{"id":"https://openalex.org/W2970307652","doi":"https://doi.org/10.1002/aic.16776","title":"Beyond function: Engineering improved peptides for therapeutic applications","display_name":"Beyond function: Engineering improved peptides for therapeutic applications","publication_year":2019,"publication_date":"2019-08-30","ids":{"openalex":"https://openalex.org/W2970307652","doi":"https://doi.org/10.1002/aic.16776","mag":"2970307652"},"language":"en","primary_location":{"id":"doi:10.1002/aic.16776","doi":"https://doi.org/10.1002/aic.16776","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aic.16776","pdf_url":null,"source":{"id":"https://openalex.org/S147177414","display_name":"AIChE Journal","issn_l":"0001-1541","issn":["0001-1541","1547-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIChE Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058688282","display_name":"Sayanee Adhikari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayanee Adhikari","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083254375","display_name":"Jesse A. Leissa","orcid":"https://orcid.org/0000-0001-8831-8934","observed_orcids":["https://orcid.org/0000-0001-8831-8934"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse A. Leissa","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053412329","display_name":"Amy J. Karlsson","orcid":"https://orcid.org/0000-0002-9962-925X","observed_orcids":["https://orcid.org/0000-0002-9962-925X"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy J. Karlsson","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland","Fischell Department of Bioengineering, University of Maryland, College Park, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-9962-925X","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Fischell Department of Bioengineering, University of Maryland, College Park, Maryland","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053412329"],"corresponding_institution_ids":["https://openalex.org/I66946132"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.9096,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71513504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"66","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/peptide-engineering","display_name":"peptide engineering","score":0.8690000176429749},{"id":"https://openalex.org/keywords/rational-design","display_name":"rational design","score":0.7739999890327454},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.9990000128746033},{"id":"https://openalex.org/keywords/computational-design","display_name":"computational design","score":0.5109999775886536},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.6579999923706055},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.968999981880188},{"id":"https://openalex.org/keywords/proteolytic-stability","display_name":"proteolytic stability","score":0.9710000157356262},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/binding-specificity","display_name":"binding specificity","score":0.871999979019165},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.6649067401885986},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5694594383239746},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48647329211235046},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45860040187835693},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4514254629611969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4234265983104706},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.41809168457984924},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35102489590644836},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3299514651298523},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.30230721831321716},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.26976537704467773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26131418347358704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21806728839874268},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19783523678779602},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13038423657417297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07534044981002808}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/aic.16776","doi":"https://doi.org/10.1002/aic.16776","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aic.16776","pdf_url":null,"source":{"id":"https://openalex.org/S147177414","display_name":"AIChE Journal","issn_l":"0001-1541","issn":["0001-1541","1547-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIChE Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4066692820","display_name":null,"funder_award_id":"1511718","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W250970305","https://openalex.org/W570881241","https://openalex.org/W1885513900","https://openalex.org/W1907174433","https://openalex.org/W1908459048","https://openalex.org/W1963826185","https://openalex.org/W1964958576","https://openalex.org/W1968280815","https://openalex.org/W1974456685","https://openalex.org/W1979159575","https://openalex.org/W1979325667","https://openalex.org/W1985718285","https://openalex.org/W1985718949","https://openalex.org/W1986099885","https://openalex.org/W1987489304","https://openalex.org/W1990557050","https://openalex.org/W1990789777","https://openalex.org/W1992349385","https://openalex.org/W1992450378","https://openalex.org/W2000316834","https://openalex.org/W2007109740","https://openalex.org/W2014059004","https://openalex.org/W2022951267","https://openalex.org/W2023084240","https://openalex.org/W2025329055","https://openalex.org/W2027047097","https://openalex.org/W2027665553","https://openalex.org/W2028113659","https://openalex.org/W2029758652","https://openalex.org/W2032904922","https://openalex.org/W2034265369","https://openalex.org/W2034883412","https://openalex.org/W2036698204","https://openalex.org/W2037993661","https://openalex.org/W2042181696","https://openalex.org/W2044573804","https://openalex.org/W2044597283","https://openalex.org/W2046319392","https://openalex.org/W2048322056","https://openalex.org/W2050139756","https://openalex.org/W2050466522","https://openalex.org/W2057632290","https://openalex.org/W2061005802","https://openalex.org/W2063937171","https://openalex.org/W2070360032","https://openalex.org/W2071039565","https://openalex.org/W2072959841","https://openalex.org/W2076339383","https://openalex.org/W2077643998","https://openalex.org/W2082432950","https://openalex.org/W2084119008","https://openalex.org/W2087972722","https://openalex.org/W2088877201","https://openalex.org/W2091245340","https://openalex.org/W2092845657","https://openalex.org/W2093619322","https://openalex.org/W2100542975","https://openalex.org/W2103385859","https://openalex.org/W2108364209","https://openalex.org/W2117767830","https://openalex.org/W2119452210","https://openalex.org/W2120216126","https://openalex.org/W2123542377","https://openalex.org/W2123687265","https://openalex.org/W2131701729","https://openalex.org/W2137959581","https://openalex.org/W2143678630","https://openalex.org/W2148612893","https://openalex.org/W2153133904","https://openalex.org/W2155387120","https://openalex.org/W2166085772","https://openalex.org/W2169868793","https://openalex.org/W2170551524","https://openalex.org/W2175687390","https://openalex.org/W2183464285","https://openalex.org/W2196763066","https://openalex.org/W2211918045","https://openalex.org/W2264058135","https://openalex.org/W2283234806","https://openalex.org/W2290716277","https://openalex.org/W2294780803","https://openalex.org/W2298183398","https://openalex.org/W2403862021","https://openalex.org/W2406203201","https://openalex.org/W2427197815","https://openalex.org/W2434992191","https://openalex.org/W2553977609","https://openalex.org/W2556148213","https://openalex.org/W2583666712","https://openalex.org/W2593483585","https://openalex.org/W2595654377","https://openalex.org/W2601440627","https://openalex.org/W2604779599","https://openalex.org/W2607678445","https://openalex.org/W2626639854","https://openalex.org/W2654516686","https://openalex.org/W2724823461","https://openalex.org/W2725935952","https://openalex.org/W2765546463","https://openalex.org/W2770351712","https://openalex.org/W2892617128","https://openalex.org/W2893520080","https://openalex.org/W2897495955","https://openalex.org/W2898968827","https://openalex.org/W2901993470","https://openalex.org/W2912168115","https://openalex.org/W2981416314"],"related_works":["https://openalex.org/W7207657250","https://openalex.org/W4414965924","https://openalex.org/W2167191424","https://openalex.org/W7166844263","https://openalex.org/W2785250581","https://openalex.org/W7216381712","https://openalex.org/W4391886538","https://openalex.org/W4403077690","https://openalex.org/W2157595073","https://openalex.org/W1930414632"],"abstract_inverted_index":{"Abstract":[0],"Peptides":[1],"are":[2],"a":[3,69,90],"promising":[4],"source":[5],"of":[6,13,36,64,71,86],"new":[7],"therapeutics,":[8],"but":[9],"the":[10,34,62,73],"biophysical":[11],"characteristics":[12,63],"natural":[14],"peptides,":[15,87],"including":[16],"their":[17,25],"stability":[18],"and":[19,50,53,81,84],"propensity":[20],"to":[21,32,60],"aggregate,":[22],"can":[23,57],"limit":[24],"success.":[26],"Protein":[27],"engineering":[28,72,96],"offers":[29],"powerful":[30],"tools":[31],"improve":[33],"properties":[35],"peptides":[37],"for":[38],"biological":[39],"applications.":[40],"In":[41],"this":[42],"review,":[43],"we":[44],"explain":[45],"rational":[46],"design,":[47],"directed":[48],"evolution,":[49],"computational":[51],"methods":[52,56],"how":[54],"these":[55],"be":[58],"applied":[59],"improving":[61],"peptides.":[65,98],"We":[66],"also":[67],"provide":[68],"discussion":[70],"thermodynamic":[74],"stability,":[75,80],"self\u2010assembly,":[76],"reduced":[77],"aggregation,":[78],"proteolytic":[79],"binding":[82],"affinity":[83],"specificity":[85],"along":[88],"with":[89],"perspective":[91],"on":[92],"future":[93],"directions":[94],"in":[95],"therapeutic":[97]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-09-05T00:00:00"}