Christian University, Jakarta","institution_ids":["https://openalex.org/I3129847783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027264655","display_name":"Adit Widodo Santoso","orcid":"https://orcid.org/0000-0003-2133-8265","observed_orcids":["https://orcid.org/0000-0003-2133-8265"]},"institutions":[{"id":"https://openalex.org/I3129847783","display_name":"Krida Wacana Christian University","ror":"https://ror.org/05bq6ng76","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129847783"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Adit Widodo Santoso","raw_affiliation_strings":["Department of Herbal Medicine, Krida Wacana Christian University, Jakarta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Herbal Medicine, Krida Wacana Christian University, Jakarta","institution_ids":["https://openalex.org/I3129847783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060341217","display_name":"Kris Herawan Timotius","orcid":"https://orcid.org/0000-0001-7232-0001","observed_orcids":["https://orcid.org/0000-0001-7232-0001"]},"institutions":[{"id":"https://openalex.org/I3129847783","display_name":"Krida Wacana Christian University","ror":"https://ror.org/05bq6ng76","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129847783"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Kris Herawan Timotius","raw_affiliation_strings":["Department of Biochemistry, Krida Wacana Christian University, Jakarta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Krida Wacana Christian University, Jakarta","institution_ids":["https://openalex.org/I3129847783"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3129847783"],"apc_list":null,"apc_paid":null,"fwci":3.4509,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93228698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":1.0},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.8849999904632568},{"id":"https://openalex.org/keywords/enzyme-inhibition-kinetics","display_name":"enzyme inhibition kinetics","score":0.5830000042915344},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mixed-inhibition","display_name":"mixed-type inhibition","score":0.859000027179718},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7260000109672546},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.718999981880188},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.9417657852172852},{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.914656400680542},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.8728468418121338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8010793328285217},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7347911596298218},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.6715015172958374},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.5803369283676147},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5465863943099976},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5380243062973022},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3870390057563782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37230128049850464},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0807129442691803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21705/mcbs.v3i2.60","doi":"https://doi.org/10.21705/mcbs.v3i2.60","is_oa":true,"landing_page_url":"https://doi.org/10.21705/mcbs.v3i2.60","pdf_url":null,"source":{"id":"https://openalex.org/S4210240226","display_name":"Molecular and Cellular Biomedical Sciences","issn_l":"2527-3442","issn":["2527-3442","2527-4384"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315016","host_organization_name":"Cell and BioPharmaceutical Institute","host_organization_lineage":["https://openalex.org/P4310315016"],"host_organization_lineage_names":["Cell and BioPharmaceutical Institute"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biomedical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b63d258678424c67acc2bd916fafaf07","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b63d258678424c67acc2bd916fafaf07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MCBS (Molecular and Cellular Biomedical Sciences), Vol 3, Iss 2, Pp 67-74 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21705/mcbs.v3i2.60","doi":"https://doi.org/10.21705/mcbs.v3i2.60","is_oa":true,"landing_page_url":"https://doi.org/10.21705/mcbs.v3i2.60","pdf_url":null,"source":{"id":"https://openalex.org/S4210240226","display_name":"Molecular and Cellular Biomedical Sciences","issn_l":"2527-3442","issn":["2527-3442","2527-4384"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315016","host_organization_name":"Cell and BioPharmaceutical Institute","host_organization_lineage":["https://openalex.org/P4310315016"],"host_organization_lineage_names":["Cell and BioPharmaceutical Institute"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biomedical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054209992","https://openalex.org/W4402717135","https://openalex.org/W2114372041","https://openalex.org/W187719115","https://openalex.org/W2803522209","https://openalex.org/W2355566233","https://openalex.org/W7010230743","https://openalex.org/W7212253204","https://openalex.org/W4411208639","https://openalex.org/W3145294861"],"abstract_inverted_index":{"Background:":[0],"Plant-phenolics":[1],"and":[2,8,23,33,36,43,49,61,73,86,129,159,164,209,215,227,229],"flavonoids,":[3],"including":[4,57],"gallic":[5,28,232],"acid,":[6,233],"quercetin":[7,31,236],"rutin,":[9,235],"are":[10],"considered":[11],"as":[12],"safe":[13],"inhibitors":[14],"for":[15],"\u03b1-glucosidase.":[16],"This":[17,217],"study":[18],"aimed":[19],"to":[20,200],"compare":[21],"antioxidant":[22,48,77,95,208],"\u03b1-glucosidase":[24,53,210],"inhibitory":[25,50,211],"activities":[26,110,138],"of":[27,40,111,135,156,185],"acid":[29,84],"(GA),":[30],"(QUE)":[32],"rutin":[34],"(RUT).Materials":[35],"Methods:":[37],"Pure":[38],"compounds":[39,70,113,177],"GA,":[41,157,225],"QUE,":[42,72,158,226],"RUT":[44,130,160,228],"were":[45,54,161],"used.":[46],"Their":[47],"activity":[51,78,96,212],"on":[52,98,105],"investigated":[55],"spectroscopically,":[56],"their":[58,106],"kinetic":[59],"analysis":[60],"interaction":[62],"mechanism":[63],"by":[64],"docking":[65,173],"simulation.Results:":[66],"All":[67],"the":[68,81,93,109,112,115,181,188,192,201,222],"tested":[69],"(GA,":[71],"RUT)":[74],"showed":[75],"good":[76],"better":[79,207],"than":[80,140,213],"standards":[82],"ascorbic":[83],"(AA)":[85],"butylated":[87],"hydroxytoluene":[88],"(BHT),":[89],"with":[90,137,187],"QUE":[91,124,147,205],"showing":[92],"highest":[94],"based":[97],"2,2-diphenyl1-picrylhydrazyl":[99],"(DPPH)":[100],"radical":[101],"scavenging":[102],"activity.":[103],"Based":[104],"reducing":[107],"properties,":[108],"follow":[114],"following":[116],"order:":[117],"AA":[118],">":[119,121,123,125],"GA":[120,128,214],"BHT":[122],"RUT.":[126,216],"Both":[127],"induced":[131],"a":[132,150],"competitive":[133],"type":[134,152],"inhibition,":[136],"stronger":[139],"acarbose":[141],"(IC50":[142],"=":[143],"823":[144],"\u03bcg/mL),":[145],"whereas":[146],"inhibited":[148],"in":[149,180,196],"mixed":[151],"manner.":[153],"The":[154,168],"IC50":[155],"220.12,":[162],"65.52,":[163],"224.55":[165],"\u03bcg/mL":[166],"respectively.":[167],"results":[169],"obtained":[170],"from":[171],"molecular":[172],"indicate":[174],"that":[175],"all":[176],"have":[178],"affinity":[179],"active":[182],"site":[183],"pocket":[184],"\u03b1-glucosidase,":[186,234],"hydrogen":[189],"bond":[190],"being":[191],"major":[193],"force":[194],"involved":[195],"each":[197],"compound":[198],"binding":[199],"enzyme.Conclusion:":[202],"In":[203],"conclusion,":[204],"has":[206],"work":[218],"provides":[219],"insights":[220],"into":[221],"interactions":[223],"between":[224],"\u03b1-glucosidase.Keywords:":[230],"docking,":[231]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-09-05T00:00:00"}
