{"id":"https://openalex.org/W2970601657","doi":"https://doi.org/10.1093/tropej/fmy067","title":"Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital","display_name":"Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital","publication_year":2018,"publication_date":"2018-10-08","ids":{"openalex":"https://openalex.org/W2970601657","doi":"https://doi.org/10.1093/tropej/fmy067","mag":"2970601657","pmid":"https://pubmed.ncbi.nlm.nih.gov/30544245"},"language":"en","primary_location":{"id":"doi:10.1093/tropej/fmy067","doi":"https://doi.org/10.1093/tropej/fmy067","is_oa":false,"landing_page_url":"https://doi.org/10.1093/tropej/fmy067","pdf_url":null,"source":{"id":"https://openalex.org/S138039823","display_name":"Journal of Tropical Pediatrics","issn_l":"0142-6338","issn":["0142-6338","1465-3664"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tropical Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069666491","display_name":"Memela Makiwane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Memela Makiwane","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089203897","display_name":"Eric H. Decloedt","orcid":"https://orcid.org/0000-0003-1815-5150","observed_orcids":["https://orcid.org/0000-0003-1815-5150"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Eric Decloedt","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072683436","display_name":"Maxwell Chirehwa","orcid":"https://orcid.org/0000-0002-1685-4882","observed_orcids":["https://orcid.org/0000-0002-1685-4882"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Maxwell Chirehwa","raw_affiliation_strings":["Division of Epidemiology and Biostatistics, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Biostatistics, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058578660","display_name":"Bernd Rosenkranz","orcid":"https://orcid.org/0000-0002-9867-8826","observed_orcids":["https://orcid.org/0000-0002-9867-8826"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Bernd Rosenkranz","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046394206","display_name":"Mariana Kruger","orcid":"https://orcid.org/0000-0002-6838-0180","observed_orcids":["https://orcid.org/0000-0002-6838-0180"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mariana Kruger","raw_affiliation_strings":["Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":0.5564,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.63567871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"65","issue":"4","first_page":"389","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":1.0},{"id":"https://openalex.org/keywords/hospitalized-children","display_name":"hospitalized children","score":0.9509999752044678},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.5199999809265137},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hiv-infected-children","display_name":"HIV-infected children","score":0.9549999833106995},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6200000047683716},{"id":"https://openalex.org/keywords/naranjo-probability-scale","display_name":"Naranjo probability scale","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.960789680480957},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.750458300113678},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5963702201843262},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.581238329410553},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.5328360795974731},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.48598989844322205},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.46541547775268555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44227585196495056},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29254990816116333},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007297","descriptor_name":"Inpatients","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D062606","descriptor_name":"Tertiary Care Centers","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/tropej/fmy067","doi":"https://doi.org/10.1093/tropej/fmy067","is_oa":false,"landing_page_url":"https://doi.org/10.1093/tropej/fmy067","pdf_url":null,"source":{"id":"https://openalex.org/S138039823","display_name":"Journal of Tropical Pediatrics","issn_l":"0142-6338","issn":["0142-6338","1465-3664"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tropical Pediatrics","raw_type":"journal-article"},{"id":"pmid:30544245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30544245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of tropical pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/102625","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/102625","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1514719969","https://openalex.org/W1615616856","https://openalex.org/W1765287762","https://openalex.org/W1887737698","https://openalex.org/W1928147381","https://openalex.org/W1992746042","https://openalex.org/W2013986436","https://openalex.org/W2033667161","https://openalex.org/W2044987461","https://openalex.org/W2067978628","https://openalex.org/W2073967477","https://openalex.org/W2085074082","https://openalex.org/W2086233011","https://openalex.org/W2093040387","https://openalex.org/W2115361107","https://openalex.org/W2152766444","https://openalex.org/W2153972688","https://openalex.org/W2161669645","https://openalex.org/W2289432210","https://openalex.org/W2563833043"],"related_works":["https://openalex.org/W2998538261","https://openalex.org/W6939297021","https://openalex.org/W7064558491","https://openalex.org/W3154819496","https://openalex.org/W7117455124","https://openalex.org/W3143163492","https://openalex.org/W2738876018","https://openalex.org/W4391396302","https://openalex.org/W2886849935","https://openalex.org/W2363815377"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,103,148],"prevalence":[2,20,149],"of":[3,21,80,82,86,105,112,119,130,145,150],"adverse":[4],"drug":[5],"reaction":[6],"(ADR)":[7],"rates":[8],"in":[9,11,23,30,77,101],"children":[10],"sub-Saharan":[12],"Africa":[13],"is":[14,35],"unknown.":[15],"OBJECTIVES:":[16],"To":[17],"describe":[18],"the":[19,59,68,97,106,157],"ADRs":[22,53,76,107,127,151],"paediatric":[24],"in-patients":[25],"at":[26],"a":[27,36,40],"tertiary":[28],"hospital":[29],"South":[31],"Africa.":[32],"METHODS:":[33],"This":[34],"prospective":[37],"study":[38,42],"during":[39],"3-month":[41],"period.":[43],"Data":[44],"collected":[45],"included":[46],"age,":[47],"sex,":[48],"diagnosis,":[49],"medicines":[50],"received":[51],"and":[52,64,114],"experienced.":[54],"Causality":[55],"were":[56,74,108],"assessed,":[57],"using":[58],"10-question":[60],"Naranjo":[61],"probability":[62],"scale":[63],"classified":[65],"according":[66],"to":[67],"Hartwig":[69],"severity":[70],"scale.":[71],"RESULTS:":[72],"There":[73],"61":[75],"18.4%":[78],"(52":[79],"282)":[81],"patients.":[83],"Median":[84],"age":[85],"patients":[87,123,142],"was":[88,96,152,156],"1.4":[89],"years":[90],"(interquartile":[91],"range:":[92],"0.5-5.3":[93],"years).":[94],"ADR":[95],"primary":[98],"admission":[99],"reason":[100,158],"31%.":[102],"majority":[104],"moderate":[109],"45.9%":[110],"(28":[111],"61),":[113],"only":[115],"11.5%":[116],"severe":[117],"(7":[118],"61).":[120],"Paediatric":[121],"oncology":[122],"suffered":[124],"significantly":[125],"more":[126],"(56.5%;":[128],"13":[129],"23)":[131],"[odds":[132],"ratio":[133],"7.3":[134],"(3.0-17.9),":[135],"p":[136],"<":[137],"0.01],":[138],"followed":[139],"by":[140],"HIV-infected":[141],"(42.9%;":[143],"9":[144],"21).":[146],"CONCLUSION:":[147],"18.4%,":[153],"while":[154],"31%":[155],"for":[159],"admission.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-09-05T00:00:00"}
