{"id":"https://openalex.org/W2970256231","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","title":"Senolytics in Idiopathic Pulmonary Fibrosis: Preliminary Results from a First-in-Human, Open-Label, Pilot Study","display_name":"Senolytics in Idiopathic Pulmonary Fibrosis: Preliminary Results from a First-in-Human, Open-Label, Pilot Study","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2970256231","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","mag":"2970256231"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B17. ADVANCES IN ILD THERAPY","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061287912","display_name":"Anoop M. Nambiar","orcid":"https://orcid.org/0000-0003-2778-0433","observed_orcids":["https://orcid.org/0000-0003-2778-0433"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. Nambiar","raw_affiliation_strings":["Division of Pulmonary &amp; Critical Care, Department of Medicine, University of Texas Health San Antonio and South Texas Veterans Health Care System, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary &amp; Critical Care, Department of Medicine, University of Texas Health San Antonio and South Texas Veterans Health Care System, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4210144081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019907813","display_name":"Jamie Nicole Justice","orcid":"https://orcid.org/0000-0003-2953-4404","observed_orcids":["https://orcid.org/0000-0003-2953-4404"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.N. Justice","raw_affiliation_strings":["Sticht Center for Healthy Aging &amp; Alzheimer's Prevention, Internal Medicine-Gerontology &amp; Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sticht Center for Healthy Aging &amp; Alzheimer's Prevention, Internal Medicine-Gerontology &amp; Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111927058","display_name":"Rodolfo M. Pascual","orcid":"https://orcid.org/0009-0007-2049-3278","observed_orcids":["https://orcid.org/0009-0007-2049-3278"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Pascual","raw_affiliation_strings":["Internal Medicine \u2013 Pulmonary, Critical Care, Allergy, Immunologic Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine \u2013 Pulmonary, Critical Care, Allergy, Immunologic Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043033429","display_name":"Shahrukh Khurshid Hashmi","orcid":"https://orcid.org/0000-0002-8914-7927","observed_orcids":["https://orcid.org/0000-0002-8914-7927"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.K. Hashmi","raw_affiliation_strings":["Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034798967","display_name":"Tamar Tchkonia","orcid":"https://orcid.org/0000-0003-4623-7145","observed_orcids":["https://orcid.org/0000-0003-4623-7145"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Tchkonia","raw_affiliation_strings":["Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014342029","display_name":"Nathan K. LeBrasseur","orcid":"https://orcid.org/0000-0002-2002-0418","observed_orcids":["https://orcid.org/0000-0002-2002-0418"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.K. LeBrasseur","raw_affiliation_strings":["Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009102749","display_name":"James L. Kirkland","orcid":"https://orcid.org/0000-0003-1676-4905","observed_orcids":["https://orcid.org/0000-0003-1676-4905"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.L. Kirkland","raw_affiliation_strings":["Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Senescence Program, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034471398","display_name":"Nicolas Musi","orcid":"https://orcid.org/0000-0003-4242-2888","observed_orcids":["https://orcid.org/0000-0003-4242-2888","https://orcid.org/0009-0004-4063-9041"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Musi","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, Center for Healthy Aging, University of Texas Health San Antonio and South Texas Veterans Health Care System, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, Center for Healthy Aging, University of Texas Health San Antonio and South Texas Veterans Health Care System, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4210144081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089876350","display_name":"Stephen B. Kritchevsky","orcid":"https://orcid.org/0000-0003-3336-6781","observed_orcids":["https://orcid.org/0000-0003-3336-6781"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.B. Kritchevsky","raw_affiliation_strings":["Sticht Center for Healthy Aging &amp; Alzheimer's Prevention, Internal Medicine-Gerontology &amp; Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sticht Center for Healthy Aging &amp; Alzheimer's Prevention, Internal Medicine-Gerontology &amp; Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A2639","last_page":"A2639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.996999979019165},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/open-label-pilot-study","display_name":"open-label pilot study","score":0.8090000152587891},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.37299999594688416},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5315769910812378},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.473135381937027},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44177788496017456},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.4206762909889221},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3361637592315674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24906358122825623},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2184079885482788}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","doi":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2639","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B17. ADVANCES IN ILD THERAPY","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225327787","https://openalex.org/W2906721882","https://openalex.org/W4322490917","https://openalex.org/W3025083407","https://openalex.org/W2892364204","https://openalex.org/W2970361431","https://openalex.org/W4367606347","https://openalex.org/W3041600585","https://openalex.org/W2991564211","https://openalex.org/W2971163678"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-09-05T00:00:00"}
