{"id":"https://openalex.org/W2970514927","doi":"https://doi.org/10.1021/acs.biochem.9b00494","title":"Structural and Functional Characterization of Dynamic Oligomerization in Burkholderia cenocepacia HMG-CoA Reductase","display_name":"Structural and Functional Characterization of Dynamic Oligomerization in Burkholderia cenocepacia HMG-CoA Reductase","publication_year":2019,"publication_date":"2019-08-30","ids":{"openalex":"https://openalex.org/W2970514927","doi":"https://doi.org/10.1021/acs.biochem.9b00494","mag":"2970514927","pmid":"https://pubmed.ncbi.nlm.nih.gov/31469273"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.9b00494","doi":"https://doi.org/10.1021/acs.biochem.9b00494","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00494","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085083469","display_name":"Riley B. Peacock","orcid":"https://orcid.org/0000-0003-1520-3532","observed_orcids":["https://orcid.org/0000-0003-1520-3532"]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riley B. Peacock","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074474780","display_name":"Chad W. Hicks","orcid":"https://orcid.org/0000-0002-6040-6227","observed_orcids":["https://orcid.org/0000-0002-6040-6227"]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad W. Hicks","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander M. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. Walker","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington 99164, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington 99164, United States","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029470919","display_name":"Sophia M. Dewing","orcid":"https://orcid.org/0000-0001-7744-4177","observed_orcids":["https://orcid.org/0000-0001-7744-4177"]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia M. Dewing","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087884831","display_name":"Kevin M. Lewis","orcid":"https://orcid.org/0000-0003-3403-9520","observed_orcids":["https://orcid.org/0000-0003-3403-9520"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Lewis","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington 99164, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington 99164, United States","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067662243","display_name":"Jean-Claude Abboud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Claude Abboud","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040657559","display_name":"Samuel W. A. Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel W. A. Stewart","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071667418","display_name":"ChulHee Kang","orcid":"https://orcid.org/0000-0002-0693-7860","observed_orcids":["https://orcid.org/0000-0002-0693-7860"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChulHee Kang","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington 99164, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington 99164, United States","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053131026","display_name":"Jeffrey M. Watson","orcid":"https://orcid.org/0000-0002-6939-0137","observed_orcids":["https://orcid.org/0000-0002-6939-0137"]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey M. Watson","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States"],"raw_orcid":"https://orcid.org/0000-0002-6939-0137","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, Washington 99258, United States","institution_ids":["https://openalex.org/I119888943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053131026"],"corresponding_institution_ids":["https://openalex.org/I119888943"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.3609,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.5025586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"38","first_page":"3960","last_page":"3970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/burkholderia-cenocepacia","display_name":"Burkholderia cenocepacia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-oligomerization","display_name":"enzyme oligomerization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/coenzyme-a-binding","display_name":"coenzyme A binding","score":0.7129999995231628},{"id":"https://openalex.org/keywords/adp-binding","display_name":"ADP binding","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2777979451","wikidata":"https://www.wikidata.org/wiki/Q4810500","display_name":"Burkholderia cenocepacia","level":4,"score":0.966086745262146},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.7116875052452087},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.6089088916778564},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5815314650535583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5693680047988892},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5551862716674805},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5397760272026062},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4813547730445862},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46376535296440125},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.45262429118156433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22348809242248535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057508","descriptor_name":"Burkholderia cenocepacia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.biochem.9b00494","doi":"https://doi.org/10.1021/acs.biochem.9b00494","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00494","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:31469273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31469273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W103141858","https://openalex.org/W1539796472","https://openalex.org/W1974220469","https://openalex.org/W1976499671","https://openalex.org/W1981860025","https://openalex.org/W1998088403","https://openalex.org/W1998333865","https://openalex.org/W2005392755","https://openalex.org/W2014444112","https://openalex.org/W2019598308","https://openalex.org/W2035503835","https://openalex.org/W2041322069","https://openalex.org/W2060049336","https://openalex.org/W2060872117","https://openalex.org/W2067425615","https://openalex.org/W2076970771","https://openalex.org/W2079762287","https://openalex.org/W2099620162","https://openalex.org/W2106049883","https://openalex.org/W2106777560","https://openalex.org/W2107290798","https://openalex.org/W2108305553","https://openalex.org/W2112940531","https://openalex.org/W2113012330","https://openalex.org/W2144081223","https://openalex.org/W2146087626","https://openalex.org/W2150981663","https://openalex.org/W2180229411","https://openalex.org/W2540602866","https://openalex.org/W2607135575","https://openalex.org/W2773975952","https://openalex.org/W2891626898","https://openalex.org/W2899799681"],"related_works":["https://openalex.org/W2911721353","https://openalex.org/W2019598308","https://openalex.org/W2131253747","https://openalex.org/W2891626898","https://openalex.org/W1509120250","https://openalex.org/W1509182641","https://openalex.org/W7025298650","https://openalex.org/W2911587116","https://openalex.org/W2107290798","https://openalex.org/W2773975952"],"abstract_inverted_index":{"The":[0],"enzyme":[1,88,109],"3-hydroxy-3-methylglutaryl":[2],"coenzyme":[3,141],"A":[4,142],"(HMG-CoA)":[5],"reductase":[6],"(HMGR),":[7],"in":[8,56,135],"most":[9],"organisms,":[10,36],"catalyzes":[11,45],"the":[12,16,22,31,38,46,57,87,92,113,118,121,128,136,153],"four-electron":[13],"reduction":[14],"of":[15,59,73,82,91,95,102,131],"thioester":[17],"(":[18,25],"S":[19],")-HMG-CoA":[20],"to":[21,68,140],"primary":[23],"alcohol":[24],"R":[26],")-mevalonate,":[27],"utilizing":[28,49],"NADPH":[29],"as":[30,52,70],"hydride":[32,54],"donor.":[33],"In":[34],"some":[35],"including":[37,104],"opportunistic":[39],"lung":[40],"pathogen":[41],"Burkholderia":[42],"cenocepacia,":[43],"it":[44],"reverse":[47],"reaction,":[48],"NAD":[50],"+":[51],"a":[53,100],"acceptor":[55],"oxidation":[58],"mevalonate.":[60],"B.":[61,132,161],"cenocepacia":[62,133,162],"HMGR":[63,134],"has":[64],"been":[65],"previously":[66],"shown":[67],"exist":[69],"an":[71],"ensemble":[72],"multiple":[74,122],"non-additive":[75],"oligomeric":[76],"states,":[77],"each":[78],"with":[79],"different":[80],"levels":[81],"enzymatic":[83],"activity,":[84],"suggesting":[85],"that":[86,111,116],"exhibits":[89,168],"characteristics":[90],"morpheein":[93],"model":[94],"allostery.":[96],"We":[97,124],"have":[98,125],"characterized":[99,166],"number":[101],"factors,":[103],"pH,":[105],"substrate":[106],"concentration,":[107,110],"and":[108,143,159],"modulate":[112],"structural":[114],"transitions":[115],"influence":[117],"interconversion":[119],"among":[120,155,165],"oligomers.":[123],"also":[126],"determined":[127],"crystal":[129],"structure":[130],"hexameric":[137,146],"state":[138],"bound":[139],"ADP.":[144],"This":[145],"assembly":[147],"provides":[148],"important":[149],"clues":[150],"about":[151],"how":[152],"transition":[154],"oligomers":[156],"might":[157],"occur,":[158],"why":[160],"HMGR,":[163],"unique":[164],"HMGRs,":[167],"morpheein-like":[169],"behavior.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-09-05T00:00:00"}
