{"id":"https://openalex.org/W2969979878","doi":"https://doi.org/10.2174/1871520619666190820151043","title":"Pyrrolo[1,2-a]azepines Coupled with Benzothiazole and Fluorinated Aryl Thiourea Scaffolds as Promising Antioxidant and Anticancer Agents","display_name":"Pyrrolo[1,2-a]azepines Coupled with Benzothiazole and Fluorinated Aryl Thiourea Scaffolds as Promising Antioxidant and Anticancer Agents","publication_year":2019,"publication_date":"2019-01-10","ids":{"openalex":"https://openalex.org/W2969979878","doi":"https://doi.org/10.2174/1871520619666190820151043","mag":"2969979878","pmid":"https://pubmed.ncbi.nlm.nih.gov/31429695"},"language":"en","primary_location":{"id":"doi:10.2174/1871520619666190820151043","doi":"https://doi.org/10.2174/1871520619666190820151043","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871520619666190820151043","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081050736","display_name":"Rahul V. Patel","orcid":"https://orcid.org/0000-0003-1586-5595","observed_orcids":["https://orcid.org/0000-0003-1586-5595"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Rahul V. Patel","raw_affiliation_strings":["Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1586-5595","affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038711115","display_name":"Bhupendra M. Mistry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bhupendra M. Mistry","raw_affiliation_strings":["Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101162355","display_name":"Riyaz Syed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Riyaz Syed","raw_affiliation_strings":["Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 085, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 085, India","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076135990","display_name":"Nikhil M. Parekh","orcid":"https://orcid.org/0009-0008-1641-9267","observed_orcids":["https://orcid.org/0009-0008-1641-9267"]},"institutions":[{"id":"https://openalex.org/I4405269504","display_name":"Shroff S.R. Rotary Institute of Chemical Technology","ror":"https://ror.org/04cgps432","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405269504"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nikhil M. Parekh","raw_affiliation_strings":["Shroff S.R. Rotary Institute of Chemical Technology, Valia 393 135, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shroff S.R. Rotary Institute of Chemical Technology, Valia 393 135, India","institution_ids":["https://openalex.org/I4405269504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046604727","display_name":"Han\u2010Seung Shin","orcid":"https://orcid.org/0000-0001-6061-5988","observed_orcids":["https://orcid.org/0000-0001-6061-5988"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Han-Seung Shin","raw_affiliation_strings":["Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyenggi-do, 410820, Korea","institution_ids":["https://openalex.org/I205490536"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046604727","https://openalex.org/A5081050736"],"corresponding_institution_ids":["https://openalex.org/I205490536"],"apc_list":null,"apc_paid":null,"fwci":0.3725,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.41139457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"19","issue":"15","first_page":"1855","last_page":"1862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzothiazole","display_name":"benzothiazole","score":0.9100000262260437},{"id":"https://openalex.org/keywords/heterocyclic-derivatives","display_name":"heterocyclic derivatives","score":0.7490000128746033},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2777456753","wikidata":"https://www.wikidata.org/wiki/Q419096","display_name":"Benzothiazole","level":2,"score":0.8548511266708374},{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.8016986846923828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6904535293579102},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5977915525436401},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.5449811220169067},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.48683232069015503},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.486752986907959},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.43442755937576294},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4235073924064636},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41578930616378784},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37065643072128296},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3488498330116272},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3248278796672821},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.25456976890563965},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2372068166732788},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20065158605575562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.178018718957901},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.16121318936347961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09318426251411438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1871520619666190820151043","doi":"https://doi.org/10.2174/1871520619666190820151043","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871520619666190820151043","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:31429695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31429695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2680359125","display_name":null,"funder_award_id":"(13(8906-A)/2017-pool)","funder_id":"https://openalex.org/F4320327556","funder_display_name":"CSIR - Indian Institute of Chemical Biology"},{"id":"https://openalex.org/G4675430665","display_name":null,"funder_award_id":"(research funds 2018-2019)","funder_id":"https://openalex.org/F4320321213","funder_display_name":"Dongguk University"}],"funders":[{"id":"https://openalex.org/F4320321213","display_name":"Dongguk University","ror":"https://ror.org/057q6n778"},{"id":"https://openalex.org/F4320327556","display_name":"CSIR - Indian Institute of Chemical Biology","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W294343711","https://openalex.org/W1661727823","https://openalex.org/W1763830919","https://openalex.org/W1925147343","https://openalex.org/W1974671081","https://openalex.org/W1984042925","https://openalex.org/W2012991711","https://openalex.org/W2042270035","https://openalex.org/W2042755027","https://openalex.org/W2062877698","https://openalex.org/W2065331068","https://openalex.org/W2065853716","https://openalex.org/W2068594750","https://openalex.org/W2074926529","https://openalex.org/W2078409561","https://openalex.org/W2084427829","https://openalex.org/W2088791119","https://openalex.org/W2108291259","https://openalex.org/W2131898720","https://openalex.org/W2136600532","https://openalex.org/W2214639019","https://openalex.org/W2255363071","https://openalex.org/W2264719596","https://openalex.org/W2314317208","https://openalex.org/W2316203962","https://openalex.org/W2319092684","https://openalex.org/W2460398614","https://openalex.org/W2555213724","https://openalex.org/W2760663859","https://openalex.org/W2781525129"],"related_works":["https://openalex.org/W2765452047","https://openalex.org/W2945028567","https://openalex.org/W2179739405","https://openalex.org/W4317929739","https://openalex.org/W2004592535","https://openalex.org/W2585684341","https://openalex.org/W2335435211","https://openalex.org/W4387241597","https://openalex.org/W2007155734","https://openalex.org/W1925147343"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"remains":[2],"a":[3,27,125,166],"major":[4],"health":[5],"concern":[6],"throughout":[7],"history":[8],"and":[9,39,47,72,105,115,159,169,181,195,203],"is":[10,26],"responsible":[11],"for":[12,30],"huge":[13],"numbers":[14,202],"of":[15,20,78,97,117,135,197,205,216],"deaths":[16],"globally.":[17],"The":[18,109],"sensitivity":[19],"cancer":[21,57,64,67],"cells":[22,142],"to":[23,130,150,177],"anticancer":[24,182],"drugs":[25],"crucial":[28],"factor":[29],"developing":[31],"effective":[32],"treatments.":[33],"METHODS:":[34],"Pyrrolo[1,2-a]azepines":[35,163],"coupled":[36],"with":[37,165,192],"benzothiazole":[38,167],"fluorinated":[40,170],"aryl":[41,171],"thiourea":[42,122,172,210],"scaffolds":[43],"have":[44],"been":[45],"synthesized,":[46],"their":[48],"potential":[49],"as":[50,61],"cytotoxic":[51,137],"agents":[52],"was":[53,81,100],"investigated":[54],"against":[55,86,139],"different":[56],"cell":[58,89],"lines":[59],"such":[60],"human":[62],"ovarian":[63],"(SK-OV-3),":[65],"cervical":[66],"(HeLa),":[68],"colon":[69],"adenocarcinoma":[70],"(HT-29)":[71],"non-small-cell":[73],"lung":[74],"carcinoma":[75],"(A549).":[76],"Cytotoxicity":[77],"new":[79,98,146],"compounds":[80],"confirmed":[82,156],"using":[83,157],"SRB":[84],"assay":[85,138],"non-cancer":[87,140],"MDCK":[88,141],"line.":[90],"In":[91],"addition,":[92],"free":[93],"radical":[94],"scavenging":[95],"activity":[96],"pyrrolo[1,2-a]azepines":[99],"examined":[101],"by":[102],"adopting":[103],"DPPH":[104],"ABTS":[106],"assays.":[107],"RESULTS:":[108],"results":[110],"concluded":[111],"that":[112,144],"the":[113,121,136,193,198,209,213,217],"presence":[114],"position":[116,204],"fluorine":[118,206],"atom(s)":[119],"on":[120,208],"unit":[123,211],"played":[124],"significant":[126],"role":[127],"in":[128],"order":[129],"gain":[131],"anticipated":[132],"efficacies.":[133],"Results":[134],"showed":[143,187],"these":[145],"derivatives":[147],"are":[148],"safe":[149],"study":[151],"further.":[152],"New":[153,184],"structures":[154],"were":[155,174],"spectral":[158],"elemental":[160],"analyses.":[161],"CONCLUSION:":[162],"endowed":[164],"entity":[168],"substituents":[173],"derived":[175],"aiming":[176],"furnish":[178],"remarkable":[179],"antioxidant":[180],"activities.":[183],"molecules":[185],"generated":[186],"interesting":[188],"biological":[189,214],"result":[190],"correlated":[191],"structure":[194],"substituent":[196],"final":[199],"derivatives.":[200],"Specifically,":[201],"atoms":[207],"influenced":[212],"profile":[215],"mentioned":[218],"compounds.":[219]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-29T00:00:00"}