{"id":"https://openalex.org/W2970349059","doi":"https://doi.org/10.1200/po.19.00103","title":"Endometrial Cancers in BRCA1 or BRCA2 Germline Mutation Carriers: Assessment of Homologous Recombination DNA Repair Defects","display_name":"Endometrial Cancers in BRCA1 or BRCA2 Germline Mutation Carriers: Assessment of Homologous Recombination DNA Repair Defects","publication_year":2019,"publication_date":"2019-08-29","ids":{"openalex":"https://openalex.org/W2970349059","doi":"https://doi.org/10.1200/po.19.00103","mag":"2970349059","pmid":"https://pubmed.ncbi.nlm.nih.gov/32914019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7446423"},"language":"en","primary_location":{"id":"doi:10.1200/po.19.00103","doi":"https://doi.org/10.1200/po.19.00103","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.19.00103","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7446423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101100015","display_name":"Evan S. Smith","orcid":"https://orcid.org/0009-0004-6863-9123","observed_orcids":["https://orcid.org/0009-0004-6863-9123"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan S. Smith","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072735395","display_name":"Arnaud Da Cruz Paula","orcid":"https://orcid.org/0000-0001-7694-8760","observed_orcids":["https://orcid.org/0000-0001-7694-8760"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnaud Da Cruz Paula","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050336579","display_name":"Karen Anne Cadoo","orcid":"https://orcid.org/0000-0002-8384-7148","observed_orcids":["https://orcid.org/0000-0002-8384-7148"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen A. Cadoo","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002011120","display_name":"Nadeem R. Abu\u2010Rustum","orcid":"https://orcid.org/0000-0001-9689-1298","observed_orcids":["https://orcid.org/0000-0001-9689-1298"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadeem R. Abu-Rustum","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103214291","display_name":"Xin Pei","orcid":"https://orcid.org/0000-0001-9961-6152","observed_orcids":["https://orcid.org/0000-0001-9961-6152"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Pei","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047642576","display_name":"David N. Brown","orcid":"https://orcid.org/0000-0002-8249-3632","observed_orcids":["https://orcid.org/0000-0002-8249-3632"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N. Brown","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000177956","display_name":"Lorenzo Ferrando","orcid":"https://orcid.org/0000-0002-4025-7930","observed_orcids":["https://orcid.org/0000-0002-4025-7930"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Lorenzo Ferrando","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY","University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084952201","display_name":"Ana Paula Martins Sebasti\u00e3o","orcid":"https://orcid.org/0000-0002-2993-577X","observed_orcids":["https://orcid.org/0000-0002-2993-577X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Paula Martins Sebastiao","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027048828","display_name":"Nadeem Riaz","orcid":"https://orcid.org/0000-0001-9873-5862","observed_orcids":["https://orcid.org/0000-0001-9873-5862"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadeem Riaz","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045514288","display_name":"Mark E. Robson","orcid":"https://orcid.org/0000-0002-3109-1692","observed_orcids":["https://orcid.org/0000-0002-3109-1692"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Robson","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053542215","display_name":"Robert A. Soslow","orcid":"https://orcid.org/0000-0002-7269-5898","observed_orcids":["https://orcid.org/0000-0002-7269-5898"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Soslow","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077235697","display_name":"Jorge Sergio Reis-Filho","orcid":"https://orcid.org/0000-0003-2969-3173","observed_orcids":["https://orcid.org/0000-0003-2969-3173"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge S. Reis-Filho","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062778506","display_name":"Diana L. Mandelker","orcid":"https://orcid.org/0000-0003-4154-0567","observed_orcids":["https://orcid.org/0000-0003-4154-0567"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Mandelker","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britta Weigelt","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3663,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.88881757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":1.0},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/germline-mutation-carriers","display_name":"germline mutation carriers","score":0.8769999742507935},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9150000214576721},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mlh1-promoter-methylation","display_name":"MLH1 promoter methylation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7204368114471436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6943777203559875},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.614289402961731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6026636958122253},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.529033362865448},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5229976177215576},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.5093203783035278},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5046447515487671},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46578091382980347},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.44638654589653015},{"id":"https://openalex.org/C2909462720","wikidata":"https://www.wikidata.org/wiki/Q421651","display_name":"BRCA2 Protein","level":5,"score":0.4269505441188812},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.39381977915763855},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3103991150856018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.265759140253067},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.20009157061576843},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.1574244201183319},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1505570113658905}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1200/po.19.00103","doi":"https://doi.org/10.1200/po.19.00103","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.19.00103","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7446423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7446423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},{"id":"pmid:32914019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32914019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:unige.iris.cineca.it:11567/1121317","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/1121317","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7446423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7446423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000856337","display_name":"Clinical Scholars Biomedical Research Training Program","funder_award_id":"T32CA009512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1489710007","https://openalex.org/W1548784819","https://openalex.org/W1926715094","https://openalex.org/W1991396678","https://openalex.org/W2011575493","https://openalex.org/W2028588553","https://openalex.org/W2033713913","https://openalex.org/W2041440766","https://openalex.org/W2051978340","https://openalex.org/W2054069333","https://openalex.org/W2062568878","https://openalex.org/W2063110349","https://openalex.org/W2087025655","https://openalex.org/W2088989339","https://openalex.org/W2106157865","https://openalex.org/W2117564738","https://openalex.org/W2147629880","https://openalex.org/W2170490448","https://openalex.org/W2204191358","https://openalex.org/W2227934581","https://openalex.org/W2276335691","https://openalex.org/W2346356080","https://openalex.org/W2405513305","https://openalex.org/W2417035249","https://openalex.org/W2466624553","https://openalex.org/W2531124377","https://openalex.org/W2559289379","https://openalex.org/W2596164112","https://openalex.org/W2613362156","https://openalex.org/W2621170119","https://openalex.org/W2748606465","https://openalex.org/W2753565653","https://openalex.org/W2763584377","https://openalex.org/W2764165143","https://openalex.org/W2764292139","https://openalex.org/W2773354488","https://openalex.org/W2788045273","https://openalex.org/W2796208126","https://openalex.org/W2796408191","https://openalex.org/W2801029282","https://openalex.org/W2900288204","https://openalex.org/W2902886329","https://openalex.org/W2909941416","https://openalex.org/W2939332654","https://openalex.org/W4211042604"],"related_works":["https://openalex.org/W2947199984","https://openalex.org/W2954281033","https://openalex.org/W3121826978","https://openalex.org/W4403488019","https://openalex.org/W1973188720","https://openalex.org/W7125685914","https://openalex.org/W2971477415","https://openalex.org/W3133959868","https://openalex.org/W7009964037","https://openalex.org/W3112730709"],"abstract_inverted_index":{"PURPOSE":[0],"Endometrial":[1],"cancer":[2,15],"(EC)":[3],"is":[4],"not":[5,213],"considered":[6],"a":[7,200,249],"component":[8],"of":[9,36,61,124,170,172,203,258,269],"the":[10,137,173,232],"hereditary":[11],"breast":[12],"and":[13,82,85,129,150,158,165,191,231,266,287,291],"ovarian":[14],"syndrome":[16],"but":[17,212],"can":[18],"arise":[19],"in":[20,43,51,106,208,226,280],"patients":[21,66,139],"with":[22,33,67,210,240],"germline":[23,71],"BRCA1/2":[24,29,53,77,215,229,264],"(g":[25],"BRCA1/2)":[26],"mutations.":[27,155,181],"Biallelic":[28],"alterations":[30,58,167,243,265],"are":[31],"associated":[32],"genomic":[34,130,201,267],"features":[35,60,132,268],"homologous":[37,275],"recombination":[38],"DNA":[39,87],"repair":[40],"deficiency":[41],"(HRD)":[42],"cancer.":[44],"We":[45],"sought":[46],"to":[47,90,110,245],"determine":[48],"if":[49],"ECs":[50,103,108,161,177,209,234,261,279],"g":[52,76,101,147,153,184,228,259],"mutation":[54,78,282],"carriers":[55,79,283],"harbor":[56,262],"biallelic":[57,163,227,242,263],"and/or":[59],"HRD.":[62],"METHODS":[63],"Of":[64,136],"769":[65],"EC":[68,186],"who":[69,141],"underwent":[70],"panel":[72],"testing,":[73],"10":[74],"pathogenic":[75,146],"were":[80,104,133,205],"identified,":[81],"their":[83],"tumor-":[84],"normal-derived":[86],"was":[88,192,224],"subjected":[89,109,244],"massively":[91],"parallel":[92],"sequencing":[93,112,247],"targeting":[94],"at":[95],"least":[96],"410":[97],"cancer-related":[98],"genes.":[99],"Three":[100],"BRCA1/2-associated":[102,260],"identified":[105],"232":[107],"whole-exome":[111,246],"by":[113],"The":[114,217,236],"Cancer":[115,237],"Genome":[116,238],"Atlas.":[117],"Somatic":[118],"mutations,":[119],"copy":[120],"number":[121],"alterations,":[122],"loss":[123,169],"heterozygosity,":[125],"microsatellite":[126],"instability":[127],"(MSI),":[128],"HRD":[131,221],"assessed.":[134],"RESULTS":[135],"13":[138],"included":[140],"had":[142,187],"EC,":[143],"eight":[144],"harbored":[145,152,162,178],"BRCA1":[148,164,241],"mutations":[149],"five":[151],"BRCA2":[154,166,281],"Eight":[156],"(100%)":[157],"two":[159],"(40%)":[160],"through":[168],"heterozygosity":[171],"wild-type":[174],"allele.":[175],"All":[176],"somatic":[179],"TP53":[180],"One":[182],"monoallelic/sporadic":[183],"BRCA2-associated":[185],"MLH1":[188],"promoter":[189],"methylation":[190],"MSI":[193,289],"high.":[194],"High":[195],"large-scale":[196],"state":[197],"transition":[198],"scores,":[199],"feature":[202],"HRD,":[204,270],"found":[206],"only":[207],"bi-":[211],"monoallelic":[214],"alterations.":[216],"Signature":[218],"Multivariate":[219],"Analysis":[220],"signature":[222,253],"Sig3":[223],"enriched":[225],"ECs,":[230],"three":[233],"from":[235,274,295],"Atlas":[239],"displayed":[248],"dominant":[250],"HRD-related":[251],"mutational":[252],"3.":[254],"CONCLUSION":[255],"A":[256],"subset":[257],"which":[271],"may":[272,292],"benefit":[273,294],"recombination\u2013directed":[276],"treatment":[277],"regimens.":[278],"might":[284],"be":[285],"sporadic":[286],"even":[288],"high,":[290],"potentially":[293],"immune-checkpoint":[296],"inhibition.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-09-05T00:00:00"}