{"id":"https://openalex.org/W2970375141","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","title":"A cis-eQTL Allele Lowering Gene Expression of CHL3L1 Is Associated with Late-Onset Adult Asthma in Japanese","display_name":"A cis-eQTL Allele Lowering Gene Expression of CHL3L1 Is Associated with Late-Onset Adult Asthma in Japanese","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2970375141","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","mag":"2970375141"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B32. ASTHMA: MECHANISMS OF DISEASE I","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082767765","display_name":"Rie Shigemasa","orcid":"https://orcid.org/0000-0003-0670-7210","observed_orcids":["https://orcid.org/0000-0003-0670-7210"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Shigemasa","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046559396","display_name":"Jun Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J. Kanazawa","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067846506","display_name":"Haruna Kitazawa","orcid":"https://orcid.org/0000-0001-7234-1275","observed_orcids":["https://orcid.org/0000-0001-7234-1275"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Kitazawa","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065562694","display_name":"Hironori Masuko","orcid":"https://orcid.org/0000-0002-5917-7973","observed_orcids":["https://orcid.org/0000-0002-5917-7973"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Masuko","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Hyodo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Hyodo","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046657844","display_name":"Yohei Yatagai","orcid":"https://orcid.org/0000-0002-4029-8222","observed_orcids":["https://orcid.org/0000-0002-4029-8222"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Yatagai","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080209460","display_name":"Tohru Sakamoto","orcid":"https://orcid.org/0000-0002-8876-1466","observed_orcids":["https://orcid.org/0000-0002-8876-1466"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Sakamoto","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Kaneko","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Iijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139719","display_name":"Tsukuba Medical Center Hospital","ror":"https://ror.org/03tjj1227","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210139719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Iijima","raw_affiliation_strings":["Tsukuba Medical Center, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Medical Center, Tsukuba,  Japan","institution_ids":["https://openalex.org/I4210139719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017887067","display_name":"Tateaki Naito","orcid":"https://orcid.org/0000-0003-4047-2929","observed_orcids":["https://orcid.org/0000-0003-4047-2929"]},"institutions":[{"id":"https://openalex.org/I4210139719","display_name":"Tsukuba Medical Center Hospital","ror":"https://ror.org/03tjj1227","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210139719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Naito","raw_affiliation_strings":["Tsukuba Medical Center, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Medical Center, Tsukuba,  Japan","institution_ids":["https://openalex.org/I4210139719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002731286","display_name":"Takefumi Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210141661","display_name":"Ibarakihigashi National Hospital","ror":"https://ror.org/040xmsv41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210141661"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Saito","raw_affiliation_strings":["National Hospital organization Ibaraki Higashi National Hospital, Tokai,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital organization Ibaraki Higashi National Hospital, Tokai,  Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210141661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048903492","display_name":"Emiko Noguchi","orcid":"https://orcid.org/0000-0001-9319-1763","observed_orcids":["https://orcid.org/0000-0001-9319-1763"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E. Noguchi","raw_affiliation_strings":["Medical Genetics, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025695892","display_name":"Satoshi Konno","orcid":"https://orcid.org/0000-0001-6439-2443","observed_orcids":["https://orcid.org/0000-0001-6439-2443"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Konno","raw_affiliation_strings":["Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081243390","display_name":"Masaharu Nishimura","orcid":"https://orcid.org/0000-0002-6456-4361","observed_orcids":["https://orcid.org/0000-0002-6456-4361"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Nishimura","raw_affiliation_strings":["Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091637","display_name":"Tomomitsu Hirota","orcid":"https://orcid.org/0009-0002-9791-2980","observed_orcids":["https://orcid.org/0009-0002-9791-2980"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Hirota","raw_affiliation_strings":["Research Center for Medical Science, The Jikei University School of  Medicine, Tokyo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Medical Science, The Jikei University School of  Medicine, Tokyo,  Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026942255","display_name":"Mayumi Tamari","orcid":"https://orcid.org/0000-0002-5755-9177","observed_orcids":["https://orcid.org/0000-0002-5755-9177"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Tamari","raw_affiliation_strings":["Research Center for Medical Science, The Jikei University School of  Medicine, Tokyo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Medical Science, The Jikei University School of  Medicine, Tokyo,  Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113054260","display_name":"N. Hizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Hizawa","raw_affiliation_strings":["Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, University of Tsukuba, Tsukuba,  Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A2930","last_page":"A2930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.25459998846054077,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cis-eqtl","display_name":"cis-eQTL","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/asthma-susceptibility","display_name":"asthma susceptibility","score":0.675000011920929},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6759999990463257},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.7980701327323914},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7567276954650879},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5939639806747437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5449270009994507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4865521490573883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40234532952308655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3340255320072174},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1448718011379242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14107534289360046},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1371380090713501}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2930","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B32. ASTHMA: MECHANISMS OF DISEASE I","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944297063","https://openalex.org/W3166267119","https://openalex.org/W2317363916","https://openalex.org/W2022253361","https://openalex.org/W2227954494","https://openalex.org/W2143078461","https://openalex.org/W2959068529","https://openalex.org/W4220955599","https://openalex.org/W2936870614","https://openalex.org/W3130761703"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-05T00:00:00"}