{"id":"https://openalex.org/W2970525739","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","title":"Association of Small Airway Epithelium Expression of Keratin 6A in COPD Smokers with SNPs in Regions Linked to Lung Cancer","display_name":"Association of Small Airway Epithelium Expression of Keratin 6A in COPD Smokers with SNPs in Regions Linked to Lung Cancer","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2970525739","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","mag":"2970525739"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B28. HOW AIRWAYS MALFUNCTION: NEW CONCEPTS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008468841","display_name":"Jacqueline Salit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Salit","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038401891","display_name":"Wu\u2010Lin Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.-L. Zuo","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067806686","display_name":"Yael Strulovici\u2010Barel","orcid":"https://orcid.org/0000-0002-3723-0008","observed_orcids":["https://orcid.org/0000-0002-3723-0008"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Strulovici-Barel","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101684704","display_name":"Matthew James Thomas","orcid":"https://orcid.org/0000-0003-3472-3904","observed_orcids":["https://orcid.org/0000-0003-3472-3904"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.J. Thomas","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081670676","display_name":"J\u00fcrgen Schymeinsky","orcid":"https://orcid.org/0000-0002-6900-2907","observed_orcids":["https://orcid.org/0000-0002-6900-2907"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Schymeinsky","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053133308","display_name":"Karsten Quast","orcid":"https://orcid.org/0000-0003-3922-5701","observed_orcids":["https://orcid.org/0000-0003-3922-5701"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Quast","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss,  Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Visvanathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Visvanathan","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019579602","display_name":"Jay S. Fine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.S. Fine","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.G. Crystal","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY, United States","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A2820","last_page":"A2820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/krt6a","display_name":"KRT6A","score":0.9729999899864197},{"id":"https://openalex.org/keywords/small-airway-epithelium","display_name":"small airway epithelium","score":0.9559999704360962},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.7409999966621399},{"id":"https://openalex.org/keywords/smokers","display_name":"smokers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lung-cancer-susceptibility","display_name":"lung cancer susceptibility","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.719558596611023},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.6814842224121094},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5685421228408813},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5318951606750488},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4425419270992279},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.43393343687057495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4276721477508545},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4269178807735443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3930268883705139},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3235577344894409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24253451824188232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22307711839675903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20973196625709534},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15940964221954346},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2820","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B28. HOW AIRWAYS MALFUNCTION: NEW CONCEPTS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2099156318","https://openalex.org/W2319304653","https://openalex.org/W2335762907","https://openalex.org/W2333930871","https://openalex.org/W2325687434","https://openalex.org/W7154463475","https://openalex.org/W4225327768","https://openalex.org/W2318006801","https://openalex.org/W2326407383","https://openalex.org/W2313788581"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-09-05T00:00:00"}