{"id":"https://openalex.org/W2970622816","doi":"https://doi.org/10.1152/ajpgi.00194.2019","title":"Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis","display_name":"Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis","publication_year":2019,"publication_date":"2019-08-28","ids":{"openalex":"https://openalex.org/W2970622816","doi":"https://doi.org/10.1152/ajpgi.00194.2019","mag":"2970622816","pmid":"https://pubmed.ncbi.nlm.nih.gov/31460790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6879889"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00194.2019","doi":"https://doi.org/10.1152/ajpgi.00194.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00194.2019","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00194.2019","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00194.2019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067770887","display_name":"Jasmohan Singh Bajaj","orcid":"https://orcid.org/0000-0003-4928-3681","observed_orcids":["https://orcid.org/0000-0003-4928-3681"]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jasmohan S. Bajaj","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":"https://orcid.org/0000-0003-4928-3681","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083068675","display_name":"Masoumeh Sikaroodi","orcid":"https://orcid.org/0000-0002-8592-1145","observed_orcids":["https://orcid.org/0000-0002-8592-1145"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoumeh Sikaroodi","raw_affiliation_strings":["Microbiome Analysis Center, George Mason University, Manassas, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analysis Center, George Mason University, Manassas, Virginia","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091824025","display_name":"Andrew Fagan","orcid":"https://orcid.org/0000-0003-4390-8839","observed_orcids":["https://orcid.org/0000-0003-4390-8839"]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Fagan","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110250680","display_name":"Douglas M. Heuman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Heuman","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112316412","display_name":"HoChong Gilles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HoChong Gilles","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022290912","display_name":"Edith A. Gavis","orcid":"https://orcid.org/0000-0002-2393-619X","observed_orcids":["https://orcid.org/0000-0002-2393-619X"]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith A. Gavis","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069307755","display_name":"Michael A. Fuchs","orcid":"https://orcid.org/0000-0002-5557-682X","observed_orcids":["https://orcid.org/0000-0002-5557-682X"]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Fuchs","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","McGuire Veterans Affairs Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"McGuire Veterans Affairs Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047587284","display_name":"Javier Gonz\u00e1lez\u2010Maeso","orcid":"https://orcid.org/0000-0003-3105-3204","observed_orcids":["https://orcid.org/0000-0003-3105-3204","https://orcid.org/0000-0001-9029-5057"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Gonzalez-Maeso","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049514759","display_name":"Shahzor Nizam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahzor Nizam","raw_affiliation_strings":["Microbiome Analysis Center, George Mason University, Manassas, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analysis Center, George Mason University, Manassas, Virginia","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024426792","display_name":"Patrick Martin Gillevet","orcid":"https://orcid.org/0000-0001-7734-5566","observed_orcids":["https://orcid.org/0000-0001-7734-5566"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Gillevet","raw_affiliation_strings":["Microbiome Analysis Center, George Mason University, Manassas, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analysis Center, George Mason University, Manassas, Virginia","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101996058","display_name":"James B. Wade","orcid":"https://orcid.org/0000-0003-1759-0337","observed_orcids":["https://orcid.org/0000-0003-1759-0337"]},"institutions":[{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Wade","raw_affiliation_strings":["Department of Psychiatry, Virginia Commonwealth University Medical Center, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Virginia Commonwealth University Medical Center, Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067770887"],"corresponding_institution_ids":["https://openalex.org/I2801770128","https://openalex.org/I72019824"],"apc_list":null,"apc_paid":null,"fwci":4.8764,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96060646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"317","issue":"5","first_page":"G661","last_page":"G669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.781000018119812},{"id":"https://openalex.org/keywords/combat-exposure","display_name":"combat exposure","score":0.7900000214576721},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.765999972820282},{"id":"https://openalex.org/keywords/escherichia-shigella","display_name":"Escherichia-Shigella","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ruminococcaceae","display_name":"Ruminococcaceae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding-protein","display_name":"lipopolysaccharide-binding protein","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pathobionts","display_name":"pathobionts","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2991847609","wikidata":"https://www.wikidata.org/wiki/Q202387","display_name":"Posttraumatic stress","level":2,"score":0.6769222021102905},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6550496816635132},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5937187671661377},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5230708718299866},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43815168738365173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42096590995788574},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4107131361961365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3303108811378479},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.29788947105407715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24226796627044678}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004925","descriptor_name":"Escherichia","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012760","descriptor_name":"Shigella","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014728","descriptor_name":"Veterans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00194.2019","doi":"https://doi.org/10.1152/ajpgi.00194.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00194.2019","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00194.2019","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6879889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6879889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},{"id":"pmid:31460790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31460790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/ajpgi.00194.2019","doi":"https://doi.org/10.1152/ajpgi.00194.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00194.2019","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00194.2019","source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2155095335","display_name":"Preclinical role of HDAC2 in mGlu2-dependent schizophrenia treatment","funder_award_id":"R01MH111940","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3087056098","display_name":null,"funder_award_id":"I0CX001076","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G3479891709","display_name":null,"funder_award_id":"I01 CX001076","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5040968163","display_name":"Center for Clinical and Translational Research","funder_award_id":"UL1TR002649","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7992464556","display_name":"Modulation of Gut-Brain Axis Using Fecal Microbiome Transplant Capsules in Cirrhosis","funder_award_id":"R21TR002024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000863526","display_name":"Function of GPCR heteromeric complexes in brain","funder_award_id":"R01MH084894","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2970622816.pdf","grobid_xml":"https://content.openalex.org/works/W2970622816.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1452946734","https://openalex.org/W1518286619","https://openalex.org/W1715339469","https://openalex.org/W1968750085","https://openalex.org/W1977429705","https://openalex.org/W1983700957","https://openalex.org/W1983814959","https://openalex.org/W1989045560","https://openalex.org/W2026352845","https://openalex.org/W2026658658","https://openalex.org/W2044238207","https://openalex.org/W2058029859","https://openalex.org/W2062063065","https://openalex.org/W2065010232","https://openalex.org/W2067498508","https://openalex.org/W2097232234","https://openalex.org/W2104423086","https://openalex.org/W2105932465","https://openalex.org/W2110300022","https://openalex.org/W2124945869","https://openalex.org/W2130838343","https://openalex.org/W2133856765","https://openalex.org/W2138196119","https://openalex.org/W2147242053","https://openalex.org/W2148503945","https://openalex.org/W2149348195","https://openalex.org/W2152245456","https://openalex.org/W2152791743","https://openalex.org/W2154911132","https://openalex.org/W2167333965","https://openalex.org/W2171438143","https://openalex.org/W2191597235","https://openalex.org/W2326225552","https://openalex.org/W2332863458","https://openalex.org/W2333932404","https://openalex.org/W2338541571","https://openalex.org/W2399464963","https://openalex.org/W2414212485","https://openalex.org/W2550807593","https://openalex.org/W2623146054","https://openalex.org/W2734898627","https://openalex.org/W2782247821","https://openalex.org/W2798083116","https://openalex.org/W2806340304","https://openalex.org/W2885749736","https://openalex.org/W2918256091","https://openalex.org/W2943508390","https://openalex.org/W2944180775","https://openalex.org/W2950709739","https://openalex.org/W2953224948","https://openalex.org/W2955707745","https://openalex.org/W4210990778"],"related_works":["https://openalex.org/W2782247821","https://openalex.org/W4411982636","https://openalex.org/W4200447134","https://openalex.org/W4411661270","https://openalex.org/W4399913497","https://openalex.org/W4407895190","https://openalex.org/W4405912177","https://openalex.org/W4387782576","https://openalex.org/W7125520181","https://openalex.org/W4406115557"],"abstract_inverted_index":{"Posttraumatic":[0,291],"stress":[1,292],"disorder":[2,293],"(PTSD)":[3,294],"is":[4,33,249],"associated":[5,250,300,307],"with":[6,211,229,251,270,297,301,308,315,332],"cirrhosis":[7,21,50,298],"in":[8,20,49,155,232,241,295,313,370],"veterans,":[9,246],"and":[10,47,66,75,83,98,105,144,148,177,194,196,203,259,264,321,323,330],"therapeutic":[11,286],"results":[12],"are":[13],"suboptimal.":[14],"An":[15],"altered":[16,240,265,367],"gut-liver-brain":[17],"axis":[18,267,369],"exists":[19],"due":[22],"to":[23,41,201,278,319,328,355],"hepatic":[24,339],"encephalopathy":[25],"(HE),":[26],"but":[27,141,167],"the":[28,215,352,361,366],"added":[29],"impact":[30],"of":[31,37,206,223],"PTSD":[32,88,104,133,156,172,187,233,248,314],"unclear.":[34],"The":[35],"aim":[36],"this":[38],"study":[39],"was":[40,89,153,209,217,226,239,275,299,306],"define":[42],"linkages":[43],"between":[44,96],"gut":[45,279,310,362],"microbiota":[46,81,97,237,363],"cognition":[48,99,231],"with/without":[51,103,106],"PTSD.":[52,242],"Cirrhotic":[53],"veterans":[54,113,296],"(with/without":[55],"prior":[56,338],"HE)":[57],"underwent":[58],"cognitive":[59,252,303],"testing":[60],"[PHES,":[61],"inhibitory":[62],"control":[63],"test":[64,69],"(ICT),":[65],"block":[67],"design":[68],"(BDT)],":[70],"serum":[71],"lipopolysaccharide-binding":[72],"protein":[73],"(LBP)":[74],"stool":[76],"collection":[77],"for":[78,219,337,346,358],"16S":[79],"rRNA":[80],"composition,":[82],"predicted":[84,183],"function":[85],"analysis":[86],"(PiCRUST).":[87],"diagnosed":[90],"using":[91],"DSM-V":[92],"criteria.":[93],"Correlation":[94],"networks":[95],"were":[100,108,131],"created.":[101],"Patients":[102],"HE":[107],"compared.":[109],"Ninety-three":[110],"combat-exposed":[111,272],"male":[112,244],"[":[114],"(58":[115],"yr,":[116],"MELD":[117,178],"11,":[118],"34%":[119],"HE,":[120],"31%":[121],"combat-PTSD":[122],"(42":[123],"no-HE/PTSD,":[124],"19":[125],"PTSD-only,":[126],"22":[127],"HE-only,":[128],"10":[129],"PTSD+HE)]":[130],"included.":[132],"patients":[134,188],"had":[135],"similar":[136],"demographics,":[137],"alcohol":[138],"history,":[139],"MELD,":[140],"worse":[142],"ICT/BDT,":[143],"higher":[145,190,257,316],"antidepressant":[146],"use":[147],"LBP":[149],"levels.":[150],"Microbial":[151],"diversity":[152,184,312],"lower":[154,197,254,260,309,324],"(2.1":[157],"\u00b1":[158,162],"0.5":[159],"vs.":[160],"2.5":[161],"0.5,":[163],"P":[164,174,180],"=":[165,175],"0.03)":[166],"unaffected":[168],"by":[169],"alcohol/antidepressant":[170],"use.":[171],"(":[173,179,192],"0.02)":[176],"<":[181],"0.001)":[182],"on":[185],"regression.":[186],"showed":[189],"pathobionts":[191,317],"Enterococcus":[193,208,320],"Escherichia/Shigella)":[195],"autochthonous":[198,220,261],"genera":[199],"belonging":[200,318,327],"Lachnospiraceaeae":[202,329],"Ruminococcaceae":[204],"regardless":[205,222],"HE.":[207],"correlated":[210],"poor":[212,230,302],"cognition,":[213],"while":[214],"opposite":[216],"true":[218],"taxa":[221,262,326],"PTSD/HE.":[224],"Escherichia/Shigella":[225,322],"only":[227],"linked":[228,277],"patients.":[234,273,372],"Gut-brain":[235],"axis-associated":[236],"functionality":[238,268],"In":[243],"cirrhotic":[245],"combat-related":[247],"impairment,":[253],"microbial":[255,311],"diversity,":[256],"pathobionts,":[258],"composition":[263],"gut-brain":[266,368],"compared":[269],"non-PTSD":[271],"Cognition":[274],"differentially":[276],"microbiota,":[280],"which":[281],"could":[282,364],"represent":[283],"a":[284],"new":[285],"target.":[287],"NEW":[288],"&":[289],"NOTEWORTHY":[290],"performance.":[304],"This":[305],"beneficial":[325],"Ruminococcaceae,":[331],"functional":[333],"alterations":[334],"despite":[335],"accounting":[336],"encephalopathy,":[340],"psychoactive":[341],"drug":[342],"use,":[343],"or":[344],"model":[345],"end-stage":[347],"liver":[348],"disease":[349],"score.":[350],"Given":[351],"suboptimal":[353],"response":[354],"current":[356],"therapies":[357],"PTSD,":[359],"targeting":[360],"benefit":[365],"these":[371]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-05T00:00:00"}