{"id":"https://openalex.org/W2969989336","doi":"https://doi.org/10.31557/apjcp.2019.20.7.2153","title":"Polymorphisms of XRCC3 and XRCC7 and Colorectal Cancer Risk in Khorasan Razavi Province, Iran","display_name":"Polymorphisms of XRCC3 and XRCC7 and Colorectal Cancer Risk in Khorasan Razavi Province, Iran","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2969989336","doi":"https://doi.org/10.31557/apjcp.2019.20.7.2153","mag":"2969989336","pmid":"https://pubmed.ncbi.nlm.nih.gov/31350979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6745221"},"language":"en","primary_location":{"id":"doi:10.31557/apjcp.2019.20.7.2153","doi":"https://doi.org/10.31557/apjcp.2019.20.7.2153","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2019.20.7.2153","pdf_url":"http://journal.waocp.org/article_88653_dbe767df97bbe17debce1d5d5bb14f87.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://journal.waocp.org/article_88653_dbe767df97bbe17debce1d5d5bb14f87.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065866917","display_name":"Jamshid Mehrzad","orcid":"https://orcid.org/0000-0001-8700-3914","observed_orcids":["https://orcid.org/0000-0001-8700-3914"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Jamshid Mehrzad","raw_affiliation_strings":["Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran. Email: mehrzadjam@yahoo.com","Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran. Email: mehrzadjam@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110943564","display_name":"Mahdieh Dayyani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahdieh Dayyani","raw_affiliation_strings":["Department of Radiation Oncology, Reza Radiotherapy Oncology Center, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Reza Radiotherapy Oncology Center, Mashhad, Iran","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042200093","display_name":"Mohammadreza Erfanian-Korasani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I4210113978","display_name":"Islamic Azad University of Nishapur","ror":"https://ror.org/029rt7q74","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210113978"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammadreza Erfanian Khorasani","raw_affiliation_strings":["Department of Biotechnology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I4210113978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065866917"],"corresponding_institution_ids":["https://openalex.org/I110525433"],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.4706,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67194102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"20","issue":"7","first_page":"2153","last_page":"2158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/xrcc3","display_name":"XRCC3","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.7139999866485596},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8320000171661377},{"id":"https://openalex.org/keywords/razavi-khorasan-province","display_name":"Khorasan Razavi Province","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C2779755913","wikidata":"https://www.wikidata.org/wiki/Q18032395","display_name":"XRCC3","level":5,"score":0.9217052459716797},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.804938793182373},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7194969654083252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6222593784332275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49940013885498047},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42953944206237793},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.42723894119262695},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3865049481391907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3566354811191559},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3066178858280182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3060004413127899},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3033539950847626},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.16059231758117676},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051747","descriptor_name":"DNA-Activated Protein Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.31557/apjcp.2019.20.7.2153","doi":"https://doi.org/10.31557/apjcp.2019.20.7.2153","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2019.20.7.2153","pdf_url":"http://journal.waocp.org/article_88653_dbe767df97bbe17debce1d5d5bb14f87.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6745221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6745221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"},{"id":"pmid:31350979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31350979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.31557/apjcp.2019.20.7.2153","doi":"https://doi.org/10.31557/apjcp.2019.20.7.2153","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2019.20.7.2153","pdf_url":"http://journal.waocp.org/article_88653_dbe767df97bbe17debce1d5d5bb14f87.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969989336.pdf","grobid_xml":"https://content.openalex.org/works/W2969989336.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2009243321","https://openalex.org/W2014589422","https://openalex.org/W2023106016","https://openalex.org/W2027189919","https://openalex.org/W2035088189","https://openalex.org/W2046458419","https://openalex.org/W2047717400","https://openalex.org/W2066583644","https://openalex.org/W2088865756","https://openalex.org/W2095247019","https://openalex.org/W2095761412","https://openalex.org/W2097791641","https://openalex.org/W2100343950","https://openalex.org/W2118391523","https://openalex.org/W2119274866","https://openalex.org/W2119963439","https://openalex.org/W2120491838","https://openalex.org/W2121463566","https://openalex.org/W2129499391","https://openalex.org/W2132580914","https://openalex.org/W2150368211","https://openalex.org/W2160771966","https://openalex.org/W2163649532","https://openalex.org/W2167858141","https://openalex.org/W2230978303","https://openalex.org/W2291559162","https://openalex.org/W2418747592","https://openalex.org/W2792615672","https://openalex.org/W2799794864","https://openalex.org/W2887135816","https://openalex.org/W2891507647"],"related_works":["https://openalex.org/W2118391523","https://openalex.org/W7070723587","https://openalex.org/W2179689430","https://openalex.org/W2160771966","https://openalex.org/W2047938497","https://openalex.org/W1969880267","https://openalex.org/W2001391041","https://openalex.org/W4406924239","https://openalex.org/W4387333726","https://openalex.org/W2095247019"],"abstract_inverted_index":{"Background:":[0],"Colorectal":[1],"cancer":[2],"(CRC)":[3],"is":[4],"highly":[5],"prevalent":[6],"cancer,":[7],"which":[8],"should":[9,183],"be":[10,85,184],"genetically":[11],"studied":[12,160],"among":[13],"different":[14],"peoples":[15],"of":[16,22,30,80,108,155,157,173],"the":[17,28,36,96,106,109,126,136,153,158,168],"world.":[18],"Objective:":[19],"The":[20,78],"aim":[21],"this":[23,54],"study":[24],"was":[25,82,115,148],"to":[26,84,125],"evaluate":[27],"effect":[29],"XRCC3T241M,":[31],"XRCC3":[32,91,137],"A17893G":[33,138],"and,":[34],"for":[35],"first":[37],"time,":[38],"XRCC7":[39,110,176],"I3434T":[40,111],"polymorphisms":[41,161],"on":[42],"CRC":[43,60,81,113,169,181],"risk":[44,114,188],"in":[45,88,95,120,167,180],"Khorasan":[46],"Razavi":[47],"Province,":[48],"Iran.":[49],"Materials":[50],"and":[51,61,64,75,164,175,182],"Methods:":[52],"In":[53,105,145],"case-control":[55],"study,":[56],"180":[57],"patients":[58],"with":[59,143,162],"160":[62],"sex-":[63],"age-matched":[65],"healthy":[66],"controls":[67],"were":[68,71],"studied.":[69],"Genotypes":[70],"determined":[72],"by":[73],"RFLP-PCR":[74],"ARMS-PCR.":[76],"Results:":[77],"incidence":[79],"observed":[83],"significantly":[86,116],"more":[87],"a":[89,187],"heterozygous":[90],"C/T":[92],"genotype":[93,98,128],"than":[94],"CC":[97],"(OR":[99,129],"2.210,":[100],"95%":[101,131],"CI":[102,132],"1.073-4.548,":[103],"p=0.030).":[104],"case":[107],"polymorphism,":[112],"(4.3":[117],"fold)":[118],"higher":[119],"I/T+T/T":[121],"variant":[122],"subjects":[123],"compared":[124],"I/I":[127],"4.394,":[130],"2.721-7.096,":[133],"p=0.000).":[134],"Moreover,":[135],"polymorphism":[139],"did":[140],"not":[141],"correlate":[142],"CRC.":[144],"addition,":[146],"there":[147],"no":[149],"significant":[150],"difference":[151],"between":[152],"distribution":[154],"genotypes":[156],"three":[159],"demographic":[163],"clinicopathological":[165],"features":[166],"patients.":[170],"Conclusion:":[171],"Polymorphisms":[172],"XRRC3":[174],"genes":[177],"are":[178],"involved":[179],"considered":[185],"as":[186],"factor.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-29T00:00:00"}